John Rice

View Scopus Profile

John Rice

Professor of Mathematics in Psychiatry, Professor of Biostatistics, Professor of Genetics

 https://orcid.org/0000-0002-2765-3824

    Willing to Mentor

    Available to Mentor:

    PhD/MSTP Students

    • 42306
      Citations
    1978 …2023

    Research activity per year

    If you made any changes in Pure these will be visible here soon.

    Search results

    • 2023

      Genetic nurture effects for alcohol use disorder

      COGA Collaborators, Thomas, N. S., Salvatore, J. E., Kuo, S. I. C., Aliev, F., McCutcheon, V. V., Meyers, J. M., Bucholz, K. K., Brislin, S. J., Chan, G., Edenberg, H. J., Kamarajan, C., Kramer, J. R., Kuperman, S., Pandey, G., Plawecki, M. H., Schuckit, M. A., Dick, D. M., Porjesz, B., Hesselbrock, V., & 12 othersForoud, T., Agrawal, A., Liu, Y., Pandey, A., Bierut, L., Rice, J., Tischfield, J., Hart, R., Almasy, L., Goate, A., Slesinger, P. & Scott, D., Feb 2023, In: Molecular Psychiatry. 28, 2, p. 759-766 8 p.

      Research output: Contribution to journal › Article › peer-review

      1 Scopus citations

    • The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study

      Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, Feb 15 2023, In: Biological Psychiatry. 93, 4, p. 362-369 8 p.

      Research output: Contribution to journal › Article › peer-review

      1 Scopus citations
    • 2022

      Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

      Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, German Borderline Genomics Consortium, MVP Suicide Exemplar Workgroup & VA Million Veteran Program, Feb 1 2022, In: Biological Psychiatry. 91, 3, p. 313-327 15 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      53 Scopus citations

    • Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

      Maihofer, A. X., Choi, K. W., Coleman, J. R. I., Daskalakis, N. P., Denckla, C. A., Ketema, E., Morey, R. A., Polimanti, R., Ratanatharathorn, A., Torres, K., Wingo, A. P., Zai, C. C., Aiello, A. E., Almli, L. M., Amstadter, A. B., Andersen, S. B., Andreassen, O. A., Arbisi, P. A., Ashley-Koch, A. E., Austin, S. B., & 161 othersAvdibegović, E., Borglum, A. D., Babić, D., Bækvad-Hansen, M., Baker, D. G., Beckham, J. C., Bierut, L. J., Bisson, J. I., Boks, M. P., Bolger, E. A., Bradley, B., Brashear, M., Breen, G., Bryant, R. A., Bustamante, A. C., Bybjerg-Grauholm, J., Calabrese, J. R., Caldas-de-Almeida, J. M., Chen, C. Y., Dale, A. M., Dalvie, S., Deckert, J., Delahanty, D. L., Dennis, M. F., Disner, S. G., Domschke, K., Duncan, L. E., Džubur Kulenović, A., Erbes, C. R., Evans, A., Farrer, L. A., Feeny, N. C., Flory, J. D., Forbes, D., Franz, C. E., Galea, S., Garrett, M. E., Gautam, A., Gelaye, B., Gelernter, J., Geuze, E., Gillespie, C. F., Goçi, A., Gordon, S. D., Guffanti, G., Hammamieh, R., Hauser, M. A., Heath, A. C., Hemmings, S. M. J., Hougaard, D. M., Jakovljević, M., Jett, M., Johnson, E. O., Jones, I., Jovanovic, T., Qin, X. J., Karstoft, K. I., Kaufman, M. L., Kessler, R. C., Khan, A., Kimbrel, N. A., King, A. P., Koen, N., Kranzler, H. R., Kremen, W. S., Lawford, B. R., Lebois, L. A. M., Lewis, C., Liberzon, I., Linnstaedt, S. D., Logue, M. W., Lori, A., Lugonja, B., Luykx, J. J., Lyons, M. J., Maples-Keller, J. L., Marmar, C., Martin, N. G., Maurer, D., Mavissakalian, M. R., McFarlane, A., McGlinchey, R. E., McLaughlin, K. A., McLean, S. A., Mehta, D., Mellor, R., Michopoulos, V., Milberg, W., Miller, M. W., Morris, C. P., Mors, O., Mortensen, P. B., Nelson, E. C., Nordentoft, M., Norman, S. B., O'Donnell, M., Orcutt, H. K., Panizzon, M. S., Peters, E. S., Peterson, A. L., Peverill, M., Pietrzak, R. H., Polusny, M. A., Rice, J. P., Risbrough, V. B., Roberts, A. L., Rothbaum, A. O., Rothbaum, B. O., Roy-Byrne, P., Ruggiero, K. J., Rung, A., Rutten, B. P. F., Saccone, N. L., Sanchez, S. E., Schijven, D., Seedat, S., Seligowski, A. V., Seng, J. S., Sheerin, C. M., Silove, D., Smith, A. K., Smoller, J. W., Sponheim, S. R., Stein, D. J., Stevens, J. S., Teicher, M. H., Thompson, W. K., Trapido, E., Uddin, M., Ursano, R. J., van den Heuvel, L. L., Van Hooff, M., Vermetten, E., Vinkers, C. H., Voisey, J., Wang, Y., Wang, Z., Werge, T., Williams, M. A., Williamson, D. E., Winternitz, S., Wolf, C., Wolf, E. J., Yehuda, R., Young, K. A., Young, R. M. D., Zhao, H., Zoellner, L. A., Haas, M., Lasseter, H., Provost, A. C., Salem, R. M., Sebat, J., Shaffer, R. A., Wu, T., Ripke, S., Daly, M. J., Ressler, K. J., Koenen, K. C., Stein, M. B. & Nievergelt, C. M., Apr 1 2022, In: Biological Psychiatry. 91, 7, p. 626-636 11 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      7 Scopus citations

    • Evaluation of Adenosine A2A receptor gene polymorphisms as risk factors of methamphetamine use disorder susceptibility and predictors of craving degree

      Wang, H., Ma, Y., Wang, X., Zhang, W., Han, W., Liu, H., Li, M., Xiao, J., Wei, H., Wang, C., Sindhwani, S., Zhang, T., Guan, F. & Rice, J. P., Oct 2022, In: Psychiatry Research. 316, 114790.

      Research output: Contribution to journal › Article › peer-review

      5 Scopus citations

    • Genetic diversity fuels gene discovery for tobacco and alcohol use

      23andMe Research Team & the BioBank Japan Project, Dec 22 2022, In: Nature. 612, 7941, p. 720-724 5 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      6 Scopus citations

    • Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk

      COGA Collaborators, Dec 2022, In: Translational psychiatry. 12, 1, 420.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1 Scopus citations

    • Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder

      The Million Veteran Program, Post Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, Dec 4 2022, In: Psychological medicine. 52, 16, p. 3975-3984 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      5 Scopus citations

    • Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

      Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium & iPSYCH, Jan 1 2022, In: Biological Psychiatry. 91, 1, p. 102-117 16 p.

      Research output: Contribution to journal › Article › peer-review

      17 Scopus citations

    • Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis

      COGA Consortium & Spit for Science Working Group, Nov 2022, In: Molecular Psychiatry. 27, 11, p. 4453-4463 11 p.

      Research output: Contribution to journal › Article › peer-review

      2 Scopus citations
    • 2021

      A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts

      Schizophrenia Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Nov 1 2021, In: Biological Psychiatry. 90, 9, p. 611-620 10 p.

      Research output: Contribution to journal › Article › peer-review

      44 Scopus citations

    • Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

      Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jun 1 2021, In: Molecular Psychiatry. 26, 6, p. 2457-2470 14 p.

      Research output: Contribution to journal › Article › peer-review

      26 Scopus citations

    • Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

      Bipolar Disorder Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Apr 1 2021, In: Molecular Psychiatry. 26, 4, p. 1286-1298 13 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      21 Scopus citations

    • Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank (Molecular Psychiatry, (2020), 25, 7, (1430-1446), 10.1038/s41380-019-0546-6)

      on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Sep 1 2021, In: Molecular Psychiatry. 26, 9, p. 5465 1 p.

      Research output: Contribution to journal › Comment/debate

      Open Access

    • Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

      HUNT All-In Psychiatry, Jun 2021, In: Nature Genetics. 53, 6, p. 817-829 13 p.

      Research output: Contribution to journal › Article › peer-review

      236 Scopus citations

    • Model-based assessment of replicability for genome-wide association meta-analysis

      GWAS and Sequencing Consortium of Alcohol and Nicotine Use (GSCAN), Dec 1 2021, In: Nature communications. 12, 1, 1964.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      12 Scopus citations

    • Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases

      The Collaborative Study on the Genetics of Alcoholism (COGA), Dec 1 2021, In: Nature communications. 12, 1, 5071.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      17 Scopus citations

    • Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

      COGA Collaborators, Oct 2021, In: Nature neuroscience. 24, 10, p. 1367-1376 10 p.

      Research output: Contribution to journal › Article › peer-review

      53 Scopus citations

    • Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

      Munn-Chernoff, M. A., Johnson, E. C., Chou, Y. L., Coleman, J. R. I., Thornton, L. M., Walters, R. K., Yilmaz, Z., Baker, J. H., Hübel, C., Gordon, S., Medland, S. E., Watson, H. J., Gaspar, H. A., Bryois, J., Hinney, A., Leppä, V. M., Mattheisen, M., Ripke, S., Yao, S., Giusti-Rodríguez, P., & 332 othersHanscombe, K. B., Adan, R. A. H., Alfredsson, L., Ando, T., Andreassen, O. A., Berrettini, W. H., Boehm, I., Boni, C., Boraska Perica, V., Buehren, K., Burghardt, R., Cassina, M., Cichon, S., Clementi, M., Cone, R. D., Courtet, P., Crow, S., Crowley, J. J., Danner, U. N., Davis, O. S. P., de Zwaan, M., Dedoussis, G., Degortes, D., DeSocio, J. E., Dick, D. M., Dikeos, D., Dina, C., Dmitrzak-Weglarz, M., Docampo, E., Duncan, L. E., Egberts, K., Ehrlich, S., Escaramís, G., Esko, T., Estivill, X., Farmer, A., Favaro, A., Fernández-Aranda, F., Fichter, M. M., Fischer, K., Föcker, M., Foretova, L., Forstner, A. J., Forzan, M., Franklin, C. S., Gallinger, S., Giegling, I., Giuranna, J., Gonidakis, F., Gorwood, P., Gratacos Mayora, M., Guillaume, S., Guo, Y., Hakonarson, H., Hatzikotoulas, K., Hauser, J., Hebebrand, J., Helder, S. G., Herms, S., Herpertz-Dahlmann, B., Herzog, W., Huckins, L. M., Hudson, J. I., Imgart, H., Inoko, H., Janout, V., Jiménez-Murcia, S., Julià, A., Kalsi, G., Kaminská, D., Karhunen, L., Karwautz, A., Kas, M. J. H., Kennedy, J. L., Keski-Rahkonen, A., Kiezebrink, K., Kim, Y. R., Klump, K. L., Knudsen, G. P. S., La Via, M. C., Le Hellard, S., Levitan, R. D., Li, D., Lilenfeld, L., Lin, B. D., Lissowska, J., Luykx, J., Magistretti, P. J., Maj, M., Mannik, K., Marsal, S., Marshall, C. R., Mattingsdal, M., McDevitt, S., McGuffin, P., Metspalu, A., Meulenbelt, I., Micali, N., Mitchell, K., Monteleone, A. M., Monteleone, P., Nacmias, B., Navratilova, M., Ntalla, I., O'Toole, J. K., Ophoff, R. A., Padyukov, L., Palotie, A., Pantel, J., Papezova, H., Pinto, D., Rabionet, R., Raevuori, A., Ramoz, N., Reichborn-Kjennerud, T., Ricca, V., Ripatti, S., Ritschel, F., Roberts, M., Rotondo, A., Rujescu, D., Rybakowski, F., Santonastaso, P., Scherag, A., Scherer, S. W., Schmidt, U., Schork, N. J., Schosser, A., Seitz, J., Slachtova, L., Slagboom, P. E., Slof-Op't Landt, M. C. T., Slopien, A., Sorbi, S., Świątkowska, B., Szatkiewicz, J. P., Tachmazidou, I., Tenconi, E., Tortorella, A., Tozzi, F., Treasure, J., Tsitsika, A., Tyszkiewicz-Nwafor, M., Tziouvas, K., van Elburg, A. A., van Furth, E. F., Wagner, G., Walton, E., Widen, E., Zeggini, E., Zerwas, S., Zipfel, S., Bergen, A. W., Boden, J. M., Brandt, H., Crawford, S., Halmi, K. A., Horwood, L. J., Johnson, C., Kaplan, A. S., Kaye, W. H., Mitchell, J., Olsen, C. M., Pearson, J. F., Pedersen, N. L., Strober, M., Werge, T., Whiteman, D. C., Woodside, D. B., Grove, J., Henders, A. K., Larsen, J. T., Parker, R., Petersen, L. V., Jordan, J., Kennedy, M. A., Birgegård, A., Lichtenstein, P., Norring, C., Landén, M., Mortensen, P. B., Polimanti, R., McClintick, J. N., Adkins, A. E., Aliev, F., Bacanu, S. A., Batzler, A., Bertelsen, S., Biernacka, J. M., Bigdeli, T. B., Chen, L. S., Clarke, T. K., Degenhardt, F., Docherty, A. R., Edwards, A. C., Foo, J. C., Fox, L., Frank, J., Hack, L. M., Hartmann, A. M., Hartz, S. M., Heilmann-Heimbach, S., Hodgkinson, C., Hoffmann, P., Hottenga, J. J., Konte, B., Lahti, J., Lahti-Pulkkinen, M., Lai, D., Ligthart, L., Loukola, A., Maher, B. S., Mbarek, H., McIntosh, A. M., McQueen, M. B., Meyers, J. L., Milaneschi, Y., Palviainen, T., Peterson, R. E., Ryu, E., Saccone, N. L., Salvatore, J. E., Sanchez-Roige, S., Schwandt, M., Sherva, R., Streit, F., Strohmaier, J., Thomas, N., Wang, J. C., Webb, B. T., Wedow, R., Wetherill, L., Wills, A. G., Zhou, H., Boardman, J. D., Chen, D., Choi, D. S., Copeland, W. E., Culverhouse, R. C., Dahmen, N., Degenhardt, L., Domingue, B. W., Frye, M. A., Gäebel, W., Hayward, C., Ising, M., Keyes, M., Kiefer, F., Koller, G., Kramer, J., Kuperman, S., Lucae, S., Lynskey, M. T., Maier, W., Mann, K., Männistö, S., Müller-Myhsok, B., Murray, A. D., Nurnberger, J. I., Preuss, U., Räikkönen, K., Reynolds, M. D., Ridinger, M., Scherbaum, N., Schuckit, M. A., Soyka, M., Treutlein, J., Witt, S. H., Wodarz, N., Zill, P., Adkins, D. E., Boomsma, D. I., Bierut, L. J., Brown, S. A., Bucholz, K. K., Costello, E. J., de Wit, H., Diazgranados, N., Eriksson, J. G., Farrer, L. A., Foroud, T. M., Gillespie, N. A., Goate, A. M., Goldman, D., Grucza, R. A., Hancock, D. B., Harris, K. M., Hesselbrock, V., Hewitt, J. K., Hopfer, C. J., Iacono, W. G., Johnson, E. O., Karpyak, V. M., Kendler, K. S., Kranzler, H. R., Krauter, K., Lind, P. A., McGue, M., MacKillop, J., Madden, P. A. F., Maes, H. H., Magnusson, P. K. E., Nelson, E. C., Nöthen, M. M., Palmer, A. A., Penninx, B. W. J. H., Porjesz, B., Rice, J. P., Rietschel, M., Riley, B. P., Rose, R. J., Shen, P. H., Silberg, J., Stallings, M. C., Tarter, R. E., Vanyukov, M. M., Vrieze, S., Wall, T. L., Whitfield, J. B., Zhao, H., Neale, B. M., Wade, T. D., Heath, A. C., Montgomery, G. W., Martin, N. G., Sullivan, P. F., Kaprio, J., Breen, G., Gelernter, J., Edenberg, H. J., Bulik, C. M. & Agrawal, A., Jan 2021, In: Addiction Biology. 26, 1, e12880.

      Research output: Contribution to journal › Article › peer-review

      19 Scopus citations
    • 2020

      A large-scale genome-wide association study meta-analysis of cannabis use disorder

      Psychiatric Genomics Consortium Substance Use Disorders Workgroup, Dec 1 2020, In: The Lancet Psychiatry. 7, 12, p. 1032-1045 14 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      86 Scopus citations

    • A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

      Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dec 1 2020, In: Nature communications. 11, 1, 2301.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      46 Scopus citations

    • Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

      Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Mar 1 2020, In: Biological Psychiatry. 87, 5, p. 419-430 12 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      16 Scopus citations

    • Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

      Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jul 1 2020, In: Molecular Psychiatry. 25, 7, p. 1430-1446 17 p.

      Research output: Contribution to journal › Article › peer-review

      66 Scopus citations

    • Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

      Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium, Oct 1 2020, In: Molecular Psychiatry. 25, 10, p. 2392-2409 18 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      56 Scopus citations

    • Polygenic risk for anxiety influences anxiety comorbidity and suicidal behavior in bipolar disorder

      Bipolar Genome Study Consortium (BiGS), Dec 1 2020, In: Translational psychiatry. 10, 1, 298.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      13 Scopus citations

    • The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

      Bipolar Disorder Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jul 15 2020, In: Biological Psychiatry. 88, 2, p. 169-184 16 p.

      Research output: Contribution to journal › Article › peer-review

      89 Scopus citations
    • 2019

      Assessment of bidirectional relationships between physical activity and depression among adults a 2-sample Mendelian randomization study

      Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Apr 2019, In: JAMA psychiatry. 76, 4, p. 399-408 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      241 Scopus citations

    • Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

      Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23andMe Research Team, Jan 2019, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      15 Scopus citations

    • Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

      23andMe Research Team & HUNT All-In Psychiatry, Feb 1 2019, In: Nature Genetics. 51, 2, p. 237-244 8 p.

      Research output: Contribution to journal › Letter › peer-review

      721 Scopus citations

    • Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder

      Budde, M., Friedrichs, S., Alliey-Rodriguez, N., Ament, S., Badner, J. A., Berrettini, W. H., Bloss, C. S., Byerley, W., Cichon, S., Comes, A. L., Coryell, W., Craig, D. W., Degenhardt, F., Edenberg, H. J., Foroud, T., Forstner, A. J., Frank, J., Gershon, E. S., Goes, F. S., Greenwood, T. A., & 40 othersGuo, Y., Hipolito, M., Hood, L., Keating, B. J., Koller, D. L., Lawson, W. B., Liu, C., Mahon, P. B., McInnis, M. G., McMahon, F. J., Meier, S. M., Mühleisen, T. W., Murray, S. S., Nievergelt, C. M., Nurnberger, J. I., Nwulia, E. A., Potash, J. B., Quarless, D., Rice, J., Roach, J. C., Scheftner, W. A., Schork, N. J., Shekhtman, T., Shilling, P. D., Smith, E. N., Streit, F., Strohmaier, J., Szelinger, S., Treutlein, J., Witt, S. H., Zandi, P. P., Zhang, P., Zöllner, S., Bickeböller, H., Falkai, P. G., Kelsoe, J. R., Nöthen, M. M., Rietschel, M., Schulze, T. G. & Malzahn, D., Jan 2019, In: European Neuropsychopharmacology. 29, 1, p. 156-170 15 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      6 Scopus citations

    • Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

      CHD Exome+ Consortium & Consortium for Genetics of Smoking Behaviour, Jun 1 2019, In: Biological Psychiatry. 85, 11, p. 946-955 10 p.

      Research output: Contribution to journal › Article › peer-review

      41 Scopus citations

    • Genome-wide association study identifies 30 loci associated with bipolar disorder

      eQTLgen Consortium, BIOS Consortium & the Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, May 1 2019, In: Nature Genetics. 51, 5, p. 793-803 11 p.

      Research output: Contribution to journal › Article › peer-review

      744 Scopus citations

    • Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts

      Zhang, X., Abdellaoui, A., Rucker, J., de Jong, S., Potash, J. B., Weissman, M. M., Shi, J., Knowles, J. A., Pato, C., Pato, M., Sobell, J., Smit, J. H., Hottenga, J. J., de Geus, E. J. C., Lewis, C. M., Buttenschøn, H. N., Craddock, N., Jones, I., Jones, L., McGuffin, P., & 13 othersMors, O., Owen, M. J., Preisig, M., Rietschel, M., Rice, J. P., Rivera, M., Uher, R., Gejman, P. V., Sanders, A. R., Boomsma, D., Penninx, B. W. J. H., Breen, G. & Levinson, D. F., Jun 15 2019, In: Biological Psychiatry. 85, 12, p. 1065-1073 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      17 Scopus citations

    • Identification of common genetic risk variants for autism spectrum disorder

      Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23andMe Research Team, Mar 1 2019, In: Nature Genetics. 51, 3, p. 431-444 14 p.

      Research output: Contribution to journal › Article › peer-review

      887 Scopus citations

    • Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

      Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dec 1 2019, In: Nature communications. 10, 1, 2548.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      69 Scopus citations

    • International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

      Nievergelt, C. M., Maihofer, A. X., Klengel, T., Atkinson, E. G., Chen, C. Y., Choi, K. W., Coleman, J. R. I., Dalvie, S., Duncan, L. E., Gelernter, J., Levey, D. F., Logue, M. W., Polimanti, R., Provost, A. C., Ratanatharathorn, A., Stein, M. B., Torres, K., Aiello, A. E., Almli, L. M., Amstadter, A. B., & 159 othersAndersen, S. B., Andreassen, O. A., Arbisi, P. A., Ashley-Koch, A. E., Austin, S. B., Avdibegovic, E., Babić, D., Bækvad-Hansen, M., Baker, D. G., Beckham, J. C., Bierut, L. J., Bisson, J. I., Boks, M. P., Bolger, E. A., Børglum, A. D., Bradley, B., Brashear, M., Breen, G., Bryant, R. A., Bustamante, A. C., Bybjerg-Grauholm, J., Calabrese, J. R., Caldas- de- Almeida, J. M., Dale, A. M., Daly, M. J., Daskalakis, N. P., Deckert, J., Delahanty, D. L., Dennis, M. F., Disner, S. G., Domschke, K., Dzubur-Kulenovic, A., Erbes, C. R., Evans, A., Farrer, L. A., Feeny, N. C., Flory, J. D., Forbes, D., Franz, C. E., Galea, S., Garrett, M. E., Gelaye, B., Geuze, E., Gillespie, C., Uka, A. G., Gordon, S. D., Guffanti, G., Hammamieh, R., Harnal, S., Hauser, M. A., Heath, A. C., Hemmings, S. M. J., Hougaard, D. M., Jakovljevic, M., Jett, M., Johnson, E. O., Jones, I., Jovanovic, T., Qin, X. J., Junglen, A. G., Karstoft, K. I., Kaufman, M. L., Kessler, R. C., Khan, A., Kimbrel, N. A., King, A. P., Koen, N., Kranzler, H. R., Kremen, W. S., Lawford, B. R., Lebois, L. A. M., Lewis, C. E., Linnstaedt, S. D., Lori, A., Lugonja, B., Luykx, J. J., Lyons, M. J., Maples-Keller, J., Marmar, C., Martin, A. R., Martin, N. G., Maurer, D., Mavissakalian, M. R., McFarlane, A., McGlinchey, R. E., McLaughlin, K. A., McLean, S. A., McLeay, S., Mehta, D., Milberg, W. P., Miller, M. W., Morey, R. A., Morris, C. P., Mors, O., Mortensen, P. B., Neale, B. M., Nelson, E. C., Nordentoft, M., Norman, S. B., O’Donnell, M., Orcutt, H. K., Panizzon, M. S., Peters, E. S., Peterson, A. L., Peverill, M., Pietrzak, R. H., Polusny, M. A., Rice, J. P., Ripke, S., Risbrough, V. B., Roberts, A. L., Rothbaum, A. O., Rothbaum, B. O., Roy-Byrne, P., Ruggiero, K., Rung, A., Rutten, B. P. F., Saccone, N. L., Sanchez, S. E., Schijven, D., Seedat, S., Seligowski, A. V., Seng, J. S., Sheerin, C. M., Silove, D., Smith, A. K., Smoller, J. W., Sponheim, S. R., Stein, D. J., Stevens, J. S., Sumner, J. A., Teicher, M. H., Thompson, W. K., Trapido, E., Uddin, M., Ursano, R. J., van den Heuvel, L. L., Van Hooff, M., Vermetten, E., Vinkers, C. H., Voisey, J., Wang, Y., Wang, Z., Werge, T., Williams, M. A., Williamson, D. E., Winternitz, S., Wolf, C., Wolf, E. J., Wolff, J. D., Yehuda, R., Young, R. M. D., Young, K. A., Zhao, H., Zoellner, L. A., Liberzon, I., Ressler, K. J., Haas, M. & Koenen, K. C., Dec 1 2019, In: Nature communications. 10, 1, 4558.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      204 Scopus citations

    • Polygenic risk for circulating reproductive hormone levels and their influence on hippocampal volume and depression susceptibility

      Smeeth, D. M., Dima, D., Jones, L., Jones, I., Craddock, N., Owen, M. J., Rietschel, M., Maier, W., Korszun, A., Rice, J. P., Mors, O., Preisig, M., Uher, R., Lewis, C. M., Thuret, S. & Powell, T. R., Aug 2019, In: Psychoneuroendocrinology. 106, p. 284-292 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      12 Scopus citations
    • 2018

      A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

      Schizophrenia and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Jun 25 2018, In: BMC genomics. 19, 1, 494.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      14 Scopus citations

    • Analysis of shared heritability in common disorders of the brain

      The Brainstorm Consortium, Jun 22 2018, In: Science. 360, 6395, 8757.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1086 Scopus citations

    • Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

      Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Dec 1 2018, In: Communications Biology. 1, 1, 163.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      14 Scopus citations

    • CYP2A6 metabolism in the development of smoking behaviors in young adults

      Olfson, E., Bloom, J., Bertelsen, S., Budde, J. P., Breslau, N., Brooks, A., Culverhouse, R., Chan, G., Chen, L. S., Chorlian, D., Dick, D. M., Edenberg, H. J., Hartz, S., Hatsukami, D., Hesselbrock, V. M., Johnson, E. O., Kramer, J. R., Kuperman, S., Meyers, J. L., Nurnberger, J., & 8 othersPorjesz, B., Saccone, N. L., Schuckit, M. A., Stitzel, J., Tischfield, J. A., Rice, J. P., Goate, A. & Bierut, L. J., Jan 2018, In: Addiction Biology. 23, 1, p. 437-447 11 p.

      Research output: Contribution to journal › Article › peer-review

      7 Scopus citations

    • Detecting significant genotype–phenotype association rules in bipolar disorder: market research meets complex genetics

      Breuer, R., Mattheisen, M., Frank, J., Krumm, B., Treutlein, J., Kassem, L., Strohmaier, J., Herms, S., Mühleisen, T. W., Degenhardt, F., Cichon, S., Nöthen, M. M., Karypis, G., Kelsoe, J., Greenwood, T., Nievergelt, C., Shilling, P., Shekhtman, T., Edenberg, H., Craig, D., & 32 othersSzelinger, S., Nurnberger, J., Gershon, E., Alliey-Rodriguez, N., Zandi, P., Goes, F., Schork, N., Smith, E., Koller, D., Zhang, P., Badner, J., Berrettini, W., Bloss, C., Byerley, W., Coryell, W., Foroud, T., Guo, Y., Hipolito, M., Keating, B., Lawson, W., Liu, C., Mahon, P., McInnis, M., Murray, S., Nwulia, E., Potash, J., Rice, J., Scheftner, W., Zöllner, S., McMahon, F. J., Rietschel, M. & Schulze, T. G., Dec 1 2018, In: International Journal of Bipolar Disorders. 6, 1, 24.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      5 Scopus citations

    • Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

      Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jul 15 2018, In: Biological Psychiatry. 84, 2, p. 138-147 10 p.

      Research output: Contribution to journal › Article › peer-review

      65 Scopus citations

    • Exome sequencing of a large family identifies potential candidate genes contributing risk to bipolar disorder

      Zhang, T., Hou, L., Chen, D. T., McMahon, F. J., Wang, J. C. & Rice, J. P., Mar 1 2018, In: Gene. 645, p. 119-123 5 p.

      Research output: Contribution to journal › Article › peer-review

      23 Scopus citations

    • Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

      Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. M. F., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. F. T., Bigdeli, T. B., Binder, E. B., Blackwood, D. R. H., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N., & 196 othersCastelao, E., Christensen, J. H., Clarke, T. K., Coleman, J. I. R., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Crowley, C. A., Dashti, H. S., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., DIrek, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Eriksson, N., Escott-Price, V., Kiadeh, F. H. F., Finucane, H. K., Forstner, A. J., Frank, J., Gaspar, H. A., Gill, M., Giusti-Rodríguez, P., Goes, F. S., Gordon, S. D., Grove, J., Hall, L. S., Hannon, E., Hansen, C. S., Hansen, T. F., Herms, S., Hickie, I. B., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J. J., Hougaard, D. M., Hu, M., Hyde, C. L., Ising, M., Jansen, R., Jin, F., Jorgenson, E., Knowles, J. A., Kohane, I. S., Kraft, J., Kretzschmar, W. W., Krogh, J., Kutalik, Z., Lane, J. M., Li, Y., Li, Y., Lind, P. A., Liu, X., Lu, L., MacIntyre, D. J., MacKinnon, D. F., Maier, R. M., Maier, W., Marchini, J., Mbarek, H., McGrath, P., McGuffin, P., Medland, S. E., Mehta, DI., Middeldorp, C. M., Mihailov, E., Milaneschi, Y., Milani, L., Mill, J., Mondimore, F. M., Montgomery, G. W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nivard, M. G., Nyholt, D. R., O'Reilly, P. F., Oskarsson, H., Owen, M. J., Painter, J. N., Pedersen, C. B., Pedersen, M. G., Peterson, R. E., Pettersson, E., Peyrot, W. J., Pistis, G., Posthuma, D., Purcell, S. M., Quiroz, J. A., Qvist, P., Rice, J. P., Riley, B. P., Rivera, M., Saeed Mirza, S., Saxena, R., Schoevers, R., Schulte, E. C., Shen, L., Shi, J., Shyn, S. I., Sigurdsson, E., Sinnamon, G. B. C., Smit, J. H., Smith, D. J., Stefansson, H., Steinberg, S., Stockmeier, C. A., Streit, F., Strohmaier, J., Tansey, K. E., Teismann, H., Teumer, A., Thompson, W., Thomson, P. A., Thorgeirsson, T. E., Tian, C., Traylor, M., Treutlein, J., Trubetskoy, V., Uitterlinden, A. G., Umbricht, D., Van Der Auwera, S., Van Hemert, A. M., Viktorin, A., Visscher, P. M., Wang, Y., Webb, B. T., Weinsheimer, S. M., Wellmann, J., Willemsen, G., Witt, S. H., Wu, Y., Xi, H. S., Yang, J., Zhang, F., Arolt, V., Baune, B. T., Berger, K., Boomsma, D. I., Cichon, S., Dannlowski, U., De Geus, E. C. J., Depaulo, J. R., Domenici, E., Domschke, K., Esko, T., Grabe, H. J., Hamilton, S. P., Hayward, C., Heath, A. C., Hinds, D. A., Kendler, K. S., Kloiber, S., Lewis, G., Li, Q. S., Lucae, S., Madden, P. F. A., Magnusson, P. K., Martin, N. G., McIntosh, A. M., Metspalu, A., Mors, O., Mortensen, P. B., Müller-Myhsok, B., Nordentoft, M., Nöthen, M. M., O'Donovan, M. C., Paciga, S. A., Pedersen, N. L., Penninx, B. W. J. H., Perlis, R. H., Porteous, D. J., Potash, J. B., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T. G., Smoller, J. W., Stefansson, K., Tiemeier, H., Uher, R., Völzke, H., Weissman, M. M., Werge, T., Winslow, A. R., Lewis, C. M., Levinson, D. F., Breen, G., Børglum, A. D. & Sullivan, P. F., May 1 2018, In: Nature Genetics. 50, 5, p. 668-681 14 p.

      Research output: Contribution to journal › Article › peer-review

      1357 Scopus citations

    • Genome-wide association study identifies a novel locus for cannabis dependence

      Agrawal, A., Chou, Y. L., Carey, C. E., Baranger, D. A. A., Zhang, B., Sherva, R., Wetherill, L., Kapoor, M., Wang, J. C., Bertelsen, S., Anokhin, A. P., Hesselbrock, V., Kramer, J., Lynskey, M. T., Meyers, J. L., Nurnberger, J. I., Rice, J. P., Tischfield, J., Bierut, L. J., Degenhardt, L., & 16 othersFarrer, L. A., Gelernter, J., Hariri, A. R., Heath, A. C., Kranzler, H. R., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Porjesz, B., Wang, T., Whitfield, J. B., Edenberg, H. J., Foroud, T., Goate, A. M., Bogdan, R. & Nelson, E. C., May 1 2018, In: Molecular Psychiatry. 23, 5, p. 1293-1302 10 p.

      Research output: Contribution to journal › Article › peer-review

      29 Scopus citations

    • Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

      Generation Scotland & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dec 2018, In: PloS one. 13, 12, e0209160.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      8 Scopus citations

    • Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

      Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium douglas.ruderfer@vanderbilt.edu, Psychosis Endophenotypes International Consortium & Wellcome Trust Case Control Consortium, Jun 14 2018, In: Cell. 173, 7, p. 1705-1715.e16

      Research output: Contribution to journal › Article › peer-review

      Open Access
      360 Scopus citations

    • Improving genetic prediction by leveraging genetic correlations among human diseases and traits

      Maier, R. M., Zhu, Z., Lee, S. H., Trzaskowski, M., Ruderfer, D. M., Stahl, E. A., Ripke, S., Wray, N. R., Yang, J., Visscher, P. M., Robinson, M. R., Forstner, A. J., Mcquillin, A., Trubetskoy, V., Wang, W., Wang, Y., Coleman, J. R. I., Gaspar, H. A., De Leeuw, C. A., Whitehead Pavlides, J. M., & 221 othersOlde Loohuis, L. M., Pers, T. H., Lee, P. H., Charney, A. W., Dobbyn, A. L., Huckins, L., Boocock, J., Giambartolomei, C., Roussos, P., Mullins, N., Awasthi, S., Agerbo, E., Als, T. D., Pedersen, C. B., Grove, J., Kupka, R., Regeer, E. J., Anjorin, A., Casas, M., Mahon, P. B., Allardyce, J., Escott-Price, V., Forty, L., Fraser, C., Kogevinas, M., Frank, J., Streit, F., Strohmaier, J., Treutlein, J., Witt, S. H., Kennedy, J. L., Strauss, J. S., Garnham, J., O'donovan, C., Slaney, C., Steinberg, S., Thorgeirsson, T. E., Hautzinger, M., Steffens, M., Perlis, R. H., Sánchez-Mora, C., Hipolito, M., Lawson, W. B., Nwulia, E. A., Levy, S. E., Foroud, T. M., Jamain, S., Young, A. H., Mckay, J. D., Albani, D., Zandi, P., Potash, J. B., Zhang, P., Raymond Depaulo, J., Bergen, S. E., Juréus, A., Karlsson, R., Kandaswamy, R., Mcguffin, P., Rivera, M., Lissowska, J., Cruceanu, C., Lucae, S., Cervantes, P., Budde, M., Gade, K., Heilbronner, U., Pedersen, M. G., Morris, D. W., Weickert, C. S., Weickert, T. W., Macintyre, D. J., Lawrence, J., Elvsåshagen, T., Smeland, O. B., Djurovic, S., Xi, S., Green, E. K., Czerski, P. M., Hauser, J., Xu, W., Vedder, H., Oruc, L., Spijker, A. T., Gordon, S. D., Medland, S. E., Curtis, D., Mühleisen, T. W., Badner, J., Scheftner, W. A., Sigurdsson, E., Schork, N. J., Schatzberg, A. F., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hansen, C. S., Knowles, J. A., Szelinger, S., Montgomery, G. W., Boks, M., Adolfsson, A. N., Hoffmann, P., Bauer, M., Pfennig, A., Leber, M., Kittel-Schneider, S., Reif, A., Del-Favero, J., Fischer, S. B., Herms, S., Reinbold, C. S., Degenhardt, F., Koller, A. C., Maaser, A., Ori, A., Dale, A. M., Fan, C. C., Greenwood, T. A., Nievergelt, C. M., Shehktman, T., Shilling, P. D., Byerley, W., Bunney, W., Alliey-Rodriguez, N., Clarke, T. K., Liu, C., Coryell, W., Akil, H., Burmeister, M., Flickinger, M., Li, J. Z., Mcinnis, M. G., Meng, F., Thompson, R. C., Watson, S. J., Zollner, S., Guan, W., Green, M. J., Craig, D., Sobell, J. L., Milani, L., Gordon-Smith, K., Knott, S. V., Perry, A., Parra, J. G., Mayoral, F., Rivas, F., Rice, J. P., Barchas, J. D., Børglum, A. D., Mortensen, P. B., Mors, O., Grigoroiu-Serbanescu, M., Bellivier, F., Etain, B., Leboyer, M., Ramos-Quiroga, J. A., Agartz, I., Amin, F., Azevedo, M. H., Bass, N., Black, D. W., Blackwood, D. H. R., Bruggeman, R., Buccola, N. G., Choudhury, K., Cloninger, C. R., Corvin, A., Craddock, N., Daly, M. J., Datta, S., Donohoe, G. J., Duan, J., Dudbridge, F., Fanous, A., Freedman, R., Freimer, N. B., Friedl, M., Gill, M., Gurling, H., De Haan, L., Hamshere, M. L., Hartmann, A. M., Holmans, P. A., Kahn, R. S., Keller, M. C., Kenny, E., Kirov, G. K., Krabbendam, L., Krasucki, R., Lencz, T., Levinson, D. F., Lieberman, J. A., Lin, D. Y., Linszen, D. H., Magnusson, P. K. E., Maier, W., Malhotra, A. K., Mattheisen, M., Mattingsdal, M., Mccarroll, S. A., Medeiros, H., Melle, I., Milanova, V., Myin-Germeys, I., Neale, B. M., Ophoff, R. A., Owen, M. J., Pimm, J., Purcell, S. M., Puri, V., Quested, D. J., Rossin, L., Sanders, A. R., Shi, J., Sklar, P., St Clair, D., Stroup, T. S., Van Os, J., Wiersma, D. & Zammit, S., Dec 1 2018, In: Nature communications. 9, 1, 989.

      Research output: Contribution to journal › Editorial

      Open Access
      86 Scopus citations

    • Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability

      Duncan, L. E., Ratanatharathorn, A., Aiello, A. E., Almli, L. M., Amstadter, A. B., Ashley-Koch, A. E., Baker, D. G., Beckham, J. C., Bierut, L. J., Bisson, J., Bradley, B., Chen, C. Y., Dalvie, S., Farrer, L. A., Galea, S., Garrett, M. E., Gelernter, J. E., Guffanti, G., Hauser, M. A., Johnson, E. O., & 29 othersKessler, R. C., Kimbrel, N. A., King, A., Koen, N., Kranzler, H. R., Logue, M. W., Maihofer, A. X., Martin, A. R., Miller, M. W., Morey, R. A., Nugent, N. R., Rice, J. P., Ripke, S., Roberts, A. L., Saccone, N. L., Smoller, J. W., Stein, D. J., Stein, M. B., Sumner, J. A., Uddin, M., Ursano, R. J., Wildman, D. E., Yehuda, R., Zhao, H., Daly, M. J., Liberzon, I., Ressler, K. J., Nievergelt, C. M. & Koenen, K. C., Mar 1 2018, In: Molecular Psychiatry. 23, 3, p. 666-673 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      246 Scopus citations