Kelly Bolton

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Kelly Bolton

Assistant Professor of Medicine

 https://orcid.org/0000-0001-6584-3357

    Willing to Mentor

    Available to Mentor:

    PhD/MSTP Students

    • 4356
      Citations
    20062024

    Research activity per year

    Personal profile

    Research interests

    Dr. Bolton a physician-scientist with a background in medical oncology and genetic epidemiology. The focus of her research is regarding the interplay between inherited genetic variation, environmental factors, and acquired mutations in shaping the earliest stages of carcinogenesis. This will provide mechanistic insights into cancer dependencies and vulnerabilities that could help guide the development of novel therapies. Her goal is to translate genetic markers of cancer risk into clinical action through the development of chemoprevention and early detection studies. As such she has ongoing clinical trials in chemoprevention. In her clinical work, she specializes in the management of individuals at high risk of hematologic malignancy based on genomic profile (both acquired and germline genetic variation).

    Clinical interests

    Genetic predisposition to cancer clonal hematopoiesis

    Available to Mentor:

    • PhD/MSTP Students

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    • A novel method for rapid estimation of active bone marrow dose for radiotherapy patients in epidemiological studies

      Yeom, Y. S., Braunstein, L., Morton, L. M., Bolton, K. L., Choi, J. W., Choi, H. Y., Greenstein, N. & Lee, C., Jun 2024, In: Medical physics. 51, 6, p. 4472-4481 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • ArCH: improving the performance of clonal hematopoiesis variant calling and interpretation

      Chan, I. C. C., Panchot, A., Schmidt, E., McNulty, S., Wiley, B. J., Liu, J., Turner, K., Moukarzel, L., Wong, W. S. W., Tran, D., Beeler, J. S., Batchi-Bouyou, A. L., Machiela, M. J., Karyadi, D. M., Krajacich, B. J., Zhao, J., Kruglyak, S., Lajoie, B., Levy, S. & Patel, M. & 6 others, Kantoff, P. W., Mason, C. E., Link, D. C., Druley, T. E., Stopsack, K. H. & Bolton, K. L., Apr 1 2024, In: Bioinformatics. 40, 4, btae121.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      3 Scopus citations

    • Donor-Derived Malignancy and Transplantation Morbidity: Risks of Patient and Donor Genetics in Allogeneic Hematopoietic Stem Cell Transplantation

      Williams, L. S., Williams, K. M., Gillis, N., Bolton, K., Damm, F., Deuitch, N. T., Farhadfar, N., Gergis, U., Keel, S. B., Michelis, F. V., Panch, S. R., Porter, C. C., Sucheston-Campbell, L., Tamari, R., Stefanski, H. E., Godley, L. A. & Lai, C., Mar 2024, In: Transplantation and Cellular Therapy. 30, 3, p. 255-267 13 p.

      Research output: Contribution to journal › Review article › peer-review

      9 Scopus citations

    • Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight

      Garcia-Medina, J. S., Sienkiewicz, K., Narayanan, S. A., Overbey, E. G., Grigorev, K., Ryon, K. A., Burke, M., Proszynski, J., Tierney, B., Schmidt, C. M., Mencia-Trinchant, N., Klotz, R., Ortiz, V., Foox, J., Chin, C., Najjar, D., Matei, I., Chan, I., Cruchaga, C. & Kleinman, A. & 23 others, Kim, J. K., Lucaci, A., Loy, C., Mzava, O., De Vlaminck, I., Singaraju, A., Taylor, L. E., Schmidt, J. C., Schmidt, M. A., Blease, K., Moreno, J., Boddicker, A., Zhao, J., Lajoie, B., Altomare, A., Kruglyak, S., Levy, S., Yu, M., Hassane, D. C., Bailey, S. M., Bolton, K., Mateus, J. & Mason, C. E., Mar 1 2024, In: Precision Clinical Medicine. 7, 1, pbae007.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      6 Scopus citations

    • Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions

      AOCS Group, OPAL Study Group, The Ovarian Cancer Association Consortium (OCAC), Dareng, E. O., Coetzee, S. G., Tyrer, J. P., Peng, P. C., Rosenow, W., Chen, S., Davis, B. D., Dezem, F. S., Seo, J. H., Nameki, R., Reyes, A. L., Aben, K. K. H., Anton-Culver, H., Antonenkova, N. N., Aravantinos, G., Bandera, E. V. & Beane Freeman, L. E. & 136 others, Beckmann, M. W., Beeghly-Fadiel, A., Benitez, J., Bernardini, M. Q., Bjorge, L., Black, A., Bogdanova, N. V., Bolton, K. L., Brenton, J. D., Budzilowska, A., Butzow, R., Cai, H., Campbell, I., Cannioto, R., Chang-Claude, J., Chanock, S. J., Chen, K., Chenevix-Trench, G., Chiew, Y. E., Cook, L. S., DeFazio, A., Dennis, J., Doherty, J. A., Dörk, T., du Bois, A., Dürst, M., Eccles, D. M., Ene, G., Fasching, P. A., Flanagan, J. M., Fortner, R. T., Fostira, F., Gentry-Maharaj, A., Giles, G. G., Goodman, M. T., Gronwald, J., Haiman, C. A., Håkansson, N., Heitz, F., Hildebrandt, M. A. T., Høgdall, E., Høgdall, C. K., Huang, R. Y., Jensen, A., Jones, M. E., Kang, D., Karlan, B. Y., Karnezis, A. N., Kelemen, L. E., Kennedy, C. J., Khusnutdinova, E. K., Kiemeney, L. A., Kjaer, S. K., Kupryjanczyk, J., Labrie, M., Lambrechts, D., Larson, M. C., Le, N. D., Lester, J., Li, L., Lubiński, J., Lush, M., Marks, J. R., Matsuo, K., May, T., McLaughlin, J. R., McNeish, I. A., Menon, U., Missmer, S., Modugno, F., Moffitt, M., Monteiro, A. N., Moysich, K. B., Narod, S. A., Nguyen-Dumont, T., Odunsi, K., Olsson, H., Onland-Moret, N. C., Park, S. K., Pejovic, T., Permuth, J. B., Piskorz, A., Prokofyeva, D., Riggan, M. J., Risch, H. A., Rodríguez-Antona, C., Rossing, M. A., Sandler, D. P., Setiawan, V. W., Shan, K., Song, H., Southey, M. C., Steed, H., Sutphen, R., Swerdlow, A. J., Teo, S. H., Terry, K. L., Thompson, P. J., Vestrheim Thomsen, L. C., Titus, L., Trabert, B., Travis, R., Tworoger, S. S., Valen, E., Van Nieuwenhuysen, E., Edwards, D. V., Vierkant, R. A., Webb, P. M., Weinberg, C. R., Weise, R. M., Wentzensen, N., White, E., Winham, S. J., Wolk, A., Woo, Y. L., Wu, A. H., Yan, L., Yannoukakos, D., Zeinomar, N., Zheng, W., Ziogas, A., Berchuck, A., Goode, E. L., Huntsman, D. G., Pearce, C. L., Ramus, S. J., Sellers, T. A., Freedman, M. L., Lawrenson, K., Schildkraut, J. M., Hazelett, D., Plummer, J. T., Kar, S., Jones, M. R., Pharoah, P. D. P. & Gayther, S. A., Jun 6 2024, In: American journal of human genetics. 111, 6, p. 1061-1083 23 p.

      Research output: Contribution to journal › Article › peer-review

      1 Scopus citations
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