• 6783 Citations
1987 …2020

Research output per year

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Personal profile

Research interests

Our laboratory is focused on tumor immunology and understanding mechanisms of immunotherapy. Using syngeneic murine sarcoma models we are investigating the efficacy of both tumor specific neo-antigen vaccines and combination immune checkpoint therapy using both in vivo and high dimensional analyses to identify cellular populations and pathways that function for tumor elimination. These results may identify biomarkers or critical targets to inform and promote new translational studies. Dr. Sheehan is the Co-Head of the Immunomonitoring Laboratory within the Bursky Center for Human Immunology and Immunotherapy Programs, a Siteman Cancer Center Shared Resource that provides the structure, instrumentation and expertise to monitor the impact of specific immunotherapies on human and mouse immunologic profiles, interrogate mechanisms and pathways related to the treatment protocols and advance the conceptual basis for targeted treatment strategies. Dr. Sheehan is also the Director of the Hybridoma Center within the Division of Immunobiology that assists investigators in the development of novel monoclonal antibodies.

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Research Output

  • 6783 Citations
  • 52 Article
  • 3 Comment/debate
  • 1 Review article

Distinct roles of interferon alpha and beta in controlling chikungunya virus replication and modulating neutrophil-mediated inflammation

Cook, L. E., Locke, M. C., Young, A. R., Monte, K., Hedberg, M. L., Shimak, R. M., Sheehan, K. C. F., Veis, D. J., Diamond, M. S. & Lenschow, D. J., Jan 1 2020, In : Journal of virology. 94, 1, e00841-19.

Research output: Contribution to journalArticle

  • 9 Scopus citations

    MHC-II neoantigens shape tumour immunity and response to immunotherapy

    Alspach, E., Lussier, D. M., Miceli, A. P., Kizhvatov, I., DuPage, M., Luoma, A. M., Meng, W., Lichti, C. F., Esaulova, E., Vomund, A. N., Runci, D., Ward, J. P., Gubin, M. M., Medrano, R. F. V., Arthur, C. D., White, J. M., Sheehan, K. C. F., Chen, A., Wucherpfennig, K. W., Jacks, T. & 3 others, Unanue, E. R., Artyomov, M. N. & Schreiber, R. D., Oct 31 2019, In : Nature. 574, 7780, p. 696-701 6 p.

    Research output: Contribution to journalArticle

  • 64 Scopus citations

    Erratum: High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy (Cell (2018) 175(4) (1014–1030.e19), (S009286741831242X) (10.1016/j.cell.2018.09.030))

    Gubin, M. M., Esaulova, E., Ward, J. P., Malkova, O. N., Runci, D., Wong, P., Noguchi, T., Arthur, C. D., Meng, W., Alspach, E., Medrano, R. F. V., Fronick, C., Fehlings, M., Newell, E. W., Fulton, R., Sheehan, K., Oh, S., Schreiber, R. & Artomov, M., Nov 15 2018, In : Cell. 175, 5, p. 1443 1 p.

    Research output: Contribution to journalComment/debate

  • 11 Scopus citations

    High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

    Gubin, M. M., Esaulova, E., Ward, J. P., Malkova, O. N., Runci, D., Wong, P., Noguchi, T., Arthur, C. D., Meng, W., Alspach, E., Medrano, R. F. V., Fronick, C., Fehlings, M., Newell, E. W., Fulton, R., Sheehan, K., Oh, S., Schreiber, R. & Artomov, M., Nov 1 2018, In : Cell. 175, 4, p. 1014-1030.e19

    Research output: Contribution to journalArticle

  • 53 Scopus citations

    Blockade of interferon beta, but not interferon alpha, signaling controls persistent viral infection

    Ng, C. T., Sullivan, B. M., Teijaro, J. R., Lee, A. M., Welch, M., Rice, S., Sheehan, K. C. F., Schreiber, R. D. & Oldstone, M. B. A., May 13 2015, In : Cell Host and Microbe. 17, 5, p. 653-661 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 84 Scopus citations