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Kenneth Murphy

Professor of Pathology and Immunology, Howard Hughes Medical Institute Investigator in Pathology and Immunology, Eugene Opie First Centennial Professor of Pathology and Immunology

    • 49557 Citations
    1976 …2020

    Research output per year

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    Research interests

    The major theme of the laboratory is the study of lineage commitment programs within the immune system. The vertebrate immune system has innate and adaptive components, differing in the diversity of the molecular targets they recognize. Innate immunity is triggered by relatively few conserved molecular features derived from pathogens. Adaptive immunity is concerned with recognizing a greatly increased spectrum of molecules, through the generation of a highly diverse set of antigen receptors expressed on T and B lymphocytes. Our laboratory is interested in understanding the regulatory mechanisms controlling the development of cell lineages within both arms of the immune response. Specifically, current projects include the development of dendritic cells, macrophages, and neutrophils from common precursors, the transcriptional basis for T helper subset differentiation, and the identification of novel receptors and signaling molecules involved in regulating dendritic cell function. Finally, newer projects include the study of earlier fate decisions during embryonic development, such as the mechanisms that generate mesoderm, from which the entire immune system is derived.

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    Research Output

    An important role for CD4+ T cells in adaptive immunity to Toxoplasma gondii in mice lacking the transcription factor Batf3

    Tussiwand, R., Behnke, M. S., Kretzer, N. M., Grajales-Reyes, G. E., Murphy, T. L., Schreiber, R. D., Murphy, K. M. & Sibley, L. D., Jul 1 2020, In : mSphere. 5, 4, e00634-20.

    Research output: Contribution to journal › Article

    Open Access

    • cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity

    Ferris, S. T., Durai, V., Wu, R., Theisen, D. J., Ward, J. P., Bern, M. D., Davidson, J. T., Bagadia, P., Liu, T., Briseño, C. G., Li, L., Gillanders, W., Wu, G. F., Yokoyama, W. M., Murphy, T. L., Schreiber, R. D. & Murphy, K. M., Aug 27 2020, In : Nature. 584, 7822, p. 624-629 6 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Chikungunya Virus Evades Antiviral CD8+ T Cell Responses To Establish Persistent Infection in Joint-Associated Tissues

    Davenport, B. J., Bullock, C., McCarthy, M. K., Hawman, D. W., Murphy, K. M., Kedl, R. M., Diamond, M. S. & Morrison, T. E., Apr 16 2020, In : Journal of virology. 94, 9

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

    Hegde, S., Krisnawan, V. E., Herzog, B. H., Zuo, C., Breden, M. A., Knolhoff, B. L., Hogg, G. D., Tang, J. P., Baer, J. M., Mpoy, C., Lee, K. B., Alexander, K. A., Rogers, B. E., Murphy, K. M., Hawkins, W. G., Fields, R. C., DeSelm, C. J., Schwarz, J. K. & DeNardo, D. G., Mar 16 2020, In : Cancer Cell. 37, 3, p. 289-307.e9

    Research output: Contribution to journal › Article

    Open Access
    • 14 Scopus citations

    Genetic models of human and mouse dendritic cell development and function

    Anderson, D. A., Dutertre, C. A., Ginhoux, F. & Murphy, K. M., 2020, (Accepted/In press) In : Nature Reviews Immunology.

    Research output: Contribution to journal › Review article