Personal profile
Research interests
The immune system is able to control the function of various metabolic organs and contributes to metabolic abnormalities seen in diseases such as obesity and type 2 diabetes. The Brestoff Lab’s research focuses on understanding how immune cells and metabolic organs interact to maintain normal metabolism and to support adaptation to physiologic challenges such as high-fat diet feeding, changes in environmental temperature, and fasting. We employ cutting-edge techniques in immunology, metabolism, and mitochondria biology to study the immunometabolic pathways that are required for metabolic health and that contribute to disease pathogenesis. Ultimately, our goal is to discover novel biological pathways that can be targeted therapeutically or that can be leveraged to develop new diagnostic tests.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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A Gut-Restricted Liver X Receptor Agonist Ameliorates Liver Injury in Experimental Short Bowel Syndrome
Kim, A., Alligood, D. M., Maram, L., Phelps, H. M., Cameron, M., DeRousse, J. T., Han, J., Dunning, T. J., Mintz, R. L., Park, A., Lee, D. D., Davis, D. L., Huckstep, C. G., Field, R. L., Hegazy, L., Zinselmeyer, B. H., Brestoff, J. R., Martin, C. A., Warner, B. W. & Elgendy, B. & 1 others, , May 2026, In: Gastroenterology. 170, 5, p. 1017-1032 16 p.Research output: Contribution to journal › Article › peer-review
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Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts
Tiash, S., Patel, S. A., Russo, M., Suresh, A., Pang, B., Pai, Y. L., Jia, W., Field, R. L., Pietka, T., Abumrad, N. A., Smith, G. I., Samovski, D., Klein, S., Brestoff, J. R. & Crewe, C., 2026, (Accepted/In press) In: Cell metabolism.Research output: Contribution to journal › Article › peer-review
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Mitochondrial transfer from immune to tumor cells enables lymph node metastasis
Terasaki, A., Bhatnagar, K., Weiner, A. T., Tan, Y., Szeifert, V., Huang, H. L., Wiggers, L., Rodrigues, V., Rada, C. C., Shankar, V., Saito, S., Ankomah, P. O., Roth, T., Chiu, B., West, R., Li, L., Reticker-Flynn, N., Axelrod, J. D., Brestoff, J. R. & Li, B. & 2 others, , Feb 3 2026, In: Cell metabolism. 38, 2, p. 388-398.e7Research output: Contribution to journal › Article › peer-review
4 Link opens in a new tab Scopus citations -
Cell Metabolism 20th anniversary Voices: Part 3 of 3
Potthoff, M., Gupta, R. K., Lee, C., Long, J. Z., Brestoff, J. R. & de Bock, K., Jun 3 2025, In: Cell metabolism. 37, 6, p. 1243-1246 4 p.Research output: Contribution to journal › Comment/debate
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Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis
Erlich, E. C., Alayo, Q. A., Kim, A., Han, J., Mintz, R. L., Huckstep, C. G., Ruiz, H. S., Field, R. L., Dunning, T. J., Saleh, L. S., Hoofnagle, M. H., Tumanov, A. V., Guilak, F., Brestoff, J. R., Czepielewski, R. S. & Randolph, G. J., Oct 2025, In: Nature immunology. 26, 10, p. 1781-1793 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations