John Cooper

Head of the Department of Biochemistry, Professor of Biochemistry and Molecular Biophysics, Professor of Cell Biology and Physiology

    • 18455 Citations
    1982 …2020

    Research output per year

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    Personal profile

    Research interests

    The long-term goal of our research is to understand the molecular basis of cell motility, including the role of motility in human disease, especially cancer. How do actin, microtubules and their motors control the shape and movement of cells? How are these elements of the cytoskeleton regulated by signals from the cell cycle machinery and from outside the cell? We study these questions in cultured human cells and zebrafish, using the strengths of each system. We utilize a variety of technical approaches encompassing genetics, biochemistry and cell biology. The major current focus of the lab is on actin assembly and membrane dynamics in animal cells. We are studying how actin-binding proteins regulated by signals from cancer-causing viruses and growth factors direct the polymerization of actin, which causes cells to move and change shape.

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    Research Output

    Comparative Analysis of CPI-Motif Regulation of Biochemical Functions of Actin Capping Protein

    McConnell, P., Mekel, M., Kozlov, A. G., Mooren, O. L., Lohman, T. M. & Cooper, J. A., Mar 24 2020, In : Biochemistry. 59, 11, p. 1202-1215 14 p.

    Research output: Contribution to journalArticle

  • Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange

    Johnson, B., McConnell, P., Kozlov, A. G., Mekel, M., Lohman, T. M., Gross, M. L., Amarasinghe, G. K. & Cooper, J. A., May 29 2018, In : Cell Reports. 23, 9, p. 2795-2804 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Scopus citations

    A novel mode of capping protein-regulation by twinfilin

    Johnston, A. B., Hilton, D. M., McConnell, P., Johnson, B., Harris, M. T., Simone, A., Amarasinghe, G. K., Cooper, J. A. & Goode, B. L., Oct 2018, In : eLife. 7, e41313.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Scopus citations

    Contractile protein biochemistry in the Pollard Lab in Baltimore

    Kiehart, D. P. & Cooper, J. A., Dec 1 2018, In : Biophysical Reviews. 10, 6, p. 1483-1485 3 p.

    Research output: Contribution to journalReview article

  • Septins regulate junctional integrity of endothelial monolayers

    Kim, J. & Cooper, J. A., Jul 15 2018, In : Molecular biology of the cell. 29, 14, p. 1693-1703 11 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations