Jianmin Cui

2024

Attenuating midline thalamus bursting to mitigate absence epilepsy

Dong, P., Bakhurin, K., Li, Y., Mikati, M. A., Cui, J., Grill, W. M., Yin, H. H. & Yang, H., Jul 9 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 28, p. e2403763121

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Arrhythmia-associated calmodulin variants interact with KCNQ1 to confer aberrant membrane trafficking and function

Kang, P. W., Woodbury, L., Angsutararux, P., Sambare, N., Shi, J., Marras, M., Abella, C., Bedi, A., Zinn, D. S., Cui, J. & Silva, J. R., Nov 1 2023, In: PNAS Nexus. 2, 11, pgad335.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Incorporating physics to overcome data scarcity in predictive modeling of protein function: A case study of BK channels

Nordquist, E., Zhang, G., Barethiya, S., Ji, N., White, K. M., Han, L., Jia, Z., Shi, J., Cui, J. & Chen, J., Sep 2023, In: PLoS computational biology. 19, 9 September, e1011460.

Research output: Contribution to journal › Article › peer-review

Open Access

Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound

Yang, Y., Yuan, J., Field, R. L., Ye, D., Hu, Z., Xu, K., Xu, L., Gong, Y., Yue, Y., Kravitz, A. V., Bruchas, M. R., Cui, J., Brestoff, J. R. & Chen, H., May 2023, In: Nature Metabolism. 5, 5, p. 789-803 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

TRPV1-mediated sonogenetic neuromodulation of motor cortex in freely moving mice

Xu, K., Yang, Y., Hu, Z., Yue, Y., Gong, Y., Cui, J., Culver, J. P., Bruchas, M. R. & Chen, H., Feb 1 2023, In: Journal of Neural Engineering. 20, 1, 016055.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2022

A benzodiazepine activator locks K_v7.1 channels open by electro-mechanical uncoupling

Schreiber, J. A., Möller, M., Zaydman, M., Zhao, L., Beller, Z., Becker, S., Ritter, N., Hou, P., Shi, J., Silva, J., Wrobel, E., Strutz-Seebohm, N., Decher, N., Schmitt, N., Meuth, S. G., Düfer, M., Wünsch, B., Cui, J. & Seebohm, G., Dec 2022, In: Communications Biology. 5, 1, 301.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

An allosteric modulator activates BK channels by perturbing coupling between Ca²⁺ binding and pore opening

Zhang, G., Xu, X., Jia, Z., Geng, Y., Liang, H., Shi, J., Marras, M., Abella, C., Magleby, K. L., Silva, J. R., Chen, J., Zou, X. & Cui, J., Dec 2022, In: Nature communications. 13, 1, 6784.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine

Yang, N. D., Kanyo, R., Zhao, L., Li, J., Kang, P. W., Dou, A. K., White, K. M. F., Shi, J., Nerbonne, J. M., Kurata, H. T. & Cui, J., Jul 2022, In: Science Advances. 8, 29, eabo3625.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Neuronal mechanism of a BK channelopathy in absence epilepsy and dyskinesia

Dong, P., Zhang, Y., Hunanyan, A. S., Mikati, M. A., Cui, J. & Yang, H., Mar 22 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 12, e2200140119.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2021

Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects

Lin, Y., Grinter, S. Z., Lu, Z., Xu, X., Wang, H. Z., Liang, H., Hou, P., Gao, J., Clausen, C., Shi, J., Zhao, W., Ma, Z., Liu, Y., Kelli McFarland White, M. W., Zhao, L., Kang, P. W., Zhang, G., Cohen, I. S., Zou, X. & Cui, J., May 18 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 20, e2024215118.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Sonothermogenetics for noninvasive and cell-type specific deep brain neuromodulation

Yang, Y., Pacia, C. P., Ye, D., Zhu, L., Baek, H., Yue, Y., Yuan, J., Miller, M. J., Cui, J., Culver, J. P., Bruchas, M. R. & Chen, H., Jul 1 2021, In: Brain Stimulation. 14, 4, p. 790-800 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

2020

A Gain-of-Function Mutation in KCNMA1 Causes Dystonia Spells Controlled With Stimulant Therapy

Zhang, G., Gibson, R. A., McDonald, M., Liang, P., Kang, P. W., Shi, J., Yang, H., Cui, J. & Mikati, M. A., Oct 1 2020, In: Movement Disorders. 35, 10, p. 1868-1873 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

A PIP₂ substitute mediates voltage sensor-pore coupling in KCNQ activation

Liu, Y., Xu, X., Gao, J., Naffaa, M. M., Liang, H., Shi, J., Wang, H. Z., Yang, N. D., Hou, P., Zhao, W., White, K. M. F., Kong, W., Dou, A., Cui, A., Zhang, G., Cohen, I. S., Zou, X. & Cui, J., Dec 1 2020, In: Communications Biology. 3, 1, 385.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Aromatic interactions with membrane modulate human BK channel activation

Yazdani, M., Zhang, G., Jia, Z., Shi, J., Cui, J. & Chen, J., Jun 2020, In: eLife. 9, p. 1-52 52 p., e55571.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening

Kang, P. W., Westerlund, A. M., Shi, J., White, K. M. F., Dou, A. K., Cui, A. H., Silva, J. R., Delemotte, L. & Cui, J., Dec 11 2020, In: Science Advances. 6, 50, eabd6798.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Coupling of Ca²⁺and voltage activation in BK channels through the aB helix/voltage sensor interface

Geng, Y., Deng, Z., Zhang, G., Budelli, G., Butler, A., Yuan, P., Cui, J., Salkoff, L. & Magleby, K. L., Jun 23 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 25, p. 14512-14521 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state

Taylor, K. C., Kang, P. W., Hou, P., Yang, N. D., Kuenze, G., Smith, J. A., Shi, J., Huang, H., White, K. M., Peng, D., George, A. L., Meiler, J., McFeeters, R. L., Cui, J. & Sanders, C. R., Feb 2020, In: eLife. 9, e53901.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

TMEM16A-inhibitor loaded pH-responsive nanoparticles: A novel dual-targeting antitumor therapy for lung adenocarcinoma

Guo, S., Qiu, L., Chen, Y., Wang, X., Ma, B., Qu, C., Cui, J., Zhang, H., Xing, C., Zhan, Y. & An, H., Aug 2020, In: Biochemical Pharmacology. 178, 114062.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Two-stage electro–mechanical coupling of a K_V channel in voltage-dependent activation

Hou, P., Kang, P. W., Kongmeneck, A. D., Yang, N. D., Liu, Y., Shi, J., Xu, X., White, K. M. F., Zaydman, M. A., Kasimova, M. A., Seebohm, G., Zhong, L., Zou, X., Tarek, M. & Cui, J., Dec 1 2020, In: Nature communications. 11, 1, 676.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

2019

ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling

Hou, P., Shi, J., White, K. M. F., Gao, Y. & Cui, J., Jul 2019, In: eLife. 8, e48576.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Molecular game theory for a toxin-dominant food chain model

Li, B., Silva, J. R., Lu, X., Luo, L., Wang, Y., Xu, L., Aierken, A., Shynykul, Z., Kamau, P. M., Luo, A., Yang, J., Su, D., Yang, F., Cui, J., Yang, S. & Lai, R., Nov 1 2019, In: National Science Review. 6, 6, p. 1191-1200 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2018

Centipedes subdue giant prey by blocking KCNQ channels

Luo, L., Li, B., Wang, S., Wu, F., Wang, X., Liang, P., Ombati, R., Chen, J., Lu, X., Cui, J., Lu, Q., Zhang, L., Zhou, M., Tian, C., Yang, S. & Lai, R., Feb 13 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1646-1651 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Hydrophobic gating in BK channels

Jia, Z., Yazdani, M., Zhang, G., Cui, J. & Chen, J., Dec 1 2018, In: Nature communications. 9, 1, 3408.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

Patch-clamp and perfusion techniques to study ion channels expressed in xenopus oocytes

Zhang, G. & Cui, J., Apr 2018, In: Cold Spring Harbor Protocols. 2018, 4, p. 258-267 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2017

A clinical and mechanistic study of topical borneol-induced analgesia

Wang, S., Zhang, D., Hu, J., Jia, Q., Xu, W., Su, D., Song, H., Xu, Z., Cui, J., Zhou, M., Yang, J. & Xiao, J., Jun 2017, In: EMBO Molecular Medicine. 9, 6, p. 802-815 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Scopus citations

Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels

Zhang, G., Geng, Y., Jin, Y., Shi, J., McFarland, K., Magleby, K. L., Salkoff, L. & Cui, J., Mar 6 2017, In: The Journal of general physiology. 149, 3, p. 373-387 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening

Hou, P., Eldstrom, J., Shi, J., Zhong, L., McFarland, K., Gao, Y., Fedida, D. & Cui, J., Dec 1 2017, In: Nature communications. 8, 1, 1730.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Pro-arrhythmogenic Effects of the V141M KCNQ1 Mutation in Short QT Syndrome and Its Potential Therapeutic Targets: Insights from Modeling

Lee, H. C., Rudy, Y., Liang, H., Chen, C. C., Luo, C. H., Sheu, S. H. & Cui, J., Oct 1 2017, In: Journal of Medical and Biological Engineering. 37, 5, p. 780-789 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Thiazolidine reacts with thioreactive biomolecules

Su, D., Nian, Y., Zhang, F., Hu, J., Cui, J., Zhou, M., Yang, J. & Wang, S., Mar 1 2017, In: Free Radical Biology and Medicine. 104, p. 272-279 8 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2016

Extrapolating microdomain Ca²⁺ dynamics using BK channels as a Ca²⁺ sensor

Hou, P., Xiao, F., Liu, H., Yuchi, M., Zhang, G., Wu, Y., Wang, W., Zeng, W., Ding, M., Cui, J., Wu, Z., Wang, L. Y. & Ding, J., Jan 18 2016, In: Scientific reports. 6, 17343.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

LRP6 acts as a scaffold protein in cardiac gap junction assembly

Li, J., Li, C., Liang, D., Lv, F., Yuan, T., The, E., Ma, X., Wu, Y., Zhen, L., Xie, D., Wang, S., Liu, Y., Huang, J., Shi, J., Liu, Y., Shi, D., Xu, L., Lin, L., Peng, L. & Cui, J. & 2 others, Zhu, W. & Chen, Y. H., Jun 2 2016, In: Nature communications. 7, 11775.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

TRPA1 and TRPV1 contribute to iodine antiseptics-associated pain and allergy

Su, D., Zhao, H., Hu, J., Tang, D., Cui, J., Zhou, M., Yang, J. & Wang, S., Oct 1 2016, In: EMBO Reports. 17, 10, p. 1422-1430 9 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Ultrasound modulates ion channel currents

Kubanek, J., Shi, J., Marsh, J., Chen, D., Deng, C. & Cui, J., Apr 26 2016, In: Scientific reports. 6, 24170.

Research output: Contribution to journal › Article › peer-review

Open Access

236 Scopus citations

2015

Direct Measurement of Cardiac Na⁺ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations

Varga, Z., Zhu, W., Schubert, A. R., Pardieck, J. L., Krumholz, A., Hsu, E. J., Zaydman, M. A., Cui, J. & Silva, J. R., Oct 1 2015, In: Circulation: Arrhythmia and Electrophysiology. 8, 5, p. 1228-1239 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6

Kasimova, M. A., Zaydman, M. A., Cui, J. & Tarek, M., Jan 6 2015, In: Scientific reports. 5, 7474.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

2014

A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca²⁺ sensors in BK channels

Zhang, G., Yang, H., Liang, H., Yang, J., Shi, J., McFarland, K., Chen, Y. & Cui, J., Sep 10 2014, In: Journal of Neuroscience. 34, 37, p. 12280-12288 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Conopeptide Vt3.1 preferentially inhibits BK potassium channels containing β4 subunits via electrostatic interactions

Li, M., Chang, S., Yang, L., Shi, J., McFarland, K., Yang, X., Moller, A., Wang, C., Zou, X., Chi, C. & Cui, J., Feb 21 2014, In: Journal of Biological Chemistry. 289, 8, p. 4735-4742 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel

Zaydman, M. A., Kasimova, M. A., McFarland, K., Beller, Z., Hou, P., Kinser, H. E., Liang, H., Zhang, G., Shi, J., Tarek, M. & Cui, J., 2014, In: eLife. 3, p. e03606 e03606.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

2013

FMRP Regulates Neurotransmitter Release and Synaptic Information Transmission by Modulating Action Potential Duration via BK Channels

Deng, P. Y., Rotman, Z., Blundon, J. A., Cho, Y., Cui, J., Cavalli, V., Zakharenko, S. S. & Klyachko, V. A., Feb 20 2013, In: Neuron. 77, 4, p. 696-711 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

275 Scopus citations

Interaction between residues in the Mg²⁺-binding site regulates BK channel activation

Yang, J., Yang, H., Sun, X., Delaloye, K., Yang, X., Moller, A., Shi, J. & Cui, J., Feb 2013, In: Journal of General Physiology. 141, 2, p. 217-228 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Intracellular ATP binding is required to activate the slowly activating K+ channel IKs

Li, Y., Gao, J., Lu, Z., McFarland, K., Shi, J., Bock, K., Cohen, I. S. & Cui, J., Nov 19 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 47, p. 18922-18927 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening

Zaydman, M. A., Silva, J. R., Delaloye, K., Li, Y., Liang, H., Larsson, H. P., Shi, J. & Cui, J., Aug 6 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 32, p. 13180-13185 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

149 Scopus citations

Modulation of KCNQ1 alternative splicing regulates cardiac I_Ks and action potential repolarization

Lee, H. C., Rudy, Y., Po-Yuan, P., Sheu, S. H., Chang, J. G. & Cui, J., Aug 2013, In: Heart rhythm. 10, 8, p. 1220-1228 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

The interface between membrane-spanning and cytosolic domains in Ca²⁺-dependent K⁺ channels is involved in β subunit modulation of gating

Sun, X., Shi, J., Delaloye, K., Yang, X., Yang, H., Zhang, G. & Cui, J., 2013, In: Journal of Neuroscience. 33, 27, p. 11253-11261 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2012

Controlled permeation of cell membrane by single bubble acoustic cavitation

Zhou, Y., Yang, K., Cui, J., Ye, J. Y. & Deng, C. X., Jan 10 2012, In: Journal of Controlled Release. 157, 1, p. 103-111 9 p.

Research output: Contribution to journal › Article › peer-review

151 Scopus citations

Regulation of voltage-activated K⁺ channel gating by transmembrane β subunits

Sun, X., Zaydman, M. A. & Cui, J., 2012, In: Frontiers in Pharmacology. 3 APR, Article 63.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

2011

KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP₂) sensitivity of I_Ks to modulate channel activity

Li, Y., Zaydman, M. A., Wu, D., Shi, J., Guan, M., Virgin-Downey, B. & Cui, J., May 31 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 22, p. 9095-9100 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

92 Scopus citations

Patch clamp and perfusion techniques for studying ion channels expressed in xenopus oocytes

Yang, J., Delaloye, K., Lee, U. S. & Cui, J., Jan 2011, In: Journal of Visualized Experiments. 47, e2269.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Prolyl hydroxylase 2: A novel regulator of β ₂-adrenoceptor internalization

Yan, B., Huo, Z., Liu, Y., Lin, X., Li, J., Peng, L., Zhao, H., Zhou, Z. N., Liang, X., Liu, Y., Zhu, W., Liang, D., Li, L., Sun, Y., Cui, J. & Chen, Y. H., Dec 2011, In: Journal of Cellular and Molecular Medicine. 15, 12, p. 2712-2722 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2010

An Epilepsy/Dyskinesia-Associated Mutation Enhances BK Channel Activation by Potentiating Ca²⁺ Sensing

Yang, J., Krishnamoorthy, G., Saxena, A., Zhang, G., Shi, J., Yang, H., Delaloye, K., Sept, D. & Cui, J., Jun 2010, In: Neuron. 66, 6, p. 871-883 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

96 Scopus citations

Jianmin Cui

Research output

Search results