Research Output per year
Research Output per year
Personal profile
Research interests
We are interested in delineating the biology of novel anticancer targets. Our current focus is on two proteins - the actin-binding factor profilin-1 and the polyubiquitin-specific protein segregase p97/VCP. Profilin-1 is an essential gene for eukaryotic cells, yet showing paradoxical anti-cancer activities in multiple types of human cancer. We hypothesize that it has ‘moonlighting” nuclear functions which represses the expression of various pro-cancer genes, spatially separate from its actin-regulatory activities in the cytoplasm. This “spatial confinement” model reconciles its paradoxical cellular functions and is the main focus of our research effort. In parallel, we are studying p97/VCP which is an evolutionarily conserved AAA+ ATPase regulating cellular proteostasis via facilitating the turnover of a myriad of polyubiquinated proteins within various cellular structures and protein complexes. Our current interest is its role in chromatin-associated protein degradation which occurs dynamically during DNA damage response and is crucial for maintaining genome stability.
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Research Output
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Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
Zhu, C., Rogers, A., Asleh, K., Won, J., Gao, D., Leung, S., Li, S., Vij, K. R., Zhu, J., Held, J. M., You, Z., Nielsen, T. O. & Shao, J., Jun 9 2020, In: Cell Reports. 31, 10, 107745.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response
Shao, J., Sep 2 2020, In: Molecular and Cellular Oncology. 7, 5, 1796179.Research output: Contribution to journal › Comment/debate
Open Access -
TYK2 promotes malignant peripheral nerve sheath tumor progression through inhibition of cell death
Qin, W., Godec, A., Zhang, X., Zhu, C., Shao, J., Tao, Y., Bu, X. & Hirbe, A. C., Sep 1 2019, In: Cancer medicine. 8, 11, p. 5232-5241 10 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer
Lei, J. T., Shao, J., Zhang, J., Iglesia, M., Chan, D. W., Cao, J., Anurag, M., Singh, P., He, X., Kosaka, Y., Matsunuma, R., Crowder, R., Hoog, J., Phommaly, C., Goncalves, R., Ramalho, S., Peres, R. M. R., Punturi, N., Schmidt, C., Bartram, A. & 23 others, , Aug 7 2018, In: Cell Reports. 24, 6, p. 1434-1444.e7Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets
Gates, L. A., Gu, G., Chen, Y., Rohira, A. D., Lei, J. T., Hamilton, R. A., Yu, Y., Lonard, D. M., Wang, J., Wang, S. P., Edwards, D. G., Lavere, P. F., Shao, J., Yi, P., Jain, A., Jung, S. Y., Malovannaya, A., Li, S., Shao, J., Roeder, R. G. & 5 others, , Aug 16 2018, In: Oncogene. 37, 33, p. 4581-4598 18 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations