Jennifer Alexander-Brett

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Jennifer Alexander-Brett

Assistant Professor of Medicine, Assistant Professor of Pathology and Immunology

 https://orcid.org/0000-0002-2685-7139

    Willing to Mentor

    Available to Mentor:

    PhD/MSTP Students, Undergraduate Students, Post-Baccalaureate Students, PhD/MSTP Students, Health Professions (Medical, OT, PT, Dental, Audiology, etc.) Students, Postdocs, Residents and Fellows

    • 2077
      Citations
    19992024

    Research activity per year

    Personal profile

    Research interests

    My research interests focus on cytokine pathways relevant to lung epithelial stem cell function in airway disease. Taking a translational approach to disease mechanism, I employ human airway specimens, mouse models, stem cell culture, molecular and structural biology. My postdoctoral work under the mentorship of Dr. Michael Holtzman has to date involved the phenotypic and functional characterization of disease-associated IL-33 expressing airway cells and their pathogenic role in driving chronic airway disease. As I transition to independence, my research on this cytokine system will focus on the pathway of cellular IL-33 activation/release, including biochemical and structural definition of intracellular (nuclear, transcriptional regulatory) and extracellular aspects of this unique dual-functioning cytokine. Results of this analysis will guide efforts toward development of IL-33 antagonists as therapeutics for chronic airway disease.

    My clinical interests include lung transplantation, particularly management of factors contributing to development of chronic allograft rejection, and critical care medicine.

    Clinical interests

    Lung transplant medicine, critical care medicine

    Mentoring

    JAB lab is committed to wellness, diversity and inclusion.

    Available to Mentor:

    • PhD/MSTP Students
    • Undergraduate Students
    • Post-Baccalaureate Students
    • Health Professions Students
    • Postdocs
    • Residents and Fellows

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    Collaborations and top research areas from the last five years

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    • Activator protein transcription factors coordinate human IL-33 expression from noncanonical promoters in chronic airway disease

      Raphael, H. E., Hassan, G. F., Osorio, O. A., Cohen, L. S., Payne, M. D., Katz-Kiriakos, E., Tata, I., Hicks, J., Byers, D. E., Zhang, B. & Alexander-Brett, J., 2024, In: JCI Insight. 9, 5, e174786.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      2 Scopus citations

    • IL-33: Friend or foe in transplantation?

      Hassan, G. F., Cohen, L. S. & Alexander-Brett, J., Aug 2024, In: Journal of Heart and Lung Transplantation. 43, 8, p. 1235-1240 6 p.

      Research output: Contribution to journal › Review article › peer-review

      Open Access
      1 Scopus citations

    • Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

      MISEV Consortium, Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q. L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. Ỹ. G., Mohanty, S., Möller, A. & Nieuwland, R. & 181 others, Ochiya, T., Sahoo, S., Torrecilhas, A. C., Zheng, L., Zijlstra, A., Abuelreich, S., Bagabas, R., Bergese, P., Bridges, E. M., Brucale, M., Burger, D., Carney, R. P., Cocucci, E., Crescitelli, R., Hanser, E., Harris, A. L., Haughey, N. J., Hendrix, A., Ivanov, A. R., Jovanovic-Talisman, T., Kruh-Garcia, N. A., Faustino, V. K. L., Kyburz, D., Lässer, C., Lennon, K. M., Lötvall, J., Maddox, A. L., Martens-Uzunova, E. S., Mizenko, R. R., Newman, L. A., Ridolfi, A., Rohde, E., Rojalin, T., Rowland, A., Saftics, A., Sandau, U. S., Saugstad, J. A., Shekari, F., Swift, S., Ter-Ovanesyan, D., Tosar, J. P., Useckaite, Z., Valle, F., Varga, Z., van der Pol, E., van Herwijnen, M. J. C., Wauben, M. H. M., Wehman, A. M., Williams, S., Zendrini, A., Zimmerman, A. J., Théry, C., Witwer, K. W., Ahmad, S., Ahmed, D. A. K., Ahmed, S. H., Aikawa, E., Akbar, N., Akiyoshi, K., Al-Adra, D. P., Al-Masawa, M. E., Albanese, M., Alberro, A., Alcaraz, M. J., Alexander-Brett, J., Alexander, K. L., Ali, N., Alibhai, F. J., Allelein, S., Allenby, M. C., Almeida, F., de Almeida, L. P., Almousa, S. W., Altan-Bonnet, N., Altei, W. F., Alvarez-Llamas, G., Alvarez, C. L., An, H. J., Anand, K., Andaloussi, S. E. L., Anderson, J. D., Andriantsitohaina, R., Ansari, K. I., Anselmo, A., Antoniou, A., Aqil, F., Arab, T., Archer, F., Arif, S., Armstrong, D. A., Arntz, O. J., Arsène, P., Arteaga-Blanco, L., Asokan, N., Aspelin, T., Atkin-Smith, G. K., Aubert, D., Ayyar, K. K., Azlan, M., Azoidis, I., Bécot, A., Bach, J. M., Bachurski, D., Bae, S., Bagge, R. O., Baj-Krzyworzeka, M., Balaj, L., Balbi, C., van Balkom, B. W. M., Ballal, A. R., Bano, A., Banzet, S., Bare, Y., Barile, L., Barman, B., Barranco, I., Barreca, V., Bart, G., Barteneva, N. S., Basso, M., Batish, M., Bauer, N. R., Baxter, A. A., Bazié, W. W., Bazzan, E., Beaumont, J. E. J., Bebawy, M., Bebelman, M. P., Bedina-Zavec, A., Beetler, D. J., Beke-Somfai, T., Belleannée, C., Benedikter, B. J., Benediktsdóttir, B. E., Berardi, A. C., Bergamelli, M., Bertolini, I., Bhattacharyya, A., Bhattacharyya, S. N., Biller, S. J., Billottet, C., Bissler, J. J., Blanc-Brude, O., Blijdorp, C. J., Bobis-Wozowicz, S., Bodart-Santos, V., Bodnár, B. R., Boilard, E., Boireau, W., Bokun, V., Bollard, S. M., Bollini, S., Bongiovanni, A., Bongiovanni, L., Bonifay, A., Boppart, M. D., Borràs, F. E., Bosch, S., Boselli, D., Bottini, M., Bouffard, J., Boulanger, C. M., Boutros, P. C., Boyadjian, O., Boysen, A. T., Bozkurt, B. T., Bramich, K. P., Braun, F., Del Carmen Bravo-Miana, R., Breakefield, X. O., Brenna, S., Brennan, K., Brennan, M., Breyne, K., Brigstock, D. R., Brisson, A. R., Brodie, C., Bruno, K. A., Bucci, C., Buch, S. & Buck, A., Feb 2024, In: Journal of Extracellular Vesicles. 13, 2, e12404.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      551 Scopus citations

    • Modulation of TMEM16B channel activity by the calcium-activated chloride channel regulator 4 (CLCA4) in human cells

      Sala-Rabanal, M., Yurtsever, Z., Berry, K. N., McClenaghan, C., Foy, A. J., Hanson, A., Steinberg, D. F., Greven, J. A., Kluender, C. E., Alexander-Brett, J. M., Nichols, C. G. & Brett, T. J., Jul 2024, In: Journal of Biological Chemistry. 300, 7, 107432.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Proteins in Tumor-Derived Plasma Extracellular Vesicles Indicate Tumor Origin

      Barlin, M., Erdmann-Gilmore, P., Mudd, J. L., Zhang, Q., Seymour, R. W., Guo, Z., Miessner, J. R., Goedegebuure, S. P., Bi, Y., Osorio, O. A., Alexander-Brett, J., Li, S., Ma, C. X., Fields, R. C., Townsend, R. R. & Held, J. M., Jan 2023, In: Molecular and Cellular Proteomics. 22, 1, 100476.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      8 Scopus citations
    View all 30 Research outputs