Jennifer Lodge

Vice Chancellor for Research, Professor of Molecular Microbiology, Associate Dean for Research

  • 3557 Citations
1983 …2020

Research output per year

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Research interests

Fungal infections cause substantial morbidity and mortality, particularly in immunocompromised patients. Current antifungal agents are not adequate to control these infections. The fungal pathogen, Cryptococcus neoformans causes fatal meningioencephalitis with over one million new cases every year resulting in 600,000 deaths, mostly in sub-saharan Africa. An attractive target for antifungal agents is the cell wall, since the cell wall is an essential organelle and the cell wall biosynthetic enzymes are absent in humans. Our laboratory is identifying novel targets for antifungal agents and is focusing in three main areas. The first is biosynthesis of chitin-related polysaccharides in the wall, including chitosan, the deacetylated form of chitin. The second is resistance to oxidative and nitrosative stresses that Cryptococcus encounters and successfully overcomes inside phagocytic cells. The third is signal transduction pathways that lead to remodeling of the cell wall and resistance to oxidative and nitrosative stress.

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Research Output

Cryptococcus neoformans chitin synthase 3 plays a critical role in dampening host inflammatory responses

Hole, C. R., Lam, W. C., Upadhya, R. & Lodge, J. K., Jan 1 2020, In : mBio. 11, 1, e03373-19.

Research output: Contribution to journalArticle

Open Access
  • Melanin deposition in two Cryptococcus species depends on cell-wall composition and flexibility

    Chrissian, C., Camacho, E., Fu, M. S., Prados-Rosales, R., Chatterjee, S., Cordero, R. J. B. X., Lodge, J. K. X., Casadevall, A. & Stark, R. E., Jan 1 2020, In : Journal of Biological Chemistry. 295, 7, p. 1815-1828 14 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Chitosan biosynthesis and virulence in the human fungal pathogen Cryptococcus gattii

    Lam, W. C., Upadhya, R., Specht, C. A., Ragsdale, A. E., Hole, C. R., Levitz, S. M. & Lodge, J. K., Jan 1 2019, In : mSphere. 4, 5, e00644-19.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Erratum: The monothiol glutaredoxin Grx4 regulates iron homeostasis and virulence in cryptococcus neoformans (mBio, (2018) 9(6), e02377-18, 10.1128/mBio.02377-18)

    Attarian, R., Hu, G., Sánchez-León, E., Caza, M., Croll, D., Do, E., Bach, H., Missall, T., Lodge, J., Jung, W. H. & Kronstad, J. W., Mar 1 2019, In : mBio. 10, 2, e00647-19.

    Research output: Contribution to journalComment/debate

    Open Access
  • The aminoalkylindole bml-190 negatively regulates chitosan synthesis via the cyclic amp/protein kinase a1 pathway in cryptococcus neoformans

    Maybruck, B. T., Lam, W. C., Specht, C. A., Ilagan, M. X. G., Donlin, M. J. & Lodge, J. K., Nov 1 2019, In : mBio. 10, 6, e02264-19.

    Research output: Contribution to journalArticle

    Open Access