Kelly Bolton

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Kelly Bolton

Assistant Professor of Medicine

 https://orcid.org/0000-0001-6584-3357

    Willing to Mentor

    Available to Mentor:

    PhD/MSTP Students

    • 4781
      Citations
    20062025

    Research activity per year

    Search results

    • 2025

      A blueprint for pursuing therapeutic interventions and early phase clinical trials in clonal haematopoiesis

      Haque, T., Shastri, A., Desai, P., Xie, Z., Hammond, D., King, Z., Kishtagari, A., Madanat, Y. F., Abaza, Y., Silver, A. J., Singh, A., Borate, U. M., Heimlich, J. B., Slosky, D. A., Bolton, K. L., Patnaik, M. S., Bick, A. G., Verma, A. K., Jaiswal, S. & Steensma, D. P. & 1 others, Savona, M. R., Feb 2025, In: British Journal of Haematology. 206, 2, p. 416-427 12 p.

      Research output: Contribution to journal › Review article › peer-review

      2 Scopus citations
    • 2024

      A novel method for rapid estimation of active bone marrow dose for radiotherapy patients in epidemiological studies

      Yeom, Y. S., Braunstein, L., Morton, L. M., Bolton, K. L., Choi, J. W., Choi, H. Y., Greenstein, N. & Lee, C., Jun 2024, In: Medical physics. 51, 6, p. 4472-4481 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • ArCH: improving the performance of clonal hematopoiesis variant calling and interpretation

      Chan, I. C. C., Panchot, A., Schmidt, E., McNulty, S., Wiley, B. J., Liu, J., Turner, K., Moukarzel, L., Wong, W. S. W., Tran, D., Beeler, J. S., Batchi-Bouyou, A. L., Machiela, M. J., Karyadi, D. M., Krajacich, B. J., Zhao, J., Kruglyak, S., Lajoie, B., Levy, S. & Patel, M. & 6 others, Kantoff, P. W., Mason, C. E., Link, D. C., Druley, T. E., Stopsack, K. H. & Bolton, K. L., Apr 1 2024, In: Bioinformatics. 40, 4, btae121.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      3 Scopus citations

    • Clinical and Therapeutic Implications of Clonal Hematopoiesis

      Petrone, G., Turker, I., Natarajan, P. & Bolton, K. L., Aug 27 2024, In: Annual Review of Genomics and Human Genetics. 25, 1, p. 329-351 23 p.

      Research output: Contribution to journal › Review article › peer-review

      Open Access
      5 Scopus citations

    • Clonal Hematopoiesis and Clinical Outcomes in Metastatic Castration-Resistant Prostate Cancer Patients Given Androgen Receptor Pathway Inhibitors (Alliance A031201)

      Jensen, J. L., Bobek, O., Chan, I. C. C., Miller, B. C., Hillman, D. W., Heller, G., Druley, T., Armstrong, A. J., Morris, M. J., Milowsky, M. I., Beltran, H., Bolton, K. L. & Coombs, C. C., Nov 1 2024, In: Clinical Cancer Research. 30, 21, p. 4910-4919 10 p.

      Research output: Contribution to journal › Article › peer-review

      2 Scopus citations

    • Donor-Derived Malignancy and Transplantation Morbidity: Risks of Patient and Donor Genetics in Allogeneic Hematopoietic Stem Cell Transplantation

      Williams, L. S., Williams, K. M., Gillis, N., Bolton, K., Damm, F., Deuitch, N. T., Farhadfar, N., Gergis, U., Keel, S. B., Michelis, F. V., Panch, S. R., Porter, C. C., Sucheston-Campbell, L., Tamari, R., Stefanski, H. E., Godley, L. A. & Lai, C., Mar 2024, In: Transplantation and Cellular Therapy. 30, 3, p. 255-267 13 p.

      Research output: Contribution to journal › Review article › peer-review

      13 Scopus citations

    • Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight

      Garcia-Medina, J. S., Sienkiewicz, K., Narayanan, S. A., Overbey, E. G., Grigorev, K., Ryon, K. A., Burke, M., Proszynski, J., Tierney, B., Schmidt, C. M., Mencia-Trinchant, N., Klotz, R., Ortiz, V., Foox, J., Chin, C., Najjar, D., Matei, I., Chan, I., Cruchaga, C. & Kleinman, A. & 23 others, Kim, J. K., Lucaci, A., Loy, C., Mzava, O., De Vlaminck, I., Singaraju, A., Taylor, L. E., Schmidt, J. C., Schmidt, M. A., Blease, K., Moreno, J., Boddicker, A., Zhao, J., Lajoie, B., Altomare, A., Kruglyak, S., Levy, S., Yu, M., Hassane, D. C., Bailey, S. M., Bolton, K., Mateus, J. & Mason, C. E., Mar 1 2024, In: Precision Clinical Medicine. 7, 1, pbae007.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      12 Scopus citations

    • Impact of cancer therapy on clonal hematopoiesis mutations and subsequent clinical outcomes

      Nead, K. T., Kim, T., Joo, L. J., McDowell, T. L., Wong, J. W., Chan, I. C. C., Brock, E., Zhao, J., Xu, T., Tang, C., Lee, C. L., Abe, J. I., Bolton, K. L., Liao, Z., Scheet, P. A. & Lin, S. H., Oct 8 2024, In: Blood Advances. 8, 19, p. 5215-5224 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      5 Scopus citations

    • Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions

      AOCS Group, OPAL Study Group, The Ovarian Cancer Association Consortium (OCAC), Dareng, E. O., Coetzee, S. G., Tyrer, J. P., Peng, P. C., Rosenow, W., Chen, S., Davis, B. D., Dezem, F. S., Seo, J. H., Nameki, R., Reyes, A. L., Aben, K. K. H., Anton-Culver, H., Antonenkova, N. N., Aravantinos, G., Bandera, E. V. & Beane Freeman, L. E. & 136 others, Beckmann, M. W., Beeghly-Fadiel, A., Benitez, J., Bernardini, M. Q., Bjorge, L., Black, A., Bogdanova, N. V., Bolton, K. L., Brenton, J. D., Budzilowska, A., Butzow, R., Cai, H., Campbell, I., Cannioto, R., Chang-Claude, J., Chanock, S. J., Chen, K., Chenevix-Trench, G., Chiew, Y. E., Cook, L. S., DeFazio, A., Dennis, J., Doherty, J. A., Dörk, T., du Bois, A., Dürst, M., Eccles, D. M., Ene, G., Fasching, P. A., Flanagan, J. M., Fortner, R. T., Fostira, F., Gentry-Maharaj, A., Giles, G. G., Goodman, M. T., Gronwald, J., Haiman, C. A., Håkansson, N., Heitz, F., Hildebrandt, M. A. T., Høgdall, E., Høgdall, C. K., Huang, R. Y., Jensen, A., Jones, M. E., Kang, D., Karlan, B. Y., Karnezis, A. N., Kelemen, L. E., Kennedy, C. J., Khusnutdinova, E. K., Kiemeney, L. A., Kjaer, S. K., Kupryjanczyk, J., Labrie, M., Lambrechts, D., Larson, M. C., Le, N. D., Lester, J., Li, L., Lubiński, J., Lush, M., Marks, J. R., Matsuo, K., May, T., McLaughlin, J. R., McNeish, I. A., Menon, U., Missmer, S., Modugno, F., Moffitt, M., Monteiro, A. N., Moysich, K. B., Narod, S. A., Nguyen-Dumont, T., Odunsi, K., Olsson, H., Onland-Moret, N. C., Park, S. K., Pejovic, T., Permuth, J. B., Piskorz, A., Prokofyeva, D., Riggan, M. J., Risch, H. A., Rodríguez-Antona, C., Rossing, M. A., Sandler, D. P., Setiawan, V. W., Shan, K., Song, H., Southey, M. C., Steed, H., Sutphen, R., Swerdlow, A. J., Teo, S. H., Terry, K. L., Thompson, P. J., Vestrheim Thomsen, L. C., Titus, L., Trabert, B., Travis, R., Tworoger, S. S., Valen, E., Van Nieuwenhuysen, E., Edwards, D. V., Vierkant, R. A., Webb, P. M., Weinberg, C. R., Weise, R. M., Wentzensen, N., White, E., Winham, S. J., Wolk, A., Woo, Y. L., Wu, A. H., Yan, L., Yannoukakos, D., Zeinomar, N., Zheng, W., Ziogas, A., Berchuck, A., Goode, E. L., Huntsman, D. G., Pearce, C. L., Ramus, S. J., Sellers, T. A., Freedman, M. L., Lawrenson, K., Schildkraut, J. M., Hazelett, D., Plummer, J. T., Kar, S., Jones, M. R., Pharoah, P. D. P. & Gayther, S. A., Jun 6 2024, In: American journal of human genetics. 111, 6, p. 1061-1083 23 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      7 Scopus citations

    • Phenotypic heterogeneity associated with a novel MECOM variant: Mild thrombocytopenia to hydrops fetalis

      Jaspersen, S. L., Stacy, A. V., McGlynn, M. C., Gooch, C. F., Wilson, D. & Bolton, K. L., Jul 2024, In: Pediatric Blood and Cancer. 71, 7, e30991.

      Research output: Contribution to journal › Letter › peer-review

    • Plasma Proteomic Signature Predicts Myeloid Neoplasm Risk

      Tran, D., Beeler, J. S., Liu, J., Wiley, B., Chan, I. C. C., Xin, Z., Kramer, M. H., Batchi-Bouyou, A. L., Zong, X., Walter, M. J., Petrone, G. E. M., Chlamydas, S., Ferraro, F., Oh, S. T., Link, D. C., Busby, B., Cao, Y. & Bolton, K. L., Aug 1 2024, In: Clinical Cancer Research. 30, 15, p. 3220-3228 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      4 Scopus citations

    • Predicting cytopenias, progression, and survival in patients with clonal cytopenia of undetermined significance: a prospective cohort study

      Cargo, C., Bernard, E., Beinortas, T., Bolton, K. L., Glover, P., Warren, H., Payne, D., Ali, R., Khan, A., Short, M., Van Hoppe, S., Smith, A., Taylor, J., Evans, P., Papaemmanuil, E. & Crouch, S., Jan 2024, In: The Lancet Haematology. 11, 1, p. e51-e61

      Research output: Contribution to journal › Article › peer-review

      14 Scopus citations

    • Social, Behavioral, and Clinical Risk Factors Are Associated with Clonal Hematopoiesis

      Young, C. D., Hubbard, A. K., Saint-Maurice, P. F., Chan, I. C. C., Cao, Y., Tran, D., Bolton, K. L., Chanock, S. J., Matthews, C. E., Moore, S. C., Loftfield, E. & Machiela, M. J., Nov 1 2024, In: Cancer Epidemiology Biomarkers and Prevention. 33, 11, p. 1423-1432 10 p.

      Research output: Contribution to journal › Article › peer-review

      1 Scopus citations

    • The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

      Overbey, E. G., Kim, J. K., Tierney, B. T., Park, J., Houerbi, N., Lucaci, A. G., Garcia Medina, S., Damle, N., Najjar, D., Grigorev, K., Afshin, E. E., Ryon, K. A., Sienkiewicz, K., Patras, L., Klotz, R., Ortiz, V., MacKay, M., Schweickart, A., Chin, C. R. & Sierra, M. A. & 89 others, Valenzuela, M. F., Dantas, E., Nelson, T. M., Cekanaviciute, E., Deards, G., Foox, J., Narayanan, S. A., Schmidt, C. M., Schmidt, M. A., Schmidt, J. C., Mullane, S., Tigchelaar, S. S., Levitte, S., Westover, C., Bhattacharya, C., Lucotti, S., Wain Hirschberg, J., Proszynski, J., Burke, M., Kleinman, A. S., Butler, D. J., Loy, C., Mzava, O., Lenz, J., Paul, D., Mozsary, C., Sanders, L. M., Taylor, L. E., Patel, C. O., Khan, S. A., Suhail Mohamad, M., Byhaqui, S. G. A., Aslam, B., Gajadhar, A. S., Williamson, L., Tandel, P., Yang, Q., Chu, J., Benz, R. W., Siddiqui, A., Hornburg, D., Blease, K., Moreno, J., Boddicker, A., Zhao, J., Lajoie, B., Scott, R. T., Gilbert, R. R., Lai Polo, S. H., Altomare, A., Kruglyak, S., Levy, S., Ariyapala, I., Beer, J., Zhang, B., Hudson, B. M., Rininger, A., Church, S. E., Beheshti, A., Church, G. M., Smith, S. M., Crucian, B. E., Zwart, S. R., Matei, I., Lyden, D. C., Garrett-Bakelman, F., Krumsiek, J., Chen, Q., Miller, D., Shuga, J., Williams, S., Nemec, C., Trudel, G., Pelchat, M., Laneuville, O., De Vlaminck, I., Gross, S., Bolton, K. L., Bailey, S. M., Granstein, R., Furman, D., Melnick, A. M., Costes, S. V., Shirah, B., Yu, M., Menon, A. S., Mateus, J., Meydan, C. & Mason, C. E., Aug 29 2024, In: Nature. 632, 8027, p. 1145-1154 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      32 Scopus citations

    • Unraveling facets of MECOM-associated syndrome: somatic genetic rescue, clonal hematopoiesis, and phenotype expansion

      Venugopal, P., Arts, P., Fox, L. C., Simons, A., Hiwase, D. K., Bardy, P. G., Swift, A., Ross, D. M., van Vulpen, L. F. D., Buijs, A., Bolton, K. L., Getta, B., Furlong, E., Carter, T., Krapels, I., Hoeks, M., Al Kindy, A., Al Kindy, F., de Munnik, S. & Evans, P. & 31 others, Frank, M. S. B., Bournazos, A. M., Cooper, S. T., Ha, T. T., Jackson, M. R., Arriola-Martinez, L., Phillips, K., Brennan, Y., Bakshi, M., Ambler, K., Gao, S., Kassahn, K. S., Kenyon, R., Hung, K., Babic, M., McGovern, A., Rawlings, L., Vakulin, C., Dejong, L., Fathi, R., McRae, S., Myles, N., Ladon, D., Jongmans, M., Kuiper, R. P., Poplawski, N. K., Barbaro, P., Blombery, P., Brown, A. L., Hahn, C. N. & Scott, H. S., Jul 9 2024, In: Blood Advances. 8, 13, p. 3437-3443 7 p.

      Research output: Contribution to journal › Letter › peer-review

      1 Scopus citations
    • 2023

      Associations between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients with Solid Tumors

      Franch-Expósito, S., Mehine, M., Ptashkin, R. N., Bolton, K. L., Bandlamudi, C., Srinivasan, P., Zhang, L., Goodell, M. A., Gedvilaite, E., Menghrajani, K., Sánchez-Vela, P., Mandelker, D., Comen, E., Norton, L., Benayed, R., Gao, T., Papaemmanuil, E., Taylor, B., Levine, R. & Offit, K. & 3 others, Stadler, Z., Berger, M. F. & Zehir, A., 2023, In: JCO Precision Oncology. 7, e2300070.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      10 Scopus citations

    • Clinical Importance of Clonal Hematopoiesis in Metastatic Gastrointestinal Tract Cancers

      Diplas, B. H., Ptashkin, R., Chou, J. F., Sabwa, S., Foote, M. B., Rousseau, B., Argilés, G., White, J. R., Stewart, C. M., Bolton, K., Chalasani, S. B., Desai, A. M., Goldberg, Z., Gu, P., Li, J., Shcherba, M., Zervoudakis, A., Cercek, A., Yaeger, R. & Segal, N. H. & 7 others, Ilson, D. H., Ku, G. Y., Zehir, A., Capanu, M., Janjigian, Y. Y., Diaz, L. A. & Maron, S. B., Feb 2 2023, In: JAMA Network Open. 6, 2, e2254221.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      6 Scopus citations

    • Clonal Hematopoiesis and Risk of Incident Lung Cancer

      Tian, R., Wiley, B., Liu, J., Zong, X., Truong, B., Zhao, S., Uddin, M. M., Niroula, A., Miller, C. A., Mukherjee, S., Heiden, B. T., Luo, J., Puri, V., Kozower, B. D., Walter, M. J., Ding, L., Link, D. C., Amos, C. I., Ebert, B. L. & Govindan, R. & 3 others, Natarajan, P., Bolton, K. L. & Cao, Y., Mar 1 2023, In: Journal of Clinical Oncology. 41, 7, p. 1423-1433 11 p.

      Research output: Contribution to journal › Article › peer-review

      31 Scopus citations

    • Clonal hematopoiesis in survivors of childhood cancer

      Friedman, D. N., Chan, I. C. C., Moskowitz, C. S., Li, S., Turner, K., Liu, J., Bouvier, N., Walsh, M. F., Spitzer, B., Kung, A. L., Berger, M., Cooper, M. A., Pusic, I., Uy, G., Link, D., Druley, T. E., Diaz, L. A., Levine, R. L., Shukla, N. & Bolton, K. L., Aug 8 2023, In: Blood Advances. 7, 15, p. 4102-4106 5 p.

      Research output: Contribution to journal › Letter › peer-review

      Open Access
      14 Scopus citations

    • Genetic causes and cardiovascular consequences of clonal hematopoiesis in the UK Biobank

      Beeler, J. S., Bick, A. G. & Bolton, K. L., Jan 2023, In: Nature Cardiovascular Research. 2, 1, p. 13-15 3 p.

      Research output: Contribution to journal › Comment/debate

      Open Access
      3 Scopus citations

    • Germline predisposition to clonal hematopoiesis

      Liu, J., Osman, A. E. G., Bolton, K. & Godley, L. A., Sep 2023, In: Leukemia Research. 132, 107344.

      Research output: Contribution to journal › Review article › peer-review

      1 Scopus citations

    • How low can you go? Methodologic considerations in clonal hematopoiesis variant calling

      Beeler, J. S. & Bolton, K. L., Dec 2023, In: Leukemia Research. 135, 107419.

      Research output: Contribution to journal › Article › peer-review

      1 Scopus citations

    • Tracking the evolution of therapy-related myeloid neoplasms using chemotherapy signatures

      Diamond, B., Ziccheddu, B., Maclachlan, K., Taylor, J., Boyle, E., Ossa, J. A., Jahn, J., Affer, M., Totiger, T. M., Coffey, D., Chandhok, N., Watts, J., Cimmino, L., Lu, S. X., Bolli, N., Bolton, K., Landau, H., Park, J. H., Ganesh, K. & McPherson, A. & 13 others, Sekeres, M. A., Lesokhin, A., Chung, D. J., Zhang, Y., Ho, C., Roshal, M., Tyner, J., Nimer, S., Papaemmanuil, E., Usmani, S., Morgan, G., Landgren, O. & Maura, F., May 11 2023, In: Blood. 141, 19, p. 2359-2371 13 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      32 Scopus citations

    • Tumor Genomic Profile Is Associated With Arterial Thromboembolism Risk in Patients With Solid Cancer

      Feldman, S., Gupta, D., Navi, B. B., Grace Ho, K. W., Willeit, P., Devlin, S., Bolton, K. L., Arcila, M. E. & Mantha, S., Apr 2023, In: JACC: CardioOncology. 5, 2, p. 246-255 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      13 Scopus citations
    • 2022

      Association of clonal hematopoiesis mutations with clinical outcomes: A systematic review and meta-analysis

      Nowakowska, M. K., Kim, T., Thompson, M. T., Bolton, K. L., Deswal, A., Lin, S. H., Scheet, P., Wehner, M. R. & Nead, K. T., Apr 2022, In: American journal of hematology. 97, 4, p. 411-420 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      18 Scopus citations

    • Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia

      Spitzer, B., Rutherford, K. D., Gundem, G., McGovern, E. M., Millard, N. E., Arango, J. E. O., Cheung, I. Y., Gao, T., Levine, M. F., Zhang, Y., Medina-Martínez, J. S., Feng, Y., Ptashkin, R. N., Bolton, K. L., Farnoud, N., Zhou, Y., Patel, M. A., Asimomitis, G., Cobbs, C. C. & Mohibullah, N. & 10 others, Huberman, K. H., Arcilla, M. E., Kushner, B. H., Modak, S., Kung, A. L., Zehir, A., Levine, R. L., Armstron, S. A., Cheung, N. K. V. & Papaemmanuil, E., Apr 15 2022, In: Clinical Cancer Research. 28, 8, p. 1614-1627 14 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      8 Scopus citations

    • DNAMethylation Profiles of Ovarian Clear Cell Carcinoma

      Cunningham, J. M., Winham, S. J., Wang, C., Weiglt, B., Fu, Z., Armasu, S. M., McCauley, B. M., Brand, A. H., Chiew, Y. E., Elishaev, E., Gourley, C., Kennedy, C. J., Laslavic, A., Lester, J., Piskorz, A., Sekowska, M., Brenton, J. D., Churchman, M., DeFazio, A. & Drapkin, R. & 10 others, Elias, K. M., Huntsman, D. G., Karlan, B. Y., Kobel, M., Konner, J., Lawrenson, K., Papaemmanuil, E., Bolton, K. L., Modugno, F. & Goode, E. L., Jan 2022, In: Cancer Epidemiology Biomarkers and Prevention. 31, 1, p. 132-141 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      15 Scopus citations

    • Effect of Clonal Hematopoiesis on Cardiovascular Disease in People Living with HIV

      Wiley, B., Parsons, T. M., Burkart, S., Young, A. L., Erlandson, K. M., Tassiopoulos, K. K., Wu, K., Gurnett, C., Presti, R. M., Bolton, K. L. & Challen, G. A., Oct 2022, In: Experimental Hematology. 114, p. 18-21 4 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      10 Scopus citations

    • Estimation of intrafamilial DNA contamination in family trio genome sequencing using deviation from Mendelian inheritance

      Yoon, C. J., Kim, S. Y., Nam, C. H., Lee, J., Park, J. W., Mun, J., Park, S., Lee, S., Yi, B., Min, K. I., Wiley, B., Bolton, K. L., Lee, J. H., Kim, E., Yoo, H. J., Jun, J. K., Choi, J. S., Griffith, M., Griffith, O. L. & Ju, Y. S., Nov 2022, In: Genome research. 32, 11-12, p. 2134-2144 11 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      4 Scopus citations

    • Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes

      Bolton, K. L., Chen, D., de la Fuente, R. C., Fu, Z., Murali, R., Köbel, M., Tazi, Y., Cunningham, J. M., Chan, I. C. C., Wiley, B. J., Moukarzel, L. A., Winham, S. J., Armasu, S. M., Lester, J., Elishaev, E., Laslavic, A., Kennedy, C. J., Piskorz, A., Sekowska, M. & Brand, A. H. & 18 others, Chiew, Y. E., Pharoah, P., Elias, K. M., Drapkin, R., Churchman, M., Gourley, C., DeFazio, A., Karlan, B., Brenton, J. D., Weigelt, B., Anglesio, M. S., Huntsman, D., Gayther, S., Konner, J., Modugno, F., Lawrenson, K., Goode, E. L. & Papaemmanuil, E., Nov 15 2022, In: Clinical Cancer Research. 28, 22, p. 4947-4956 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      42 Scopus citations

    • The proteome of clear cell ovarian carcinoma

      Ji, J. X., Cochrane, D. R., Negri, G. L., Colborne, S., Spencer Miko, S. E., Hoang, L. N., Farnell, D., Tessier-Cloutier, B., Huvila, J., Thompson, E., Leung, S., Chiu, D., Chow, C., Ta, M., Köbel, M., Feil, L., Anglesio, M., Goode, E. L., Bolton, K. & Morin, G. B. & 1 others, Huntsman, D. G., Dec 2022, In: Journal of Pathology. 258, 4, p. 325-338 14 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      11 Scopus citations

    • Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value in endometriosis-associated ovarian carcinomas

      Heinze, K., Nazeran, T. M., Lee, S., Krämer, P., Cairns, E. S., Chiu, D. S., Leung, S. C. Y., Kang, E. Y., Meagher, N. S., Kennedy, C. J., Boros, J., Kommoss, F., Vollert, H. W., Heitz, F., du Bois, A., Harter, P., Grube, M., Kraemer, B., Staebler, A. & Kommoss, F. K. F. & 62 others, Heublein, S., Sinn, H. P., Singh, N., Laslavic, A., Elishaev, E., Olawaiye, A., Moysich, K., Modugno, F., Sharma, R., Brand, A. H., Harnett, P. R., DeFazio, A., Fortner, R. T., Lubinski, J., Lener, M., Tołoczko-Grabarek, A., Cybulski, C., Gronwald, H., Gronwald, J., Coulson, P., El-Bahrawy, M. A., Jones, M. E., Schoemaker, M. J., Swerdlow, A. J., Gorringe, K. L., Campbell, I., Cook, L., Gayther, S. A., Carney, M. E., Shvetsov, Y. B., Hernandez, B. Y., Wilkens, L. R., Goodman, M. T., Mateoiu, C., Linder, A., Sundfeldt, K., Kelemen, L. E., Gentry-Maharaj, A., Widschwendter, M., Menon, U., Bolton, K. L., Alsop, J., Shah, M., Jimenez-Linan, M., Pharoah, P. D. P., Brenton, J. D., Cushing-Haugen, K. L., Harris, H. R., Doherty, J. A., Gilks, B., Ghatage, P., Huntsman, D. G., Nelson, G. S., Tinker, A. V., Lee, C. H., Goode, E. L., Nelson, B. H., Ramus, S. J., Kommoss, S., Talhouk, A., Köbel, M. & Anglesio, M. S., Apr 2022, In: Journal of Pathology. 256, 4, p. 388-401 14 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      24 Scopus citations

    • What Clonal Hematopoiesis Can Teach Us About MDS

      Chan, I. C. C., Wiley, B. J. & Bolton, K. L., Feb 8 2022, In: Frontiers in Oncology. 12, 794021.

      Research output: Contribution to journal › Review article › peer-review

      Open Access
      1 Scopus citations
    • 2021

      Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (Nature Medicine, (2020), 26, 10, (1549-1556), 10.1038/s41591-020-1008-z)

      Bernard, E., Nannya, Y., Hasserjian, R. P., Devlin, S. M., Tuechler, H., Medina-Martinez, J. S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M. F., Arango, J. E., Zhou, Y., Solé, F., Cargo, C. A., Haase, D., Creignou, M., Germing, U., Zhang, Y. & Gundem, G. & 59 others, Sarian, A., van de Loosdrecht, A. A., Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M. Y., Thol, F., Pinheiro, R. F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F. P. S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J. M., Klimek, V. M., Savona, M. R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Della Porta, M. G., Smith, A. G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D. S., Stevenson, K. E., Menghrajani, K., Bolton, K. L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M. T., Shih, L. Y., Fontenay, M., Jansen, J. H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B. L., Bejar, R., Greenberg, P. L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S. & Papaemmanuil, E., Mar 2021, In: Nature medicine. 27, 3, p. 562 1 p.

      Research output: Contribution to journal › Comment/debate

      Open Access
      2 Scopus citations

    • Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (Nature Medicine, (2020), 26, 10, (1549-1556), 10.1038/s41591-020-1008-z)

      Bernard, E., Nannya, Y., Hasserjian, R. P., Devlin, S. M., Tuechler, H., Medina-Martinez, J. S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M. F., Arango, J. E., Zhou, Y., Solé, F., Cargo, C. A., Haase, D., Creignou, M., Germing, U., Zhang, Y. & Gundem, G. & 60 others, Sarian, A., van de Loosdrecht, A. A., Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M. Y., Thol, F., Pinheiro, R. F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F. P. S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J. M., Klimek, V. M., Savona, M. R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Della Porta, M. G., Elias, H. K., Smith, A. G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D. S., Stevenson, K. E., Menghrajani, K., Bolton, K. L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M. T., Shih, L. Y., Fontenay, M., Jansen, J. H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B. L., Bejar, R., Greenberg, P. L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S. & Papaemmanuil, E., May 2021, In: Nature medicine. 27, 5, p. 927 1 p.

      Research output: Contribution to journal › Comment/debate

      Open Access
      3 Scopus citations

    • Clonal hematopoiesis is associated with risk of severe Covid-19

      Bolton, K. L., Koh, Y., Foote, M. B., Im, H., Jee, J., Sun, C. H., Safonov, A., Ptashkin, R., Moon, J. H., Lee, J. Y., Jung, J., Kang, C. K., Song, K. H., Choe, P. G., Park, W. B., Kim, H. B., Oh, M. D., Song, H., Kim, S. & Patel, M. & 25 others, Derkach, A., Gedvilaite, E., Tkachuk, K. A., Wiley, B. J., Chan, I. C., Braunstein, L. Z., Gao, T., Papaemmanuil, E., Esther Babady, N., Pessin, M. S., Kamboj, M., Diaz, L. A., Ladanyi, M., Rauh, M. J., Natarajan, P., Machiela, M. J., Awadalla, P., Joseph, V., Offit, K., Norton, L., Berger, M. F., Levine, R. L., Kim, E. S., Kim, N. J. & Zehir, A., Dec 1 2021, In: Nature communications. 12, 1, 5975.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      91 Scopus citations

    • Erratum: Clonal hematopoiesis before, during, and after human spaceflight (Cell Reports (2020) 33(10), (S2211124720314479), (10.1016/j.celrep.2020.108458))

      Mencia-Trinchant, N., MacKay, M. J., Chin, C., Afshinnekoo, E., Foox, J., Meydan, C., Butler, D., Mozsary, C., Vernice, N. A., Darby, C., Schatz, M. C., Bailey, S. M., Melnick, A. M., Guzman, M. L., Bolton, K., Braunstein, L. Z., Garrett-Bakelman, F., Levine, R. L., Hassane, D. C. & Mason, C. E., Feb 9 2021, In: Cell Reports. 34, 6, 108740.

      Research output: Contribution to journal › Comment/debate

      Open Access
      5 Scopus citations

    • Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors

      Dunbar, A., Bolton, K. L., Devlin, S. M., Sanchez-Vega, F., Gao, J., Mones, J. V., Wills, J., Kelly, D., Farina, M., Cordner, K. B., Park, Y., Kishore, S., Juluru, K., Iyengar, N. M., Levine, R. L., Zehir, A., Park, W., Khorana, A. A., Soff, G. A. & Mantha, S., Apr 15 2021, In: Blood. 137, 15, p. 2103-2113 11 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      74 Scopus citations

    • Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

      Gao, T., Ptashkin, R., Bolton, K. L., Sirenko, M., Fong, C., Spitzer, B., Menghrajani, K., Ossa, J. E. A., Zhou, Y., Bernard, E., Levine, M., Martinez, J. S. M., Zhang, Y., Franch-Expósito, S., Patel, M., Braunstein, L. Z., Kelly, D., Yabe, M., Benayed, R. & Caltabellotta, N. M. & 11 others, Philip, J., Paraiso, E., Mantha, S., Solit, D. B., Diaz, L. A., Berger, M. F., Klimek, V., Levine, R. L., Zehir, A., Devlin, S. M. & Papaemmanuil, E., Dec 2021, In: Nature communications. 12, 1, 338.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      74 Scopus citations

    • The clinical implications of clonal hematopoiesis in hematopoietic cell transplantation

      Nawas, M. T., Schetelig, J., Damm, F., Levine, R. L., Perales, M. A., Giralt, S. A., VanDenBrink, M. R., Arcila, M. E., Zehir, A., Papaemmanuil, E., Klussmeier, A., Schmidt, A. H., Maiwald, S., Bolton, K. L. & Tamari, R., Mar 2021, In: Blood Reviews. 46, 100744.

      Research output: Contribution to journal › Review article › peer-review

      21 Scopus citations
    • 2020

      Cancer therapy shapes the fitness landscape of clonal hematopoiesis

      Bolton, K. L., Ptashkin, R. N., Gao, T., Braunstein, L., Devlin, S. M., Kelly, D., Patel, M., Berthon, A., Syed, A., Yabe, M., Coombs, C. C., Caltabellotta, N. M., Walsh, M., Offit, K., Stadler, Z., Mandelker, D., Schulman, J., Patel, A., Philip, J. & Bernard, E. & 44 others, Gundem, G., Ossa, J. E. A., Levine, M., Martinez, J. S. M., Farnoud, N., Glodzik, D., Li, S., Robson, M. E., Lee, C., Pharoah, P. D. P., Stopsack, K. H., Spitzer, B., Mantha, S., Fagin, J., Boucai, L., Gibson, C. J., Ebert, B. L., Young, A. L., Druley, T., Takahashi, K., Gillis, N., Ball, M., Padron, E., Hyman, D. M., Baselga, J., Norton, L., Gardos, S., Klimek, V. M., Scher, H., Bajorin, D., Paraiso, E., Benayed, R., Arcila, M. E., Ladanyi, M., Solit, D. B., Berger, M. F., Tallman, M., Garcia-Closas, M., Chatterjee, N., Diaz, L. A., Levine, R. L., Morton, L. M., Zehir, A. & Papaemmanuil, E., Nov 1 2020, In: Nature Genetics. 52, 11, p. 1219-1226 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      455 Scopus citations

    • Chemotherapy and COVID-19 Outcomes in Patients with Cancer

      Jee, J., Foote, M. B., Lumish, M., Stonestrom, A. J., Wills, B., Narendra, V., Avutu, V., Murciano-Goroff, Y. R., Chan, J. E., Derkach, A., Philip, J., Belenkaya, R., Kerpelev, M., Maloy, M., Watson, A., Fong, C., Janjigian, Y., Diaz, L. A., Bolton, K. L. & Pessin, M. S., Oct 20 2020, In: Journal of Clinical Oncology. 38, 30, p. 3538-3546 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      207 Scopus citations

    • Clonal Hematopoiesis Before, During, and After Human Spaceflight

      Trinchant, N. M., MacKay, M. J., Chin, C., Afshinnekoo, E., Foox, J., Meydan, C., Butler, D., Mozsary, C., Vernice, N. A., Darby, C., Schatz, M. C., Bailey, S. M., Melnick, A. M., Guzman, M., Bolton, K., Braunstein, L. Z., Garrett-Bakelman, F., Levine, R. L., Hassane, D. & Mason, C. E., Dec 8 2020, In: Cell Reports. 33, 10, 108458.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      38 Scopus citations

    • Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

      Bernard, E., Nannya, Y., Hasserjian, R. P., Devlin, S. M., Tuechler, H., Medina-Martinez, J. S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M. F., Arango, J. E., Zhou, Y., Solé, F., Cargo, C. A., Haase, D., Creignou, M., Germing, U., Zhang, Y. & Gundem, G. & 59 others, Sarian, A., van de Loosdrecht, A. A., Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M. Y., Thol, F., Pinheiro, R. F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F. P. S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J. M., Klimek, V. M., Savona, M. R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Della Porta, M. G., Smith, A. G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D. S., Stevenson, K. E., Menghrajani, K., Bolton, K. L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M. T., Shih, L. Y., Fontenay, M., Jansen, J. H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B. L., Bejar, R., Greenberg, P. L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S. & Papaemmanuil, E., Oct 1 2020, In: Nature medicine. 26, 10, p. 1549-1556 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      450 Scopus citations

    • Single-cell mutation analysis of clonal evolution in myeloid malignancies

      Miles, L. A., Bowman, R. L., Merlinsky, T. R., Csete, I. S., Ooi, A. T., Durruthy-Durruthy, R., Bowman, M., Famulare, C., Patel, M. A., Mendez, P., Ainali, C., Demaree, B., Delley, C. L., Abate, A. R., Manivannan, M., Sahu, S., Goldberg, A. D., Bolton, K. L., Zehir, A. & Rampal, R. & 4 others, Carroll, M. P., Meyer, S. E., Viny, A. D. & Levine, R. L., Nov 19 2020, In: Nature. 587, 7834, p. 477-482 6 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      329 Scopus citations

    • The Clinical Challenge of Clonal Hematopoiesis, a Newly Recognized Cardiovascular Risk Factor

      Sidlow, R., Lin, A. E., Gupta, D., Bolton, K. L., Steensma, D. P., Levine, R. L., Ebert, B. L. & Libby, P., Aug 2020, In: JAMA Cardiology. 5, 8, p. 958-961 4 p.

      Research output: Contribution to journal › Review article › peer-review

      38 Scopus citations

    • The Clinical Management of Clonal Hematopoiesis: Creation of a Clonal Hematopoiesis Clinic

      Bolton, K. L., Zehir, A., Ptashkin, R. N., Patel, M., Gupta, D., Sidlow, R., Papaemmanuil, E., Berger, M. F. & Levine, R. L., Apr 2020, In: Hematology/Oncology Clinics of North America. 34, 2, p. 357-367 11 p.

      Research output: Contribution to journal › Review article › peer-review

      51 Scopus citations

    • What to tell your patient with clonal hematopoiesis and why: insights from 2 specialized clinics

      Steensma, D. P. & Bolton, K. L., Oct 2020, In: Blood. 136, 14, p. 1623-1631 9 p.

      Research output: Contribution to journal › Review article › peer-review

      Open Access
      52 Scopus citations
    • 2019

      Clonal Hematopoiesis: Crossroads of Aging, Cardiovascular Disease, and Cancer: JACC Review Topic of the Week

      Libby, P., Sidlow, R., Lin, A. E., Gupta, D., Jones, L. W., Moslehi, J., Zeiher, A., Jaiswal, S., Schulz, C., Blankstein, R., Bolton, K. L., Steensma, D., Levine, R. L. & Ebert, B. L., Jul 30 2019, In: Journal of the American College of Cardiology. 74, 4, p. 567-577 11 p.

      Research output: Contribution to journal › Review article › peer-review

      Open Access
      182 Scopus citations

    • Managing clonal hematopoiesis in patients with solid tumors

      Bolton, K. L., Gillis, N. K., Coombs, C. C., Takahashi, K., Zehir, A., Bejar, R., Garcia-Manero, G., Futreal, A., Jensen, B. C., Diaz, L. A., Gupta, D., Mantha, S., Klimek, V., Papaemmanuil, E., Levine, R. & Padron, E., Jan 1 2019, In: Journal of Clinical Oncology. 37, 1, p. 7-11 5 p.

      Research output: Contribution to journal › Comment/debate

      Open Access
      57 Scopus citations