Kathleen Schoch

2023

Evaluating the efficacy of purchased antisense oligonucleotides to reduce mouse and human tau in vivo

Vemula, P., Schoch, K. M. & Miller, T. M., 2023, In: Frontiers in Molecular Neuroscience. 16, 1320182.

Research output: Contribution to journal › Article › peer-review

Open Access

Protective Effects of Lovastatin in a Population-Based ALS Study and Mouse Model

Kreple, C. J., Searles Nielsen, S., Schoch, K. M., Shen, T., Shabsovich, M., Song, Y., Racette, B. A. & Miller, T. M., May 2023, In: Annals of neurology. 93, 5, p. 881-892 12 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice

Iyer, K., Schoch, K. M., Verbeck, A., Galasso, G., Chen, H., Smith, S., Oldenborg, A., Miller, T. M., Karch, C. M. & Bonni, A., Nov 2023, In: PloS one. 18, 11 November, e0294731.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma

Sun, R., Han, R., McCornack, C., Khan, S., Tabor, G. T., Chen, Y., Hou, J., Jiang, H., Schoch, K. M., Mao, D. D., Cleary, R., Yang, A., Liu, Q., Luo, J., Petti, A., Miller, T. M., Ulrich, J. D., Holtzman, D. M. & Kim, A. H., 2023, In: Science Advances. 9, 19, eade3559.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

2022

Antisense Oligonucleotides for the Study and Treatment of ALS

Boros, B. D., Schoch, K. M., Kreple, C. J. & Miller, T., Jul 2022, In: Neurotherapeutics. 19, 4, p. 1145-1158 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

63 Scopus citations

Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction

Ezerskiy, L. A., Schoch, K. M., Sato, C., Beltcheva, M., Horie, K., Rigo, F., Martynowicz, R., Karch, C. M., Bateman, R. J. & Miller, T. M., Jan 11 2022, In: JCI Insight. 7, 1, 152012.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2021

Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice

Schoch, K., Ezerskiy, L. A., Morhaus, M. M., Bannon, R. N., Sauerbeck, A., Shabsovich, M., Jafar-Nejad, P., Rigo, F. & Miller, T. M., Jul 6 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 27, e2100356118.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Improving scientific communication with service, education and career development

Dicks, A., Bhatia, H., Clemens, A. W., Locke, M. C., Mueller, E. A., Murphy, D., Pomper, N., Robinson, A. E. & Schoch, K. M., Oct 2021, In: Nature Biotechnology. 39, 10, p. 1309-1313 5 p.

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Is presymptomatic ALS perivascular?

Kreple, C., Schoch, K. & Miller, T. M., Apr 2021, In: Nature medicine. 27, 4, p. 585-586 2 p.

Research output: Contribution to journal › Comment/debate

1 Scopus citations

TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy

Alquezar, C., Schoch, K. M., Geier, E. G., Ramos, E. M., Scrivo, A., Li, K. H., Argouarch, A. R., Mlynarski, E. E., Dombroski, B., DeTure, M., Dickson, D. W., Yokoyama, J. S., Cuervo, A. M., Burlingame, A. L., Schellenberg, G. D., Miller, T. M., Miller, B. L. & Kao, A. W., Nov 2021, In: Science Advances. 7, 45, eabg3897.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

2018

Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models

McCampbell, A., Cole, T., Wegener, A. J., Tomassy, G. S., Setnicka, A., Farley, B. J., Schoch, K. M., Hoye, M. L., Shabsovich, M., Sun, L., Luo, Y., Zhang, M., Thankamony, S., Salzman, D. W., Cudkowicz, M., Graham, D. L., Bennett, C. F., Kordasiewicz, H. B., Swayze, E. E. & Miller, T. M., Aug 1 2018, In: Journal of Clinical Investigation. 128, 8, p. 3558-3567 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

198 Scopus citations

Protein production is an early biomarker for RNA-targeted therapies

Self, W. K., Schoch, K. M., Alex, J., Barthélemy, N., Bollinger, J. G., Sato, C., Cole, T., Kordasiewicz, H. B., Swayze, E., Bateman, R. J. & Miller, T. M., Dec 2018, In: Annals of Clinical and Translational Neurology. 5, 12, p. 1492-1504 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Synthesis and in vitro characterization of a P2X7 radioligand [¹²³I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease

Jin, H., Han, J., Resing, D., Liu, H., Yue, X., Miller, R. L., Schoch, K. M., Miller, T. M., Perlmutter, J. S., Egan, T. M. & Tu, Z., Feb 5 2018, In: European Journal of Pharmacology. 820, p. 8-17 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

2017

Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases

Schoch, K. M. & Miller, T. M., Jun 21 2017, In: Neuron. 94, 6, p. 1056-1070 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

226 Scopus citations

MicroRNA profiling reveals marker of motor neuron disease in ALS models

Hoye, M. L., Koval, E. D., Wegener, A. J., Hyman, T. S., Yang, C., O’Brien, D. R., Miller, R. L., Cole, T., Schoch, K. M., Shen, T., Kunikata, T., Richard, J. P., Gutmann, D. H., Maragakis, N. J., Kordasiewicz, H. B., Dougherty, J. D. & Miller, T. M., May 31 2017, In: Journal of Neuroscience. 37, 22, p. 5574-5586 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

DeVos, S. L., Miller, R. L., Schoch, K. M., Holmes, B. B., Kebodeaux, C. S., Wegener, A. J., Chen, G., Shen, T., Tran, H., Nichols, B., Zanardi, T. A., Kordasiewicz, H. B., Swayze, E. E., Bennett, C. F., Diamond, M. I. & Miller, T. M., Jan 25 2017, In: Science translational medicine. 9, 374, eaag0481.

Research output: Contribution to journal › Article › peer-review

Open Access

347 Scopus citations

2016

Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

Schoch, K. M., DeVos, S. L., Miller, R. L., Chun, S. J., Norrbom, M., Wozniak, D. F., Dawson, H. N., Bennett, C. ., Rigo, F. & Miller, T. M., Jun 1 2016, In: Neuron. 90, 5, p. 941-947 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

130 Scopus citations

2013

Brain injury-induced proteolysis is reduced in a novel calpastatin- overexpressing transgenic mouse

Schoch, K. M., Von Reyn, C. R., Bian, J., Telling, G. C., Meaney, D. F. & Saatman, K. E., Jun 2013, In: Journal of Neurochemistry. 125, 6, p. 909-920 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration

Ma, M., Ferguson, T. A., Schoch, K. M., Li, J., Qian, Y., Shofer, F. S., Saatman, K. E. & Neumar, R. W., Aug 2013, In: Neurobiology of Disease. 56, p. 34-46 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

99 Scopus citations

2012

Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury

Schoch, K. M., Evans, H. N., Brelsfoard, J. M., Madathil, S. K., Takano, J., Saido, T. C. & Saatman, K. E., Aug 2012, In: Experimental Neurology. 236, 2, p. 371-382 12 p.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Genetic Manipulation of Cell Death and Neuroplasticity Pathways in Traumatic Brain Injury

Schoch, K. M., Madathil, S. K. & Saatman, K. E., Apr 2012, In: Neurotherapeutics. 9, 2, p. 323-337 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

29 Scopus citations

Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains

Hunt, R. F., Haselhorst, L. A., Schoch, K. M., Bach, E. C., Rios-Pilier, J., Scheff, S. W., Saatman, K. E. & Smith, B. N., Mar 2012, In: Epilepsy Research. 99, 1-2, p. 167-170 4 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Kathleen Schoch

Research output

Search results