L. David Sibley

Professor of Molecular Microbiology, Alan A and Edith L Wolff Distinguished Professor

    • 23389 Citations
    1984 …2020

    Research output per year

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    Personal profile

    Research interests

    We are involved in basic cellular and molecular biology studies of the parasite Toxoplasma gondii, an extremely widespread parasite that is an important opportunist pathogen in humans. Factors that predict disease severity are presently poorly understood and toxoplasmosis presents a model system for the study of genetic components that underlie pathogen virulence as well as control innate and adaptive immunity in the host. We have developed molecular methods for analyzing the genetic diversity of T. gondii in clinical isolates and are collaborating with research teams in Brazil, Africa, Asia, and Europe. These studies aim to define global patterns of genetic diversity in T. gondii as they relate to clinical toxoplasmosis. Our basic scientific investigations have identified several novel pathways that mediate parasite survival and disease potential and we are currently exploring the use of small molecule inhibitors to target these pathways, thus potentially providing improved therapies.

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    Research Output

    An important role for CD4+ T cells in adaptive immunity to Toxoplasma gondii in mice lacking the transcription factor Batf3

    Tussiwand, R., Behnke, M. S., Kretzer, N. M., Grajales-Reyes, G. E., Murphy, T. L., Schreiber, R. D., Murphy, K. M. & Sibley, L. D., Jul 1 2020, In : mSphere. 5, 4, e00634-20.

    Research output: Contribution to journalArticle

    Open Access
  • Assays for Monitoring Toxoplasma gondii Infectivity in the Laboratory Mouse

    Wang, Q. & Sibley, L. D., Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 99-116 18 p. (Methods in Molecular Biology; vol. 2071).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 1 Scopus citations

    Defining stage-specific activity of potent new inhibitors of cryptosporidium parvum growth in vitro

    Funkhouser-Jones, L. J., Ravindran, S. & Sibley, L. D., Mar 1 2020, In : mBio. 11, 2, e00052-20.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    High-Throughput Measurement of Microneme Secretion in Toxoplasma gondii

    Brown, K. M., Sibley, L. D. & Lourido, S., Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 157-169 13 p. (Methods in Molecular Biology; vol. 2071).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • In Vitro Culture of Cryptosporidium parvum Using Stem Cell-Derived Intestinal Epithelial Monolayers

    Wilke, G., Wang, Y., Ravindran, S., Stappenbeck, T., Witola, W. H. & Sibley, L. D., Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 351-372 22 p. (Methods in Molecular Biology; vol. 2052).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 2 Scopus citations