Research output per year
Research output per year
Personal profile
Research interests
We are interested in the discovery and development of novel therapeutics for treatment and prevention of cancer and infectious disease. One aim of our current research focuses on the identification of unconventional allosteric inhibitors of the trypsin-like serine proteases, HGFA, matriptase, and hepsin. These proteases are up-regulated in many invasive cancers and regulate the activation of hepatocyte growth factor (HGF) and macrophage stimulating protein (MSP-1). Another aim of our research centers on the developing small-molecule antagonists of the UPEC bacterial adhesion protein FimH for the treatment of urinary tract infections (UTI).
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections
Maddirala, A. R., Tamadonfar, K., Pinkner, J. S., Sanick, D., Hultgren, S. J. & Janetka, J. W., Mar 14 2024, In: Journal of Medicinal Chemistry. 67, 5, p. 3668-3678 11 p.Research output: Contribution to journal › Article › peer-review
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Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19
Boon, A. C. M., Bricker, T. L., Fritch, E. J., Leist, S. R., Gully, K., Baric, R. S., Graham, R. L., Troan, B. V., Mahoney, M. & Janetka, J. W., May 2024, In: Journal of virology. 98, 5Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis
Belitškin, D., Munne, P., Pant, S. M., Anttila, J. M., Suleymanova, I., Belitškina, K., Kirchhofer, D., Janetka, J., Käsper, T., Jalil, S., Pouwels, J., Tervonen, T. A. & Klefström, J., Mar 2024, In: Molecular Oncology. 18, 3, p. 547-561 15 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer
Jones, V. T., Graves-Deal, R., Cao, Z., Bogatcheva, G., Ramirez, M. A., Harmych, S. J., Higginbotham, J. N., Sharma, V., Damalanka, V. C., Wahoski, C. C., Joshi, N., Irudayam, M. J., Roland, J. T., Ayers, G. D., Liu, Q., Coffey, R. J., Janetka, J. W. & Singh, B., Dec 2024, In: Cellular and Molecular Life Sciences. 81, 1, 28.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Mechanism-Based Macrocyclic Inhibitors of Serine Proteases
Damalanka, V. C., Banas, V., De Bona, P., Kashipathy, M. M., Battaile, K., Lovell, S. & Janetka, J. W., Mar 28 2024, In: Journal of Medicinal Chemistry. 67, 6, p. 4833-4854 22 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations