Personal profile
Research interests
We are interested in the discovery and development of novel therapeutics for treatment and prevention of cancer and infectious disease. One aim of our current research focuses on the identification of unconventional allosteric inhibitors of the trypsin-like serine proteases, HGFA, matriptase, and hepsin. These proteases are up-regulated in many invasive cancers and regulate the activation of hepatocyte growth factor (HGF) and macrophage stimulating protein (MSP-1). Another aim of our research centers on the developing small-molecule antagonists of the UPEC bacterial adhesion protein FimH for the treatment of urinary tract infections (UTI).
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1
Banas, V., Seehra, K., Mahoney, M., Alisio, C., Kyriukha, Y., Weiland, E., Fath, M., Han, Z., Bricker, T., Tartell, M., Whelan, S., Boon, A. C. M. & Janetka, J. W., Jan 15 2026, In: European Journal of Medicinal Chemistry. 302, 118385.Research output: Contribution to journal › Article › peer-review
2 Link opens in a new tab Scopus citations -
Anthelmintics Derived from the Kinase Inhibitor SGI-1776 for the Treatment of Gastrointestinal Worm Infections
Elfawal, M. A., Banas, V., Rosa, B. A., Mahoney, M., Goetz, E., Chen, P., Aroian, R. V., Janetka, J. W. & Mitreva, M., Nov 14 2025, In: ACS Infectious Diseases. 11, 11, p. 3196-3211 16 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Ciliated cells promote high infectious potential of influenza A virus through the efficient intracellular activation of hemagglutinin
Guo, Z., Banas, V. S., He, Y., Weiland, E., Xu, J., Tan, Y., Xiao, Z., Brody, S. L., Boon, A. C. M., Janetka, J. W. & Vahey, M. D., Sep 2025, In: Journal of virology. 99, 9Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections
Banas, V., Elfawal, M. A., Rosa, B. A., Mahoney, M., Kauffman, J., Goetz, E., Chen, P., Aroian, R. V., Mitreva, M. & Janetka, J. W., Feb 14 2025, In: ACS Infectious Diseases. 11, 2, p. 506-517 12 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Mechanisms of uropathogenic E. coli mucosal association in the gastrointestinal tract
Azimzadeh, P. N., Birchenough, G. M., Gualbuerto, N. C., Pinkner, J. S., Tamadonfar, K. O., Beatty, W., Hannan, T. J., Dodson, K. W., Ibarra, E. C., Kim, S., Schreiber, H. L., Janetka, J. W., Kau, A. L., Earl, A. M., Miller, M. J., Hansson, G. C. & Hultgren, S. J., Jan 31 2025, In: Science Advances. 11, 5, eadp7066.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations