Jonathan R. Brestoff

Assistant Professor of Pathology and Immunology

    • 2029 Citations
    20082020

    Research output per year

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    Personal profile

    Research interests

    The immune system is able to control the function of various metabolic organs and contributes to metabolic abnormalities seen in diseases such as obesity and type 2 diabetes. The Brestoff Lab’s research focuses on understanding how immune cells and metabolic organs interact to maintain normal metabolism and to support adaptation to physiologic challenges such as high-fat diet feeding, changes in environmental temperature, and fasting. We employ cutting-edge techniques in immunology, metabolism, and mitochondria biology to study the immunometabolic pathways that are required for metabolic health and that contribute to disease pathogenesis. Ultimately, our goal is to discover novel biological pathways that can be targeted therapeutically or that can be leveraged to develop new diagnostic tests.

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    Research Output

    Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis

    Mack, M. R., Brestoff, J. R., Berrien-Elliott, M. M., Trier, A. M., Yang, T. L. B., McCullen, M., Collins, P. L., Niu, H., Bodet, N. D., Wagner, J. A., Park, E., Xu, A. Z., Wang, F., Chibnall, R., Council, M. L., Heffington, C., Kreisel, F., Margolis, D. J., Sheinbein, D., Lovato, P. & 7 others, Vivier, E., Cella, M., Colonna, M., Yokoyama, W. M., Oltz, G., Fehniger, T. A. & Kim, B. S., Feb 26 2020, In : Science translational medicine. 12, 532, aay1005.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Hepatic lipids promote liver metastasis

    Li, Y., Su, X., Rohatgi, N., Zhang, Y., Parker, J., Shoghi, K. I., Xu, Y., Semenkovich, C., Harris, C. A., Peterson, L. L., Weibaecher, K. N., Teitelbaum, S. L. & Zou, W., Sep 3 2020, In : JCI Insight. 5, 17

    Research output: Contribution to journalArticle

    Open Access
  • Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure

    Zou, W., Rohatgi, N., Brestoff, J. R., Moley, J. R., Li, Y., Williams, J. W., Alippe, Y., Pan, H., Pietka, T. A., Mbalaviele, G., Newberry, E. P., Davidson, N. O., Dey, A., Shoghi, K. I., Head, R. D., Wickline, S. A., Randolph, G. J., Abumrad, N. A. & Teitelbaum, S. L., May 1 2020, In : Journal of Clinical Investigation. 130, 5, p. 2644-2656 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Bone marrow biopsy needle type affects core biopsy specimen length and quality and aspirate hemodilution

    Brestoff, J. R., Toland, A., Afaneh, K., Qavi, A. J., Press, B., Westervelt, P., Kreisel, F. & Hassan, A., Jan 7 2019, In : American journal of clinical pathology. 151, 2, p. 194-197 4 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Congenital lipodystrophy induces severe osteosclerosis

    Zou, W., Rohatgi, N., Brestoff, J. R., Zhang, Y., Scheller, E. L., Craft, C. S., Brodt, M. D., Migotsky, N., Silva, M. J., Harris, C. A. & Teitelbaum, S. L., Jun 2019, In : PLoS genetics. 15, 6, e1008244.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations