Personal profile
Research interests
Plants are amazing chemists capable of generating an array of small molecules with different biological effects. Our research seeks to broadly understand how environmental changes re-model biochemical pathways in plants at the molecular, cellular, and organism levels with the aim of engineering these systems to address agricultural and environmental problems. Current work in the lab employs a combination of x-ray crystallography, enzymology, molecular biology, proteomics, and plant biology to address the following questions: What are the biochemical networks involved in responding to specific environmental stresses and how are they organized? How do different biochemical mechanisms regulate these pathways? What are the connective systems that allow for integration and cross-talk between metabolic pathways in plants? Can we re-engineer plant pathways and the links between different control systems to improve plant performance under environmental stresses?
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Expanding the Landscape of Dual Action Antifolate Antibacterials through 2,4-Diamino-1,6-dihydro-1,3,5-triazines
Georgiades, J. D., Berkovich, D. A., McKee, S. R., Smith, A. R., Sankaran, B., Flentie, K. N., Castañeda, C. H., Grohmann, D. G., Rohatgi, R., Lasky, C., Mason, T. A., Champine, J. E., Miller, P. A., Möllmann, U., Moraski, G. C., Franzblau, S. G., Miller, M. J., Stallings, C. L., Jez, J. M. & Hathaway, B. A. & 1 others, , Mar 14 2025, In: ACS Infectious Diseases. 11, 3, p. 689-702 14 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Glycosylated cannabinoids meet computational enzyme design
Jez, J. M., Nov 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 45, e2525454122.Research output: Contribution to journal › Comment/debate
Open Access -
Supramolecular structures: An introduction to the JBC reviews thematic series
Jez, J. M. & Peti, W., Dec 2025, In: Journal of Biological Chemistry. 301, 12, 110905.Research output: Contribution to journal › Comment/debate
Open Access -
The Biotech Explorers Pathway equips students for STEM futures: Career feature
Robinson, A. E., Cascella, B., Wegorzewska, M. M., Berkovich, D. A. & Jez, J. M., May 2025, In: Nature Biotechnology. 43, 5, p. 823-827 5 p.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Scopus citations -
4-Aldrithiol-based photometric assay for detection of methylthioalkylmalate synthase activity
Kitainda, V. & Jez, J., Jan 2024, Siderophore and Related Natural Products Biosynthesis. Wencewicz, T. (ed.). Academic Press Inc., p. 229-245 17 p. (Methods in Enzymology; vol. 702).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Link opens in a new tab Scopus citations