Kory Lavine

Associate Professor of Medicine, Associate Professor of Developmental Biology, Associate Professor of Pathology and Immunology

    • 4113 Citations

    Research output per year

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    Personal profile

    Research interests

    Heart failure is the leading cause of mortality in the industrial world. Current therapies aim to minimize the extent of maladaptive remodeling. A wealth of basic and clinical studies implicate that overactivity of ß-adrenergic, angiotensin and aldosterone signaling contributes to pathologic remodeling and blockade of these pathways improves cardiac function and long term survival. Despite these interventions many patients will eventually progress to end stage heart failure and the need for cardiac transplantation is a common outcome. These unfortunate results underscore the need for an improved understanding of how the heart responds to injury, identification of novel drug targets and further development of such therapies. Our group has developed novel animal models of cardiac injury to study a critically important and poorly understood process, cardiac recovery. Using these models, we aim to uncover the molecular mechanisms governing this essential process and identify new therapeutics for the treatment of heart failure.

    Areas of Clinical Interest

    Advanced heart failure, cardiac transplantation, circulatory assist devices.

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    Research Output

  • Eosinophils Confer Protection Following Myocardial Infarction

    Lavine, K. J., Jul 2020, In : JACC: Basic to Translational Science. 5, 7, p. 682-684 3 p.

    Research output: Contribution to journalEditorial

    Open Access

    Heterogeneous origins and functions of mouse skeletal muscle-resident macrophages

    Wang, X., Sathe, A. A., Smith, G. R., Ruf-Zamojski, F., Nair, V., Lavine, K. J., Xing, C., Sealfon, S. C. & Zhou, L., Aug 25 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 34, p. 20729-20740 12 p.

    Research output: Contribution to journalArticle

  • ImmGen at 15

    The Immunological Genome Project, Jul 1 2020, In : Nature immunology. 21, 7, p. 700-703 4 p.

    Research output: Contribution to journalComment/debate

    Open Access