Jonathan Sheehan

2024

Integrative analysis of pathogenic variants in glucose-6-phosphatase based on an AlphaFold2 model

Sinclair, M., Stein, R. A., Sheehan, J. H., Hawes, E. M., O'Brien, R. M., Tajkhorshid, E. & Claxton, D. P., Feb 1 2024, In: PNAS Nexus. 3, 2, pgae036.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2022

A novel, likely pathogenic variant in UBTF-related neurodegeneration with brain atrophy is associated with a severe divergent neurodevelopmental phenotype

Tinker, R. J., Guess, T., Rinker, D. C., Sheehan, J. H., Lubarsky, D., Porath, B., Mosera, M., Mayo, P., Solem, E., Lee, L. A., Sharam, A. & Brault, J., Dec 2022, In: Molecular Genetics and Genomic Medicine. 10, 12, e2054.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Personalized structural biology reveals the molecular mechanisms underlying heterogeneous epileptic phenotypes caused by de novo KCNC2 variants

Undiagnosed Diseases Network, Oct 13 2022, In: Human Genetics and Genomics Advances. 3, 4, 100131.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2021

Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity

Hanker, A. B., Brown, B. P., Meiler, J., Marín, A., Jayanthan, H. S., Ye, D., Lin, C. C., Akamatsu, H., Lee, K. M., Chatterjee, S., Sudhan, D. R., Servetto, A., Brewer, M. R., Koch, J. P., Sheehan, J. H., He, J., Lalani, A. S. & Arteaga, C. L., Aug 9 2021, In: Cancer Cell. 39, 8, p. 1099-1114.e8

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

Familial Autonomic Ganglionopathy Caused by Rare CHRNA3 Genetic Variants

Shibao, C. A., Joos, K., Phillips, J. A., Cogan, J., Newman, J. H., Hamid, R., Meiler, J., Capra, J., Sheehan, J., Vetrini, F., Yang, Y., Black, B., Diedrich, A., Roberston, D. & Biaggioni, I., Jul 13 2021, In: Neurology. 97, 2, p. E145-E155

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design

Schoeder, C. T., Schmitz, S., Adolf-Bryfogle, J., Sevy, A. M., Finn, J. A., Sauer, M. F., Bozhanova, N. G., Mueller, B. K., Sangha, A. K., Bonet, J., Sheehan, J. H., Kuenze, G., Marlow, B., Smith, S. T., Woods, H., Bender, B. J., Martina, C. E., Del Alamo, D., Kodali, P. & Gulsevin, A. & 5 others, Schief, W. R., Correia, B. E., Crowe, J. E., Meiler, J. & Moretti, R., Mar 23 2021, In: Biochemistry. 60, 11, p. 825-846 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2020

Integrating structural and evolutionary data to interpret variation and pathogenicity in adapter protein complex 4

Gadbery, J. E., Abraham, A., Needle, C. D., Moth, C., Sheehan, J., Capra, J. A. & Jackson, L. P., Jun 1 2020, In: Protein Science. 29, 6, p. 1535-1549 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Phenotypic profiling in subjects heterozygous for 1 of 2 rare variants in the hypophosphatasia gene (ALPL)

Tilden, D. R., Sheehan, J. H., Newman, J. H., Meiler, J., Capra, J. A., Ramirez, A., Simmons, J. & Dahir, K., Aug 1 2020, In: Journal of the Endocrine Society. 4, 8, bvaa084.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin

Maddur, A. A., Kroh, H. K., Aschenbrenner, M. E., Gibson, B. H. Y., Panizzi, P., Sheehan, J. H., Meiler, J., Bock, P. E. & Verhamme, I. M., Apr 24 2020, In: Journal of Biological Chemistry. 295, 17, p. 5614-5625 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2019

IgG4-related disease: Association with a rare gene variant expressed in cytotoxic T cells

Undiagnosed Disease Network, Jun 2019, In: Molecular Genetics and Genomic Medicine. 7, 6, e686.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Molecular dynamics simulation of homo-DNA: The role of crystal packing in duplex conformation

Sheehan, J. H., Smith, J. A., Pallan, P. S., Lybrand, T. P. & Egli, M., Oct 2019, In: Crystals. 9, 10, 532.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2018

PIK3CA C2 domain deletions hyperactivate phosphoinositide 3-kinase (PI3K), generate oncogene dependence, and are exquisitely sensitive to PI3Ka inhibitors

Croessmann, S., Sheehan, J. H., Lee, K. M., Sliwoski, G., He, J., Nagy, R., Riddle, D., Mayer, I. A., Balko, J. M., Lanman, R., Miller, V. A., Cantley, L. C., Meiler, J. & Arteaga, C. L., Mar 15 2018, In: Clinical Cancer Research. 24, 6, p. 1426-1435 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia

Sivley, R. M., Sheehan, J. H., Kropski, J. A., Cogan, J., Blackwell, T. S., Phillips, J. A., Bush, W. S., Meiler, J. & Capra, J. A., Jan 23 2018, In: BMC bioinformatics. 19, 1, 18.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2017

An acquired HER2^T798I gatekeeper mutation induces resistance to neratinib in a patient with HER2 mutant-driven breast cancer

Hanker, A. B., Brewer, M. R., Sheehan, J. H., Koch, J. P., Sliwoski, G. R., Nagy, R., Lanman, R., Berger, M. F., Hyman, D. M., Solit, D. B., He, J., Miller, V., Cutler, R. E., Lalani, A. S., Cross, D., Lovly, C. M., Meiler, J. & Arteaga, C. L., 2017, In: Cancer discovery. 7, 6, p. 575-585 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

Pore polarity and charge determine differential block of Kir1.1 and Kir7.1 potassium channels by small-molecule inhibitor VU590

Kharade, S. V., Sheehan, J. H., Figueroa, E. E., Meiler, J. & Denton, J. S., Sep 2017, In: Molecular pharmacology. 92, 3, p. 338-346 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2016

EGFR fusions as novel therapeutic targets in lung cancer

Konduri, K., Gallant, J. N., Chae, Y. K., Giles, F. J., Gitlitz, B. J., Gowen, K., Ichihara, E., Owonikoko, T. K., Peddareddigari, V., Ramalingam, S. S., Reddy, S. K., Eaby-Sandy, B., Vavalà, T., Whiteley, A., Chen, H., Yan, Y., Sheehan, J. H., Meiler, J., Morosini, D. & Ross, J. S. & 4 others, Stephens, P. J., Miller, V. A., Ali, S. M. & Lovly, C. M., Jun 2016, In: Cancer discovery. 6, 6, p. 601-611 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

101 Scopus citations

ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels

Swale, D. R., Kurata, H., Kharade, S. V., Sheehan, J., Raphemot, R., Voigtritter, K. R., Figueroa, E. E., Meiler, J., Blobaum, A. L., Lindsley, C. W., Hopkins, C. R. & Denton, J. S., Jul 20 2016, In: ACS Chemical Neuroscience. 7, 7, p. 1013-1023 11 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Protocols for Molecular Modeling with Rosetta3 and RosettaScripts

Bender, B. J., Cisneros, A., Duran, A. M., Finn, J. A., Fu, D., Lokits, A. D., Mueller, B. K., Sangha, A. K., Sauer, M. F., Sevy, A. M., Sliwoski, G., Sheehan, J. H., DiMaio, F., Meiler, J. & Moretti, R., Aug 30 2016, In: Biochemistry. 55, 34, p. 4748-4763 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

151 Scopus citations

2015

Computational and functional analyses of a small-molecule binding site in ROMK

Swale, D. R., Sheehan, J. H., Banerjee, S., Husni, A. S., Nguyen, T. T., Meiler, J. & Denton, J. S., Mar 10 2015, In: Biophysical Journal. 108, 5, p. 1094-1103 10 p., 6398.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

EGFR kinase domain duplication (EGFR -KDD) is a novel oncogenic driver in lung cancer that is clinically responsive to afatinib

Gallant, J. N., Sheehan, J. H., Shaver, T. M., Bailey, M., Lipson, D., Chandramohan, R., Brewer, M. R., York, S. J., Kris, M. G., Pietenpol, J. A., Ladanyi, M., Miller, V. A., Ali, S. M., Meiler, J. & Lovly, C. M., Nov 2015, In: Cancer discovery. 5, 11, p. 1155-1163 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

95 Scopus citations

Genetic analysis of the localization of APOBEC3F to human immunodeficiency virus type 1 virion cores

Donahue, J. P., Levinson, R. T., Sheehan, J. H., Sutton, L., Taylor, H. E., Meiler, J., D'Aquila, R. T. & Song, C., 2015, In: Journal of virology. 89, 4, p. 2415-2424 10 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2014

NFI transcription factors interact with FOXA1 to regulate prostate-specific gene expression

Grabowska, M. M., Elliott, A. D., DeGraff, D. J., Anderson, P. D., Anumanthan, G., Yamashita, H., Sun, Q., Friedman, D. B., Hachey, D. L., Yu, X., Sheehan, J. H., Ahn, J. M., Raj, G. V., Piston, D. W., Gronostajski, R. M. & Matusik, R. J., Jun 2014, In: Molecular Endocrinology. 28, 6, p. 949-964 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

2013

Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock

Egli, M., Pattanayek, R., Sheehan, J. H., Xu, Y., Mori, T., Smith, J. A. & Johnson, C. H., Feb 19 2013, In: Biochemistry. 52, 7, p. 1208-1220 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Small-molecule ligand docking into comparative models with Rosetta

Combs, S. A., Deluca, S. L., Deluca, S. H., Lemmon, G. H., Nannemann, D. P., Nguyen, E. D., Willis, J. R., Sheehan, J. H. & Meiler, J., Jul 2013, In: Nature Protocols. 8, 7, p. 1277-1298 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

139 Scopus citations

2012

Second-site suppressors of HIV-1 capsid mutations: Restoration of intracellular activities without correction of intrinsic capsid stability defects

Yang, R., Shi, J., Byeon, I. J. L., Ahn, J., Sheehan, J. H., Meiler, J., Gronenborn, A. M. & Aiken, C., Apr 19 2012, In: Retrovirology. 9, 30.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

2011

Measurement of aptamer-protein interactions with back-scattering interferometry

Olmsted, I. R., Xiao, Y., Cho, M., Csordas, A. T., Sheehan, J. H., Meiler, J., Soh, H. T. & Bornhop, D. J., Dec 1 2011, In: Analytical Chemistry. 83, 23, p. 8867-8870 4 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

2010

Glycosylation of β2 subunits regulates GABA_A receptor biogenesis and channel gating

Lo, W. Y., Lagrange, A. H., Hernandez, C. C., Harrison, R., Dell, A., Haslam, S. M., Sheehan, J. H. & Macdonald, R. L., Oct 8 2010, In: Journal of Biological Chemistry. 285, 41, p. 31348-31361 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Unique gating properties of C. elegans ClC anion channel splice variants are determined by altered CBS domain conformation and the R-helix linker

Dave, S., Sheehan, J. H., Meiler, J. & Strange, K., 2010, In: Channels. 4, 4, p. 289-301 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2009

The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating

Fallen, K., Banerjee, S., Sheehan, J., Addison, D., Lewis, L. M., Meiler, J. & Denton, J. S., 2009, In: Channels. 3, 1, p. 57-68 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

2006

Structure of the N-terminal calcium sensor domain of centrin reveals the biochemical basis for domain-specific function

Sheehan, J. H., Bunick, C. G., Hu, H., Fagan, P. A., Meyn, S. M. & Chazin, W. J., Feb 3 2006, In: Journal of Biological Chemistry. 281, 5, p. 2876-2881 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

2004

Designing Sequence to Control Protein Function in an EF-Hand Protein

Bunick, C. G., Nelson, M. R., Mangahas, S., Hunter, M. J., Sheehan, J. H., Mizoue, L. S., Bunick, G. J. & Chazin, W. J., May 19 2004, In: Journal of the American Chemical Society. 126, 19, p. 5990-5998 9 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

The mode of action of centrin: Binding of Ca²⁺ and a peptide fragment of Kar1p to the C-terminal domain

Hu, H., Sheehan, J. H. & Chazin, W. J., Dec 3 2004, In: Journal of Biological Chemistry. 279, 49, p. 50895-50903 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

Jonathan Sheehan

Research output

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