Krzysztof Hyrc

Associate Professor of Neurology

    • 1394 Citations
    1990 …2019

    Research output per year

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    Personal profile

    Research interests

    I manage Alafi Neuroimaging Laboratory, an imaging core facility, where I help users to design, perform and analyze experiments ranging from confocal/multiphoton imaging of fixed tissue to using advanced techniques such as FRET and photoactivation to monitor and/or change in living cell functions. I specialize in using fluorescent indicators to measure concentrations of free ions, especially calcium, in living cells. I am particularly interested in studying the mechanisms of maintaining calcium homeostasis and its dysregulation in neurons subjected to excitotoxic stimuli.

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    Research Output

    • 1394 Citations
    • 37 Article

    Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets

    Emfinger, C. H., Lőrincz, R., Wang, Y., York, N. W., Singareddy, S. S., Ikle, J. M., Tryon, R. C., McClenaghan, C., Shyr, Z. A., Huang, Y., Reissaus, C. A., Meyer, D., Piston, D. W., Hyrc, K., Remedi, M. S. & Nichols, C. G., Jun 2019, In : Physiological Reports. 7, 11, e14101.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagy

    Javaheri, A., Bajpai, G., Picataggi, A., Mani, S., Foroughi, L., Evie, H., Kovacs, A., Weinheimer, C. J., Hyrc, K., Xiao, Q., Ballabio, A., Lee, J. M., Matkovich, S. J., Razani, B., Schilling, J. D., Lavine, K. J. & Diwan, A., Nov 1 2019, In : JCI Insight. 4, 21, e127312.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Regulation of insulin receptor pathway and glucose metabolism by CD36 signaling

    Samovski, D., Dhule, P., Pietka, T., Jacome-Sosa, M., Penrose, E., Son, N. H., Flynn, C. R., Shoghi, K. I., Hyrc, K. L., Goldberg, I. J., Gamazon, E. R. & Abumrad, N. A., Jul 2018, In : Diabetes. 67, 7, p. 1272-1284 13 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway

    Liu, H., Javaheri, A., Godar, R. J., Murphy, J., Ma, X., Rohatgi, N., Mahadevan, J., Hyrc, K., Saftig, P., Marshall, C., McDaniel, M. L., Remedi, M. S., Razani, B., Urano, F. & Diwan, A., Nov 2 2017, In : Autophagy. 13, 11, p. 1952-1968 17 p.

    Research output: Contribution to journalArticle

  • 37 Scopus citations

    Preclinical PET imaging of glycoprotein non-metastatic melanoma B in triple negative breast cancer: Feasibility of an antibody-based companion diagnostic agent

    Marquez-Nostra, B. V., Lee, S., Laforest, R., Vitale, L., Nie, X., Hyrc, K., Keler, T., Hawthorne, T., Hoog, J., Li, S., Dehdashti, F., Ma, C. X. & Lapi, S. E., Jan 1 2017, In : Oncotarget. 8, 61, p. 104303-104314 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations