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Personal profile

Research interests

We are interested in understanding how embryonic and embryonic stem (ES) cells regulate self-renewal, lineage commitment, and differentiation and are studying these questions in the context of vertebrate neural development. A major focus of our work is on chromatin regulatory proteins, including the SWI-SNF and Polycomb complexes and the novel protein Geminin. These complexes critically regulate transcription to control self-renewal and differentiation in multiple cell contexts. They also regulate cell cycle progression and maintain genome integrity and their dysregulation is a pivotal aspect of multiple human malignancies.

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Research Output

  • 2937 Citations
  • 32 Article
  • 6 Review article
  • 2 Chapter
  • 2 Comment/debate

Geminin is required for Hox gene regulation to pattern the developing limb

Lewis, E. M. A., Sankar, S., Tong, C., Patterson, E. S., Waller, L. E., Gontarz, P., Zhang, B., Ornitz, D. M. & Kroll, K. L., Aug 1 2020, In : Developmental Biology. 464, 1, p. 11-23 13 p.

Research output: Contribution to journalArticle

  • A translational rheostat integrates euchromatin regulation and growth of pluripotent embryonic cells

    Meganathan, K., Prakasam, R. & Kroll, K. L., May 21 2019, In : Stem Cell Investigation. 6, May

    Research output: Contribution to journalComment/debate

    Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons

    Lewis, E. M. A., Meganathan, K., Baldridge, D., Gontarz, P., Zhang, B., Bonni, A., Constantino, J. N. & Kroll, K. L., Dec 30 2019, In : Molecular Autism. 10, 1, 51.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Development and disease in a dish: The epigenetics of neurodevelopmental disorders

    Lewis, E. M. A. & Kroll, K. L., Feb 2018, In : Epigenomics. 10, 2, p. 219-231 13 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors

    Sankar, S., Patterson, E., Lewis, E. M., Waller, L. E., Tong, C., Dearborn, J., Wozniak, D., Rubin, J. B. & Kroll, K. L., Sep 2017, In : Genes and Cancer. 8, 9-10, p. 725-744 20 p.

    Research output: Contribution to journalArticle

    Open Access