• Source: Scopus

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Personal profile

Research interests

Dr. Bolton a physician-scientist with a background in medical oncology and genetic epidemiology. The focus of her research is regarding the interplay between inherited genetic variation, environmental factors, and acquired mutations in shaping the earliest stages of carcinogenesis. This will provide mechanistic insights into cancer dependencies and vulnerabilities that could help guide the development of novel therapies. Her goal is to translate genetic markers of cancer risk into clinical action through the development of chemoprevention and early detection studies. As such she has ongoing clinical trials in chemoprevention. In her clinical work, she specializes in the management of individuals at high risk of hematologic malignancy based on genomic profile (both acquired and germline genetic variation).


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  • Association of clonal hematopoiesis mutations with clinical outcomes: A systematic review and meta-analysis

    Nowakowska, M. K., Kim, T., Thompson, M. T., Bolton, K. L., Deswal, A., Lin, S. H., Scheet, P., Wehner, M. R. & Nead, K. T., Apr 2022, In: American journal of hematology. 97, 4, p. 411-420 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • DNAMethylation Profiles of Ovarian Clear Cell Carcinoma

    Cunningham, J. M., Winham, S. J., Wang, C., Weiglt, B., Fu, Z., Armasu, S. M., McCauley, B. M., Brand, A. H., Chiew, Y. E., Elishaev, E., Gourley, C., Kennedy, C. J., Laslavic, A., Lester, J., Piskorz, A., Sekowska, M., Brenton, J. D., Churchman, M., DeFazio, A., Drapkin, R. & 10 others, Elias, K. M., Huntsman, D. G., Karlan, B. Y., Kobel, M., Konner, J., Lawrenson, K., Papaemmanuil, E., Bolton, K. L., Modugno, F. & Goode, E. L., Jan 2022, In: Cancer Epidemiology Biomarkers and Prevention. 31, 1, p. 132-141 10 p.

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations
  • Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value in endometriosis-associated ovarian carcinomas

    Heinze, K., Nazeran, T. M., Lee, S., Krämer, P., Cairns, E. S., Chiu, D. S., Leung, S. C. Y., Kang, E. Y., Meagher, N. S., Kennedy, C. J., Boros, J., Kommoss, F., Vollert, H. W., Heitz, F., du Bois, A., Harter, P., Grube, M., Kraemer, B., Staebler, A., Kommoss, F. K. F. & 62 others, Heublein, S., Sinn, H. P., Singh, N., Laslavic, A., Elishaev, E., Olawaiye, A., Moysich, K., Modugno, F., Sharma, R., Brand, A. H., Harnett, P. R., DeFazio, A., Fortner, R. T., Lubinski, J., Lener, M., Tołoczko-Grabarek, A., Cybulski, C., Gronwald, H., Gronwald, J., Coulson, P., El-Bahrawy, M. A., Jones, M. E., Schoemaker, M. J., Swerdlow, A. J., Gorringe, K. L., Campbell, I., Cook, L., Gayther, S. A., Carney, M. E., Shvetsov, Y. B., Hernandez, B. Y., Wilkens, L. R., Goodman, M. T., Mateoiu, C., Linder, A., Sundfeldt, K., Kelemen, L. E., Gentry-Maharaj, A., Widschwendter, M., Menon, U., Bolton, K. L., Alsop, J., Shah, M., Jimenez-Linan, M., Pharoah, P. D. P., Brenton, J. D., Cushing-Haugen, K. L., Harris, H. R., Doherty, J. A., Gilks, B., Ghatage, P., Huntsman, D. G., Nelson, G. S., Tinker, A. V., Lee, C. H., Goode, E. L., Nelson, B. H., Ramus, S. J., Kommoss, S., Talhouk, A., Köbel, M. & Anglesio, M. S., Apr 2022, In: Journal of Pathology. 256, 4, p. 388-401 14 p.

    Research output: Contribution to journalArticlepeer-review

  • What Clonal Hematopoiesis Can Teach Us About MDS

    Chan, I. C. C., Wiley, B. J. & Bolton, K. L., Feb 8 2022, In: Frontiers in Oncology. 12, 794021.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
  • Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (Nature Medicine, (2020), 26, 10, (1549-1556), 10.1038/s41591-020-1008-z)

    Bernard, E., Nannya, Y., Hasserjian, R. P., Devlin, S. M., Tuechler, H., Medina-Martinez, J. S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M. F., Arango, J. E., Zhou, Y., Solé, F., Cargo, C. A., Haase, D., Creignou, M., Germing, U., Zhang, Y., Gundem, G. & 60 others, Sarian, A., van de Loosdrecht, A. A., Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M. Y., Thol, F., Pinheiro, R. F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F. P. S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J. M., Klimek, V. M., Savona, M. R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Della Porta, M. G., Elias, H. K., Smith, A. G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D. S., Stevenson, K. E., Menghrajani, K., Bolton, K. L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M. T., Shih, L. Y., Fontenay, M., Jansen, J. H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B. L., Bejar, R., Greenberg, P. L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S. & Papaemmanuil, E., May 2021, In: Nature medicine. 27, 5, p. 927 1 p.

    Research output: Contribution to journalComment/debate

    Open Access