Research output per year
Research output per year
Personal profile
Research interests
We are interested in delineating the biology of novel anticancer targets. Our current focus is on two proteins - the actin-binding factor profilin-1 and the polyubiquitin-specific protein segregase p97/VCP. Profilin-1 is an essential gene for eukaryotic cells, yet showing paradoxical anti-cancer activities in multiple types of human cancer. We hypothesize that it has ‘moonlighting” nuclear functions which represses the expression of various pro-cancer genes, spatially separate from its actin-regulatory activities in the cytoplasm. This “spatial confinement” model reconciles its paradoxical cellular functions and is the main focus of our research effort. In parallel, we are studying p97/VCP which is an evolutionarily conserved AAA+ ATPase regulating cellular proteostasis via facilitating the turnover of a myriad of polyubiquinated proteins within various cellular structures and protein complexes. Our current interest is its role in chromatin-associated protein degradation which occurs dynamically during DNA damage response and is crucial for maintaining genome stability.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Profilin-1 regulates DNA replication forks in a context-dependent fashion by interacting with SNF2H and BOD1L
Zhu, C., Iwase, M., Li, Z., Wang, F., Quinet, A., Vindigni, A. & Shao, J., Dec 2022, In: Nature communications. 13, 1, 6531.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1
Zhu, C., Kim, S. J., Mooradian, A., Wang, F., Li, Z., Holohan, S., Collins, P. L., Wang, K., Guo, Z., Hoog, J., Ma, C. X., Oltz, G., Held, J. M. & Shao, J., Feb 16 2021, In: Cell Reports. 34, 7, 108749.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Phospho-ser784-vcp drives resistance of pancreatic ductal adenocarcinoma to genotoxic chemotherapies and predicts the chemo-sensitizing effect of vcp inhibitor
Wang, F., Vij, K., Li, L., Dodhiawala, P., Lim, K. H. & Shao, J., Oct 1 2021, In: Cancers. 13, 20, 5076.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Ser71 Phosphorylation Inhibits Actin-Binding of Profilin-1 and Its Apoptosis-Sensitizing Activity
Wang, F., Zhu, C., Cai, S., Boudreau, A., Kim, S. J., Bissell, M. & Shao, J., Jun 21 2021, In: Frontiers in Cell and Developmental Biology. 9, 692269.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
Zhu, C., Rogers, A., Asleh, K., Won, J., Gao, D., Leung, S., Li, S., Vij, K. R., Zhu, J., Held, J. M., You, Z., Nielsen, T. O. & Shao, J., Jun 9 2020, In: Cell Reports. 31, 10, 107745.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations