Joseph Dougherty

Associate Professor of Genetics, Associate Professor of Psychiatry

    • 2760 Citations
    20012020

    Research output per year

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    Personal profile

    Research interests

    Our laboratory is interested in the genetics and genomics of behavior in health and disease. We utilize a variety of techniques, including human molecular genetics, informatics, mouse behavior, in vitro neuroscience, and neuroanatomy. We are continuously developing novel methods for transgenesis, gene manipulation, and transcriptional profiling of the brain. These tools help us to develop mouse models for discovery and modeling of genetic variations based on human patient populations, in order to understand the cellular and molecular underpinnings of behavior. We are particularly focused on neurodevelopmental disorders, including the autism spectrum.

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    Research Output

    An inducible Cre mouse line to sparsely target nervous system cells, including Remak Schwann cells

    Sapkota, D. & Dougherty, J. D., Feb 20 2020, In : Neural Development. 15, 1, 2.

    Research output: Contribution to journalArticle

    Open Access
  • A viral toolkit for recording transcription factor-DNA interactions in live mouse tissues

    Cammack, A. J., Moudgil, A., Chen, J., Vasek, M. J., Shabsovich, M., McCullough, K., Yen, A., Lagunas, T., Maloney, S. E., He, J., Chen, X., Hooda, M., Wilkinson, M. N., Miller, T. M., Mitra, R. D. & Dougherty, J. D., May 5 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 18, p. 10003-10014 12 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system

    Pomper, N., Liu, Y., Hoye, M. L., Dougherty, J. D. & Miller, T. M., Dec 1 2020, In : Scientific reports. 10, 1, 4921.

    Research output: Contribution to journalArticle

    Open Access
  • Functions of Gtf2i and Gtf2ird1 in the developing brain: Transcription, DNA binding and long-term behavioral consequences

    Kopp, N. D., Nygaard, K. R., Liu, Y., McCullough, K. B., Maloney, S. E., Gabel, H. W. & Dougherty, J. D., Jun 3 2020, In : Human molecular genetics. 29, 9, p. 1498-1519 22 p.

    Research output: Contribution to journalArticle