Personal profile
Research interests
Our research focuses on defining gene regulatory networks that control neural cell specification, neurogenesis, and the generation of specific neuronal cell types. We are interested in understanding how epigenetic regulation modulates these networks and how their dysregulation contributes to neurodevelopmental disorders including epilepsy and autism spectrum disorder and intellectual disability syndromes. This work uses directed differentiation of human pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells), mouse models, and a wide range of cellular, molecular, and genomic approaches, to define roles for transcriptional and epigenetic regulation in shaping developmental transitions
Mentoring
Please see the mentoring statement on our lab's website.
Available to Mentor:
- PhD Students
- Health Professions (Medical, OT, PT, Dental, Audiology, etc.) Students
- Post-Baccalaureate Students
- Postdocs
- Residents and Fellows
- Undergraduate Students
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Collaborations and top research areas from the last five years
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A survey of hypothalamic phenotypes identifies molecular and behavioral consequences of MYT1L haploinsufficiency in male and female mice
Maloney, S. E., McCullough, K. B., Chaturvedi, S. M., Selmanovic, D., Chase, R., Chen, J., Wu, S., Granadillo, J. L., Kroll, K. L. & Dougherty, J. D., Aug 2025, In: Hormones and Behavior. 174, 105796.Research output: Contribution to journal › Article › peer-review
Open Access -
Autism- and intellectual disability-associated MYT1L mutation alters human cortical interneuron differentiation, maturation, and physiology
Prakasam, R., Determan, J., Chapman, G., Narasimhan, M., Shen, R., Saleh, M., Kaushik, K., Gontarz, P., Meganathan, K., Hakim, B., Zhang, B., Huettner, J. E. & Kroll, K. L., Mar 11 2025, In: Stem Cell Reports. 20, 3, 102421.Research output: Contribution to journal › Article › peer-review
Open Access -
Lifespan in rodents with MYT1L heterozygous mutation
Schreiber, A., Swift, R. G., Wilson, L., Kroll, K. L., Dougherty, J. D. & Maloney, S. E., Dec 2025, In: Scientific reports. 15, 1, 4998.Research output: Contribution to journal › Article › peer-review
Open Access -
Requirements for the neurodevelopmental disorder-associated gene ZNF292 in human cortical interneuron development and function
Kaushik, K., Chapman, G., Prakasam, R., Batool, F., Saleh, M., Determan, J., Huettner, J. E. & Kroll, K. L., May 27 2025, In: Cell Reports. 44, 5, 115597.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Defining cis-regulatory elements and transcription factors that control human cortical interneuron development
Chapman, G., Determan, J., Jetter, H., Kaushik, K., Prakasam, R. & Kroll, K. L., Jun 21 2024, In: iScience. 27, 6, 109967.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations