Jeremy Strain

2024

Accuracy of TrUE-Net in comparison to established white matter hyperintensity segmentation methods: An independent validation study

ADOPIC and ADNI Investigators, Jan 2024, In: NeuroImage. 285, 120494.

Research output: Contribution to journal › Article › peer-review

Open Access

Evolution of white matter hyperintensity segmentation methods and implementation over the past two decades; an incomplete shift towards deep learning

CSF and Blood, Genetics, Neuropathology, NACC, DIAN, Cerebrovascular Disease (CVD) Risk, Hippocampal Sclerosis (HS-TDP43) Risk, Artificial Intelligence and Machine Learning, for the ADOPIC, ADNI Investigators, Biostats, Database and Bioinformatics, Cognition & Imaging, Oct 2024, In: Brain Imaging and Behavior. 18, 5, p. 1310-1322 13 p.

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage

Joseph-Mathurin, N., Feldman, R. L., Lu, R., Shirzadi, Z., Toomer, C., Saint Clair, J. R., Ma, Y., McKay, N. S., Strain, J. F., Kilgore, C., Friedrichsen, K. A., Chen, C. D., Gordon, B. A., Chen, G., Hornbeck, R. C., Massoumzadeh, P., McCullough, A. A., Wang, Q., Li, Y. & Wang, G. & 38 others, Keefe, S. J., Schultz, S. A., Cruchaga, C., Preboske, G. M., Jack, C. R., Llibre-Guerra, J. J., Allegri, R. F., Ances, B. M., Berman, S. B., Brooks, W. S., Cash, D. M., Day, G. S., Fox, N. C., Fulham, M., Ghetti, B., Johnson, K. A., Jucker, M., Klunk, W. E., la Fougère, C., Levin, J., Niimi, Y., Oh, H., Perrin, R. J., Reischl, G., Ringman, J. M., Saykin, A. J., Schofield, P. R., Su, Y., Supnet-Bell, C., Vöglein, J., Yakushev, I., Brickman, A. M., Morris, J. C., McDade, E., Xiong, C., Bateman, R. J., Chhatwal, J. P. & Benzinger, T. L. S., Apr 2024, In: Alzheimer's and Dementia. 20, 4, p. 2680-2697 18 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2023

Brain aerobic glycolysis and resilience in Alzheimer disease

Goyal, M. S., Blazey, T., Metcalf, N. V., McAvoy, M. P., Strain, J. F., Rahmani, M., Durbin, T. J., Xiong, C., Benzinger, T. L. S., Morris, J. C., Raichle, M. E. & Vlassenko, A. G., Feb 14 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 7, e2212256120.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer’s disease

Dominantly Inherited Alzheimer Network, Wheelock, M. D., Strain, J. F., Mansfield, P., Tu, J. C., Tanenbaum, A., Preische, O., Chhatwal, J. P., Cash, D. M., Cruchaga, C., Fagan, A. M., Fox, N. C., Graff-Radford, N. R., Hassenstab, J., Jack, C. R., Karch, C. M., Levin, J., McDade, E. M., Perrin, R. J. & Schofield, P. R. & 147 others, Xiong, C., Morris, J. C., Bateman, R. J., Jucker, M., Benzinger, T. L. S., Ances, B. M., Eggebrecht, A. T., Gordon, B. A., Adams, S., Allegri, R., Araki, A., Barthelemy, N., Bateman, R., Bechara, J., Benzinger, T., Berman, S., Bodge, C., Brandon, S., Brooks, W., Brosch, J., Buck, J., Buckles, V., Carter, K., Cash, D., Cash, L., Chen, C., Chhatwal, J., Chrem, P., Chua, J., Chui, H., Cruchaga, C., Day, G. S., De La Cruz, C., Denner, D., Diffenbacher, A., Dincer, A., Donahue, T., Douglas, J., Duong, D., Egido, N., Esposito, B., Fagan, A., Farlow, M., Feldman, B., Fitzpatrick, C., Flores, S., Fox, N., Franklin, E., Friedrichsen, N., Fujii, H., Gardener, S., Ghetti, B., Goate, A., Goldberg, S., Goldman, J., Gonzalez, A., Gordon, B., Gräber-Sultan, S., Graff-Radford, N., Graham, M., Gray, J., Gremminger, E., Grilo, M., Groves, A., Haass, C., Häsler, L., Hassenstab, J., Hellm, C., Herries, E., Hoechst-Swisher, L., Hofmann, A., Holtzman, D., Hornbeck, R., Igor, Y., Ihara, R., Ikeuchi, T., Ikonomovic, S., Ishii, K., Jack, C., Jerome, G., Johnson, E., Jucker, M., Karch, C., Käser, S., Kasuga, K., Keefe, S., Klunk, W., Koeppe, R., Koudelis, D., Kuder-Buletta, E., Laske, C., Lee, J. H., Levey, A., Levin, J., Li, Y., Lopez, O., Marsh, J., Martinez, R., Martins, R., Mason, N. S., Masters, C., Mawuenyega, K., McCullough, A., McDade, E., Mejia, A., Morenas-Rodriguez, E., Mori, H., Morris, J., Mountz, J., Mummery, C., Nadkami, N., Nagamatsu, A., Neimeyer, K., Niimi, Y., Noble, J., Norton, J., Nuscher, B., O’Connor, A., Obermüller, U., Patira, R., Perrin, R., Ping, L., Preische, O., Renton, A., Ringman, J., Salloway, S., Sanchez-Valle, R., Schofield, P., Senda, M., Seyfried, N., Shady, K., Shimada, H., Sigurdson, W., Smith, J., Smith, L., Snitz, B., Sohrabi, H., Stephens, S., Taddei, K., Thompson, S., Vöglein, J., Wang, P., Wang, Q., Weamer, E., Xiong, C., Xu, J. & Xu, X., Jul 1 2023, In: Brain. 146, 7, p. 2928-2943 16 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Longitudinal Relationships of White Matter Hyperintensities and Alzheimer Disease Biomarkers Across the Adult Life Span

Luo, J., Ma, Y., Agboola, F. J., Grant, E., Morris, J. C., Mcdade, E., Fagan, A. M., Benzinger, T. L. S., Hassenstab, J., Bateman, R. J., Perrin, R. J., Gordon, B. A., Goyal, M., Strain, J. F., Yakushev, I., Day, G. S. & Xiong, C., Jul 11 2023, In: Neurology. 101, 2, p. E164-E177

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Neuroinflammation and amyloid deposition in the progression of mixed Alzheimer and vascular dementia

Ying, C., Kang, P., Binkley, M. M., Ford, A., Chen, Y., Hassenstab, J., Wang, Q., Strain, J., Morris, J., Lee, J.-M., Benzinger, T. & An, H., Jan 2023, In: NeuroImage: Clinical. 38, 103373.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

White matter hyperintensity longitudinal morphometric analysis in association with Alzheimer disease

Strain, J. F., Phuah, C. L., Adeyemo, B., Cheng, K., Womack, K. B., McCarthy, J., Goyal, M., Chen, Y., Sotiras, A., An, H., Xiong, C., Scharf, A., Newsom-Stewart, C., Morris, J. C., Benzinger, T. L. S., Lee, J. M. & Ances, B. M., Oct 2023, In: Alzheimer's and Dementia. 19, 10, p. 4488-4497 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2022

Abnormal Magnetic Resonance Image Signature in Virologically Stable HIV Individuals

Strain, J. F., Cooley, S. A., Tomov, D., Boerwinkle, A. & Ances, B. M., Dec 15 2022, In: Journal of Infectious Diseases. 226, 12, p. 2161-2169 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Association of Data-Driven White Matter Hyperintensity Spatial Signatures with Distinct Cerebral Small Vessel Disease Etiologies

Phuah, C. L., Chen, Y., Strain, J. F., Yechoor, N., Laurido-Soto, O. J., Ances, B. M. & Lee, J. M., Dec 6 2022, In: Neurology. 99, 23, p. E2535-E2547

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

Cardiorespiratory Fitness Is Associated with Better White Matter Integrity in Persons Living with HIV

Kilgore, C. B., Strain, J. F., Nelson, B., Cooley, S. A., Rosenow, A., Glans, M., Cade, T., Reeds, D. N., Paul, R. H. & Ances, B. M., Apr 15 2022, In: Journal of Acquired Immune Deficiency Syndromes. 89, 5, p. 558-565 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Covariance-based vs. correlation-based functional connectivity dissociates healthy aging from Alzheimer disease

Dominantly Inherited Alzheimer Network, Nov 1 2022, In: NeuroImage. 261, 119511.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease

Strain, J. F., Barthelemy, N., Horie, K., Gordon, B. A., Kilgore, C., Aschenbrenner, A., Cruchaga, C., Xiong, C., Joseph-Mathurin, N., Hassenstab, J., Fagan, A. M., Li, Y., Karch, C. M., Perrin, R. J., Berman, S. B., Chhatwal, J. P., Graff-Radford, N. R., Mori, H., Levin, J. & Noble, J. M. & 9 others, Allegri, R., Schofield, P. R., Marcus, D. S., Holtzman, D. M., Morris, J. C., Benzinger, T. L. S., McDade, E. M., Bateman, R. J. & Ances, B. M., Jun 15 2022, In: Neurobiology of Disease. 168, 105714.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Machine Learning Quantifies Accelerated White-Matter Aging in Persons With HIV

Petersen, K. J., Strain, J., Cooley, S., Vaida, F. & Ances, B. M., Jul 1 2022, In: Journal of Infectious Diseases. 226, 1, p. 49-58 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Reversal of unilateral hand movement dysfunction by high definition transcranial direct current stimulation in a patient with chronic traumatic brain injury

Chiang, H. S., Shakal, S., Strain, J. F., Womack, K., Kraut, M., Vanneste, S. & Hart, J., Mar 1 2022, In: Brain Stimulation. 15, 2, p. 283-285 3 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

The Structural and Functional Correlates of Frailty in Persons with Human Immunodeficiency Virus

Strain, J. F., Cooley, S., Kilgore, C., Nelson, B., Doyle, J., Thompson, R., Westerhaus, E., Petersen, K. J., Wisch, J. & Ances, B. M., Nov 15 2022, In: Clinical Infectious Diseases. 75, 10, p. 1740-1746 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2021

Effects of anticholinergic medication use on brain integrity in persons living with HIV and persons without HIV

Cooley, S. A., Paul, R. H., Strain, J. F., Boerwinkle, A., Kilgore, C. & Ances, B. M., Mar 1 2021, In: AIDS. 35, 3, p. 381-391 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Modeling autosomal dominant Alzheimer's disease with machine learning

for the Dominantly Inherited Alzheimer Network (DIAN), Jun 2021, In: Alzheimer's and Dementia. 17, 6, p. 1005-1016 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease

Smith, R. X., Strain, J. F., Tanenbaum, A., Fagan, A. M., Hassenstab, J., McDade, E., Schindler, S. E., Gordon, B. A., Xiong, C., Chhatwal, J., Jack, C., Karch, C., Berman, S., Brosch, J. R., Lah, J. J., Brickman, A. M., Cash, D. M., Fox, N. C., Graff-Radford, N. R. & Levin, J. & 11 others, Noble, J., Holtzman, D. M., Masters, C. L., Farlow, M. R., Laske, C., Schofield, P. R., Marcus, D. S., Morris, J. C., Benzinger, T. L. S., Bateman, R. J. & Ances, B. M., Apr 2021, In: Brain connectivity. 11, 3, p. 239-249 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2020

Comparison of [¹¹C]-PBR28 Binding Between Persons Living With HIV and HIV-Uninfected Individuals

Boerwinkle, A. H., Strain, J. F., Burdo, T., Doyle, J., Christensen, J., Su, Y., Wisch, J. K., Cooley, S. A., Vaida, F., Smith, M. D., Jafri, H., Paul, R. H., Benzinger, T. L. S. & Ances, B. M., Oct 1 2020, In: Journal of Acquired Immune Deficiency Syndromes. 85, 2, p. 244-251 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Machine Learning Analysis Reveals Novel Neuroimaging and Clinical Signatures of Frailty in HIV

Paul, R. H., Cho, K. S., Luckett, P., Strain, J. F., Belden, A. C., Bolzenius, J. D., Navid, J., Garcia-Egan, P. M., Cooley, S. A., Wisch, J. K., Boerwinkle, A. H., Tomov, D., Obosi, A., Mannarino, J. A. & Ances, B. M., Aug 1 2020, In: Journal of Acquired Immune Deficiency Syndromes. 84, 4, p. 414-421 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging

Samara, A., Murphy, T., Strain, J., Rutlin, J., Sun, P., Neyman, O., Sreevalsan, N., Shimony, J. S., Ances, B. M., Song, S. K., Hershey, T. & Eisenstein, S. A., Jan 14 2020, In: Frontiers in Human Neuroscience. 13, 464.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease

for the Dominantly Inherited Alzheimer Network, Aug 2020, In: Neurobiology of Disease. 142, 104960.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

2019

Altered neuropsychological performance and reduced brain volumetrics in people living with HIV on integrase strand transfer inhibitors

O'Halloran, J. A., Cooley, S. A., Strain, J. F., Boerwinkle, A., Paul, R., Presti, R. M. & Ances, B. M., Jul 15 2019, In: AIDS. 33, 9, p. 1477-1483 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

HIV infection and cerebral small vessel disease are independently associated with brain atrophy and cognitive impairment

Sanford, R., Strain, J., Dadar, M., Maranzano, J., Bonnet, A., Mayo, N. E., Scott, S. C., Fellows, L. K., Ances, B. M. & Louis Collins, D., Jun 1 2019, In: AIDS. 33, 7, p. 1197-1205 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Structural signature of sporadic Creutzfeldt–Jakob disease

Navid, J., Day, G. S., Strain, J., Perrin, R. J., Bucelli, R. C., Dincer, A., Wisch, J. K., Soleimani-Meigooni, D., Morris, J. C., Benzinger, T. L. S. & Ances, B. M., Aug 2019, In: European Journal of Neurology. 26, 8, p. 1037-1043 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals

Cooley, S. A., Strain, J. F., Beaumont, H., Boerwinkle, A. H., Doyle, J., Morris, J. C., Benzinger, T. L. & Ances, B. M., Jun 5 2019, In: Journal of Infectious Diseases. 220, 1, p. 68-72 5 p., jiy663.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2018

Loss of white matter integrity reflects tau accumulation in Alzheimer disease defined regions

Strain, J. F., Smith, R. X., Beaumont, H., Roe, C. M., Gordon, B. A., Mishra, S., Adeyemo, B., Christensen, J. J., Su, Y., Morris, J. C., Benzinger, T. L. S. & Ances, B. M., Jul 24 2018, In: Neurology. 91, 4, p. E313-E318

Research output: Contribution to journal › Article › peer-review

Open Access

72 Scopus citations

2017

Calibrated imaging reveals altered grey matter metabolism related to white matter microstructure and symptom severity in multiple sclerosis

Hubbard, N. A., Turner, M. P., Ouyang, M., Himes, L., Thomas, B. P., Hutchison, J. L., Faghihahmadabadi, S., Davis, S. L., Strain, J. F., Spence, J., Krawczyk, D. C., Huang, H., Lu, H., Hart, J., Frohman, T. C., Frohman, E. M., Okuda, D. T. & Rypma, B., Nov 2017, In: Human Brain Mapping. 38, 11, p. 5375-5390 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Diffusion basis spectral imaging detects ongoing brain inflammation in virologically well-controlled HIV+ Patients

Strain, J. F., Burdo, T. H., Song, S. K., Sun, P., El-Ghazzawy, O., Nelson, B., Westerhaus, E., Baker, L., Vaida, F. & Ances, B. M., 2017, In: Journal of Acquired Immune Deficiency Syndromes. 76, 4, p. 423-430 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Measurement of peripheral vision reaction time identifies white matter disruption in patients with mild traumatic brain injury

Womack, K. B., Paliotta, C., Strain, J. F., Ho, J. S., Skolnick, Y., Lytton, W. W., Turtzo, L. C., McColl, R., Diaz-Arrastia, R. & Bergold, P. J., Apr 15 2017, In: Journal of neurotrauma. 34, 8, p. 1539-1545 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

White Matter Changes and Confrontation Naming in Retired Aging National Football League Athletes

Strain, J. F., Didehbani, N., Spence, J., Conover, H., Bartz, E. K., Mansinghani, S., Jeroudi, M. K., Rao, N. K., Fields, L. M., Kraut, M. A., Cullum, C. M., Hart, J. & Womack, K. B., Jan 15 2017, In: Journal of neurotrauma. 34, 2, p. 372-379 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

2016

Asynchrony in executive networks predicts cognitive slowing in multiple sclerosis

Hubbard, N. A., Hutchison, J. L., Turner, M. P., Sundaram, S., Oasay, L., Robinson, D., Strain, J., Weaver, T., Davis, S. L., Remington, G. M., Huang, H., Biswal, B. B., Hart, J., Frohman, T. C., Frohman, E. M. & Rypma, B., Jan 1 2016, In: Neuropsychology. 30, 1, p. 75-86 12 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Multiple sclerosis-related white matter microstructural change alters the BOLD hemodynamic response

Hubbard, N. A., Turner, M., Hutchison, J. L., Ouyang, A., Strain, J., Oasay, L., Sundaram, S., Davis, S., Remington, G., Brigante, R., Huang, H., Hart, J., Frohman, T., Frohman, E., Biswal, B. B. & Rypma, B., Nov 1 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 11, p. 1872-1884 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2015

Imaging correlates of memory and concussion history in retired National Football League athletes

Strain, J. F., Womack, K. B., Didehbani, N., Spence, J. S., Conover, H., Hart, J., Kraut, M. A. & Cullum, C. M., Jul 1 2015, In: JAMA Neurology. 72, 7, p. 773-780 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Scopus citations

Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors

Chapman, S. B., Aslan, S., Spence, J. S., Hart, J. J., Bartz, E. K., Didehbani, N., Keebler, M. W., Gardner, C. M., Strain, J. F., Defina, L. F. & Lu, H., Feb 1 2015, In: Cerebral Cortex. 25, 2, p. 396-405 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

209 Scopus citations

2014

Longitudinal white matter changes after traumatic axonal injury

Perez, A. M., Adler, J., Kulkarni, N., Strain, J. F., Womack, K. B., Diaz-Arrastia, R. & De La Plata, C. D. M., Sep 1 2014, In: Journal of neurotrauma. 31, 17, p. 1478-1485 8 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

West Nile virus neuroinvasive disease: Neurological manifestations and prospective longitudinal outcomes

Hart, J., Tillman, G., Kraut, M. A., Chiang, H. S., Strain, J. F., Li, Y., Agrawal, A. G., Jester, P., Gnann, J. W. & Whitley, R. J., May 9 2014, In: BMC Infectious Diseases. 14, 1, 248.

Research output: Contribution to journal › Article › peer-review

Open Access

100 Scopus citations

2013

Depressive symptoms and white matter dysfunction in retired NFL players with concussion history

Strain, J., Didehbani, N., Cullum, C. M., Mansinghani, S., Conover, H., Kraut, M. A., Hart, J. & Womack, K. B., Jul 2 2013, In: Neurology. 81, 1, p. 25-32 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

139 Scopus citations

Neuroimaging of cognitive dysfunction and depression in aging retired national football league players

Hart, J., Kraut, M. A., Womack, K. B., Strain, J., Didehbani, N., Bartz, E., Conover, H., Mansinghani, S., Lu, H. & Cullum, C. M., Mar 2013, In: JAMA Neurology. 70, 3, p. 326-335 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

271 Scopus citations

Jeremy Strain

Research output

Search results