Jonathan Heusel

2023

A comparative analysis of RAS variants in patients with disorders of somatic mosaicism

Claire Hou, Y. C., Evenson, M. J., Corliss, M. M., Mahapatra, L., Aldawood, A., Carpentieri, D. F., Chamlin, S. L., Kulungowski, A. M., Madan-Khetarpal, S., Sebastian, J., Pet, M. A., Coughlin, C. C., Willing, M. C., Pearson, G. D., Setty, B. A., El-Haffaf, Z., Cottrell, C. E., Parikh, B. A., Krysiak, K., Schroeder, M. C., & 3 othersHeusel, J. W., Neidich, J. A. & Cao, Y., Mar 2023, In: Genetics in Medicine. 25, 3, 100348.

Research output: Contribution to journal › Article › peer-review

2022

Multivariate analysis of associations between clinical sequencing and outcome in glioblastoma

Yang, P. H., Tao, Y., Luo, J., Paturu, M., Lu, H. C., Ramkissoon, S., Heusel, J. W., Leuthardt, E. C., Chicoine, M. R., Dowling, J. L., Dunn, G. P., Duncavage, E., Dahiya, S., Chattherjee, A. R. & Kim, A. H., Jan 1 2022, In: Neuro-Oncology Advances. 4, 1, vdac002.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2021

A Next-Generation Sequencing Test for Severe Congenital Neutropenia: Utility in a Broader Clinicopathologic Spectrum of Disease

McNulty, S. N., Evenson, M. J., Riley, M., Yoest, J. M., Corliss, M. M., Heusel, J. W., Duncavage, E. J. & Pfeifer, J. D., Feb 2021, In: Journal of Molecular Diagnostics. 23, 2, p. 200-211 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Somatic PIK3R1 variation as a cause of vascular malformations and overgrowth

Cottrell, C. E., Bender, N. R., Zimmermann, M. T., Heusel, J. W., Corliss, M., Evenson, M. J., Magrini, V., Corsmeier, D. J., Avenarius, M., Dudley, J. N., Johnston, J. J., Lindhurst, M. J., Vigh-Conrad, K., Davies, O. M. T., Coughlin, C. C., Frieden, I. J., Tollefson, M., Zaenglein, A. L., Ciliberto, H., Tosi, L. L., & 3 othersSemple, R. K., Biesecker, L. G. & Drolet, B. A., Oct 2021, In: Genetics in Medicine. 23, 10, p. 1882-1888 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2020

Identification of challenges and a framework for implementation of the AMP/ASCO/CAP classification guidelines for reporting somatic variants

Parikh, B. A., Love-Gregory, L., Duncavage, E. J. & Heusel, J. W., Aug 2020, In: Practical Laboratory Medicine. 21, e00170.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2019

A Multimodality Approach to Assessing Factor I Genetic Variants in Atypical Hemolytic Uremic Syndrome

Java, A., Pozzi, N., Love-Gregory, L. D., Heusel, J. W., Sung, Y. J., Hu, Z., Bertram, P., Liszewski, M. K., Cline, L. M., Ren, Z. & Atkinson, J. P., Jul 2019, In: Kidney International Reports. 4, 7, p. 1007-1017 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Beyond sequence variation: assessment of copy number variation in adult glioblastoma through targeted tumor somatic profiling

McNulty, S. N., Cottrell, C. E., Vigh-Conrad, K. A., Carter, J. H., Heusel, J. W., Ansstas, G. & Dahiya, S., Apr 2019, In: Human Pathology. 86, p. 170-181 12 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Diagnostic Utility of Next-Generation Sequencing for Disorders of Somatic Mosaicism: A Five-Year Cumulative Cohort

McNulty, S. N., Evenson, M. J., Corliss, M. M., Love-Gregory, L. D., Schroeder, M. C., Cao, Y., Lee, Y. S., Drolet, B. A., Neidich, J. A., Cottrell, C. E. & Heusel, J. W., Oct 3 2019, In: American journal of human genetics. 105, 4, p. 734-746 13 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Optimization of Population Frequency Cutoffs for Filtering Common Germline Polymorphisms from Tumor-Only Next-Generation Sequencing Data

McNulty, S. N., Parikh, B. A., Duncavage, E. J., Heusel, J. W. & Pfeifer, J. D., Sep 2019, In: Journal of Molecular Diagnostics. 21, 5, p. 903-912 10 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Tumor Mutational Profiling by Next-Generation Sequencing

McNulty, S., Love-Gregory, L. & Heusel, J. W., Jan 1 2019, Cancer Genomics for the Clinician. Springer Publishing Company, p. 15-42 28 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2018

Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation

Brestoff, J. R., Vessoni, A. T., Brenner, K. A., Uy, G. L., DiPersio, J. F., Blinder, M., Witt, C. A., Byers, D. E., Hachem, R. R., Truclock, E. P., Early, D. S., Anadkat, M. J., Musiek, A., Javidan-Nejad, C., Balfe, D. M., Rosman, I. S., Liu, C., Zhang, L., Despotis, G. J., Ruzinova, M. B., & 8 othersSehn, J. K., Amarillo, I., Heusel, J. W., Swat, W., Kim, B. S., Wartman, L. D., Yusen, R. D. & Batista, L. F. Z., May 1 2018, In: Thorax. 73, 5, p. 489-492 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Clinical Targeted Next-Generation Sequencing Shows Increased Mutational Load in Endometrioid-type Endometrial Adenocarcinoma with Deficient DNA Mismatch Repair

Lee, P. J., McNulty, S., Duncavage, E. J., Heusel, J. W. & Hagemann, I. S., Nov 1 2018, In: International Journal of Gynecological Pathology. 37, 6, p. 581-589 9 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Discriminating a common somatic ASXL1 mutation (c.1934dup; p.G646Wfs*12) from artifact in myeloid malignancies using NGS

Alberti, M. O., Srivatsan, S. N., Shao, J., McNulty, S. N., Chang, G. S., Miller, C. A., Dunlap, J. B., Yang, F., Press, R. D., Gao, Q., Ding, L., Heusel, J. W., Duncavage, E. J. & Walter, M. J., Aug 1 2018, In: Leukemia. 32, 8, p. 1874-1878 5 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Natural killer cell recruitment to the lung during influenza A virus infection is dependent on CXCR3, CCR5, and virus exposure dose

Carlin, L. E., Hemann, E. A., Zacharias, Z. R., Heusel, J. W. & Legge, K. L., Apr 17 2018, In: Frontiers in immunology. 9, APR, 781.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

2017

FGFR2 amplification in colorectal adenocarcinoma

Carter, J. H., Cottrell, C. E., McNulty, S. N., Vigh-Conrad, K. A., Lamp, S., Heusel, J. W. & Duncavage, E. J., Nov 1 2017, In: Cold Spring Harbor molecular case studies. 3, 6

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Routine use of clinical exome-based next-generation sequencing for evaluation of patients with thrombotic microangiopathies

Gaut, J. P., Jain, S., Pfeifer, J. D., Vigh-Conrad, K. A., Corliss, M., Sharma, M. K., Heusel, J. W. & Cottrell, C. E., Dec 1 2017, In: Modern Pathology. 30, 12, p. 1739-1747 9 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Targeted Next-Generation Sequencing in Molecular Subtyping of Lower-Grade Diffuse Gliomas: Application of the World Health Organization's 2016 Revised Criteria for Central Nervous System Tumors

Carter, J. H., McNulty, S. N., Cimino, P. J., Cottrell, C. E., Heusel, J. W., Vigh-Conrad, K. A. & Duncavage, E. J., Mar 1 2017, In: Journal of Molecular Diagnostics. 19, 2, p. 328-337 10 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2016

Concurrent MPL W515L and Y591D mutations in a patient with myelofibrosis

Rashidi, A., Heusel, J. W. & Oh, S. T., Sep 1 2016, In: Blood Cells, Molecules, and Diseases. 60, p. 1-2 2 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Extrinsic allospecific signals of hematopoietic origin dictate iNKT cell lineage-fate decisions during development

Strong, B. S. I., Newkold, T. J., Lee, A. E., Turner, L. E., Alhajjat, A. M., Heusel, J. W. & Shaaban, A. F., Jun 29 2016, In: Scientific reports. 6, 28837.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2015

Identification of medically actionable secondary findings in the 1000 genomes

Olfson, E., Cottrell, C. E., Davidson, N. O., Gurnett, C. A., Heusel, J. W., Stitziel, N. O., Chen, L. S., Hartz, S., Nagarajan, R., Saccone, N. L. & Bierut, L. J., Sep 2 2015, In: PloS one. 10, 9, e0135193.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Prenatal allogeneic tolerance in mice remains stable despite potent viral immune activation

Strong, B. S. I., Ryken, K. O., Lee, A. E., Turner, L. E., Wadhwani, R. K., Newkold, T. J., Alhajjat, A. M., Heusel, J. W. & Shaaban, A. F., Oct 15 2015, In: Journal of Immunology. 195, 8, p. 4001-4009 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Prenatal allospecific NK cell tolerance hinges on instructive allorecognition through the activating receptor during development

Alhajjat, A. M., Strong, B. S., Lee, A. E., Turner, L. E., Wadhwani, R. K., Ortaldo, J. R., Heusel, J. W. & Shaaban, A. F., Aug 15 2015, In: Journal of Immunology. 195, 4, p. 1506-1516 11 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2014

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge

Brownstein, C. A., Beggs, A. H., Homer, N., Merriman, B., Yu, T. W., Flannery, K. C., DeChene, E. T., Towne, M. C., Savage, S. K., Price, E. N., Holm, I. A., Luquette, L. J., Lyon, E., Majzoub, J., Neupert, P., McCallie, D., Szolovits, P., Willard, H. F., Mendelsohn, N. J., Temme, R., & 178 othersFinkel, R. S., Yum, S. W., Medne, L., Sunyaev, S. R., Adzhubey, I., Cassa, C. A., De Bakker, P. I. W., Duzkale, H., Dworzyński, P., Fairbrother, W., Francioli, L., Funke, B. H., Giovanni, M. A., Handsaker, R. E., Lage, K., Lebo, M. S., Lek, M., Leshchiner, I., MacArthur, D. G., McLaughlin, H. M., Murray, M. F., Pers, T. H., Polak, P. P., Raychaudhuri, S., Rehm, H. L., Soemedi, R., Stitziel, N. O., Vestecka, S., Supper, J., Gugenmus, C., Klocke, B., Hahn, A., Schubach, M., Menzel, M., Biskup, S., Freisinger, P., Deng, M., Braun, M., Perner, S., Smith, R. J. H., Andorf, J. L., Huang, J., Ryckman, K., Sheffield, V. C., Stone, E. M., Bair, T., Ann Black-Ziegelbein, E., Braun, T. A., Darbro, B., DeLuca, A. P., Kolbe, D. L., Scheetz, T. E., Shearer, A. E., Sompallae, R., Wang, K., Bassuk, A. G., Edens, E., Mathews, K., Moore, S. A., Shchelochkov, O. A., Trapane, P., Bossler, A., Campbell, C. A., Heusel, J. W., Kwitek, A., Maga, T., Panzer, K., Wassink, T., Van Daele, D., Azaiez, H., Booth, K., Meyer, N., Segal, M. M., Williams, M. S., Tromp, G., White, P., Corsmeier, D., Fitzgerald-Butt, S., Herman, G., Lamb-Thrush, D., McBride, K. L., Newsom, D., Pierson, C. R., Rakowsky, A. T., Maver, A., Lovrečić, L., Palandačić, A., Peterlin, B., Torkamani, A., Wedell, A., Huss, M., Alexeyenko, A., Lindvall, J. M., Magnusson, M., Nilsson, D., Stranneheim, H., Taylan, F., Gilissen, C., Hoischen, A., Van Bon, B., Yntema, H., Nelen, M., Zhang, W., Sager, J., Zhang, L., Blair, K., Kural, D., Cariaso, M., Lennon, G. G., Javed, A., Agrawal, S., Ng, P. C., Sandhu, K. S., Krishna, S., Veeramachaneni, V., Isakov, O., Halperin, E., Friedman, E., Shomron, N., Glusman, G., Roach, J. C., Caballero, J., Cox, H. C., Mauldin, D., Ament, S. A., Rowen, L., Richards, D. R., Anthony San Lucas, F., Gonzalez-Garay, M. L., Thomas Caskey, C., Bai, Y., Huang, Y., Fang, F., Zhang, Y., Wang, Z., Barrera, J., Garcia-Lobo, J. M., González-Lamuño, D., Llorca, J., Rodriguez, M. C., Varela, I., Reese, M. G., De La Vega, F. M., Kiruluta, E., Cargill, M., Hart, R. K., Sorenson, J. M., Lyon, G. J., Stevenson, D. A., Bray, B. E., Moore, B. M., Eilbeck, K., Yandell, M., Zhao, H., Hou, L., Chen, X., Yan, X., Chen, M., Li, C., Yang, C., Gunel, M., Li, P., Kong, Y., Alexander, A. C., Albertyn, Z. I., Boycott, K. M., Bulman, D. E., Gordon, P. M. K., Micheil Innes, A., Knoppers, B. M., Majewski, J., Marshall, C. R., Parboosingh, J. S., Sawyer, S. L., Samuels, M. E., Schwartzentruber, J., Kohane, I. S. & Margulies, D. M., 2014, In: Genome biology. 15, 3, R53.

Research output: Contribution to journal › Article › peer-review

Open Access

89 Scopus citations

2013

Role of NK Cell Subsets in Organ-Specific Murine Melanoma Metastasis

Ballas, Z. K., Buchta, C. M., Rosean, T. R., Heusel, J. W. & Shey, M. R., Jun 11 2013, In: PloS one. 8, 6, e65599.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

The Glycophosphatidylinositol Anchor of the MCMV Evasin, m157, Facilitates Optimal Cell Surface Expression and Ly49 Receptor Recognition

Carlin, L. E., Guseva, N. V., Shey, M. R., Ballas, Z. K. & Heusel, J. W., Jun 19 2013, In: PloS one. 8, 6, e67295.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2012

Perforin plays an unexpected role in regulating T-cell contraction during prolonged Listeria monocytogenes infection

Schmidt, N. W., Khanolkar, A., Hancox, L., Heusel, J. W. & Harty, J. T., Mar 2012, In: European Journal of Immunology. 42, 3, p. 629-640 12 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2010

Glycosylation contributes to variability in expression of murine cytomegalovirus m157 and enhances stability of interaction with the NK-cell receptor Ly49H

Guseva, N. V., Fullenkamp, C. A., Naumann, P. W., Shey, M. R., Ballas, Z. K., Houtman, J. C. D., Forbes, C. A., Scalzo, A. A. & Heusel, J. W., Sep 2010, In: European Journal of Immunology. 40, 9, p. 2618-2631 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2009

Innate immune control and regulation of influenza virus infections

McGill, J., Heusel, J. W. & Legge, K. L., Oct 2009, In: Journal of Leukocyte Biology. 86, 4, p. 803-812 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

130 Scopus citations

2008

Characterization of murine cytomegalovirus ml57 from infected cells and identification of critical residues mediating recognition by the NK cell receptor Ly49H

Davis, A. H., Guseva, N. V., Ball, B. L. & Heusel, J. W., 2008, In: Journal of Immunology. 181, 1, p. 265-275 11 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

2003

Natural killer cells: Emerging concepts in immunity to infection and implications for assessment of immunodeficiency

Heusel, J. W. & Ballas, Z. K., Dec 1 2003, In: Current opinion in pediatrics. 15, 6, p. 586-593 8 p.

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

2002

Recognition of a virus-encoded ligand by a natural killer cell activation receptor

Smith, H. R. C., Heusel, J. W., Mehta, I. K., Kim, S., Dorner, B. G., Naidenko, O. V., Iizuka, K., Furukawa, H., Beckman, D. L., Pingel, J. T., Scalzo, A. A., Fremont, D. H. & Yokoyama, W. M., Jun 25 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 13, p. 8826-8831 6 p.

Research output: Contribution to journal › Article › peer-review

449 Scopus citations

2001

Vital involvement of a natural killer cell activation receptor in resistance to viral infection

Brown, M. G., Dokun, A. O., Heusel, J. W., Smith, H. R. C., Beckman, D. L., Blattenberger, E. A., Dubbelde, C. E., Stone, L. R., Scalzo, A. A. & Yokoyama, W. M., May 4 2001, In: Science. 292, 5518, p. 934-937 4 p.

Research output: Contribution to journal › Article › peer-review

514 Scopus citations

2000

Nonstochastic coexpression of activation receptors on murine natural killer cells

Smith, H. R. C., Chuang, H. H., Wang, L. L., Salcedo, M., Heusel, J. W. & Yokoyama, W. M., Apr 17 2000, In: Journal of Experimental Medicine. 191, 8, p. 1341-1354 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

1999

Development of intra-natural killer complex [NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci

Scalzo, A. A., Brown, M. G., Chu, D. T., Heusel, J. W., Yokoyama, W. M. & Forbes, C. A., 1999, In: Immunogenetics. 49, 3, p. 238-241 4 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

1998

Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells

Ho, E. L., Heusel, J. W., Brown, M. G., Matsumoto, K., Scalzo, A. A. & Yokoyama, W. M., May 26 1998, In: Proceedings of the National Academy of Sciences of the United States of America. 95, 11, p. 6320-6325 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

1996

Long-range disruption of gene expression by a selectable marker cassette

Pham, C. T. N., Macivor, D. M., Hug, B. A., Heusel, J. W. & Ley, T. J., Nov 12 1996, In: Proceedings of the National Academy of Sciences of the United States of America. 93, 23, p. 13090-13095 6 p.

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

1995

Granzyme B Plays a Critical Role in Cytotoxic Lymphocyte‐induced Apoptosis

SHRESTA, SUJAN., HEUSEL, JONATHAN. W., MACIVOR, DEBRA. M., WESSELSCHMIDT, ROBIN. L., RUSSELL, JOHN. H. & LEY, TIMOTHY. J., Aug 1995, In: Immunological Reviews. 146, 1, p. 211-221 11 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells

Shresta, S., Macivor, D. M., Heusel, J. W., Russell, J. H. & Ley, T. J., Jun 6 1995, In: Proceedings of the National Academy of Sciences of the United States of America. 92, 12, p. 5679-5683 5 p.

Research output: Contribution to journal › Article › peer-review

208 Scopus citations

1994

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

Heusel, J. W., Wesselschmidt, R. L., Shresta, S., Russell, J. H. & Ley, T. J., Mar 25 1994, In: Cell. 76, 6, p. 977-987 11 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

1993

Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene

Heusel, J. W., Scarpati, E. M., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Shapiro, S. D. & Ley, T. J., 1993, In: Blood. 81, 6, p. 1614-1623 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1991

Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2

Heusel, J. W., Hanson, R. D., Silverman, G. A. & Ley, T. J., 1991, In: Journal of Biological Chemistry. 266, 10, p. 6152-6158 7 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Jonathan Heusel

Research output

Search results