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Personal profile

Research interests

We are interested in delineating the biology of novel anticancer targets. Our current focus is on two proteins - the actin-binding factor profilin-1 and the polyubiquitin-specific protein segregase p97/VCP. Profilin-1 is an essential gene for eukaryotic cells, yet showing paradoxical anti-cancer activities in multiple types of human cancer. We hypothesize that it has ‘moonlighting” nuclear functions which represses the expression of various pro-cancer genes, spatially separate from its actin-regulatory activities in the cytoplasm. This “spatial confinement” model reconciles its paradoxical cellular functions and is the main focus of our research effort. In parallel, we are studying p97/VCP which is an evolutionarily conserved AAA+ ATPase regulating cellular proteostasis via facilitating the turnover of a myriad of polyubiquinated proteins within various cellular structures and protein complexes. Our current interest is its role in chromatin-associated protein degradation which occurs dynamically during DNA damage response and is crucial for maintaining genome stability.

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Research Output

  • 1581 Citations
  • 24 Article
  • 1 Comment/debate
  • 1 Review article

Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

Zhu, C., Rogers, A., Asleh, K., Won, J., Gao, D., Leung, S., Li, S., Vij, K. R., Zhu, J., Held, J. M., You, Z., Nielsen, T. O. & Shao, J., Jun 9 2020, In : Cell Reports. 31, 10, 107745.

Research output: Contribution to journalArticle

Open Access
  • 1 Scopus citations

    Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response

    Shao, J., Sep 2 2020, In : Molecular and Cellular Oncology. 7, 5, 1796179.

    Research output: Contribution to journalComment/debate

    Open Access
  • TYK2 promotes malignant peripheral nerve sheath tumor progression through inhibition of cell death

    Qin, W., Godec, A., Zhang, X., Zhu, C., Shao, J., Tao, Y., Bu, X. & Hirbe, A. C., Sep 1 2019, In : Cancer medicine. 8, 11, p. 5232-5241 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer

    Lei, J. T., Shao, J., Zhang, J., Iglesia, M., Chan, D. W., Cao, J., Anurag, M., Singh, P., He, X., Kosaka, Y., Matsunuma, R., Crowder, R., Hoog, J., Phommaly, C., Goncalves, R., Ramalho, S., Peres, R. M. R., Punturi, N., Schmidt, C., Bartram, A. & 23 others, Jou, E., Devarakonda, V., Holloway, K. R., Lai, W. V., Hampton, O., Rogers, A., Tobias, E., Parikh, P. A., Davies, S. R., Li, S., Ma, C., Suman, V. J., Hunt, K. K., Watson, M., Hoadley, K. A., Thompson, E. A., Chen, X., Kavuri, S. M., Creighton, C. J., Maher, C., Perou, C. M., Haricharan, S. & Ellis, M. J., Aug 7 2018, In : Cell Reports. 24, 6, p. 1434-1444.e7

    Research output: Contribution to journalArticle

    Open Access
  • 23 Scopus citations

    Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets

    Gates, L. A., Gu, G., Chen, Y., Rohira, A. D., Lei, J. T., Hamilton, R. A., Yu, Y., Lonard, D. M., Wang, J., Wang, S. P., Edwards, D. G., Lavere, P. F., Shao, J., Yi, P., Jain, A., Jung, S. Y., Malovannaya, A., Li, S., Shao, J., Roeder, R. G. & 5 others, Ellis, M. J., Qin, J., Fuqua, S. A. W., O’Malley, B. W. & Foulds, C. E., Aug 16 2018, In : Oncogene. 37, 33, p. 4581-4598 18 p.

    Research output: Contribution to journalArticle

    Open Access
  • 15 Scopus citations