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Research interests

Traditionally, I have been working on molecular and cellular mechanisms contributing to the initiation and progression of chronic kidney disease. Once mechanisms were identified, treatment options were devised and tested for efficacy in mouse models of renal fibrosis. For the past ten years I have been in collaboration with Srikanth Singamaneni in the Department of Materials Science on the Danforth campus. We are developing sensitive and specific gold nanoparticle-based approaches to identify and quantitate biomarkers of a wide variety of diseases that are informative in the diagnosis of the relevant disease, particularly kidney disease. Additional studies center on the development of plasmonic flours to amplify fluorescence-based assays. This technology increases the sensitivity of the assays about a 1000-fold. Finally, another recently developed technology uses metal-organic frameworks (MOF) to enable preservation of biospecimens without the need for refrigeration for later analysis at established clinical laboratories. The MOF methodology will allow medical clinics to evaluate patient biospecimens in underserved regions of the United States and other countries


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