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Personal profile

Research interests

My laboratory is interested in the molecular and cellular bases of neurological and neuropsychiatric disorders. For example, metabotropic glutamate receptors play important roles modulating neuronal excitability during critical processes such as development, synaptic plasticity and learning. Inhibitors of these receptors are being used in clinical trials for disorders of these processes including Fragile X Syndrome and autism spectrum disorders. Recently we found that these receptors can be expressed on the cell surface as well as nuclear membranes where they mediate increased calcium levels. Current efforts are aimed at deducing how receptors are activated, how they are targeted to intracellular membranes, and what the long-term consequences of receptor activation are.

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Research Output

Location and Cell-Type-Specific Bias of Metabotropic Glutamate Receptor, mGlu5, Negative Allosteric Modulators

Jong, Y. J. I., Harmon, S. K. & O'Malley, K. L., Nov 20 2019, In : ACS Chemical Neuroscience. 10, 11, p. 4558-4570 13 p.

Research output: Contribution to journalArticle

  • GPCR signalling from within the cell

    Jong, Y. J. I., Harmon, S. K. & O'Malley, K. L., Nov 2018, In : British Journal of Pharmacology. 175, 21, p. 4026-4035 10 p.

    Research output: Contribution to journalReview article

  • 23 Scopus citations

    Intracellular GPCRs Play Key Roles in Synaptic Plasticity

    Jong, Y. J. I., Harmon, S. K. & O'Malley, K. L., Sep 19 2018, In : ACS Chemical Neuroscience. 9, 9, p. 2162-2172 11 p.

    Research output: Contribution to journalReview article

  • 15 Scopus citations

    Mechanisms Associated with Activation of Intracellular Metabotropic Glutamate Receptor, mGluR5

    Jong, Y. J. I. & O’Malley, K. L., Jan 1 2017, In : Neurochemical Research. 42, 1, p. 166-172 7 p.

    Research output: Contribution to journalArticle

    Open Access
  • 8 Scopus citations

    Sequences within the C terminus of the metabotropic glutamate receptor 5 (mGluR5) are responsible for inner nuclear membrane localization

    Sergin, I., Jong, Y. J. I., Harmon, S. K., Kumar, V. & O'Malley, K. L., Mar 3 2017, In : Journal of Biological Chemistry. 292, 9, p. 3637-3655 19 p.

    Research output: Contribution to journalArticle

    Open Access
  • 16 Scopus citations