Research output per year
Research output per year
Personal profile
Research interests
The overall goal of our research program is “Precision Medicine for Prostate Cancer: Developing novel therapeutics to prevent metastasis by targeting critical transcriptional networks”. The goal is to identify and characterize novel epigenetic readers/modifiers/transcription factors promoting drug resistance and metastasis of prostate cancers (PC). We have identified key transcription factor (TF) regulated networks driving proliferation of metastatic PCs. These networks serve as an important quantitative readout for TF functionality in the clinical space. Working in collaboration with Medicinal Chemists and Structural Biologists, we have recently identified several novel small molecule epigenetic inhibitors that have the potential to inhibit the expression of the TF, its networks and inhibit the growth of metastatic PCs. The eventual goal is to advance these biomarkers and novel therapeutics into clinical trials.
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Collaborations and top research areas from the last five years
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Epigenetic reprogramming of cell cycle genes by ACK1 promotes breast cancer resistance to CDK4/6 inhibitor
Sawant, M., Wilson, A., Sridaran, D., Mahajan, K., O’Conor, C. J., Hagemann, I. S., Luo, J., Weimholt, C., Li, T., Roa, J. C., Pandey, A., Wu, X. & Mahajan, N. P., Jul 14 2023, In: Oncogene. 42, 29, p. 2263-2277 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer
Nguyen, T., Sridaran, D., Chouhan, S., Weimholt, C., Wilson, A., Luo, J., Li, T., Koomen, J., Fang, B., Putluri, N., Sreekumar, A., Feng, F. Y., Mahajan, K. & Mahajan, N. P., Dec 2023, In: Nature communications. 14, 1, 3357.Research output: Contribution to journal › Article › peer-review
Open Access -
Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer
Nguyen, D. T., Yang, W., Renganathan, A., Weimholt, C., Angappulige, D. H., Nguyen, T., Sprung, R. W., Andriole, J., Kim, E. H., Mahajan, N. P. & Mahajan, K., Sep 15 2022, In: Clinical Cancer Research. 28, 18, p. 4131-4145 15 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting
Sawant, M., Mahajan, K., Renganathan, A., Weimholt, C., Luo, J., Kukshal, V., Jez, J. M., Jeon, M. S., Zhang, B., Li, T., Fang, B., Luo, Y., Lawrence, N. J., Lawrence, H. R., Feng, F. Y. & Mahajan, N. P., Jun 15 2022, In: Science translational medicine. 14, 649, eabg4132.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance
Sridaran, D., Chouhan, S., Mahajan, K., Renganathan, A., Weimholt, C., Bhagwat, S., Reimers, M., Kim, E. H., Thakur, M. K., Saeed, M. A., Pachynski, R. K., Seeliger, M. A., Todd Miller, W., Feng, F. Y. & Mahajan, N. P., Dec 2022, In: Nature communications. 13, 1, 6929.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations