Search results

  • 2024

    A novel method for rapid estimation of active bone marrow dose for radiotherapy patients in epidemiological studies

    Yeom, Y. S., Braunstein, L., Morton, L. M., Bolton, K. L., Choi, J. W., Choi, H. Y., Greenstein, N. & Lee, C., Jun 2024, In: Medical physics. 51, 6, p. 4472-4481 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • ArCH: improving the performance of clonal hematopoiesis variant calling and interpretation

    Chan, I. C. C., Panchot, A., Schmidt, E., McNulty, S., Wiley, B. J., Liu, J., Turner, K., Moukarzel, L., Wong, W. S. W., Tran, D., Beeler, J. S., Batchi-Bouyou, A. L., Machiela, M. J., Karyadi, D. M., Krajacich, B. J., Zhao, J., Kruglyak, S., Lajoie, B., Levy, S. & Patel, M. & 6 others, Kantoff, P. W., Mason, C. E., Link, D. C., Druley, T., Stopsack, K. H. & Bolton, K. L., Apr 1 2024, In: Bioinformatics. 40, 4, btae121.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Donor-Derived Malignancy and Transplantation Morbidity: Risks of Patient and Donor Genetics in Allogeneic Hematopoietic Stem Cell Transplantation

    Williams, L. S., Williams, K. M., Gillis, N., Bolton, K., Damm, F., Deuitch, N. T., Farhadfar, N., Gergis, U., Keel, S. B., Michelis, F. V., Panch, S. R., Porter, C. C., Sucheston-Campbell, L., Tamari, R., Stefanski, H. E., Godley, L. A. & Lai, C., Mar 2024, In: Transplantation and Cellular Therapy. 30, 3, p. 255-267 13 p.

    Research output: Contribution to journalReview articlepeer-review

    2 Scopus citations
  • Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight

    Garcia-Medina, J. S., Sienkiewicz, K., Narayanan, S. A., Overbey, E. G., Grigorev, K., Ryon, K. A., Burke, M., Proszynski, J., Tierney, B., Schmidt, C. M., Mencia-Trinchant, N., Klotz, R., Ortiz, V., Foox, J., Chin, C., Najjar, D., Matei, I., Chan, I., Cruchaga, C. & Kleinman, A. & 23 others, Kim, J. K., Lucaci, A., Loy, C., Mzava, O., De Vlaminck, I., Singaraju, A., Taylor, L. E., Schmidt, J. C., Schmidt, M. A., Blease, K., Moreno, J., Boddicker, A., Zhao, J., Lajoie, B., Altomare, A., Kruglyak, S., Levy, S., Yu, M., Hassane, D. C., Bailey, S. M., Bolton, K., Mateus, J. & Mason, C. E., Mar 1 2024, In: Precision Clinical Medicine. 7, 1, pbae007.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • Phenotypic heterogeneity associated with a novel MECOM variant: Mild thrombocytopenia to hydrops fetalis

    Jaspersen, S. L., Stacy, A. V., McGlynn, M. C., Gooch, C. F., Wilson, D. & Bolton, K. L., Jul 2024, In: Pediatric Blood and Cancer. 71, 7, e30991.

    Research output: Contribution to journalLetterpeer-review

  • Predicting cytopenias, progression, and survival in patients with clonal cytopenia of undetermined significance: a prospective cohort study

    Cargo, C., Bernard, E., Beinortas, T., Bolton, K. L., Glover, P., Warren, H., Payne, D., Ali, R., Khan, A., Short, M., Van Hoppe, S., Smith, A., Taylor, J., Evans, P., Papaemmanuil, E. & Crouch, S., Jan 2024, In: The Lancet Haematology. 11, 1, p. e51-e61

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations
  • 2023

    Clinical Importance of Clonal Hematopoiesis in Metastatic Gastrointestinal Tract Cancers

    Diplas, B. H., Ptashkin, R., Chou, J. F., Sabwa, S., Foote, M. B., Rousseau, B., Argilés, G., White, J. R., Stewart, C. M., Bolton, K., Chalasani, S. B., Desai, A. M., Goldberg, Z., Gu, P., Li, J., Shcherba, M., Zervoudakis, A., Cercek, A., Yaeger, R. & Segal, N. H. & 7 others, Ilson, D. H., Ku, G. Y., Zehir, A., Capanu, M., Janjigian, Y. Y., Diaz, L. A. & Maron, S. B., Feb 2 2023, In: JAMA Network Open. 6, 2, e2254221.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • Clonal Hematopoiesis and Risk of Incident Lung Cancer

    Tian, R., Wiley, B., Liu, J., Zong, X., Truong, B., Zhao, S., Uddin, M. M., Niroula, A., Miller, C. A., Mukherjee, S., Heiden, B. T., Luo, J., Puri, V., Kozower, B. D., Walter, M. J., Ding, L., Link, D. C., Amos, C. I., Ebert, B. L. & Govindan, R. & 3 others, Natarajan, P., Bolton, K. L. & Cao, Y., Mar 1 2023, In: Journal of Clinical Oncology. 41, 7, p. 1423-1433 11 p.

    Research output: Contribution to journalArticlepeer-review

    12 Scopus citations
  • Clonal hematopoiesis in survivors of childhood cancer

    Friedman, D. N., Chan, I. C. C., Moskowitz, C. S., Li, S., Turner, K., Liu, J., Bouvier, N., Walsh, M. F., Spitzer, B., Kung, A. L., Berger, M., Cooper, M. A., Pusic, I., Uy, G., Link, D., Druley, T. E., Diaz, L. A., Levine, R. L., Shukla, N. & Bolton, K. L., Aug 8 2023, In: Blood Advances. 7, 15, p. 4102-4106 5 p.

    Research output: Contribution to journalLetterpeer-review

    Open Access
    7 Scopus citations
  • Genetic causes and cardiovascular consequences of clonal hematopoiesis in the UK Biobank

    Beeler, J. S., Bick, A. G. & Bolton, K. L., Jan 2023, In: Nature Cardiovascular Research. 2, 1, p. 13-15 3 p.

    Research output: Contribution to journalComment/debate

    Open Access
    2 Scopus citations
  • Germline predisposition to clonal hematopoiesis

    Liu, J., Osman, A. E. G., Bolton, K. & Godley, L. A., Sep 2023, In: Leukemia Research. 132, 107344.

    Research output: Contribution to journalReview articlepeer-review

    1 Scopus citations
  • How low can you go? Methodologic considerations in clonal hematopoiesis variant calling

    Beeler, J. S. & Bolton, K. L., Dec 2023, In: Leukemia Research. 135, 107419.

    Research output: Contribution to journalArticlepeer-review

  • Tracking the evolution of therapy-related myeloid neoplasms using chemotherapy signatures

    Diamond, B., Ziccheddu, B., Maclachlan, K., Taylor, J., Boyle, E., Ossa, J. A., Jahn, J., Affer, M., Totiger, T. M., Coffey, D., Chandhok, N., Watts, J., Cimmino, L., Lu, S. X., Bolli, N., Bolton, K., Landau, H., Park, J. H., Ganesh, K. & McPherson, A. & 13 others, Sekeres, M. A., Lesokhin, A., Chung, D. J., Zhang, Y., Ho, C., Roshal, M., Tyner, J., Nimer, S., Papaemmanuil, E., Usmani, S., Morgan, G., Landgren, O. & Maura, F., May 11 2023, In: Blood. 141, 19, p. 2359-2371 13 p.

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations
  • Tumor Genomic Profile Is Associated With Arterial Thromboembolism Risk in Patients With Solid Cancer

    Feldman, S., Gupta, D., Navi, B. B., Grace Ho, K. W., Willeit, P., Devlin, S., Bolton, K. L., Arcila, M. E. & Mantha, S., Apr 2023, In: JACC: CardioOncology. 5, 2, p. 246-255 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    6 Scopus citations
  • 2022

    Association of clonal hematopoiesis mutations with clinical outcomes: A systematic review and meta-analysis

    Nowakowska, M. K., Kim, T., Thompson, M. T., Bolton, K. L., Deswal, A., Lin, S. H., Scheet, P., Wehner, M. R. & Nead, K. T., Apr 2022, In: American journal of hematology. 97, 4, p. 411-420 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    13 Scopus citations
  • Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia

    Spitzer, B., Rutherford, K. D., Gundem, G., McGovern, E. M., Millard, N. E., Arango, J. E. O., Cheung, I. Y., Gao, T., Levine, M. F., Zhang, Y., Medina-Martínez, J. S., Feng, Y., Ptashkin, R. N., Bolton, K. L., Farnoud, N., Zhou, Y., Patel, M. A., Asimomitis, G., Cobbs, C. C. & Mohibullah, N. & 10 others, Huberman, K. H., Arcilla, M. E., Kushner, B. H., Modak, S., Kung, A. L., Zehir, A., Levine, R. L., Armstron, S. A., Cheung, N. K. V. & Papaemmanuil, E., Apr 15 2022, In: Clinical Cancer Research. 28, 8, p. 1614-1627 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    4 Scopus citations
  • DNAMethylation Profiles of Ovarian Clear Cell Carcinoma

    Cunningham, J. M., Winham, S. J., Wang, C., Weiglt, B., Fu, Z., Armasu, S. M., McCauley, B. M., Brand, A. H., Chiew, Y. E., Elishaev, E., Gourley, C., Kennedy, C. J., Laslavic, A., Lester, J., Piskorz, A., Sekowska, M., Brenton, J. D., Churchman, M., DeFazio, A. & Drapkin, R. & 10 others, Elias, K. M., Huntsman, D. G., Karlan, B. Y., Kobel, M., Konner, J., Lawrenson, K., Papaemmanuil, E., Bolton, K. L., Modugno, F. & Goode, E. L., Jan 2022, In: Cancer Epidemiology Biomarkers and Prevention. 31, 1, p. 132-141 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    13 Scopus citations
  • Effect of Clonal Hematopoiesis on Cardiovascular Disease in People Living with HIV

    Wiley, B., Parsons, T. M., Burkart, S., Young, A. L., Erlandson, K. M., Tassiopoulos, K. K., Wu, K., Gurnett, C., Presti, R. M., Bolton, K. L. & Challen, G. A., Oct 2022, In: Experimental Hematology. 114, p. 18-21 4 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    9 Scopus citations
  • Estimation of intrafamilial DNA contamination in family trio genome sequencing using deviation from Mendelian inheritance

    Yoon, C. J., Kim, S. Y., Nam, C. H., Lee, J., Park, J. W., Mun, J., Park, S., Lee, S., Yi, B., Min, K. I., Wiley, B., Bolton, K. L., Lee, J. H., Kim, E., Yoo, H. J., Jun, J. K., Choi, J. S., Griffith, M., Griffith, O. L. & Ju, Y. S., Nov 2022, In: Genome research. 32, 11-12, p. 2134-2144 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes

    Bolton, K. L., Chen, D., de la Fuente, R. C., Fu, Z., Murali, R., Köbel, M., Tazi, Y., Cunningham, J. M., Chan, I. C. C., Wiley, B. J., Moukarzel, L. A., Winham, S. J., Armasu, S. M., Lester, J., Elishaev, E., Laslavic, A., Kennedy, C. J., Piskorz, A., Sekowska, M. & Brand, A. H. & 18 others, Chiew, Y. E., Pharoah, P., Elias, K. M., Drapkin, R., Churchman, M., Gourley, C., DeFazio, A., Karlan, B., Brenton, J. D., Weigelt, B., Anglesio, M. S., Huntsman, D., Gayther, S., Konner, J., Modugno, F., Lawrenson, K., Goode, E. L. & Papaemmanuil, E., Nov 15 2022, In: Clinical Cancer Research. 28, 22, p. 4947-4956 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    24 Scopus citations
  • The proteome of clear cell ovarian carcinoma

    Ji, J. X., Cochrane, D. R., Negri, G. L., Colborne, S., Spencer Miko, S. E., Hoang, L. N., Farnell, D., Tessier-Cloutier, B., Huvila, J., Thompson, E., Leung, S., Chiu, D., Chow, C., Ta, M., Köbel, M., Feil, L., Anglesio, M., Goode, E. L., Bolton, K. & Morin, G. B. & 1 others, Huntsman, D. G., Dec 2022, In: Journal of Pathology. 258, 4, p. 325-338 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    7 Scopus citations
  • Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value in endometriosis-associated ovarian carcinomas

    Heinze, K., Nazeran, T. M., Lee, S., Krämer, P., Cairns, E. S., Chiu, D. S., Leung, S. C. Y., Kang, E. Y., Meagher, N. S., Kennedy, C. J., Boros, J., Kommoss, F., Vollert, H. W., Heitz, F., du Bois, A., Harter, P., Grube, M., Kraemer, B., Staebler, A. & Kommoss, F. K. F. & 62 others, Heublein, S., Sinn, H. P., Singh, N., Laslavic, A., Elishaev, E., Olawaiye, A., Moysich, K., Modugno, F., Sharma, R., Brand, A. H., Harnett, P. R., DeFazio, A., Fortner, R. T., Lubinski, J., Lener, M., Tołoczko-Grabarek, A., Cybulski, C., Gronwald, H., Gronwald, J., Coulson, P., El-Bahrawy, M. A., Jones, M. E., Schoemaker, M. J., Swerdlow, A. J., Gorringe, K. L., Campbell, I., Cook, L., Gayther, S. A., Carney, M. E., Shvetsov, Y. B., Hernandez, B. Y., Wilkens, L. R., Goodman, M. T., Mateoiu, C., Linder, A., Sundfeldt, K., Kelemen, L. E., Gentry-Maharaj, A., Widschwendter, M., Menon, U., Bolton, K. L., Alsop, J., Shah, M., Jimenez-Linan, M., Pharoah, P. D. P., Brenton, J. D., Cushing-Haugen, K. L., Harris, H. R., Doherty, J. A., Gilks, B., Ghatage, P., Huntsman, D. G., Nelson, G. S., Tinker, A. V., Lee, C. H., Goode, E. L., Nelson, B. H., Ramus, S. J., Kommoss, S., Talhouk, A., Köbel, M. & Anglesio, M. S., Apr 2022, In: Journal of Pathology. 256, 4, p. 388-401 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    13 Scopus citations
  • What Clonal Hematopoiesis Can Teach Us About MDS

    Chan, I. C. C., Wiley, B. J. & Bolton, K. L., Feb 8 2022, In: Frontiers in Oncology. 12, 794021.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    1 Scopus citations
  • 2021

    Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (Nature Medicine, (2020), 26, 10, (1549-1556), 10.1038/s41591-020-1008-z)

    Bernard, E., Nannya, Y., Hasserjian, R. P., Devlin, S. M., Tuechler, H., Medina-Martinez, J. S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M. F., Arango, J. E., Zhou, Y., Solé, F., Cargo, C. A., Haase, D., Creignou, M., Germing, U., Zhang, Y. & Gundem, G. & 60 others, Sarian, A., van de Loosdrecht, A. A., Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M. Y., Thol, F., Pinheiro, R. F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F. P. S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J. M., Klimek, V. M., Savona, M. R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Della Porta, M. G., Elias, H. K., Smith, A. G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D. S., Stevenson, K. E., Menghrajani, K., Bolton, K. L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M. T., Shih, L. Y., Fontenay, M., Jansen, J. H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B. L., Bejar, R., Greenberg, P. L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S. & Papaemmanuil, E., May 2021, In: Nature medicine. 27, 5, p. 927 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
    2 Scopus citations
  • Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (Nature Medicine, (2020), 26, 10, (1549-1556), 10.1038/s41591-020-1008-z)

    Bernard, E., Nannya, Y., Hasserjian, R. P., Devlin, S. M., Tuechler, H., Medina-Martinez, J. S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M. F., Arango, J. E., Zhou, Y., Solé, F., Cargo, C. A., Haase, D., Creignou, M., Germing, U., Zhang, Y. & Gundem, G. & 59 others, Sarian, A., van de Loosdrecht, A. A., Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M. Y., Thol, F., Pinheiro, R. F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F. P. S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J. M., Klimek, V. M., Savona, M. R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Della Porta, M. G., Smith, A. G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D. S., Stevenson, K. E., Menghrajani, K., Bolton, K. L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M. T., Shih, L. Y., Fontenay, M., Jansen, J. H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B. L., Bejar, R., Greenberg, P. L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S. & Papaemmanuil, E., Mar 2021, In: Nature medicine. 27, 3, p. 562 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
    2 Scopus citations
  • Clonal hematopoiesis is associated with risk of severe Covid-19

    Bolton, K. L., Koh, Y., Foote, M. B., Im, H., Jee, J., Sun, C. H., Safonov, A., Ptashkin, R., Moon, J. H., Lee, J. Y., Jung, J., Kang, C. K., Song, K. H., Choe, P. G., Park, W. B., Kim, H. B., Oh, M. D., Song, H., Kim, S. & Patel, M. & 25 others, Derkach, A., Gedvilaite, E., Tkachuk, K. A., Wiley, B. J., Chan, I. C., Braunstein, L. Z., Gao, T., Papaemmanuil, E., Esther Babady, N., Pessin, M. S., Kamboj, M., Diaz, L. A., Ladanyi, M., Rauh, M. J., Natarajan, P., Machiela, M. J., Awadalla, P., Joseph, V., Offit, K., Norton, L., Berger, M. F., Levine, R. L., Kim, E. S., Kim, N. J. & Zehir, A., Dec 1 2021, In: Nature communications. 12, 1, 5975.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    66 Scopus citations
  • Erratum: Clonal hematopoiesis before, during, and after human spaceflight (Cell Reports (2020) 33(10), (S2211124720314479), (10.1016/j.celrep.2020.108458))

    Mencia-Trinchant, N., MacKay, M. J., Chin, C., Afshinnekoo, E., Foox, J., Meydan, C., Butler, D., Mozsary, C., Vernice, N. A., Darby, C., Schatz, M. C., Bailey, S. M., Melnick, A. M., Guzman, M. L., Bolton, K., Braunstein, L. Z., Garrett-Bakelman, F., Levine, R. L., Hassane, D. C. & Mason, C. E., Feb 9 2021, In: Cell Reports. 34, 6, 108740.

    Research output: Contribution to journalComment/debate

    Open Access
    4 Scopus citations
  • Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors

    Dunbar, A., Bolton, K. L., Devlin, S. M., Sanchez-Vega, F., Gao, J., Mones, J. V., Wills, J., Kelly, D., Farina, M., Cordner, K. B., Park, Y., Kishore, S., Juluru, K., Iyengar, N. M., Levine, R. L., Zehir, A., Park, W., Khorana, A. A., Soff, G. A. & Mantha, S., Apr 15 2021, In: Blood. 137, 15, p. 2103-2113 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    56 Scopus citations
  • Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

    Gao, T., Ptashkin, R., Bolton, K. L., Sirenko, M., Fong, C., Spitzer, B., Menghrajani, K., Ossa, J. E. A., Zhou, Y., Bernard, E., Levine, M., Martinez, J. S. M., Zhang, Y., Franch-Expósito, S., Patel, M., Braunstein, L. Z., Kelly, D., Yabe, M., Benayed, R. & Caltabellotta, N. M. & 11 others, Philip, J., Paraiso, E., Mantha, S., Solit, D. B., Diaz, L. A., Berger, M. F., Klimek, V., Levine, R. L., Zehir, A., Devlin, S. M. & Papaemmanuil, E., Dec 2021, In: Nature communications. 12, 1, 338.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    62 Scopus citations
  • The clinical implications of clonal hematopoiesis in hematopoietic cell transplantation

    Nawas, M. T., Schetelig, J., Damm, F., Levine, R. L., Perales, M. A., Giralt, S. A., VanDenBrink, M. R., Arcila, M. E., Zehir, A., Papaemmanuil, E., Klussmeier, A., Schmidt, A. H., Maiwald, S., Bolton, K. L. & Tamari, R., Mar 2021, In: Blood Reviews. 46, 100744.

    Research output: Contribution to journalReview articlepeer-review

    17 Scopus citations
  • 2020

    Cancer therapy shapes the fitness landscape of clonal hematopoiesis

    Bolton, K. L., Ptashkin, R. N., Gao, T., Braunstein, L., Devlin, S. M., Kelly, D., Patel, M., Berthon, A., Syed, A., Yabe, M., Coombs, C. C., Caltabellotta, N. M., Walsh, M., Offit, K., Stadler, Z., Mandelker, D., Schulman, J., Patel, A., Philip, J. & Bernard, E. & 44 others, Gundem, G., Ossa, J. E. A., Levine, M., Martinez, J. S. M., Farnoud, N., Glodzik, D., Li, S., Robson, M. E., Lee, C., Pharoah, P. D. P., Stopsack, K. H., Spitzer, B., Mantha, S., Fagin, J., Boucai, L., Gibson, C. J., Ebert, B. L., Young, A. L., Druley, T., Takahashi, K., Gillis, N., Ball, M., Padron, E., Hyman, D. M., Baselga, J., Norton, L., Gardos, S., Klimek, V. M., Scher, H., Bajorin, D., Paraiso, E., Benayed, R., Arcila, M. E., Ladanyi, M., Solit, D. B., Berger, M. F., Tallman, M., Garcia-Closas, M., Chatterjee, N., Diaz, L. A., Levine, R. L., Morton, L. M., Zehir, A. & Papaemmanuil, E., Nov 1 2020, In: Nature Genetics. 52, 11, p. 1219-1226 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    333 Scopus citations
  • Chemotherapy and COVID-19 Outcomes in Patients with Cancer

    Jee, J., Foote, M. B., Lumish, M., Stonestrom, A. J., Wills, B., Narendra, V., Avutu, V., Murciano-Goroff, Y. R., Chan, J. E., Derkach, A., Philip, J., Belenkaya, R., Kerpelev, M., Maloy, M., Watson, A., Fong, C., Janjigian, Y., Diaz, L. A., Bolton, K. L. & Pessin, M. S., Oct 20 2020, In: Journal of Clinical Oncology. 38, 30, p. 3538-3546 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    191 Scopus citations
  • Clonal Hematopoiesis Before, During, and After Human Spaceflight

    Trinchant, N. M., MacKay, M. J., Chin, C., Afshinnekoo, E., Foox, J., Meydan, C., Butler, D., Mozsary, C., Vernice, N. A., Darby, C., Schatz, M. C., Bailey, S. M., Melnick, A. M., Guzman, M., Bolton, K., Braunstein, L. Z., Garrett-Bakelman, F., Levine, R. L., Hassane, D. & Mason, C. E., Dec 8 2020, In: Cell Reports. 33, 10, 108458.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    27 Scopus citations
  • Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

    Bernard, E., Nannya, Y., Hasserjian, R. P., Devlin, S. M., Tuechler, H., Medina-Martinez, J. S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M. F., Arango, J. E., Zhou, Y., Solé, F., Cargo, C. A., Haase, D., Creignou, M., Germing, U., Zhang, Y. & Gundem, G. & 59 others, Sarian, A., van de Loosdrecht, A. A., Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M. Y., Thol, F., Pinheiro, R. F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F. P. S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J. M., Klimek, V. M., Savona, M. R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Della Porta, M. G., Smith, A. G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D. S., Stevenson, K. E., Menghrajani, K., Bolton, K. L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M. T., Shih, L. Y., Fontenay, M., Jansen, J. H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B. L., Bejar, R., Greenberg, P. L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S. & Papaemmanuil, E., Oct 1 2020, In: Nature medicine. 26, 10, p. 1549-1556 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    351 Scopus citations
  • Single-cell mutation analysis of clonal evolution in myeloid malignancies

    Miles, L. A., Bowman, R. L., Merlinsky, T. R., Csete, I. S., Ooi, A. T., Durruthy-Durruthy, R., Bowman, M., Famulare, C., Patel, M. A., Mendez, P., Ainali, C., Demaree, B., Delley, C. L., Abate, A. R., Manivannan, M., Sahu, S., Goldberg, A. D., Bolton, K. L., Zehir, A. & Rampal, R. & 4 others, Carroll, M. P., Meyer, S. E., Viny, A. D. & Levine, R. L., Nov 19 2020, In: Nature. 587, 7834, p. 477-482 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    258 Scopus citations
  • The Clinical Challenge of Clonal Hematopoiesis, a Newly Recognized Cardiovascular Risk Factor

    Sidlow, R., Lin, A. E., Gupta, D., Bolton, K. L., Steensma, D. P., Levine, R. L., Ebert, B. L. & Libby, P., Aug 2020, In: JAMA Cardiology. 5, 8, p. 958-961 4 p.

    Research output: Contribution to journalReview articlepeer-review

    31 Scopus citations
  • The Clinical Management of Clonal Hematopoiesis: Creation of a Clonal Hematopoiesis Clinic

    Bolton, K. L., Zehir, A., Ptashkin, R. N., Patel, M., Gupta, D., Sidlow, R., Papaemmanuil, E., Berger, M. F. & Levine, R. L., Apr 2020, In: Hematology/Oncology Clinics of North America. 34, 2, p. 357-367 11 p.

    Research output: Contribution to journalReview articlepeer-review

    40 Scopus citations
  • What to tell your patient with clonal hematopoiesis and why: insights from 2 specialized clinics

    Steensma, D. P. & Bolton, K. L., Oct 2020, In: Blood. 136, 14, p. 1623-1631 9 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    42 Scopus citations
  • 2019

    Clonal Hematopoiesis: Crossroads of Aging, Cardiovascular Disease, and Cancer: JACC Review Topic of the Week

    Libby, P., Sidlow, R., Lin, A. E., Gupta, D., Jones, L. W., Moslehi, J., Zeiher, A., Jaiswal, S., Schulz, C., Blankstein, R., Bolton, K. L., Steensma, D., Levine, R. L. & Ebert, B. L., Jul 30 2019, In: Journal of the American College of Cardiology. 74, 4, p. 567-577 11 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    145 Scopus citations
  • Managing clonal hematopoiesis in patients with solid tumors

    Bolton, K. L., Gillis, N. K., Coombs, C. C., Takahashi, K., Zehir, A., Bejar, R., Garcia-Manero, G., Futreal, A., Jensen, B. C., Diaz, L. A., Gupta, D., Mantha, S., Klimek, V., Papaemmanuil, E., Levine, R. & Padron, E., Jan 1 2019, In: Journal of Clinical Oncology. 37, 1, p. 7-11 5 p.

    Research output: Contribution to journalComment/debate

    Open Access
    47 Scopus citations
  • 2018

    Identification of clonal hematopoiesis mutations in solid tumor patients undergoing unpaired next-generation sequencing assays

    Coombs, C. C., Gillis, N. K., Tan, X., Berg, J. S., Ball, M., Balasis, M. E., Montgomery, N. D., Bolton, K. L., Parker, J. S., Mesa, T. E., Yoder, S. J., Hayward, M. C., Patel, N. M., Richards, K. L., Walko, C. M., Knepper, T. C., Soper, J. T., Weiss, J., Grilley-Olson, J. E. & Kim, W. Y. & 6 others, Shelton Earp, H., Levine, R. L., Papaemmanuil, E., Zehir, A., Neil Hayes, D. & Padron, E., Dec 1 2018, In: Clinical Cancer Research. 24, 23, p. 5918-5924 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    71 Scopus citations
  • Prevalence of clonal hematopoiesis mutations in tumor-only clinical genomic profiling of solid tumors

    Ptashkin, R. N., Mandelker, D. L., Coombs, C. C., Bolton, K., Yelskaya, Z., Hyman, D. M., Solit, D. B., Baselga, J., Arcila, M. E., Ladanyi, M., Zhang, L., Levine, R. L., Berger, M. F. & Zehir, A., Nov 2018, In: JAMA oncology. 4, 11, p. 1589-1593 5 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    127 Scopus citations
  • 2015

    Erratum: Common variants at 19p13 are associated with susceptibility to ovarian cancer (Nature Genetics (2010) 42 (880-884))

    Bolton, K. L., Tyrer, J., Song, H., Ramus, S. J., Notaridou, M., Jones, C., Sher, T., Gentry-Maharaj, A., Wozniak, E., Tsai, Y. Y., Weidhaas, J., Paik, D., Van Den Berg, D. J., Stram, D. O., Pearce, C. L., Wu, A. H., Brewster, W., Anton-Culver, H., Ziogas, A., Narod, S. A., & 96 othersLevine, D. A., Kaye, S. B., Brown, R., Paul, J., Flanagan, J., Sieh, W., Mcguire, V., Whittemore, A. S., Campbell, I., Gore, M. E., Lissowska, J., Yang, H. P., Medrek, K., Gronwald, J., Lubinski, J., Jakubowska, A., Le, N. D., Cook, L. S., Kelemen, L. E., Brooks-Wilson, A., Massuger, L. F. A. G., Kiemeney, L. A., Aben, K. K. H., Van Altena, A. M., Houlston, R., Tomlinson, I., Palmieri, R. T., Moorman, P. G., Schildkraut, J., Iversen, E. S., Phelan, C., Vierkant, R. A., Cunningham, J. M., Goode, E. L., Fridley, B. L., Kruger-Kjaer, S., Blaeker, J., Hogdall, E., Hogdall, C., Gross, J., Karlan, B. Y., Ness, R. B., Edwards, R. P., Odunsi, K., Moyisch, K. B., Baker, J. A., Modugno, F., Heikkinenen, T., Butzow, R., Nevanlinna, H., Leminen, A., Bogdanova, N., Antonenkova, N., Doerk, T., Hillemanns, P., Dürst, M., Runnebaum, I., Thompson, P. J., Carney, M. E., Goodman, M. T., Lurie, G., Wang-Gohrke, S., Hein, R., Chang-Claude, J., Rossing, M. A., Cushing-Haugen, K. L., Doherty, J., Chen, C., Rafnar, T., Besenbacher, S., Sulem, P., Stefansson, K., Birrer, M. J., Terry, K. L., Hernandez, D., Cramer, D. W., Vergote, I., Amant, F., Lambrechts, D., Despierre, E., Fasching, P. A., Beckmann, M. W., Thiel, F. C., Ekici, A. B., Chen, X., Johnatty, S. E., Webb, P. M., Beesley, J., Chanock, S., Garcia-Closas, M., Sellers, T., Easton, D. F., Berchuck, A., Chenevix-Trench, G., Pharoah, P. D. P. & Gayther, S. A., Dec 29 2015, In: Nature Genetics. 48, 1, p. 101 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • Open Access
    125 Scopus citations
  • 2014

    Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

    Wang, Z., Zhu, B., Zhang, M., Parikh, H., Jia, J., Chung, C. C., Sampson, J. N., Hoskins, J. W., Hutchinson, A., Burdette, L., Ibrahim, A., Hautman, C., Raj, P. S., Abnet, C. C., Adjei, A. A., Ahlbom, A., Albanes, D., Allen, N. E., Ambrosone, C. B. & Aldrich, M. & 331 others, Amiano, P., Amos, C., Andersson, U., Gerald Andriole, G. A., Andrulis, I. L., Arici, C., Arslan, A. A., Austin, M. A., Baris, D., Barkauskas, D. A., Bassig, B. A., Freeman, L. E. B., Berg, C. D., Berndt, S. I., Bertazzi, P. A., Biritwum, R. B., Black, A., Blot, W., Boeing, H., Boffetta, P., Bolton, K., Boutron-Ruault, M. C., Bracci, P. M., Brennan, P., Brinton, L. A., Brotzman, M., Bueno-de-Mesquita, H. B., Buring, J. E., Butler, M. A., Cai, Q., Cancel-Tassin, G., Canzian, F., Cao, G., Caporaso, N. E., Carrato, A., Carreon, T., Carta, A., Chang, G. C., Chang, I. S., Chang-Claude, J., Che, X., Chen, C. J., Chen, C. Y., Chen, C. H., Chen, C., Chen, K. Y., Chen, Y. M., Chokkalingam, A. P., Chu, L. W., Clavel-Chapelon, F., Colditz, G. A., Colt, J. S., Conti, D., Cook, M. B., Cortessis, V. K., Crawford, E. D., Cussenot, O., Davis, F. G., De Vivo, I., Deng, X., Ding, T., Dinney, C. P., Di Stefano, A. L., Diver, W. R., Duell, E. J., Elena, J. W., Fan, J. H., Feigelson, H. S., Feychting, M., Figueroa, J. D., Flanagan, A. M., Fraumeni, J. F., Freedman, N. D., Fridley, B. L., Fuchs, C. S., Gago-Dominguez, M., Gallinger, S., Gao, Y. T., Gapstur, S. M., Garcia-Closas, M., Garcia-Closas, R., Gastier-Foster, J. M., Gaziano, J. M., Gerhard, D. S., Giffen, C. A., Giles, G. G., Gillanders, E. M., Giovannucci, E. L., Goggins, M., Gokgoz, N., Goldstein, A. M., Gonzalez, C., Gorlick, R., Greene, M. H., Gross, M., Grossman, H. B., Grubb, R., Gu, J., Guan, P., Haiman, C. A., Hallmans, G., Hankinson, S. E., Harris, C. C., Hartge, P., Hattinger, C., Hayes, R. B., He, Q., Helman, L., Henderson, B. E., Henriksson, R., Hoffman-Bolton, J., Hohensee, C., Holly, E. A., Hong, Y. C., Hoover, R. N., Dean Hosgood, H., Hsiao, C. F., Hsing, A. W., Hsiung, C. A., Hu, N., Hu, W., Hu, Z., Huang, M. S., Hunter, D. J., Inskip, P. D., Ito, H., Jacobs, E. J., Jacobs, K. B., Jenab, M., Ji, B. T., Johansen, C., Johansson, M., Johnson, A., Kaaks, R., Kamat, A. M., Kamineni, A., Karagas, M., Khanna, C., Khaw, K. T., Kim, C., Kim, I. S., Kim, J. H., Kim, Y. H., Kim, Y. C., Kim, Y. T., Kang, C. H., Jung, Y. J., Kitahara, C. M., Klein, A. P., Klein, R., Kogevinas, M., Koh, W. P., Kohno, T., Kolonel, L. N., Kooperberg, C., Kratz, C. P., Krogh, V., Kunitoh, H., Kurtz, R. C., Kurucu, N., Lan, Q., Lathrop, M., Lau, C. C., Lecanda, F., Lee, K. M., Lee, M. P., Marchand, L. L., Lerner, S. P., Li, D., Liao, L. M., Lim, W. Y., Lin, D., Lin, J., Lindstrom, S., Linet, M. S., Lissowska, J., Liu, J., Ljungberg, B., Lloreta, J., Lu, D., Ma, J., Malats, N., Mannisto, S., Marina, N., Mastrangelo, G., Matsuo, K., McGlynn, K. A., McKean-Cowdin, R., McNeil, L. H., McWilliams, R. R., Melin, B. S., Meltzer, P. S., Mensah, J. E., Miao, X., Michaud, D. S., Mondul, A. M., Moore, L. E., Muir, K., Niwa, S., Olson, S. H., Orr, N., Panico, S., Park, J. Y., Patel, A. V., Patino-Garcia, A., Pavanello, S., Peeters, P. H. M., Peplonska, B., Peters, U., Petersen, G. M., Picci, P., Pike, M. C., Porru, S., Prescott, J., Pu, X., Purdue, M. P., Qiao, Y. L., Rajaraman, P., Riboli, E., Risch, H. A., Rodabough, R. J., Rothman, N., Ruder, A. M., Ryu, J. S., Sanson, M., Schned, A., Schumacher, F. R., Schwartz, A. G., Schwartz, K. L., Schwenn, M., Scotlandi, K., Seow, A., Serra, C., Serra, M., Sesso, H. D., Severi, G., Shen, H., Shen, M., Shete, S., Shiraishi, K., Shu, X. O., Siddiq, A., Sierrasesumaga, L., Sierri, S., Sihoe, A. D. L., Silverman, D. T., Simon, M., Southey, M. C., Spector, L., Spitz, M., Stampfer, M., Stattin, P., Stern, M. C., Stevens, V. L., Stolzenberg-Solomon, R. Z., Stram, D. O., Strom, S. S., Su, W. C., Sund, M., Sung, S. W., Swerdlow, A., Tan, W., Tanaka, H., Tang, W., Tang, Z. Z., Tardon, A., Tay, E., Taylor, P. R., Tettey, Y., Thomas, D. M., Tirabosco, R., Tjonneland, A., Tobias, G. S., Toro, J. R., Travis, R. C., Trichopoulos, D., Troisi, R., Truelove, A., Tsai, Y. H., Tucker, M. A., Tumino, R., Van Den Berg, D., Van Den Eeden, S. K., Vermeulen, R., Vineis, P., Visvanathan, K., Vogel, U., Wang, C., Wang, C., Wang, J., Wang, S. S., Weiderpass, E., Weinstein, S. J., Wentzensen, N., Wheeler, W., White, E., Wiencke, J. K., Wolk, A., Wolpin, B. M., Wong, M. P., Wrensch, M., Wu, C., Wu, T., Wu, X., Wu, Y. L., Wunder, J. S., Xiang, Y. B., Xu, J., Yang, H. P., Yang, P. C., Yatabe, Y., Ye, Y., Yeboah, E. D., Yin, Z., Ying, C., Yu, C. J., Yu, K., Yuan, J. M., Zanetti, K. A., Zeleniuch-Jacquotte, A., Zheng, W., Zhou, B., Mirabello, L., Savage, S. A., Kraft, P., Chanock, S. J., Yeager, M., Landi, M. T., Shi, J., Chatterjee, N. & Amundadottir, L. T., Nov 15 2014, In: Human molecular genetics. 23, 24, p. 6616-6633 18 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    83 Scopus citations
  • 2012

    Association between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer

    Bolton, K. L., Chenevix-Trench, G., Goh, C., Sadetzki, S., Ramus, S. J., Karlan, B. Y., Lambrechts, D., Despierre, E., Barrowdale, D., McGuffog, L., Healey, S., Easton, D. F., Sinilnikova, O., Benítez, J., García, M. J., Neuhausen, S., Gail, M. H., Hartge, P., Peock, S. & Frost, D. & 55 others, Evans, D. G., Eeles, R., Godwin, A. K., Daly, M. B., Kwong, A., Ma, E. S. K., Lázaro, C., Blanco, I., Montagna, M., D'Andrea, E., Nicoletto, M. O., Johnatty, S. E., Kjær, S. K., Jensen, A., Høgdall, E., Goode, E. L., Fridley, B. L., Loud, J. T., Greene, M. H., Mai, P. L., Chetrit, A., Lubin, F., Hirsh-Yechezkel, G., Glendon, G., Andrulis, I. L., Toland, A. E., Senter, L., Gore, M. E., Gourley, C., Michie, C. O., Song, H., Tyrer, J., Whittemore, A. S., McGuire, V., Sieh, W., Kristoffersson, U., Olsson, H., Borg, Å., Levine, D. A., Steele, L., Beattie, M. S., Chan, S., Nussbaum, R. L., Moysich, K. B., Gross, J., Cass, I., Walsh, C., Li, A. J., Leuchter, R., Gordon, O., Garcia-Closas, M., Gayther, S. A., Chanock, S. J., Antoniou, A. C. & Pharoah, P. D. P., Jan 25 2012, In: JAMA. 307, 4, p. 382-390 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    531 Scopus citations
  • Gene set analysis of survival following ovarian cancer implicates macrolide binding and intracellular signaling genes

    Fridley, B. L., Jenkins, G. D., Tsai, Y. Y., Song, H., Bolton, K. L., Fenstermacher, D., Tyrer, J., Ramus, S. J., Cunningham, J. M., Vierkant, R. A., Chen, Z., Chen, Y. A., Iversen, E., Menon, U., Gentry-Maharaj, A., Schildkraut, J., Sutphen, R., Gayther, S. A., Hartmann, L. C. & Pharoah, P. D. P. & 2 others, Sellers, T. A. & Goode, E. L., Mar 2012, In: Cancer Epidemiology Biomarkers and Prevention. 21, 3, p. 529-536 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    7 Scopus citations
  • Role of common genetic variants in ovarian cancer susceptibility and outcome: Progress to date from the ovarian cancer association consortium (OCAC)

    Bolton, K. L., Ganda, C., Berchuck, A., Pharaoh, P. D. P. & Gayther, S. A., Apr 2012, In: Journal of Internal Medicine. 271, 4, p. 366-378 13 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    47 Scopus citations
  • 2011

    A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival

    Batra, J., Nagle, C. M., O'Mara, T., Higgins, M., Dong, Y., Tan, O. L., Lose, F., Skeie, L. M., Srinivasan, S., Bolton, K. L., Song, H., Ramus, S. J., Gayther, S. A., Pharoah, P. D. P., Kedda, M. A., Spurdle, A. B. & Clements, J. A., Apr 1 2011, In: BMC Cancer. 11, 119.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    23 Scopus citations