Joseph Vogel

Associate Professor of Molecular Microbiology

    • 4396 Citations
    1988 …2020

    Research output per year

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    Personal profile

    Research interests

    My laboratory is interested in how pathogens are able to survive and replicate inside host cells. We have chosen to focus on one bacterial pathogen, Legionella pneumophila, that is able to grow inside the hostile environment of professional phagocytic cells such as macrophages and fresh water amoebae. Growth of L. pneumophila inside alveolar macrophages of the human lung results in a potentially fatal form of pneumonia called Legionnaires’ disease. L. pneumophila is able to survive inside host cells by preventing fusion of the nascent phagosome with the degradative compartment, the lysosome. We have discovered a large number of L. pneumophila genes that are absolutely required for intracellular replication. These genes are called “dot” for defect in organelle trafficking because mutant strains lacking these genes are unable to perturb the normal endocytic pathway of the macrophage. Based on similarities between the dot genes and bacterial conjugation systems, we believe that the dot machine constitutes an export apparatus that evolved from a plasmid transfer system. The dot secretion complex presumably is used to deposit virulence factor(s) into host cells that are then responsible for preventing phagosome-lysosome fusion. In addition to L. pneumophila, a number of other pathogens including Bordetella pertussis, Helicobacter pylori, and Brucella abortus contain related complexes which have all been classified as type IV secretion systems. Determining how these specialized export apparatuses function will allow us to understand how these pathogens cause disease and reveal methods to prevent or inhibit their action.

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    Research Output

    • 4396 Citations
    • 43 Article
    • 2 Review article
    • 1 Comment/debate
    • 1 Short survey

    Publisher Correction: In vivo structure of the Legionella type II secretion system by electron cryotomography (Nature Microbiology, (2019), 4, 12, (2101-2108), 10.1038/s41564-019-0603-6)

    Ghosal, D., Kim, K. W., Zheng, H., Kaplan, M., Truchan, H. K., Lopez, A. E., McIntire, I. E., Vogel, J. P., Cianciotto, N. P. & Jensen, G. J., Apr 1 2020, In : Nature microbiology. 5, 4, 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex

    Kim, H., Kubori, T., Yamazaki, K., Kwak, M. J., Park, S. Y., Nagai, H., Vogel, J. P. & Oh, B. H., Dec 1 2020, In : Nature communications. 11, 1, 2623.

    Research output: Contribution to journalArticle

    Open Access
  • Deubiquitination of phosphoribosyl-ubiquitin conjugates by phosphodiesterase-domain–containing Legionella effectors

    Wan, M., Sulpizio, A. G., Akturk, A., Beck, W. H. J., Lanz, M., Faça, V. M., Smolka, M. B., Vogel, J. P. & Mao, Y., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 47, p. 23518-23526 9 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    In vivo structure of the Legionella type II secretion system by electron cryotomography

    Ghosal, D., Kim, K. W., Zheng, H., Kaplan, M., Truchan, H. K., Lopez, A. E., McIntire, I. E., Vogel, J. P., Cianciotto, N. P. & Jensen, G. J., Dec 1 2019, In : Nature microbiology. 4, 12, p. 2101-2108 8 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Molecular architecture, polar targeting and biogenesis of the Legionella Dot/Icm T4SS

    Ghosal, D., Jeong, K. C., Chang, Y. W., Gyore, J., Teng, L., Gardner, A., Vogel, J. P. & Jensen, G. J., Jul 1 2019, In : Nature microbiology. 4, 7, p. 1173-1182 10 p.

    Research output: Contribution to journalArticle

  • 15 Scopus citations