Research output per year
Research output per year
Personal profile
Research interests
We are studying complications of chronic kidney disease (CKD). Our current focus is the cardiovascular complications including vascular calcification. We have determined the mechanism of hyperphosphatemia as a cardiovascular risk factor in CKD, and in translational animal studies have promising new therapeutic approaches to vascular calcification and the bone and mineral disorders of CKD. We are preparing for clinical trials of cardiovascular outcomes in CKD and for new therapeutic agents.
Clinical interests
Pediatric and adult kidney disease, chronic kidney diseases, kidney stones, the CKD-MBD, vascular calcification, kidney tubulointerstitial disease, tubulointerstitial fibrosis, transplantation of neocartilage, hyperparathyroidism, calcium and phosphorus metabolism, diabetic nephropathy
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Collaborations and top research areas from the last five years
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In chronic kidney disease altered cardiac metabolism precedes cardiac hypertrophy
Williams, M. J., Halabi, C. M., Patel, H. M., Joseph, Z., McCommis, K., Weinheimer, C., Kovacs, A., Lima, F., Finck, B., Malluche, H. & Hruska, K. A., May 2024, In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 326, 5, p. F751-F767Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Acidosis in CKD May Affect Mineralization of Newly Formed Bone According to HR-pQCT and Quantitative Back Scatter Electron Imaging
Williams, M. J. & Hruska, K. A., Apr 1 2023, In: Journal of the American Society of Nephrology. 34, 4, p. 520-523 4 p.Research output: Contribution to journal › Editorial
Open Access -
Updates in the chronic kidney disease-mineral bone disorder show the role of osteocytic proteins, a potential mechanism of the bone—Vascular paradox, a therapeutic target, and a biomarker
Williams, M. J., White, S. C., Joseph, Z. & Hruska, K. A., Jan 26 2023, In: Frontiers in Physiology. 14, 1120308.Research output: Contribution to journal › Review article › peer-review
Open Access10 Scopus citations -
FGF23-an established master regulator of phosphate metabolism
Hruska, K. A. & Williams, M. J., Jan 1 2021, Fibroblast Growth Factor 23. Elsevier, p. 7-21 15 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Androgen-Influenced Polarization of Activin A-Producing Macrophages Accompanies Post-pyelonephritic Renal Scarring
Hreha, T. N., Collins, C. A., Daugherty, A. L., Griffith, J. M., Hruska, K. A. & Hunstad, D. A., Jul 28 2020, In: Frontiers in immunology. 11, 1641.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations