Karen Dodson

2023

Structure–function correlates of fibrinogen binding by Acinetobacter adhesins critical in catheter-associated urinary tract infections

Tamadonfar, K. O., Di Venanzio, G., Pinkner, J. S., Dodson, K. W., Kalas, V., Zimmerman, M. I., Villicana, J. B., Bowman, G. R., Feldman, M. F. & Hultgren, S. J., Jan 24 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 4, e2212694120.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Establishing the role of the gut microbiota in susceptibility to recurrent urinary tract infections

Worby, C. J., Olson, B. S., Dodson, K. W., Earl, A. M. & Hultgren, S. J., Mar 1 2022, In: Journal of Clinical Investigation. 132, 5, e158497.

Research output: Contribution to journal › Review article › peer-review

Open Access

5 Scopus citations

Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women

Worby, C. J., Schreiber, H. L., Straub, T. J., van Dijk, L. R., Bronson, R. A., Olson, B. S., Pinkner, J. S., Obernuefemann, C. L. P., Muñoz, V. L., Paharik, A. E., Azimzadeh, P. N., Walker, B. J., Desjardins, C. A., Chou, W. C., Bergeron, K., Chapman, S. B., Klim, A., Manson, A. L., Hannan, T. J., Hooton, T. M., & 5 othersKau, A. L., Lai, H. H., Dodson, K. W., Hultgren, S. J. & Earl, A. M., May 2022, In: Nature microbiology. 7, 5, p. 630-639 10 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics

Nye, T. M., Tukenmez, H., Singh, P., Flores-Mireles, A. L., Obernuefemann, C. L. P., Pinkner, J. S., Sarkar, S., Bonde, M., Lindgren, A. E. G., Dodson, K. W., Johansson, J., Almqvist, F., Caparon, M. G. & Hultgren, S. J., Oct 25 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 43, e2210912119.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections

Straub, T. J., Chou, W. C., Manson, A. L., Schreiber, H. L., Walker, B. J., Desjardins, C. A., Chapman, S. B., Kaspar, K. L., Kahsai, O. J., Traylor, E., Dodson, K. W., Hullar, M. A. J., Hultgren, S. J., Khoo, C. & Earl, A. M., Dec 2021, In: BMC Microbiology. 21, 1, 53.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2020

Adaptation of arginine synthesis among uropathogenic branches of the escherichia coli phylogeny reveals adjustment to the urinary tract habitat

Hibbing, M. E., Dodson, K. W., Kalas, V., Chen, S. L. & Hultgren, S. J., Sep 1 2020, In: mBio. 11, 5, p. 1-15 15 p., e02318-20.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2018

Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

Spaulding, C. N., Schreiber, H. L., Zheng, W., Dodson, K. W., Hazen, J. E., Conover, M. S., Wang, F., Svenmarker, P., Luna-Rico, A., Francetic, O., Andersson, M., Hultgren, S. & Egelman, E. H., Jan 18 2018, In: eLife. 7, e31662.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli

Omattage, N. S., Deng, Z., Pinkner, J. S., Dodson, K. W., Almqvist, F., Yuan, P. & Hultgren, S. J., Dec 1 2018, In: Nature microbiology. 3, 12, p. 1362-1368 7 p.

Research output: Contribution to journal › Letter › peer-review

12 Scopus citations

2017

Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections

Schreiber, H. L., Conover, M. S., Chou, W. C., Hibbing, M. E., Manson, A. L., Dodson, K. W., Hannan, T. J., Roberts, P. L., Stapleton, A. E., Hooton, T. M., Livny, J., Earl, A. M. & Hultgren, S. J., Mar 22 2017, In: Science translational medicine. 9, 382, eaaf1283.

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions

Kalas, V., Pinkner, J. S., Hannan, T. J., Hibbing, M. E., Dodson, K. W., Holehouse, A. S., Zhang, H., Tolia, N. H., Gross, M. L., Pappu, R. V., Janetka, J. & Hultgren, S. J., Feb 2017, In: Science Advances. 3, 2, e1601944.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Narrowing the spectrum: The new frontier of precision antimicrobials

Paharik, A. E., Schreiber, H. L., Spaulding, C. N., Dodson, K. W. & Hultgren, S. J., Dec 14 2017, In: Genome medicine. 9, 1, 110.

Research output: Contribution to journal › Comment/debate

Open Access

24 Scopus citations

One size doesn't fit all: Unraveling the diversity of factors and interactions that drive E. coli urovirulence

Schreiber, H. L., Spaulding, C. N., Dodson, K. W., Livny, J. & Hultgren, S. J., Jan 2017, In: Annals of Translational Medicine. 5, 2, 28.

Research output: Contribution to journal › Editorial

8 Scopus citations

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

Spaulding, C. N., Klein, R. D., Ruer, S., Kau, A. L., Schreiber, H. L., Cusumano, Z. T., Dodson, K. W., Pinkner, J. S., Fremont, D. H., Janetka, J. W., Remaut, H., Gordon, J. I. & Hultgren, S. J., Jun 22 2017, In: Nature. 546, 7659, p. 528-532 5 p.

Research output: Contribution to journal › Article › peer-review

177 Scopus citations

2016

Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection

Conover, M. S., Ruer, S., Taganna, J., Kalas, V., De Greve, H., Pinkner, J. S., Dodson, K. W., Remaut, H. & Hultgren, S. J., Oct 12 2016, In: Cell Host and Microbe. 20, 4, p. 482-492 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Metabolic requirements of Escherichia coli in intracellular bacterial communities during urinary tract infection pathogenesis

Conover, M. S., Hadjifrangiskou, M., Palermo, J. J., Hibbing, M. E., Dodson, K. W. & Hultgren, S. J., Apr 12 2016, In: mBio. 7, 2, e00104-16.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling

Hospenthal, M. K., Redzej, A., Dodson, K., Ukleja, M., Frenz, B., Rodrigues, C., Hultgren, S. J., Dimaio, F., Egelman, E. H. & Waksman, G., Jan 14 2016, In: Cell. 164, 1-2, p. 269-278 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

2015

Dysregulation of escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection

Nagamatsu, K., Hannan, T. J., Guest, R. L., Kostakioti, M., Hadjifrangiskou, M., Binkley, J., Dodson, K., Raivio, T. L. & Hultgren, S. J., Feb 24 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 8, p. E871-E880

Research output: Contribution to journal › Article › peer-review

Open Access

104 Scopus citations

Establishment and characterization of UTI and CAUTI in a mouse model

Conover, M. S., Flores-Mireles, A. L., Hibbing, M. E., Dodson, K. & Hultgren, S. J., Jun 23 2015, In: Journal of Visualized Experiments. 2015, 100, e52892.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Fueling the fire with fibers: Bacterial amyloids promote inflammatory disorders

Spaulding, C. N., Dodson, K. W., Chapman, M. R. & Hultgren, S. J., 2015, In: Cell Host and Microbe. 18, 1, p. 1-2 2 p.

Research output: Contribution to journal › Short survey › peer-review

Open Access

19 Scopus citations

2014

Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli

Greene, S. E., Pinkner, J. S., Chorell, E., Dodson, K. W., Shaffer, C. L., Conover, M. S., Livny, J., Hadjifrangiskou, M., Almqvist, F. & Hultgren, S. J., Sep 26 2014, In: mBio. 5, 6, e02038-14.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

2013

Escherichia coli biofilms have an organized and complex extracellular matrix structure

Hung, C., Zhou, Y., Pinkner, J. S., Dodson, K. W., Crowley, J. R., Heuser, J., Chapman, M. R., Hadjifrangiskou, M., Henderson, J. P. & Hultgren, S. J., Sep 10 2013, In: mBio. 4, 5, e00645-13.

Research output: Contribution to journal › Article › peer-review

Open Access

159 Scopus citations

Molecular basis of usher pore gating in Escherichia coli pilus biogenesis

Volkan, E., Kalas, V., Pinkner, J. S., Dodson, K. W., Henderson, N. S., Pham, T., Waksman, G., Delcour, A. H., Thanassi, D. G. & Hultgren, S. J., Dec 17 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 51, p. 20741-20746 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation

Schwartz, D. J., Kalas, V., Pinkner, J. S., Chen, S. L., Spaulding, C. N., Dodson, K. W. & Hultgren, S. J., Sep 24 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 39, p. 15530-15537 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

2012

Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice

Guiton, P. S., Cusumano, C. K., Kline, K. A., Dodson, K. W., Han, Z., Janetka, J. W., Henderson, J. P., Caparon, M. G. & Hultgren, S. J., Sep 2012, In: Antimicrobial agents and chemotherapy. 56, 9, p. 4738-4745 8 p.

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine

Volkan, E., Ford, B. A., Pinkner, J. S., Dodson, K. W., Henderson, N. S., Thanassi, D. G., Waksman, G. & Hultgren, S. J., Jun 12 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 24, p. 9563-9568 6 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

The structure of the PapD-PapGII pilin complex reveals an open and flexible p5 pocket

Ford, B., Verger, D., Dodson, K., Volkan, E., Kostakioti, M., Elam, J., Pinkner, J., Waksman, G. & Hultgren, S., Dec 2012, In: Journal of bacteriology. 194, 23, p. 6390-6397 8 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2010

A tale of two pili: Assembly and function of pili in bacteria

Kline, K. A., Dodson, K. W., Caparon, M. G. & Hultgren, S. J., May 2010, In: Trends in Microbiology. 18, 5, p. 224-232 9 p.

Research output: Contribution to journal › Review article › peer-review

113 Scopus citations

Structural homology between the C-terminal domain of the PapC usher and its plug

Ford, B., Rêgo, A. T., Ragan, T. J., Pinkner, J., Dodson, K., Driscoll, P. C., Hultgren, S. & Waksman, G., Apr 2010, In: Journal of bacteriology. 192, 7, p. 1824-1831 8 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

The differential affinity of the usher for chaperone-subunit complexes is required for assembly of complete pili

Li, Q., Ng, T. W., Dodson, K. W., So, S. S. K., Bayle, K. M., Pinkner, J. S., Scarlata, S., Hultgren, S. J. & Thanassi, D. G., Apr 2010, In: Molecular Microbiology. 76, 1, p. 159-172 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

2009

A murine model of urinary tract infection

Hung, C. S., Dodson, K. W. & Hultgren, S. J., 2009, In: Nature Protocols. 4, 8, p. 1230-1243 14 p.

Research output: Contribution to journal › Article › peer-review

211 Scopus citations

Contribution of autolysin and sortase A during Enterococcus faecalis DNA-dependent biofilm development

Guiton, P. S., Hung, C. S., Kline, K. A., Roth, R., Kau, A. L., Hayes, E., Heuser, J., Dodson, K. W., Caparon, M. G. & Hultgren, S. J., Sep 2009, In: Infection and immunity. 77, 9, p. 3626-3638 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

114 Scopus citations

2007

Adaptor function of PapF depends on donor strand exchange in P-pilus biogenesis of Escherichia coli

Lee, Y. M., Dodson, K. W. & Hultgren, S. J., Jul 2007, In: Journal of bacteriology. 189, 14, p. 5276-5283 8 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2004

Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis

Anderson, G. G., Dodson, K. W., Hooton, T. M. & Hultgren, S. J., Sep 2004, In: Trends in Microbiology. 12, 9, p. 424-430 7 p.

Research output: Contribution to journal › Review article › peer-review

138 Scopus citations

2003

Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides

Larsson, A., Ohlsson, J., Dodson, K. W., Hultgren, S. J., Nilsson, U. & Kihlberg, J., May 15 2003, In: Bioorganic and Medicinal Chemistry. 11, 10, p. 2255-2261 7 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

2002

Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis

Thanassi, D. G., Stathopoulos, C., Dodson, K., Geiger, D. & Hultgren, S. J., Nov 2002, In: Journal of bacteriology. 184, 22, p. 6260-6269 10 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

2001

Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor

Dodson, K. W., Pinkner, J. S., Rose, T., Magnusson, G., Hultgren, S. J. & Waksman, G., Jun 15 2001, In: Cell. 105, 6, p. 733-743 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

215 Scopus citations

2000

Role of intestinal surfactant-like particles as a potential reservoir of uropathogenic Escherichia coli

Mahmood, A., Engle, M. J., Hultgren, S. J., Goetz, G. S., Dodson, K. & Alpers, D. H., Sep 1 2000, In: Biochimica et Biophysica Acta - General Subjects. 1523, 1, p. 49-55 7 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

1999

Binding of pili from uropathogenic Escherichia coli to membranes secreted by human colonocytes and enterocytes

Goetz, G. S., Mahmood, A., Hultgren, S. J., Engle, M. J., Dodson, K. & Alpers, D. H., Nov 1999, In: Infection and immunity. 67, 11, p. 6161-6163 3 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Structural basis of chaperone function and pilus biogenesis

Sauer, F. G., Fütterer, K., Pinkner, J. S., Dodson, K. W., Hultgren, S. J. & Waksman, G., Aug 13 1999, In: Science. 285, 5430, p. 1058-1061 4 p.

Research output: Contribution to journal › Article › peer-review

331 Scopus citations

1998

Periplasmic chaperone recognition motif of subunits mediates quaternary interactions in the pilus

Soto, G. E., Dodson, K. W., Ogg, D., Liu, C., Heuser, J., Knight, S., Kihlberg, J., Jones, C. H. & Hultgren, S. J., Nov 2 1998, In: EMBO Journal. 17, 21, p. 6155-6167 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

83 Scopus citations

1995

Molecular dissection of PapD interaction with PapG reveals two chaperone‐binding sites

Xu, Z., Jones, C. H., Haslam, D., Pinkner, J. S., Dodson, K., Kihlberg, J. & Hultgren, S. J., Jun 1995, In: Molecular Microbiology. 16, 5, p. 1011-1020 10 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

1994

Genetic, biochemical, and structural studies of biogenesis of adhesive pili in bacteria

Kuehn, M. J., Jacob-Dubuisson, F., Dodson, K., Slonim, L., Striker, R. & Hultgren, S. J., Jan 1 1994, In: Methods in enzymology. 236, C, p. 282-306 25 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

1993

Initiation of assembly and association of the structural elements of a bacterial pilus depend on two specialized tip proteins

Jacob-Dubuisson, F., Heuser, J., Dodson, K., Normark, S. & Hultgren, S., 1993, In: EMBO Journal. 12, 3, p. 837-847 11 p.

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Outer-membrane PapC molecular usher discriminately recognizes periplasmic chaperone-pilus subunit complexes

Dodson, K. W., Jacob-Dubuisson, F., Striker, R. T. & Hultgren, S. J., 1993, In: Proceedings of the National Academy of Sciences of the United States of America. 90, 8, p. 3670-3674 5 p.

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

1992

Adhesin presentation in bacteria requires molecular chaperones and ushers

Jones, C. H., Jacob-Dubuisson, F., Dodson, K., Kuehn, M., Slonim, L., Striker, R. & Hultgren, S. J., 1992, In: Infection and immunity. 60, 11, p. 4445-4451 7 p.

Research output: Contribution to journal › Short survey › peer-review

40 Scopus citations

1991