Keiko Hirose

Professor of Otolaryngology, Vice Chairman for Pediatrics Dept of Otolaryngology, Professor of Audiology and Communication Sciences, Professor of Pediatrics

  • 2011 Citations

Research output per year

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Personal profile

Research interests

My research program focuses on improving our understand of how inflammation reaches the inner ear; how inflammatory cells function when they are activated in the ear and how this cell population aids or hampers the repair process after cochlear injury. There are numerous processes that induce cochlear inflammation; ranging from meningitis to cochlear surgery. My long term goals are to use improved knowledge of inflammation to devise targeted therapies for progressive sensorineural hearing loss and to identify methods of preserving residual hearing in individuals who might undergo cochlear implantation. By improving our understanding of inflammation and scar formation in the inner ear; I hope to provide more specific ways to support the survival of hearing cells early during degeneration before hearing loss becomes irreversible.

Areas of Clinical Interest

Pediatric hearing loss, cochlear implantation, chronic ear surgery, cholesteatoma, conductive hearing loss, aural atresia, BAHA, ear infections, speech disorders, velopharyngeal insufficiency, cleft palate, craniofacial disorders

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Research Output

  • 2011 Citations
  • 34 Article
  • 3 Review article
  • 1 Editorial
  • 1 Letter

The role of monocytes and macrophages in the dynamic permeability of the blood-perilymph barrier

Hirose, K. & Li, S. Z., Mar 15 2019, In : Hearing research. 374, p. 49-57 9 p.

Research output: Contribution to journalArticle

  • 5 Scopus citations

    Vesicular glutamatergic transmission in noise-induced loss and repair of cochlear ribbon synapses

    Kim, K. X., Payne, S., Yang-Hood, A., Li, S. Z., Davis, B., Carlquist, J., Ghaffari, B. V., Gantz, J. A., Kallogjeri, D., Fitzpatrick, J. A. J., Ohlemiller, K. K., Hirose, K. & Rutherford, M. A., Jun 5 2019, In : Journal of Neuroscience. 39, 23, p. 4434-4447 14 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Virus-induced cochlear inflammation in newborn mice alters auditory function

    Sung, C. Y. W., Seleme, M. C., Payne, S., Jonjic, S., Hirose, K. & Britt, W., Aug 8 2019, In : JCI Insight. 4, 17, e128878.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Communication pathways to and from the inner ear and their contributions to drug delivery

    Salt, A. N. & Hirose, K., May 2018, In : Hearing research. 362, p. 25-37 13 p.

    Research output: Contribution to journalReview article

  • 34 Scopus citations

    Benign Rolandic epilepsy presenting like paradoxical vocal fold motion

    Gross, J. H., Bertrand, M. & Hirose, K., Nov 2017, In : International Journal of Pediatric Otorhinolaryngology. 102, p. 154-156 3 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations