Personal profile
Research interests
Our laboratory focuses on the fundamental issues of DNA repair and how they relate to cancer initiation, progression, and therapy responses.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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DNA repair and the contribution to chemotherapy resistance
Nesic, K., Parker, P., Swisher, E. M. & Krais, J. J., Dec 2025, In: Genome medicine. 17, 1, 62.Research output: Contribution to journal › Review article › peer-review
Open Access17 Link opens in a new tab Scopus citations -
4'-Ethynyl-2'-Deoxycytidine(EdC)PreferentiallyTargets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
Calbert, M. L., Chandramouly, G., Adams, C. M., Saez-Ayala, M., Kent, T., Tyagi, M., Ayyadevara, V. S. S. A., Wang, Y., Krais, J. J., Gordon, J., Atkins, J., Toma, M. M., Betzi, S., Boghossian, A. S., Rees, M. G., Ronan, M. M., Roth, J. A., Goldman, A. R., Gorman, N. & Mitra, R. & 8 others, , May 1 2024, In: Molecular Cancer Therapeutics. 23, 5, p. 683-699 17 p.Research output: Contribution to journal › Article › peer-review
2 Link opens in a new tab Scopus citations -
BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance
Australian Ovarian Cancer Study, Dec 2024, In: Molecular Cancer. 23, 1, 158.Research output: Contribution to journal › Letter › peer-review
Open Access22 Link opens in a new tab Scopus citations -
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors
Fried, W., Tyagi, M., Minakhin, L., Chandramouly, G., Tredinnick, T., Ramanjulu, M., Auerbacher, W., Calbert, M., Rusanov, T., Hoang, T., Borisonnik, N., Betsch, R., Krais, J. J., Wang, Y., Vekariya, U. M., Gordon, J., Morton, G., Kent, T., Skorski, T. & Johnson, N. & 3 others, , Dec 2024, In: Nature communications. 15, 1, 2862.Research output: Contribution to journal › Article › peer-review
Open Access38 Link opens in a new tab Scopus citations -
Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM
Ito, F., Li, Z., Minakhin, L., Chandramouly, G., Tyagi, M., Betsch, R., Krais, J. J., Taberi, B., Vekariya, U., Calbert, M., Skorski, T., Johnson, N., Chen, X. S. & Pomerantz, R. T., Dec 2024, In: Nature communications. 15, 1, 7003.Research output: Contribution to journal › Article › peer-review
Open Access13 Link opens in a new tab Scopus citations