Research output per year
Research output per year
Personal profile
Research interests
Our research focuses on defining gene regulatory networks that control neural cell specification, neurogenesis, and the generation of specific neuronal cell types. We are interested in understanding how epigenetic regulation modulates these networks and how their dysregulation contributes to neurodevelopmental disorders including epilepsy and autism spectrum disorder and intellectual disability syndromes. This work uses directed differentiation of human pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells), mouse models, and a wide range of cellular, molecular, and genomic approaches, to define roles for transcriptional and epigenetic regulation in shaping developmental transitions
Mentoring
Please see the mentoring statement on our lab's website.
Available to Mentor:
- PhD/MSTP Students
- Health Professions Students
- Post-Baccalaureate Students
- Postdocs
- Residents and Fellows
- Undergraduate Students
Fingerprint
Dive into the research topics where Kristen Kroll is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Defining cis-regulatory elements and transcription factors that control human cortical interneuron development
Chapman, G., Determan, J., Jetter, H., Kaushik, K., Prakasam, R. & Kroll, K. L., Jun 21 2024, In: iScience. 27, 6, 109967.Research output: Contribution to journal › Article › peer-review
Open Access -
Duplication Versus Deletion Through the Lens of 15q13.3: Clinical and Research Implications of Studying Copy Number Variants Associated with Neuropsychiatric Disorders in Induced Pluripotent Stem Cell-Derived Neurons
Antony, I., Narasimhan, M., Shen, R., Prakasam, R., Kaushik, K., Chapman, G. & Kroll, K. L., Apr 2023, In: Stem Cell Reviews and Reports. 19, 3, p. 639-650 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Can the “female protective effect” liability threshold model explain sex differences in autism spectrum disorder?
Dougherty, J., Marrus, N., Maloney, S. E., Yip, B., Sandin, S., Turner, T., Selmanovic, D., Kroll, K. L., Gutmann, D. H., Constantino, J. & Weiss, L. A., Oct 19 2022, In: Neuron. 110, 20, p. 3243-3262 20 p.Research output: Contribution to journal › Review article › peer-review
Open Access17 Scopus citations -
Cellular and molecular neurobiology of autism spectrum disorder
Chapman, G., Antony, I., Narasimhan, M., Shen, R., Elman, R. & Kroll, K. L., Jan 1 2022, The Neuroscience of Autism. Elsevier, p. 215-244 30 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
2 Scopus citations -
Derivation of cortical interneurons from human pluripotent stem cells to model neurodevelopmental disorders
Meganathan, K., Prakasam, R., Kaushik, K., Antony, I., Chapman, G. & Kroll, K. L., Jan 1 2022, Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research. Elsevier, p. 45-72 28 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review