Personal profile
Research interests
In our lab we are interested in the relationship between normal brain development and the genesis of pediatric brain tumors. We believe that a better understanding of this relationship will support the development of novel brain tumor therapies with greater efficacy and reduced toxicity. These studies require the utilization of primary tumor specimens for biological and expression studies.
Clinical interests
Pediatric hematology, pediatric oncology, brain tumor. optic glioma, neurofibromatosis
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Circadian variation in MGMT promoter methylation and expression predicts sensitivity to temozolomide in glioblastoma
Gonzalez-Aponte, M. F., Huang, Y., Leidig, W. A., Simon, T., Butt, O. H., Ruben, M. D., Kim, A. H., Rubin, J. B., Herzog, E. D. & Walch, O. J., Jan 2026, In: Journal of Neuro-Oncology. 176, 1, 36.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Daily locomotor activity declines with tumor growth and disease progression in glioblastoma
Gonzalez-Aponte, M. F., Salvatore, S. V., Damato, A. R., Katumba, R. G., Talcott, G. R., Butt, O. H., Campian, J. L., Luo, J., Rubin, J. B., Walch, O. J. & Herzog, E. D., Jan 9 2026, In: JCI Insight. 11, 1Research output: Contribution to journal › Article › peer-review
Open Access -
NF-κB and STAT3 signaling uniquely stratify survival in female glioblastoma patients
Wong, J. P., Llaci, L., Tripp, L., Jeon, M. S., Yang, L., Reinhold, N., Warrington, N. M., Luo, J., Mitra, R. D. & Rubin, J. B., Feb 20 2026, In: iScience. 29, 2, 114761.Research output: Contribution to journal › Article › peer-review
Open Access -
Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host
Gonzalez-Aponte, M. F., Damato, A. R., Simon, T., Aripova, N., Darby, F., Jeon, M. S., Luo, J., Rubin, J. B. & Herzog, E. D., Jan 13 2025, In: Cancer Cell. 43, 1, p. 144-160.e7Research output: Contribution to journal › Article › peer-review
Open Access29 Link opens in a new tab Scopus citations -
Gender and sex interactions are intrinsic components of cancer phenotypes
Rubin, J. B., Aug 2025, In: Nature Reviews Cancer. 25, 8, p. 634-648 15 p.Research output: Contribution to journal › Article › peer-review
4 Link opens in a new tab Scopus citations