Research output per year
Research output per year
- 100 - 150 out of 257 results
Search results
-
2010
Actin-Like Protein 1 (ALP1) is a component of dynamic, high molecular weight complexes in Toxoplasma gondii
Gordon, J. L., Buguliskis, J. S., Buske, P. J. & Sibley, L. D., 2010, In: Cytoskeleton. 67, 1, p. 23-31 9 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma
Lourido, S., Shuman, J., Zhang, C., Shokat, K. M., Hui, R. & Sibley, L. D., May 20 2010, In: Nature. 465, 7296, p. 359-362 4 p.Research output: Contribution to journal › Article › peer-review
Open Access283 Scopus citations -
Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole
Miranda, K., Pace, D. A., Cintron, R., Rodrigues, J. C. F., Fang, J., Smith, A., Rohloff, P., Coelho, E., De Haas, F., De Souza, W., Coppens, I., Sibley, L. D. & Moreno, S. N. J., Jun 2010, In: Molecular Microbiology. 76, 6, p. 1358-1375 18 p.Research output: Contribution to journal › Article › peer-review
Open Access133 Scopus citations -
Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of toxoplasma gondii
Behnke, M. S., Wootton, J. C., Lehmann, M. M., Radke, J. B., Lucas, O., Nawas, J., Sibley, L. D. & White, M. W., 2010, In: PloS one. 5, 8, e12354.Research output: Contribution to journal › Article › peer-review
Open Access214 Scopus citations -
Crystallization and preliminary X-ray structural analysis of nucleoside triphosphate hydrolases from Neospora caninum and Toxoplasma gondii
Matoba, K., Shiba, T., Takeuchi, T., Sibley, L. D., Seiki, M., Kikyo, F., Horiuchi, T., Asai, T. & Harada, S., Nov 2010, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 66, 11, p. 1445-1448 4 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice
Dunay, I. R., Fuchs, A. & David Sibley, L., Apr 2010, In: Infection and immunity. 78, 4, p. 1564-1570 7 p.Research output: Contribution to journal › Article › peer-review
Open Access153 Scopus citations -
Phosphorylation of immunity-related GTPases by a toxoplasma gondii-secreted kinase promotes macrophage survival and virulence
Fentress, S. J., Behnke, M. S., Dunay, I. R., Mashayekhi, M., Rommereim, L. M., Fox, B. A., Bzik, D. J., Taylor, G. A., Turk, B. E., Lichti, C. F., Townsend, R. R., Qiu, W., Hui, R., Beatty, W. L. & Sibley, L. D., Dec 16 2010, In: Cell Host and Microbe. 8, 6, p. 484-495 12 p.Research output: Contribution to journal › Article › peer-review
Open Access262 Scopus citations -
Phosphorylation of mouse immunity-related gtpase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii
Steinfeldt, T., Könen-Waisman, S., Tong, L., Pawlowski, N., Lamkemeyer, T., Sibley, L. D., Hunn, J. P. & Howard, J. C., Dec 2010, In: PLoS biology. 8, 12, e1000576.Research output: Contribution to journal › Article › peer-review
Open Access210 Scopus citations -
Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii
Buguliskis, J. S., Brossier, F., Shuman, J. & Sibley, L. D., Apr 2010, In: PLoS pathogens. 6, 4, p. 1-14 14 p.Research output: Contribution to journal › Article › peer-review
Open Access100 Scopus citations -
Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium
Wernimont, A. K., Artz, J. D., Finerty, P., Lin, Y. H., Amani, M., Allali-Hassani, A., Senisterra, G., Vedadi, M., Tempel, W., MacKenzie, F., Chau, I., Lourido, S., Sibley, L. D. & Hui, R., May 2010, In: Nature Structural and Molecular Biology. 17, 5, p. 596-601 6 p.Research output: Contribution to journal › Article › peer-review
Open Access186 Scopus citations -
Total synthesis and configurational assignment of chondramide A
Schmauder, A., Sibley, L. D. & Maier, M. E., Apr 12 2010, In: Chemistry - A European Journal. 16, 14, p. 4328-4336 9 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin
Mehta, S. & Sibley, L. D., Feb 26 2010, In: Journal of Biological Chemistry. 285, 9, p. 6835-6847 13 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations -
2009
Aldolase Is Essential for Energy Production and Bridging Adhesin-Actin Cytoskeletal Interactions during Parasite Invasion of Host Cells
Starnes, G. L., Coincon, M., Sygusch, J. & Sibley, L. D., Apr 23 2009, In: Cell Host and Microbe. 5, 4, p. 353-364 12 p.Research output: Contribution to journal › Article › peer-review
Open Access91 Scopus citations -
Artemisone and artemiside control acute and reactivated toxoplasmosis in a murine model
Dunay, I. R., Wing, C. C., Haynes, R. K. & Sibley, L. D., Oct 2009, In: Antimicrobial agents and chemotherapy. 53, 10, p. 4450-4456 7 p.Research output: Contribution to journal › Article › peer-review
Open Access80 Scopus citations -
Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii
Qiu, W., Wernimont, A., Tang, K., Taylor, S., Lunin, V., Schapira, M., Fentress, S., Hui, R. & Sibley, L. D., Apr 8 2009, In: EMBO Journal. 28, 7, p. 969-979 11 p.Research output: Contribution to journal › Article › peer-review
Open Access62 Scopus citations -
Phenotypic and gene expression changes among clonal type i strains of toxoplasma gondit
Khan, A., Behnke, M. S., Dunay, I. R., White, M. W. & David Sibley, L., Dec 2009, In: Eukaryotic Cell. 8, 12, p. 1828-1836 9 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Selection at a single locus leads to widespread expansion of toxoplasma gondii lineages that are virulent in mice
Khan, A., Taylor, S., Ajioka, J. W., Rosenthal, B. M. & Sibley, L. D., Mar 2009, In: PLoS genetics. 5, 3Research output: Contribution to journal › Article › peer-review
Open Access115 Scopus citations -
Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages
Zhao, Y., Ferguson, D. J. P., Wilson, D. C., Howard, J. C., Sibley, L. D. & Yap, G. S., Mar 15 2009, In: Journal of Immunology. 182, 6, p. 3775-3781 7 p.Research output: Contribution to journal › Article › peer-review
Open Access122 Scopus citations -
2008
Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii
Nagamune, K., Hicks, L. M., Fux, B., Brossier, F., Chini, E. N. & Sibley, L. D., Jan 10 2008, In: Nature. 451, 7175, p. 207-210 4 p.Research output: Contribution to journal › Article › peer-review
Open Access181 Scopus citations -
A novel actin-related protein is associated with daughter cell formation in Toxoplasma gondii
Gordon, J. L., Beatty, W. L. & Sibley, L. D., Sep 2008, In: Eukaryotic Cell. 7, 9, p. 1500-1512 13 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens
Zhao, Z., Fux, B., Goodwin, M., Dunay, I. R., Strong, D., Miller, B. C., Cadwell, K., Delgado, M. A., Ponpuak, M., Green, K. G., Schmidt, R. E., Mizushima, N., Deretic, V., Sibley, L. D. & Virgin, H. W., Nov 13 2008, In: Cell Host and Microbe. 4, 5, p. 458-469 12 p.Research output: Contribution to journal › Article › peer-review
Open Access351 Scopus citations -
Calcium regulation and signaling in apicomplexan parasites
Nagamune, K., Moreno, S. N., Chini, E. N. & Sibley, L. D., 2008, In: Subcellular Biochemistry. 47, p. 70-81 12 p.Research output: Contribution to journal › Article › peer-review
96 Scopus citations -
Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii
Dunay, I. R., DaMatta, R. A., Fux, B., Presti, R., Greco, S., Colonna, M. & Sibley, L. D., Aug 15 2008, In: Immunity. 29, 2, p. 306-317 12 p.Research output: Contribution to journal › Article › peer-review
Open Access350 Scopus citations -
Microneme rhomboid protease TgROM1 is required for efficient intracellular growth of Toxoplasma gondii
Brossier, F., Starnes, G. L., Beatty, W. L. & Sibley, L. D., Apr 2008, In: Eukaryotic Cell. 7, 4, p. 664-674 11 p.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
2007
Artemisinin induces calcium-dependent protein secretion in the protozoan parasite Toxoplasma gondii
Nagamune, K., Beatty, W. L. & Sibley, L. D., Nov 2007, In: Eukaryotic Cell. 6, 11, p. 2147-2156 10 p.Research output: Contribution to journal › Article › peer-review
Open Access107 Scopus citations -
Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis
Nagamune, K., Moreno, S. N. J. & Sibley, L. D., Nov 2007, In: Antimicrobial agents and chemotherapy. 51, 11, p. 3816-3823 8 p.Research output: Contribution to journal › Article › peer-review
Open Access63 Scopus citations -
High prevalence of unusual genotypes of Toxoplasma gondii infection in pork meat samples from Erechim, Southern Brazil
Belfort-Neto, R., Nussenblatt, V., Rizzo, L., Muccioli, C., Silveira, C., Nussenblatt, R., Khan, A., David Sibley, L. & Belfort, R., Mar 2007, In: Anais da Academia Brasileira de Ciencias. 79, 1, p. 111-114 4 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations -
Recent transcontinental sweep of Toxoplasma gondii driven by a single monomorphic chromosome
Khan, A., Fux, B., Su, C., Dubey, J. P., Darde, M. L., Ajioka, J. W., Rosenthal, B. M. & Sibley, L. D., Sep 11 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 37, p. 14872-14877 6 p.Research output: Contribution to journal › Article › peer-review
Open Access166 Scopus citations -
Toxoplasma gondii strains defective in oral transmission are also defective in developmental stage differentiation
Fux, B., Nawas, J., Khan, A., Gill, D. B., Su, C. & Sibley, L. D., May 2007, In: Infection and immunity. 75, 5, p. 2580-2590 11 p.Research output: Contribution to journal › Article › peer-review
68 Scopus citations -
2006
A human origin type II strain of Toxoplasma gondii causing severe encephalitis in mice
Djurković-Djaković, O., Klun, I., Khan, A., Nikolić, A., Knežević-Ušaj, S., Bobić, B. & Sibley, L. D., Jul 2006, In: Microbes and Infection. 8, 8, p. 2206-2212 7 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii
Taylor, S., Barragan, A., Su, C., Fux, B., Fentress, S. J., Tang, K., Beatty, W. L., El Hajj, H., Jerome, M., Behnke, M. S., White, M., Wootton, J. C. & Sibley, L. D., Dec 15 2006, In: Science. 314, 5806, p. 1776-1780 5 p.Research output: Contribution to journal › Article › peer-review
442 Scopus citations -
Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii
Khan, A., Böhme, U., Kelly, K. A., Adlem, E., Brooks, K., Simmonds, M., Mungall, K., Quail, M. A., Arrowsmith, C., Chillingworth, T., Churcher, C., Harris, D., Collins, M., Fosker, N., Fraser, A., Hance, Z., Jagels, K., Moule, S., Murphy, L. & O'Neil, S. & 19 others, , 2006, In: Genome research. 16, 9, p. 1119-1125 7 p.Research output: Contribution to journal › Article › peer-review
Open Access50 Scopus citations -
Comparative genomic and phylogenetic analyses of calcium ATPases and calcium-regulated proteins in the Apicomplexa
Nagamune, K. & Sibley, L. D., Aug 2006, In: Molecular biology and evolution. 23, 8, p. 1613-1627 15 p.Research output: Contribution to journal › Article › peer-review
Open Access134 Scopus citations -
Functional and biophysical analyses of the class XIV Toxoplasma gondii Myosin D
Herm-Götz, A., Delbac, F., Weiss, S., Nyitrai, M., Stratmann, R., Tomavo, S., Sibley, L. D., Geeves, M. A. & Soldati, D., Feb 2006, In: Journal of Muscle Research and Cell Motility. 27, 2, p. 139-151 13 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Genetic divergence of Toxoplasma gondii strains associated with ocular toxoplasmosis, Brazil
Khan, A., Jordan, C., Muccioli, C., Vallochi, A. L., Rizzo, L. V., Belfort, R., Vitor, R. W. A., Silveira, C. & Sibley, L. D., 2006, In: Emerging Infectious Diseases. 12, 6, p. 942-949 8 p.Research output: Contribution to journal › Article › peer-review
Open Access241 Scopus citations -
Genotyping of toxoplasma gondii by multiplex PCR and peptide-based serological testing of samples from infants in Poland diagnosed with congenital toxoplasmosis
Nowakowska, D., Colón, I., Remington, J. S., Grigg, M., Golab, E., Wilczynski, J. & Sibley, L. D., Apr 2006, In: Journal of clinical microbiology. 44, 4, p. 1382-1389 8 p.Research output: Contribution to journal › Article › peer-review
Open Access89 Scopus citations -
Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii
Boyle, J. P., Rajasekar, B., Saeij, J. P. J., Ajioka, J. W., Berriman, M., Paulsen, I., Roos, D. S., Sibley, L. D., White, M. W. & Boothroyd, J. C., Jul 4 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 27, p. 10514-10519 6 p.Research output: Contribution to journal › Article › peer-review
Open Access109 Scopus citations -
Polymorphic secreted kinases are key virulence factors in toxoplasmosis
Saeij, J. P. J., Boyle, J. P., Coller, S., Taylor, S., Sibley, L. D., Brooke-Powell, E. T., Ajioka, J. W. & Boothroyd, J. C., Dec 15 2006, In: Science. 314, 5806, p. 1780-1783 4 p.Research output: Contribution to journal › Article › peer-review
Open Access469 Scopus citations -
Two separate, conserved acidic amino acid domains within the Toxoplasma gondii MIC2 cytoplasmic tail are required for parasite survival
Starnes, G. L., Jewett, T. J., Carruthers, V. B. & Sibley, L. D., Oct 13 2006, In: Journal of Biological Chemistry. 281, 41, p. 30745-30754 10 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii
Sahoo, N., Beatty, W., Heuser, J., Sept, D. & Sibley, L. D., Feb 2006, In: Molecular biology of the cell. 17, 2, p. 895-906 12 p.Research output: Contribution to journal › Article › peer-review
Open Access108 Scopus citations -
2005
A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma
Brossier, F., Jewett, T. J., Sibley, L. D. & Urban, S., Mar 15 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 11, p. 4146-4151 6 p.Research output: Contribution to journal › Article › peer-review
181 Scopus citations -
Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasites
Gordon, J. L. & Sibley, L. D., Dec 12 2005, In: BMC genomics. 6, 179.Research output: Contribution to journal › Article › peer-review
Open Access74 Scopus citations -
Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii
Khan, A., Taylor, S., Su, C., Mackey, A. J., Boyle, J., Cole, R., Glover, D., Tang, K., Paulsen, I. T., Berriman, M., Boothroyd, J. C., Pfefferkorn, E. R., Dubey, J. P., Ajioka, J. W., Roos, D. S., Wootton, J. C. & Sibley, L. D., 2005, In: Nucleic acids research. 33, 9, p. 2980-2992 13 p.Research output: Contribution to journal › Article › peer-review
Open Access147 Scopus citations -
Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii
Chini, E. N., Nagamune, K., Wetzel, D. M. & Sibley, L. D., Jul 15 2005, In: Biochemical Journal. 389, 2, p. 269-277 9 p.Research output: Contribution to journal › Article › peer-review
Open Access61 Scopus citations -
Genotyping of Toxoplasma gondii strains from immunocompromised patients reveals high prevalence of type I strains
Khan, A., Su, C., German, M., Storch, G. A., Clifford, D. B. & Sibley, L. D., Dec 2005, In: Journal of clinical microbiology. 43, 12, p. 5881-5887 7 p.Research output: Contribution to journal › Article › peer-review
Open Access182 Scopus citations -
Gliding motility leads to active cellular invasion by Cryptosporidium parvum sporozoites
Wetzel, D. M., Schmidt, J., Kuhlenschmidt, M. S., Dubey, J. P. & Sibley, L. D., Sep 2005, In: Infection and immunity. 73, 9, p. 5379-5387 9 p.Research output: Contribution to journal › Article › peer-review
Open Access83 Scopus citations -
Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis
Robben, P. M., LaRegina, M., Kuziel, W. A. & Sibley, L. D., Jun 6 2005, In: Journal of Experimental Medicine. 201, 11, p. 1761-1769 9 p.Research output: Contribution to journal › Article › peer-review
Open Access225 Scopus citations -
Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2
Barragan, A., Brossier, F. & Sibley, L. D., Apr 2005, In: Cellular microbiology. 7, 4, p. 561-568 8 p.Research output: Contribution to journal › Article › peer-review
Open Access157 Scopus citations -
2004
ApiEST-DB: Analyzing clustered EST data of the apicomplexan parasites
Li, L., Crabtree, J., Fischer, S., Pinney, D., Stoeckert, C. J., Sibley, L. D. & Roos, D. S., Jan 1 2004, In: Nucleic acids research. 32, DATABASE ISS., p. D326-D328Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
A role for coccidian cGMP-dependent protein kinase in motility and invasion
Wiersma, H. I., Galuska, S. E., Tomley, F. M., Sibley, L. D., Liberator, P. A. & Donald, R. G. K., Mar 9 2004, In: International Journal for Parasitology. 34, 3, p. 369-380 12 p.Research output: Contribution to journal › Article › peer-review
121 Scopus citations