Jonathan Sheehan

Associate Professor of Medicine

    • 936 Citations
    20042020

    Research output per year

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    Personal profile

    Research interests

    I use computational structural biology to help biomedical researchers approach their question from a molecular viewpoint. I can contribute a mechanistic hypothesis, structural analysis, or the interpretation of experimental results in the context of a protein’s structure-function relationship.

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    Research Output

    • 936 Citations
    • 26 Article
    • 4 Review article
    • 1 Comment/debate

    Integrating structural and evolutionary data to interpret variation and pathogenicity in adapter protein complex 4

    Gadbery, J. E., Abraham, A., Needle, C. D., Moth, C., Sheehan, J., Capra, J. A. & Jackson, L. P., Jun 1 2020, In : Protein Science. 29, 6, p. 1535-1549 15 p.

    Research output: Contribution to journalArticle

  • Phenotypic profiling in subjects heterozygous for 1 of 2 rare variants in the hypophosphatasia gene (ALPL)

    Tilden, D. R., Sheehan, J. H., Newman, J. H., Meiler, J., Capra, J. A., Ramirez, A., Simmons, J. & Dahir, K., Aug 1 2020, In : Journal of the Endocrine Society. 4, 8, bvaa084.

    Research output: Contribution to journalArticle

    Open Access
  • Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin

    Maddur, A. A., Kroh, H. K., Aschenbrenner, M. E., Gibson, B. H. Y., Panizzi, P., Sheehan, J. H., Meiler, J., Bock, P. E. & Verhamme, I. M., Apr 24 2020, In : Journal of Biological Chemistry. 295, 17, p. 5614-5625 12 p.

    Research output: Contribution to journalArticle

  • Correction: Pik3ca c2 domain deletions hyperactivate phosphoinositide 3-kinase (pi3k), generate oncogene dependence, and are exquisitely sensitive to pi3ka inhibitors(Clin Cancer Res (2018) 24 (1426–35)DOI: 10.1158/1078-0432.CCR-17-2141)

    Croessmann, S., Sheehan, J. H., Lee, K. M., Sliwoski, G., He, J., Nagy, R., Riddle, D., Mayer, I. A., Balko, J. M., Lanman, R., Miller, V. A., Cantley, L. C., Meiler, J. & Arteaga, C. L., Feb 15 2019, In : Clinical Cancer Research. 25, 4, 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • IgG4-related disease: Association with a rare gene variant expressed in cytotoxic T cells

    Undiagnosed Disease Network, Jun 2019, In : Molecular Genetics and Genomic Medicine. 7, 6, e686.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations