Personal profile

Research interests

Dr. Bolton a physician-scientist with a background in medical oncology and genetic epidemiology. The focus of her research is regarding the interplay between inherited genetic variation, environmental factors, and acquired mutations in shaping the earliest stages of carcinogenesis. This will provide mechanistic insights into cancer dependencies and vulnerabilities that could help guide the development of novel therapies. Her goal is to translate genetic markers of cancer risk into clinical action through the development of chemoprevention and early detection studies. As such she has ongoing clinical trials in chemoprevention. In her clinical work, she specializes in the management of individuals at high risk of hematologic malignancy based on genomic profile (both acquired and germline genetic variation).

Clinical interests

Genetic predisposition to cancer clonal hematopoiesis

Available to Mentor:

  • PhD/MSTP Students

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Collaborations and top research areas from the last five years

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  • A novel method for rapid estimation of active bone marrow dose for radiotherapy patients in epidemiological studies

    Yeom, Y. S., Braunstein, L., Morton, L. M., Bolton, K. L., Choi, J. W., Choi, H. Y., Greenstein, N. & Lee, C., Jun 2024, In: Medical physics. 51, 6, p. 4472-4481 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • ArCH: improving the performance of clonal hematopoiesis variant calling and interpretation

    Chan, I. C. C., Panchot, A., Schmidt, E., McNulty, S., Wiley, B. J., Liu, J., Turner, K., Moukarzel, L., Wong, W. S. W., Tran, D., Beeler, J. S., Batchi-Bouyou, A. L., Machiela, M. J., Karyadi, D. M., Krajacich, B. J., Zhao, J., Kruglyak, S., Lajoie, B., Levy, S. & Patel, M. & 6 others, Kantoff, P. W., Mason, C. E., Link, D. C., Druley, T. E., Stopsack, K. H. & Bolton, K. L., Apr 1 2024, In: Bioinformatics. 40, 4, btae121.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3 Scopus citations
  • Donor-Derived Malignancy and Transplantation Morbidity: Risks of Patient and Donor Genetics in Allogeneic Hematopoietic Stem Cell Transplantation

    Williams, L. S., Williams, K. M., Gillis, N., Bolton, K., Damm, F., Deuitch, N. T., Farhadfar, N., Gergis, U., Keel, S. B., Michelis, F. V., Panch, S. R., Porter, C. C., Sucheston-Campbell, L., Tamari, R., Stefanski, H. E., Godley, L. A. & Lai, C., Mar 2024, In: Transplantation and Cellular Therapy. 30, 3, p. 255-267 13 p.

    Research output: Contribution to journalReview articlepeer-review

    9 Scopus citations
  • Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight

    Garcia-Medina, J. S., Sienkiewicz, K., Narayanan, S. A., Overbey, E. G., Grigorev, K., Ryon, K. A., Burke, M., Proszynski, J., Tierney, B., Schmidt, C. M., Mencia-Trinchant, N., Klotz, R., Ortiz, V., Foox, J., Chin, C., Najjar, D., Matei, I., Chan, I., Cruchaga, C. & Kleinman, A. & 23 others, Kim, J. K., Lucaci, A., Loy, C., Mzava, O., De Vlaminck, I., Singaraju, A., Taylor, L. E., Schmidt, J. C., Schmidt, M. A., Blease, K., Moreno, J., Boddicker, A., Zhao, J., Lajoie, B., Altomare, A., Kruglyak, S., Levy, S., Yu, M., Hassane, D. C., Bailey, S. M., Bolton, K., Mateus, J. & Mason, C. E., Mar 1 2024, In: Precision Clinical Medicine. 7, 1, pbae007.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    6 Scopus citations
  • Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions

    AOCS Group, OPAL Study Group, The Ovarian Cancer Association Consortium (OCAC), Dareng, E. O., Coetzee, S. G., Tyrer, J. P., Peng, P. C., Rosenow, W., Chen, S., Davis, B. D., Dezem, F. S., Seo, J. H., Nameki, R., Reyes, A. L., Aben, K. K. H., Anton-Culver, H., Antonenkova, N. N., Aravantinos, G., Bandera, E. V. & Beane Freeman, L. E. & 136 others, Beckmann, M. W., Beeghly-Fadiel, A., Benitez, J., Bernardini, M. Q., Bjorge, L., Black, A., Bogdanova, N. V., Bolton, K. L., Brenton, J. D., Budzilowska, A., Butzow, R., Cai, H., Campbell, I., Cannioto, R., Chang-Claude, J., Chanock, S. J., Chen, K., Chenevix-Trench, G., Chiew, Y. E., Cook, L. S., DeFazio, A., Dennis, J., Doherty, J. A., Dörk, T., du Bois, A., Dürst, M., Eccles, D. M., Ene, G., Fasching, P. A., Flanagan, J. M., Fortner, R. T., Fostira, F., Gentry-Maharaj, A., Giles, G. G., Goodman, M. T., Gronwald, J., Haiman, C. A., Håkansson, N., Heitz, F., Hildebrandt, M. A. T., Høgdall, E., Høgdall, C. K., Huang, R. Y., Jensen, A., Jones, M. E., Kang, D., Karlan, B. Y., Karnezis, A. N., Kelemen, L. E., Kennedy, C. J., Khusnutdinova, E. K., Kiemeney, L. A., Kjaer, S. K., Kupryjanczyk, J., Labrie, M., Lambrechts, D., Larson, M. C., Le, N. D., Lester, J., Li, L., Lubiński, J., Lush, M., Marks, J. R., Matsuo, K., May, T., McLaughlin, J. R., McNeish, I. A., Menon, U., Missmer, S., Modugno, F., Moffitt, M., Monteiro, A. N., Moysich, K. B., Narod, S. A., Nguyen-Dumont, T., Odunsi, K., Olsson, H., Onland-Moret, N. C., Park, S. K., Pejovic, T., Permuth, J. B., Piskorz, A., Prokofyeva, D., Riggan, M. J., Risch, H. A., Rodríguez-Antona, C., Rossing, M. A., Sandler, D. P., Setiawan, V. W., Shan, K., Song, H., Southey, M. C., Steed, H., Sutphen, R., Swerdlow, A. J., Teo, S. H., Terry, K. L., Thompson, P. J., Vestrheim Thomsen, L. C., Titus, L., Trabert, B., Travis, R., Tworoger, S. S., Valen, E., Van Nieuwenhuysen, E., Edwards, D. V., Vierkant, R. A., Webb, P. M., Weinberg, C. R., Weise, R. M., Wentzensen, N., White, E., Winham, S. J., Wolk, A., Woo, Y. L., Wu, A. H., Yan, L., Yannoukakos, D., Zeinomar, N., Zheng, W., Ziogas, A., Berchuck, A., Goode, E. L., Huntsman, D. G., Pearce, C. L., Ramus, S. J., Sellers, T. A., Freedman, M. L., Lawrenson, K., Schildkraut, J. M., Hazelett, D., Plummer, J. T., Kar, S., Jones, M. R., Pharoah, P. D. P. & Gayther, S. A., Jun 6 2024, In: American journal of human genetics. 111, 6, p. 1061-1083 23 p.

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations