Research output per year
Research output per year
Personal profile
Research interests
We are interested in understanding how embryonic and embryonic stem (ES) cells regulate self-renewal, lineage commitment, and differentiation and are studying these questions in the context of vertebrate neural development. A major focus of our work is on chromatin regulatory proteins, including the SWI-SNF and Polycomb complexes and the novel protein Geminin. These complexes critically regulate transcription to control self-renewal and differentiation in multiple cell contexts. They also regulate cell cycle progression and maintain genome integrity and their dysregulation is a pivotal aspect of multiple human malignancies.
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Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders
Cross-IDDRC Human Stem Cell Working Group, Jun 8 2021, In: Stem Cell Reports. 16, 6, p. 1446-1457 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
Epigenetic regulation during human cortical development: Seq-ing answers from the brain to the organoid
Lewis, E. M. A., Kaushik, K., Sandoval, L. A., Antony, I., Dietmann, S. & Kroll, K. L., Jul 2021, In: Neurochemistry International. 147, 105039.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Geminin is required for Hox gene regulation to pattern the developing limb
Lewis, E. M. A., Sankar, S., Tong, C., Patterson, E. S., Waller, L. E., Gontarz, P., Zhang, B., Ornitz, D. M. & Kroll, K. L., Aug 1 2020, In: Developmental Biology. 464, 1, p. 11-23 13 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
A translational rheostat integrates euchromatin regulation and growth of pluripotent embryonic cells
Meganathan, K., Prakasam, R. & Kroll, K. L., May 21 2019, In: Stem Cell Investigation. 6, MayResearch output: Contribution to journal › Comment/debate
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Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons
Lewis, E. M. A., Meganathan, K., Baldridge, D., Gontarz, P., Zhang, B., Bonni, A., Constantino, J. N. & Kroll, K. L., Dec 30 2019, In: Molecular Autism. 10, 1, 51.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations