Karen Seibert

Professor of Anesthesiology, Professor of Genetics, Professor of Pathology and Immunology

    • 21622 Citations
    1984 …2015

    Research output per year

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    Personal profile

    Research interests

    My work is focused on identifying clinical and translational research programs designed to improve diagnosis or treatment of disease. I currently serve as Co-Director of the St Louis Center for Clinical Pharmacology, a newly formed joint research program between Washington University School of Medicine and the St Louis College of Pharmacy. The “Center for Clinical Pharmacology” primarily seeks the elucidation of novel uses of existing drugs and identification of new agents in the area of analgesia. Our approach focuses on the design and execution of clinical studies that utilize clinical biomarkers, assays and endpoints that translate basic science in pain research into clinical analgesia studies. Additionally, I am a member of the Senior Leadership Team of the Siteman Cancer Center, with oversight of the research cores that support both basic and clinical research studies, providing access to specialized technologies, services and expertise to investigators at Washington University and other partnered institutions. Since being at Washington University I created the clinical genomics group known as “Genomics and Pathology Services”, a team of geneticists, molecular biologists, pathologists and bioinformaticians that developed specific clinical genomic tests in CAP/CLIA regulated laboratories for patient care and clinical research programs that span oncology, neurology and cardiology. Prior to joining Washington University School of Medicine in 2010, I spent twenty years in the pharmaceutical industry, most recently as the Head of R&D for Pfizer St Louis Laboratories, overseeing research and clinical development of new drug candidates across numerous therapeutic areas, including the marketed product, Celebrex.

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    Research Output

    Clinical next-generation sequencing in patients with non-small cell lung cancer

    Hagemann, I. S., Devarakonda, S., Lockwood, C. M., Spencer, D. H., Guebert, K., Bredemeyer, A. J., Al-Kateb, H., Nguyen, T. T., Duncavage, E. J., Cottrell, C. E., Kulkarni, S., Nagarajan, R., Seibert, K., Baggstrom, M., Waqar, S. N., Pfeifer, J. D., Morgensztern, D. & Govindan, R., Feb 1 2015, In : Cancer. 121, 4, p. 631-639 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 126 Scopus citations

    Validation of a next-generation sequencing assay for clinical molecular oncology

    Cottrell, C. E., Al-Kateb, H., Bredemeyer, A. J., Duncavage, E. J., Spencer, D. H., Abel, H. J., Lockwood, C. M., Hagemann, I. S., O'Guin, S. M., Burcea, L. C., Sawyer, C. S., Oschwald, D. M., Stratman, J. L., Sher, D. A., Johnson, M. R., Brown, J. T., Cliften, P. F., George, B., McIntosh, L. D., Shrivastava, S. & 12 others, Nguyen, T. T., Payton, J. E., Watson, M. A., Crosby, S. D., Head, R. D., Mitra, R. D., Nagarajan, R., Kulkarni, S., Seibert, K., Virgin IV, H. W., Milbrandt, J. & Pfeifer, J. D., Jan 2014, In : Journal of Molecular Diagnostics. 16, 1, p. 89-105 17 p.

    Research output: Contribution to journalArticle

  • 138 Scopus citations

    The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: The first clinical candidate

    Wang, J. L., Carter, J., Kiefer, J. R., Kurumbail, R. G., Pawlitz, J. L., Brown, D., Hartmann, S. J., Graneto, M. J., Seibert, K. & Talley, J. J., Dec 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 23, p. 7155-7158 4 p.

    Research output: Contribution to journalArticle

  • 33 Scopus citations

    Evaluation of COX-1/COX-2 selectivity and potency of a new class of COX-2 inhibitors

    Gierse, J., Nickols, M., Leahy, K., Warner, J., Zhang, Y., Cortes-Burgos, L., Carter, J., Seibert, K. & Masferrer, J., Jun 24 2008, In : European Journal of Pharmacology. 588, 1, p. 93-98 6 p.

    Research output: Contribution to journalArticle

  • 22 Scopus citations

    Valdecoxib: Assessment of cyclooxygenase-2 potency and selectivity

    Gierse, J. K., Zhang, Y., Hood, W. F., Walker, M. C., Trigg, J. S., Maziasz, T. J., Koboldt, C. M., Muhammad, J. L., Zweifel, B. S., Masferrer, J. L., Isakson, P. C. & Seibert, K., Mar 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 3, p. 1206-1212 7 p.

    Research output: Contribution to journalArticle

    Open Access
  • 67 Scopus citations