Julie Schwarz

2024

Accuracy of surveillance serum squamous cell carcinoma antigen for cervical cancer recurrence after definitive chemoradiation

Shi, V., Grover, S., Huang, Y., Thaker, P. H., Kuroki, L. M., Powell, M. A., Mutch, D. G., Contreras, J. A., Schwarz, J. K., Grigsby, P. W. & Markovina, S., Jun 1 2024, In: International Journal of Gynecological Cancer. 34, 6, p. 808-816 9 p.

Research output: Contribution to journal › Article › peer-review

GAiN: An integrative tool utilizing generative adversarial neural networks for augmented gene expression analysis

Waters, M. R., Inkman, M., Jayachandran, K., Kowalchuk, R. M., Robinson, C., Schwarz, J. K., Swamidass, S. J., Griffith, O. L., Szymanski, J. J. & Zhang, J., Feb 9 2024, In: Patterns. 5, 2, 100910.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2023

Cardiac radiation improves ventricular function in mice and humans with cardiomyopathy

Pedersen, L. N., Valenzuela Ripoll, C., Ozcan, M., Guo, Z., Lotfinaghsh, A., Zhang, S., Ng, S., Weinheimer, C., Nigro, J., Kovacs, A., Diab, A., Klaas, A., Grogan, F., Cho, Y., Ataran, A., Luehmann, H., Heck, A., Kolb, K., Strong, L. & Navara, R. & 15 others, Walls, G. M., Hugo, G., Samson, P., Cooper, D., Reynoso, F. J., Schwarz, J. K., Moore, K., Lavine, K., Rentschler, S. L., Liu, Y., Woodard, P. K., Robinson, C., Cuculich, P. S., Bergom, C. & Javaheri, A., Dec 8 2023, In: Med. 4, 12, p. 928-943.e5

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

Liu, X., Hogg, G. D., Zuo, C., Borcherding, N. C., Baer, J. M., Lander, V. E., Kang, L. I., Knolhoff, B. L., Ahmad, F., Osterhout, R. E., Galkin, A. V., Bruey, J. M., Carter, L. L., Mpoy, C., Vij, K. R., Fields, R. C., Schwarz, J. K., Park, H., Gupta, V. & DeNardo, D. G., Jun 12 2023, In: Cancer Cell. 41, 6, p. 1073-1090.e12

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Endogenous Retrovirus RNA Expression Differences between Race, Stage and HPV Status Offer Improved Prognostication among Women with Cervical Cancer

Alldredge, J., Kumar, V., Nguyen, J., Sanders, B. E., Gomez, K., Jayachandran, K., Zhang, J., Schwarz, J. & Rahmatpanah, F., Jan 2023, In: International journal of molecular sciences. 24, 2, 1492.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Epigenetic regulation during cancer transitions across 11 tumour types

Terekhanova, N. V., Karpova, A., Liang, W. W., Strzalkowski, A., Chen, S., Li, Y., Southard-Smith, A. N., Iglesia, M. D., Wendl, M. C., Jayasinghe, R. G., Liu, J., Song, Y., Cao, S., Houston, A., Liu, X., Wyczalkowski, M. A., Lu, R. J. H., Caravan, W., Shinkle, A. & Naser Al Deen, N. & 24 others, Herndon, J. M., Mudd, J., Ma, C., Sarkar, H., Sato, K., Ibrahim, O. M., Mo, C. K., Chasnoff, S. E., Porta-Pardo, E., Held, J. M., Pachynski, R., Schwarz, J. K., Gillanders, W. E., Kim, A. H., Vij, R., DiPersio, J. F., Puram, S. V., Chheda, M. G., Fuh, K. C., DeNardo, D. G., Fields, R. C., Chen, F., Raphael, B. J. & Ding, L., Nov 9 2023, In: Nature. 623, 7986, p. 432-441 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Joseph L. Roti Roti, PhD (1943-2023)

Schwarz, J. & Freeman, M. L., Jul 1 2023, In: Radiation research. 200, 1, p. 102-105 4 p.

Research output: Contribution to journal › Article › peer-review

SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production

Chen, L., Shi, V., Wang, S., Sun, L., Freeman, R., Yang, J., Inkman, M. J., Ghosh, S., Ruiz, F., Jayachandran, K., Huang, Y., Luo, J., Zhang, J., Cosper, P., Luke, C. J., Spina, C. S., Grigsby, P. W., Schwarz, J. K. & Markovina, S., Aug 1 2023, In: Journal of Clinical Investigation. 133, 15, e163841.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2022

Author Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment (Nature Communications, (2021), 12, 1, (5086), 10.1038/s41467-021-25177-3)

The NCI PDXNet Consortium, Dec 2022, In: Nature communications. 13, 1, 294.

Research output: Contribution to journal › Comment/debate

Open Access

2 Scopus citations

Expression of Potential Biomarker Targets by Immunohistochemistry in Cervical Carcinomas

Sun, L., Schroeder, M. C., Hagemann, I. S., Pfeifer, J. D., Schwarz, J., Grigsby, P. W., Markovina, S. & Lin, A., 2022, (Accepted/In press) In: International Journal of Gynecological Pathology.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Improving cervical cancer survival–A multifaceted strategy to sustain progress for this global problem

Markovina, S., Rendle, K. A., Cohen, A. C., Kuroki, L. M., Grover, S. & Schwarz, J. K., Dec 1 2022, In: Cancer. 128, 23, p. 4074-4084 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

Management and prognosis of cervical cancer patients treated with definitive radiation therapy who have partial metabolic response on post-therapy positron emission tomography

Mckinnish, T. R., Greenwade, M. M., Wilkinson-Ryan, I., Schwarz, J. K., Powell, M. A., Mutch, D. G., Massad, L. S., Grigsby, P. W., Siegel, B. A. & Thaker, P. H., Jul 2022, In: Gynecologic oncology. 166, 1, p. 173-180 8 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Monounsaturated and Diunsaturated Fatty Acids Sensitize Cervical Cancer to Radiation Therapy

Muhammad, N., Ruiz, F., Stanley, J., Rashmi, R., Cho, K., Jayachandran, K., Zahner, M. C., Huang, Y., Zhang, J., Markovina, S., Patti, G. J. & Schwarz, J. K., Dec 1 2022, In: Cancer research. 82, 24, p. 4515-4527 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Overall survival in patients with FIGO stage IVA cervical cancer

Schiff, J. P., Mintz, R., Cohen, A. C., Huang, Y., Thaker, P., Massad, L. S., Powell, M., Mutch, D., Schwarz, J. K., Markovina, S. T. & Grigsby, P. W., Aug 2022, In: Gynecologic oncology. 166, 2, p. 292-299 8 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Phase I Trial of Stereotactic MRI-Guided Online Adaptive Radiation Therapy (SMART) for the Treatment of Oligometastatic Ovarian Cancer

Henke, L. E., Stanley, J. A., Robinson, C., Srivastava, A., Contreras, J. A., Curcuru, A., Green, O. L., Massad, L. S., Kuroki, L., Fuh, K., Hagemann, A., Mutch, D., McCourt, C., Thaker, P., Powell, M., Markovina, S., Grigsby, P. W., Schwarz, J. K. & Chundury, A., Feb 1 2022, In: International Journal of Radiation Oncology Biology Physics. 112, 2, p. 379-389 11 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation

Wang, S., Luke, C. J., Pak, S. C., Shi, V., Chen, L., Moore, J., Andress, A. P., Jayachandran, K., Zhang, J., Huang, Y., Platik, M., Apicelli, A. A., Schwarz, J. K., Grigsby, P. W., Silverman, G. A. & Markovina, S., Dec 2022, In: Communications Biology. 5, 1, 46.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer

Cui Zhou, D., Jayasinghe, R. G., Chen, S., Herndon, J. M., Iglesia, M. D., Navale, P., Wendl, M. C., Caravan, W., Sato, K., Storrs, E., Mo, C. K., Liu, J., Southard-Smith, A. N., Wu, Y., Naser Al Deen, N., Baer, J. M., Fulton, R. S., Wyczalkowski, M. A., Liu, R. & Fronick, C. C. & 46 others, Fulton, L. A., Shinkle, A., Thammavong, L., Zhu, H., Sun, H., Wang, L. B., Li, Y., Zuo, C., McMichael, J. F., Davies, S. R., Appelbaum, E. L., Robbins, K. J., Chasnoff, S. E., Yang, X., Reeb, A. N., Oh, C., Serasanambati, M., Lal, P., Varghese, R., Mashl, J. R., Ponce, J., Terekhanova, N. V., Yao, L., Wang, F., Chen, L., Schnaubelt, M., Lu, R. J. H., Schwarz, J. K., Puram, S. V., Kim, A. H., Song, S. K., Shoghi, K. I., Lau, K. S., Ju, T., Chen, K., Chatterjee, D., Hawkins, W. G., Zhang, H., Achilefu, S., Chheda, M. G., Oh, S. T., Gillanders, W. E., Chen, F., DeNardo, D. G., Fields, R. C. & Ding, L., Sep 2022, In: Nature Genetics. 54, 9, p. 1390-1405 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

85 Scopus citations

Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade

Lander, V. E., Belle, J. I., Kingston, N. L., Herndon, J. M., Hogg, G. D., Liu, X., Kang, L. I., Knolhoff, B. L., Bogner, S. J., Baer, J. M., Zuo, C., Borcherding, N. C., Lander, D. P., Mpoy, C., Scott, J., Zahner, M., Rogers, B. E., Schwarz, J. K., Kim, H. & Denardo, D. G., Dec 1 2022, In: Cancer discovery. 12, 12, p. 2774-2799 26 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

The impact of tumor size and histology on local control when utilizing high-dose-rate interstitial brachytherapy for gynecologic malignancies

Schiff, J. P., Mahmood, M., Huang, Y., Powell, M. A., Mutch, D., Dyk, P. T., Lin, A., Schwarz, J. K., Markovina, S. T. & Grigsby, P. W., Jun 2022, In: Gynecologic oncology. 165, 3, p. 486-492 7 p.

Research output: Contribution to journal › Article › peer-review

2021

Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis

Zhang, D. M., Navara, R., Yin, T., Szymanski, J., Goldsztejn, U., Kenkel, C., Lang, A., Mpoy, C., Lipovsky, C. E., Qiao, Y., Hicks, S., Li, G., Moore, K. M. S., Bergom, C., Rogers, B. E., Robinson, C. G., Cuculich, P. S., Schwarz, J. K. & Rentschler, S. L., Dec 1 2021, In: Nature communications. 12, 1, 5558.

Research output: Contribution to journal › Article › peer-review

Open Access

87 Scopus citations

Genomic characterization and therapeutic targeting of hpv undetected cervical carcinomas

Ruiz, F. J., Sundaresan, A., Zhang, J., Pedamallu, C. S., Halle, M. K., Srinivasasainagendra, V., Zhang, J., Muhammad, N., Stanley, J., Markovina, S., Tiwari, H. K., Grigsby, P. W., Krakstad, C., Schwarz, J. K. & Ojesina, A. I., Sep 2021, In: Cancers. 13, 18, 4551.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

HPV transcript expression affects cervical cancer response to chemoradiation

Ruiz, F. J., Inkman, M., Rashmi, R., Muhammad, N., Gabriel, N., Miller, C., McLellan, M. D., Goldstein, M., Markovina, S., Grigsby, P., Zhang, J. & Schwarz, J., Aug 23 2021, In: JCI Insight. 6, 16, e138734.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

In Regard to Salama et al

Perkins, S., Hallahan, D. E. & Schwarz, J. K., Jul 1 2021, In: International Journal of Radiation Oncology Biology Physics. 110, 3, p. 918-919 2 p.

Research output: Contribution to journal › Letter › peer-review

Integrating imaging and RNA-seq improves outcome prediction in cervical cancer

Zhang, J., Rashmi, R., Inkman, M., Jayachandran, K., Ruiz, F., Waters, M. R., Grigsby, P. W., Markovina, S. & Schwarz, J. K., Mar 1 2021, In: Journal of Clinical Investigation. 131, 5, e139232.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Leveraging Radiobiology for Arrhythmia Management: A New Treatment Paradigm?

Zhang, D. M., Szymanski, J., Bergom, C., Cuculich, P. S., Robinson, C. G., Schwarz, J. K. & Rentschler, S. L., Nov 2021, In: Clinical Oncology. 33, 11, p. 723-734 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Localized Delivery of Cisplatin to Cervical Cancer Improves Its Therapeutic Efficacy and Minimizes Its Side Effect Profile

Federico, C., Sun, J., Muz, B., Alhallak, K., Cosper, P. F., Muhammad, N., Jeske, A., Hinger, A., Markovina, S., Grigsby, P., Schwarz, J. K. & Azab, A. K., Apr 1 2021, In: International Journal of Radiation Oncology Biology Physics. 109, 5, p. 1483-1494 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Long-Term Outcomes of Cervical Cancer Patients Treated With Definitive Chemoradiation Following a Complete Metabolic Response

Lin, A. J., Dehdashti, F., Massad, L. S., Thaker, P. H., Powell, M. A., Mutch, D. G., Schwarz, J. K., Markovina, S., Siegel, B. A. & Grigsby, P. W., May 2021, In: Clinical Oncology. 33, 5, p. 300-306 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Radiation therapy for vaginal and perirectal lesions in recurrent ovarian cancer

Johns, E. A., Stanley, J. A., Toboni, M. D., Schwarz, J. K., Zhang, F., Hagemann, A. R., Fuh, K. C., Thaker, P. H., McCourt, C. K., Mutch, D. G., Powell, M. A., Khabele, D. & Kuroki, L. M., Aug 2021, In: Gynecologic Oncology Reports. 37, 100808.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Standardized uptake value for ¹⁸F-fluorodeoxyglucose is a marker of inflammatory state and immune infiltrate in cervical cancer

Floberg, J. M., Zhang, J., Muhammad, N., DeWees, T. A., Inkman, M., Chen, K., Lin, A. J., Rashmi, R., Jayachandran, K., Edelson, B. T., Siegel, B. A., Dehdashti, F., Grigsby, P. W., Markovina, S. & Schwarz, J. K., Aug 1 2021, In: Clinical Cancer Research. 27, 15, p. 4245-4255 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2020

Alteration of Cellular Reduction Potential Will Change ⁶⁴Cu-ATSM Signal With or Without Hypoxia

Floberg, J. M., Wang, L., Bandara, N., Rashmi, R., Mpoy, C., Garbow, J. R., Rogers, B. E., Patti, G. J. & Schwarz, J. K., Mar 1 2020, In: Journal of Nuclear Medicine. 61, 3, p. 427-432 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Decreased local immune response and retained HPV gene expression during chemoradiotherapy are associated with treatment resistance and death from cervical cancer

Cosper, P. F., McNair, C., González, I., Wong, N., Knudsen, K. E., Chen, J. J., Markovina, S., Schwarz, J. K., Grigsby, P. W. & Wang, X., Apr 1 2020, In: International Journal of Cancer. 146, 7, p. 2047-2058 12 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

Hegde, S., Krisnawan, V. E., Herzog, B. H., Zuo, C., Breden, M. A., Knolhoff, B. L., Hogg, G. D., Tang, J. P., Baer, J. M., Mpoy, C., Lee, K. B., Alexander, K. A., Rogers, B. E., Murphy, K. M., Hawkins, W. G., Fields, R. C., DeSelm, C. J., Schwarz, J. K. & DeNardo, D. G., Mar 16 2020, In: Cancer Cell. 37, 3, p. 289-307.e9

Research output: Contribution to journal › Article › peer-review

Open Access

264 Scopus citations

Early posttherapy clearance of human papillomavirus and treatment response in cervical carcinoma

Srivastava, A. J., Contreras, J. A., Davis, M., Markovina, S. T., Schwarz, J. K. & Grigsby, P. W., Sep 15 2020, In: Cancer. 126, 18, p. 4168-4176 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

FIGO 2018 staging criteria for cervical cancer: Impact on stage migration and survival

Grigsby, P. W., Massad, L. S., Mutch, D. G., Powell, M. A., Thaker, P. H., McCourt, C., Hagemann, A., Fuh, K., Kuroki, L., Schwarz, J. K., Markovina, S., Lin, A. J., Dehdashti, F. & Siegel, B. A., Jun 2020, In: Gynecologic oncology. 157, 3, p. 639-643 5 p.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Glutaminase inhibitors induce thiol-mediated oxidative stress and radiosensitization in treatment-resistant cervical cancers

Rashmi, R., Jayachandran, K., Zhang, J., Menon, V., Muhammad, N., Zahner, M., Ruiz, F., Zhang, S., Cho, K., Wang, Y., Huang, X., Huang, Y., McCormick, M. L., Rogers, B. E., Spitz, D. R., Patti, G. J. & Schwarz, J. K., Dec 1 2020, In: Molecular Cancer Therapeutics. 19, 12, p. 2465-2475 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

HPV-EM: an accurate HPV detection and genotyping EM algorithm

Inkman, M. J., Jayachandran, K., Ellis, T. M., Ruiz, F., McLellan, M. D., Miller, C. A., Wu, Y., Ojesina, A. I., Schwarz, J. K. & Zhang, J., Dec 1 2020, In: Scientific reports. 10, 1, 14340.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Long-term outcomes of intensity-modulated radiation therapy (IMRT) and high dose rate brachytherapy as adjuvant therapy after radical hysterectomy for cervical cancer

Contreras, J., Srivastava, A., Chundury, A., Schwarz, J. K., Markovina, S., Thaker, P. H., Massad, L. S., Mutch, D. G., Powell, M. A., Grigsby, P. W. & Lin, A. J., Aug 1 2020, In: International Journal of Gynecological Cancer. 30, 8, p. 1157-1161 5 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Radiologic Assessment of Groin Lymph Nodes in Pelvic Malignancies

Rudra, S., Fuser, D., Dewees, T. A., Wan, L., Gang, M., Hui, C. Y., Rao, Y. J., Siegel, B. A., Dehdashti, F., Mutch, D. G., Powell, M. A., Schwarz, J. K., Grigsby, P. W., Chen, D. L. & Markovina, S., Jul 1 2020, In: International Journal of Gynecological Cancer. 30, 7, p. 947-953 7 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Results of an early safety analysis of a study of the combination of pembrolizumab and pelvic chemoradiation in locally advanced cervical cancer

Duska, L. R., Scalici, J. M., Temkin, S. M., Schwarz, J. K., Crane, E. K., Moxley, K. M., Hamilton, C. A., Wethington, S. L., Petroni, G. R., Varhegyi, N. E., Clift, S. H., Bullock, T. N. J. & Showalter, T. N., Nov 15 2020, In: Cancer. 126, 22, p. 4948-4956 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Targeting tumor metabolism to overcome radioresistance

Wahl, D., Petronek, M., Ramachandran, R., Floberg, J., Allen, B. G. & Schwarz, J. K., 2020, Cancer Drug Discovery and Development. Humana Press Inc., p. 219-263 45 p. (Cancer Drug Discovery and Development).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Therapy-induced senescence drives bone loss

Yao, Z., Murali, B., Ren, Q., Luo, X., Faget, D. V., Cole, T., Ricci, B., Thotala, D., Monahan, J., Van Deursen, J. M., Baker, D., Faccio, R., Schwarz, J. K. & Stewart, S. A., Mar 1 2020, In: Cancer research. 80, 5, p. 1171-1182 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

Tumor microenvironment as a regulator of radiation therapy: New insights into stromalmediated radioresistance

Krisnawan, V. E., Stanley, J. A., Schwarz, J. K. & Denardo, D. G., Oct 2 2020, In: Cancers. 12, 10, p. 1-25 25 p., 2916.

Research output: Contribution to journal › Review article › peer-review

Open Access

70 Scopus citations

2019

Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies

Panni, R. Z., Herndon, J. M., Zuo, C., Hegde, S., Hogg, G. D., Knolhoff, B. L., Breden, M. A., Li, X., Krisnawan, V. E., Khan, S. Q., Schwarz, J. K., Rogers, B. E., Fields, R. C., Hawkins, W. G., Gupta, V. & DeNardo, D. G., Jul 3 2019, In: Science translational medicine. 11, 499, aau9240.

Research output: Contribution to journal › Article › peer-review

Open Access