Keith Hruska

Professor of Pediatrics, Professor of Cell Biology and Physiology, Professor of Medicine

  • 17401 Citations
1970 …2020

Research output per year

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Personal profile

Research interests

We are studying complications of chronic kidney disease (CKD). Our current focus is the cardiovascular complications including vascular calcification. We have determined the mechanism of hyperphosphatemia as a cardiovascular risk factor in CKD, and in translational animal studies have promising new therapeutic approaches to vascular calcification and the bone and mineral disorders of CKD. We are preparing for clinical trials of cardiovascular outcomes in CKD and for new therapeutic agents.

Areas of Clinical Interest

Pediatric and adult kidney disease, chronic kidney diseases, kidney stones, the CKD-MBD, vascular calcification, kidney tubulointerstitial disease, tubulointerstitial fibrosis, transplantation of neocartilage, hyperparathyroidism, calcium and phosphorus metabolism, diabetic nephropathy

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Research Output

Androgen-Influenced Polarization of Activin A-Producing Macrophages Accompanies Post-pyelonephritic Renal Scarring

Hreha, T. N., Collins, C. A., Daugherty, A. L., Griffith, J. M., Hruska, K. A. & Hunstad, D., Jul 28 2020, In : Frontiers in immunology. 11, 1641.

Research output: Contribution to journalArticle

Open Access
  • New pathogenic insights inform therapeutic target development for renal osteodystrophy

    Hruska, K. A. & Mahjoub, M. R., Feb 2019, In : Kidney International. 95, 2, p. 261-263 3 p.

    Research output: Contribution to journalComment/debate

  • Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk

    Wu, J., Dong, J., Verzola, D., Hruska, K., Garibotto, G., Hu, Z., Mitch, W. E. & Thomas, S. S., Dec 1 2019, In : Journal of Cachexia, Sarcopenia and Muscle. 10, 6, p. 1210-1227 18 p.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Sotatercept Safety and Effects on Hemoglobin, Bone, and Vascular Calcification

    Coyne, D. W., Singh, H. N., Smith, W. T., Giuseppi, A. C., Connarn, J. N., Sherman, M. L., Dellanna, F., Malluche, H. H. & Hruska, K. A., Nov 2019, In : Kidney International Reports. 4, 11, p. 1585-1597 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Androgen exposure potentiates formation of intratubular communities and renal abscesses by Escherichia coli

    Olson, P. D., McLellan, L. K., Hreha, T. N., Liu, A., Briden, K. E., Hruska, K. A. & Hunstad, D. A., Sep 2018, In : Kidney International. 94, 3, p. 502-513 12 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations