Research Output per year
Personal profile
Research interests
We are interested in understanding how embryonic and embryonic stem (ES) cells regulate self-renewal, lineage commitment, and differentiation and are studying these questions in the context of vertebrate neural development. A major focus of our work is on chromatin regulatory proteins, including the SWI-SNF and Polycomb complexes and the novel protein Geminin. These complexes critically regulate transcription to control self-renewal and differentiation in multiple cell contexts. They also regulate cell cycle progression and maintain genome integrity and their dysregulation is a pivotal aspect of multiple human malignancies.
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Research Output
Geminin is required for Hox gene regulation to pattern the developing limb
Lewis, E. M. A., Sankar, S., Tong, C., Patterson, E. S., Waller, L. E., Gontarz, P., Zhang, B., Ornitz, D. M. & Kroll, K. L., Aug 1 2020, In : Developmental Biology. 464, 1, p. 11-23 13 p.Research output: Contribution to journal › Article
A translational rheostat integrates euchromatin regulation and growth of pluripotent embryonic cells
Meganathan, K., Prakasam, R. & Kroll, K. L., May 21 2019, In : Stem Cell Investigation. 6, MayResearch output: Contribution to journal › Comment/debate
Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons
Lewis, E. M. A., Meganathan, K., Baldridge, D., Gontarz, P., Zhang, B., Bonni, A., Constantino, J. N. & Kroll, K. L., Dec 30 2019, In : Molecular Autism. 10, 1, 51.Research output: Contribution to journal › Article
Open Access
2
Scopus
citations
Development and disease in a dish: The epigenetics of neurodevelopmental disorders
Lewis, E. M. A. & Kroll, K. L., Feb 2018, In : Epigenomics. 10, 2, p. 219-231 13 p.Research output: Contribution to journal › Review article
1
Scopus
citations
Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors
Sankar, S., Patterson, E., Lewis, E. M., Waller, L. E., Tong, C., Dearborn, J., Wozniak, D., Rubin, J. B. & Kroll, K. L., Sep 2017, In : Genes and Cancer. 8, 9-10, p. 725-744 20 p.Research output: Contribution to journal › Article
Open Access