• 12001 Citations
1973 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Research in this laboratory focuses on CNS (brain and spinal cord) inflammation and pathogenesis in a mouse model of multiple sclerosis. We have used genetically marked lymphocytes to study the mechanisms of their entry into the CNS to cause disease. We have found that the initial compromise of the blood brain barrier requires that lymphocytes “see” a CNS antigen in the space between blood vessels and the parenchyma (body) of the CNS. This interaction initiates a “conversation” between cells originating in the blood and cells of the parenchyma itself that determines whether or not inflammatory invasion will occur. The molecular language of this “conversation” is a group of small proteins (cytokines and chemokines) that regulate the expression of adhesion molecules (VCAM-1) on astrocytes in the parenchyma and recruit macrophages and other inflammatory cells. The VCAM-1 expression on astrocytes appears to be an important mechanism to allow both the recruitment and retention of the inflammatory infiltrate into the parenchyma, causing demyelination and axon loss associated with paralysis. We have developed a novel technique to isolate the infiltrating lymphocytes at various stages of invasion. Current experiments are focused on understanding the molecular changes in the lymphocytes as they invade the CNS to identify possible targets for preventing their invasion of the CNS. We are also focusing on the role of the astrocyte in both promoting and protecting from or healing the inflammatory process. Our results suggest that there may be regionally specific “dialects” of the conversation making some CNS regions more susceptible to invasion than others and astrocytes are an important part of those regional differences.

Fingerprint Dive into the research topics where John Russell is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 21 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

  • 12001 Citations
  • 115 Article
  • 4 Review article

Astrocyte-T cell crosstalk regulates region-specific neuroinflammation

Williams, J. L., Manivasagam, S., Smith, B. C., Sim, J., Vollmer, L. L., Daniels, B. P., Russell, J. H. & Klein, R. S., Jan 1 2020, (Accepted/In press) In : Glia.

Research output: Contribution to journalArticle

Open Access
  • 2 Scopus citations

    B cells are capable of independently eliciting rapid reactivation of encephalitogenic CD4 T cells in a murine model of multiple sclerosis

    Parker Harp, C. R., Archambault, A. S., Sim, J., Shlomchik, M. J., Russell, J. H. & Wu, G. F., Jun 2018, In : PloS one. 13, 6, e0199694.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation

    Lin, C. C., Bradstreet, T. R., Schwarzkopf, E. A., Jarjour, N. N., Chou, C., Archambault, A. S., Sim, J., Zinselmeyer, B. H., Carrero, J. A., Wu, G. F., Taneja, R., Artyomov, M. N., Russell, J. H. & Edelson, B. T., Feb 8 2016, In : Journal of Experimental Medicine. 213, 2, p. 251-271 21 p.

    Research output: Contribution to journalArticle

    Open Access
  • 34 Scopus citations

    B cell antigen presentation is sufficient to drive neuroinflammation in an animal model of multiple sclerosis

    Harp, C. R. P., Archambault, A. S., Sim, J., Ferris, S. T., Mikesell, R. J., Koni, P. A., Shimoda, M., Linington, C., Russell, J. H. & Wu, G. F., Jun 1 2015, In : Journal of Immunology. 194, 11, p. 5077-5084 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • 45 Scopus citations

    Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation

    Lin, C. C., Bradstreet, T. R., Schwarzkopf, E. A., Sim, J., Carrero, J. A., Chou, C., Cook, L. E., Egawa, T., Taneja, R., Murphy, T. L., Russell, J. H. & Edelson, B. T., Apr 3 2014, In : Nature communications. 5, 3551.

    Research output: Contribution to journalArticle

    Open Access
  • 52 Scopus citations