Kelly Bolton

Assistant Professor of Medicine

    • Source: Scopus
    20062021

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    Research interests

    Dr. Bolton a physician-scientist with a background in medical oncology and genetic epidemiology. The focus of her research is regarding the interplay between inherited genetic variation, environmental factors, and acquired mutations in shaping the earliest stages of carcinogenesis. This will provide mechanistic insights into cancer dependencies and vulnerabilities that could help guide the development of novel therapies. Her goal is to translate genetic markers of cancer risk into clinical action through the development of chemoprevention and early detection studies. As such she has ongoing clinical trials in chemoprevention. In her clinical work, she specializes in the management of individuals at high risk of hematologic malignancy based on genomic profile (both acquired and germline genetic variation).

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    • Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (Nature Medicine, (2020), 26, 10, (1549-1556), 10.1038/s41591-020-1008-z)

      Bernard, E., Nannya, Y., Hasserjian, R. P., Devlin, S. M., Tuechler, H., Medina-Martinez, J. S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M. F., Arango, J. E., Zhou, Y., Solé, F., Cargo, C. A., Haase, D., Creignou, M., Germing, U., Zhang, Y., Gundem, G. & 59 others, Sarian, A., van de Loosdrecht, A. A., Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M. Y., Thol, F., Pinheiro, R. F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F. P. S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J. M., Klimek, V. M., Savona, M. R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Della Porta, M. G., Smith, A. G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D. S., Stevenson, K. E., Menghrajani, K., Bolton, K. L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M. T., Shih, L. Y., Fontenay, M., Jansen, J. H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B. L., Bejar, R., Greenberg, P. L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S. & Papaemmanuil, E., Mar 2021, In: Nature medicine. 27, 3, p. 562 1 p.

      Research output: Contribution to journalComment/debate

      Open Access
      1 Scopus citations
    • Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (Nature Medicine, (2020), 26, 10, (1549-1556), 10.1038/s41591-020-1008-z)

      Bernard, E., Nannya, Y., Hasserjian, R. P., Devlin, S. M., Tuechler, H., Medina-Martinez, J. S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M. F., Arango, J. E., Zhou, Y., Solé, F., Cargo, C. A., Haase, D., Creignou, M., Germing, U., Zhang, Y., Gundem, G. & 60 others, Sarian, A., van de Loosdrecht, A. A., Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M. Y., Thol, F., Pinheiro, R. F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F. P. S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J. M., Klimek, V. M., Savona, M. R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Della Porta, M. G., Elias, H. K., Smith, A. G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D. S., Stevenson, K. E., Menghrajani, K., Bolton, K. L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M. T., Shih, L. Y., Fontenay, M., Jansen, J. H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B. L., Bejar, R., Greenberg, P. L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S. & Papaemmanuil, E., May 2021, In: Nature medicine. 27, 5, p. 927 1 p.

      Research output: Contribution to journalComment/debate

      Open Access
    • Erratum: Clonal hematopoiesis before, during, and after human spaceflight (Cell Reports (2020) 33(10), (S2211124720314479), (10.1016/j.celrep.2020.108458))

      Mencia-Trinchant, N., MacKay, M. J., Chin, C., Afshinnekoo, E., Foox, J., Meydan, C., Butler, D., Mozsary, C., Vernice, N. A., Darby, C., Schatz, M. C., Bailey, S. M., Melnick, A. M., Guzman, M. L., Bolton, K., Braunstein, L. Z., Garrett-Bakelman, F., Levine, R. L., Hassane, D. C. & Mason, C. E., Feb 9 2021, In: Cell Reports. 34, 6, 108740.

      Research output: Contribution to journalComment/debate

      Open Access
      1 Scopus citations
    • Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors

      Dunbar, A., Bolton, K. L., Devlin, S. M., Sanchez-Vega, F., Gao, J., Mones, J. V., Wills, J., Kelly, D., Farina, M., Cordner, K. B., Park, Y., Kishore, S., Juluru, K., Iyengar, N. M., Levine, R. L., Zehir, A., Park, W., Khorana, A. A., Soff, G. A. & Mantha, S., Apr 15 2021, In: Blood. 137, 15, p. 2103-2113 11 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      6 Scopus citations
    • Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

      Gao, T., Ptashkin, R., Bolton, K. L., Sirenko, M., Fong, C., Spitzer, B., Menghrajani, K., Ossa, J. E. A., Zhou, Y., Bernard, E., Levine, M., Martinez, J. S. M., Zhang, Y., Franch-Expósito, S., Patel, M., Braunstein, L. Z., Kelly, D., Yabe, M., Benayed, R., Caltabellotta, N. M. & 11 others, Philip, J., Paraiso, E., Mantha, S., Solit, D. B., Diaz, L. A., Berger, M. F., Klimek, V., Levine, R. L., Zehir, A., Devlin, S. M. & Papaemmanuil, E., Dec 2021, In: Nature communications. 12, 1, 338.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      10 Scopus citations