Jose Moron-Concepcion

Professor of Anesthesiology, Professor of Neuroscience, Professor of Psychiatry

    • 2056 Citations
    19982020

    Research output per year

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    Personal profile

    Research interests

    Studies in our laboratory are focused in elucidating the molecular mechanisms underlying opiate dependence. In addition, given the fact that opiates are widely used in the clinic for the treatment of acute and chronic pain conditions, and the current rise in the rates of addiction to, and misuse of prescription opiates, we are interested in examining the effects of the presence of chronic pain on opiate intake and in the motivation for opiate self-administration. Additional studies will also be conducted in order to determine the effects of chronic pain on neural circuits within the reward pathway. Finally, it has been reported that opioid receptors (mu, delta, kappa) can form heterodimers following chronic opiate administration. The formation of these receptor heteromers has been reported to be involved in the mechanisms underlying opiate tolerance. Therefore, in an additional project we will examine whether the formation of a mu-delta opioid receptor heteromer is responsible for the expression of observed analgesic tolerance upon chronic opiate administration with the overall goal to develop novel drugs to enhance the analgesic properties of the opiate without side effects (i.e. tolerance).

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    Research Output

    • 2056 Citations
    • 40 Article
    • 3 Chapter
    • 3 Review article
    • 1 Short survey

    Dose-dependent induction of CPP or CPA by intra-pVTA ethanol: Role of mu opioid receptors and effects on NMDA receptors

    Campos-Jurado, Y., Martí-Prats, L., Morón, J. A., Polache, A., Granero, L. & Hipólito, L., Jun 8 2020, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 100, 109875.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    A Neurobehavioral Approach to Addiction: Implications for the Opioid Epidemic and the Psychology of Addiction

    Bechara, A., Berridge, K. C., Bickel, W. K., Morón, J. A., Williams, S. B. & Stein, J. S., Oct 1 2019, In : Psychological Science in the Public Interest. 20, 2, p. 96-127 32 p.

    Research output: Contribution to journalArticle

    Open Access
  • 9 Scopus citations

    Opioid receptors inhibit the spinal AMPA receptor Ca 2+ permeability that mediates latent pain sensitization

    Taylor, B. K., Sinha, G. P., Donahue, R. R., Grachen, C. M., Morón, J. A. & Doolen, S., Apr 2019, In : Experimental Neurology. 314, p. 58-66 9 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Pain And Opioid Systems, Implications In The Opioid Epidemic

    Massaly, N. & Morón, J. A., Apr 2019, In : Current Opinion in Behavioral Sciences. 26, p. 69-74 6 p.

    Research output: Contribution to journalReview article

  • 2 Scopus citations

    Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System

    Massaly, N., Copits, B. A., Wilson-Poe, A. R., Hipólito, L., Markovic, T., Yoon, H. J., Liu, S., Walicki, M. C., Bhatti, D. L., Sirohi, S., Klaas, A., Walker, B. M., Neve, R., Cahill, C. M., Shoghi, K. I., Gereau, R. W., McCall, J. G., Al-Hasani, R., Bruchas, M. R. & Morón, J. A., May 8 2019, In : Neuron. 102, 3, p. 564-573.e6

    Research output: Contribution to journalArticle

  • 24 Scopus citations