Jennifer Alexander-Brett

Assistant Professor of Medicine, Assistant Professor of Pathology and Immunology

    • Source: Scopus
    19992020

    Research output per year

    If you made any changes in Pure these will be visible here soon.

    Personal profile

    Research interests

    My research interests focus on cytokine pathways relevant to lung epithelial stem cell function in airway disease. Taking a translational approach to disease mechanism, I employ human airway specimens, mouse models, stem cell culture, molecular and structural biology. My postdoctoral work under the mentorship of Dr. Michael Holtzman has to date involved the phenotypic and functional characterization of disease-associated IL-33 expressing airway cells and their pathogenic role in driving chronic airway disease. As I transition to independence, my research on this cytokine system will focus on the pathway of cellular IL-33 activation/release, including biochemical and structural definition of intracellular (nuclear, transcriptional regulatory) and extracellular aspects of this unique dual-functioning cytokine. Results of this analysis will guide efforts toward development of IL-33 antagonists as therapeutics for chronic airway disease. My clinical interests include lung transplantation, particularly management of factors contributing to development of chronic allograft rejection, and critical care medicine.

    Areas of Clinical Interest

    Lung transplant medicine, critical care medicine

    Fingerprint

    Dive into the research topics where Jennifer Alexander-Brett is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
    • 1 Similar Profiles

    Network

    Recent external collaboration on country level. Dive into details by clicking on the dots.
    If you made any changes in Pure these will be visible here soon.