Jian Campian

Associate Professor of Medicine, Associate Professor of Neurological Surgery

    • 1402 Citations
    20042020

    Research output per year

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    Personal profile

    Research interests

    My prior graduate research training, internal medicine residency as well as my medical oncology and neuro-oncology fellowship training will allow me to be well suited for translational research that bridges basic science and clinical medicine in neurological cancers. This prior experience prepared me well for a career path as an early-phase clinical trial investigator, with an emphasis on improving care for brain tumor patients. My interest on lymphopenia was sparked after an observation of increased PCP infection in brain tumor patients who were treated with radiation and steroid. I have found that 40-50% cancer patients developed severe lymphopenia after concurrent chemoradiation. Our studies have demonstrated that treatment-related lymphopenia is common, severe and long lasting in various solid tumors including glioblastoma, pancreatic cancer, non-small cell lung cancer, head and neck squamous carcinoma, rectal cancer etc. More importantly, this treatment-related lymphopenia is associated with inferior survival and patients died from tumor progression not opportunistic infections. Thus, my research has been focused on how to correct treatment-related lymphopenia in patients with malignant brain tumors, with an ultimate goal to improve overall survival in this deadly disease.

    Areas of Clinical Interest

    Neuro-oncology, immunotherapy, brain tumors, medical oncology

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    Research Output

    • 1402 Citations
    • 36 Article
    • 5 Review article
    • 1 Comment/debate
    • 1 Letter

    A randomized controlled phase III study of VB-111 combined with bevacizumab vs bevacizumab monotherapy in patients with recurrent glioblastoma (GLOBE)

    Cloughesy, T. F., Brenner, A., De Groot, J. F., Butowski, N. A., Zach, L., Campian, J. L., Ellingson, B. M., Freedman, L. S., Cohen, Y. C., Lowenton-Spier, N., Rachmilewitz Minei, T., Fain Shmueli, S., Avgeropoulos, N., Beck, J., Benkers, T., Bokstein, F., Brenner, A., Burton, E., Butowski, N., Campian, J. & 41 others, Carrillo, J., Cloughesy, T., De Groot, J., De Robles, P., Drappatz, J., Dunbar, I., Fink, K., Groves, M., Han, X., Adila, H., Jensen, R., Kowalska, A., Kumthekar, P., Lee, M., Lesser, G., Lossos, A., Lukas, R., Macdonald, D., Mammoser, A., Mechtler, L., Mohile, N., Nagpal, S., Nicholas, G., Kreisl, T., Pan, E., Peak, S., Pearlman, M., Perry, J., Peterson, R., Piccioni, D., Robins, H., Ronan, L., Salacz, M., Schiff, D., Tran, D., Zach, L., Tzuk-Shina, T., Walbert, T., Wen, P., Youst, S. & Wen, P. Y., May 15 2020, In : Neuro-oncology. 22, 5, p. 705-717 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Optimizing eligibility criteria and clinical trial conduct to enhance clinical trial participation for primary brain tumor patients

    Lee, E. Q., Lee, E. Q., Weller, M., Sul, J., Bagley, S. J., Sahebjam, S., Van Den Bent, M., Ahluwalia, M., Campian, J. L., Galanis, E., Gilbert, M. R., Holdhoff, M., Lesser, G. J., Lieberman, F. S., Mehta, M. P., Penas-Prado, M., Schreck, K. C., Strowd, R. E., Vogelbaum, M. A., Walbert, T. & 7 others, Chang, S. M., Nabors, L. B., Grossman, S., Reardon, D. A., Reardon, D. A., Wen, P. Y. & Wen, P. Y., May 15 2020, In : Neuro-oncology. 22, 5, p. 601-612 12 p.

    Research output: Contribution to journalReview article

  • A multicenter phase II study of temozolomide plus disulfiram and copper for recurrent temozolomide-resistant glioblastoma

    Huang, J., Chaudhary, R., Cohen, A. L., Fink, K., Goldlust, S., Boockvar, J., Chinnaiyan, P., Wan, L., Marcus, S. & Campian, J. L., May 1 2019, In : Journal of Neuro-Oncology. 142, 3, p. 537-544 8 p.

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma

    Johanns, T. M., Miller, C. A., Liu, C. J., Perrin, R. J., Bender, D., Kobayashi, D. K., Campian, J. L., Chicoine, M. R., Dacey, R. G., Huang, J., Fritsch, E. F., Gillanders, W. E., Artyomov, M. N., Mardis, E. R., Schreiber, R. D. & Dunn, G. P., Apr 3 2019, In : OncoImmunology. 8, 4, e1561106.

    Research output: Contribution to journalArticle

    Open Access
  • 12 Scopus citations