Research output per year
Research output per year
Personal profile
Research interests
We are interested in understanding how embryonic and embryonic stem (ES) cells regulate self-renewal, lineage commitment, and differentiation and are studying these questions in the context of vertebrate neural development. A major focus of our work is on chromatin regulatory proteins, including the SWI-SNF and Polycomb complexes and the novel protein Geminin. These complexes critically regulate transcription to control self-renewal and differentiation in multiple cell contexts. They also regulate cell cycle progression and maintain genome integrity and their dysregulation is a pivotal aspect of multiple human malignancies.
Mentoring
Please see the mentoring statement on our lab's website.
Available to Mentor:
- PhD/MSTP Students
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Duplication Versus Deletion Through the Lens of 15q13.3: Clinical and Research Implications of Studying Copy Number Variants Associated with Neuropsychiatric Disorders in Induced Pluripotent Stem Cell-Derived Neurons
Antony, I., Narasimhan, M., Shen, R., Prakasam, R., Kaushik, K., Chapman, G. & Kroll, K. L., Apr 2023, In: Stem Cell Reviews and Reports. 19, 3, p. 639-650 12 p.Research output: Contribution to journal › Review article › peer-review
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Can the “female protective effect” liability threshold model explain sex differences in autism spectrum disorder?
Dougherty, J., Marrus, N., Maloney, S. E., Yip, B., Sandin, S., Turner, T., Selmanovic, D., Kroll, K. L., Gutmann, D. H., Constantino, J. & Weiss, L. A., Oct 19 2022, In: Neuron. 110, 20, p. 3243-3262 20 p.Research output: Contribution to journal › Review article › peer-review
Open Access5 Scopus citations -
Cellular and molecular neurobiology of autism spectrum disorder
Chapman, G., Antony, I., Narasimhan, M., Shen, R., Elman, R. & Kroll, K. L., Jan 1 2022, The Neuroscience of Autism. Elsevier, p. 215-244 30 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Scopus citations -
Derivation of cortical interneurons from human pluripotent stem cells to model neurodevelopmental disorders
Meganathan, K., Prakasam, R., Kaushik, K., Antony, I., Chapman, G. & Kroll, K. L., Jan 1 2022, Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research. Elsevier, p. 45-72 28 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Regulation of human cortical interneuron development by the chromatin remodeling protein CHD2
Lewis, E. M. A., Chapman, G., Kaushik, K., Determan, J., Antony, I., Meganathan, K., Narasimhan, M., Gontarz, P., Zhang, B. & Kroll, K. L., Dec 2022, In: Scientific reports. 12, 1, 15636.Research output: Contribution to journal › Article › peer-review
Open Access