Research output per year
Research output per year
Personal profile
Research interests
I am a behavioral neuroscientist with training in molecular biology. My research interests revolve around the neurobiology and etiology of neurodevelopmental disorders. I have a strong background in the application of rodent models in behavioral assays to investigate the neurobiological mechanisms related to behavioral disruptions observed in psychiatric disorders. I am interested in determining the underlying mechanisms leading to both central and peripheral defects associated with lysosomal storage diseases (LSDs) and using that information to develop effective therapies for this class of disease.
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Collaborations and top research areas from the last five years
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Erratum: A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation (Neuron (2021) 109(23) (3775–3792.e14), (S0896627321006814), (10.1016/j.neuron.2021.09.009))
Chen, J., Lambo, M. E., Ge, X., Dearborn, J. T., Liu, Y., McCullough, K. B., Swift, R. G., Tabachnick, D. R., Tian, L., Noguchi, K., Garbow, J. R., Constantino, J. N., Gabel, H. W., Hengen, K. B., Maloney, S. E. & Dougherty, J. D., Jul 3 2024, In: Neuron. 112, 13, p. 2257 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Gene therapy ameliorates spontaneous seizures associated with cortical neuron loss in a Cln2R207X mouse model
Takahashi, K., Eultgen, E. M., Wang, S. H., Rensing, N. R., Nelvagal, H. R., Dearborn, J. T., Danos, O., Buss, N., Sands, M. S., Wong, M. & Cooper, J. D., Jun 15 2023, In: Journal of Clinical Investigation. 133, 12, e165908.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep
Nelvagal, H. R., Eaton, S. L., Wang, S. H., Eultgen, E. M., Takahashi, K., Le, S. Q., Nesbitt, R., Dearborn, J. T., Siano, N., Puhl, A. C., Dickson, P. I., Thompson, G., Murdoch, F., Brennan, P. M., Gray, M., Greenhalgh, S. N., Tennant, P., Gregson, R., Clutton, E. & Nixon, J. & 10 others, , Oct 17 2022, In: Journal of Clinical Investigation. 132, 20, e163107.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures
Dearborn, J. T., Nelvagal, H. R., Rensing, N. R., Takahashi, K., Hughes, S. M., Wishart, T. M., Cooper, J. D., Wong, M. & Sands, M. S., Dec 2022, In: Scientific reports. 12, 1, 11286.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation
Chen, J., Lambo, M. E., Ge, X., Dearborn, J. T., Liu, Y., McCullough, K. B., Swift, R. G., Tabachnick, D. R., Tian, L., Noguchi, K., Garbow, J. R., Constantino, J. N., Gabel, H. W., Hengen, K. B., Maloney, S. E. & Dougherty, J. D., Dec 1 2021, In: Neuron. 109, 23, p. 3775-3792.e14Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations