Research output per year
Research output per year
Personal profile
Research interests
The immune system is able to control the function of various metabolic organs and contributes to metabolic abnormalities seen in diseases such as obesity and type 2 diabetes. The Brestoff Lab’s research focuses on understanding how immune cells and metabolic organs interact to maintain normal metabolism and to support adaptation to physiologic challenges such as high-fat diet feeding, changes in environmental temperature, and fasting. We employ cutting-edge techniques in immunology, metabolism, and mitochondria biology to study the immunometabolic pathways that are required for metabolic health and that contribute to disease pathogenesis. Ultimately, our goal is to discover novel biological pathways that can be targeted therapeutically or that can be leveraged to develop new diagnostic tests.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Lipid-associated macrophages reshape BAT cell identity in obesity
Sciarretta, F., Ninni, A., Zaccaria, F., Chiurchiù, V., Bertola, A., Karlinsey, K., Jia, W., Ceci, V., Di Biagio, C., Xu, Z., Gaudioso, F., Tortolici, F., Tiberi, M., Zhang, J., Carotti, S., Boudina, S., Grumati, P., Zhou, B., Brestoff, J. R. & Ivanov, S. & 2 others, , Jul 23 2024, In: Cell Reports. 43, 7, 114447.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A guide to studying mitochondria transfer
Tiash, S., Brestoff, J. R. & Crewe, C., Nov 2023, In: Nature Cell Biology. 25, 11, p. 1551-1553 3 p.Research output: Contribution to journal › Comment/debate
7 Scopus citations -
A Single Reference Interval for Interpreting Serum Free Light Chains across Patients with Varying Renal Function
Azimi, V., Slade, M., Fiala, M., Fortier, J. M., Stockerl-Goldstein, K., Frater, J. L., Brestoff, J. R., Jackups, R. & Zaydman, M. A., Jun 1 2023, In: Clinical chemistry. 69, 6, p. 595-605 11 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
A type 2 immune circuit in the stomach controls mammalian adaptation to dietary chitin
Kim, D. H., Wang, Y., Jung, H., Field, R. L., Zhang, X., Liu, T. C., Ma, C., Fraser, J. S., Brestoff, J. R. & Van Dyken, S. J., Sep 8 2023, In: Science. 381, 6662, p. 1092-1098 7 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Burning Fat to Fuel EVs
Crewe, C. & Brestoff, J. R., Nov 2023, In: Diabetes. 72, 11, p. 1521-1523 3 p.Research output: Contribution to journal › Comment/debate
Open Access