Research Output per year
Research Output per year
Assistant Professor of Medicine
Research output per year
We are interested in delineating the biology of novel anticancer targets. Our current focus is on two proteins - the actin-binding factor profilin-1 and the polyubiquitin-specific protein segregase p97/VCP. Profilin-1 is an essential gene for eukaryotic cells, yet showing paradoxical anti-cancer activities in multiple types of human cancer. We hypothesize that it has ‘moonlighting” nuclear functions which represses the expression of various pro-cancer genes, spatially separate from its actin-regulatory activities in the cytoplasm. This “spatial confinement” model reconciles its paradoxical cellular functions and is the main focus of our research effort. In parallel, we are studying p97/VCP which is an evolutionarily conserved AAA+ ATPase regulating cellular proteostasis via facilitating the turnover of a myriad of polyubiquinated proteins within various cellular structures and protein complexes. Our current interest is its role in chromatin-associated protein degradation which occurs dynamically during DNA damage response and is crucial for maintaining genome stability.
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Comment/debate
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review