Jen -ID Division Philips

Associate Professor of Medicine, Associate Professor of Molecular Microbiology

    • 2064 Citations
    1992 …2020

    Research output per year

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    Personal profile

    Research interests

    Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB), one of the world’s most deadly infections. Mtb disrupts anti-microbial pathways of macrophages, cells that normally kill bacteria. Mtb establishes persistent infection despite inducing robust antigen specific T cell responses. How Mtb undermines these host immune functions is the focus of our work. We are identifying and characterizing host-pathogen interactions that provide mechanistic insight into how Mtb alters cellular trafficking, antigen presentation, and cytokine responses of macrophages and dendritic cells. In studying the molecular mechanisms by which Mtb sabotages cellular functions, we hope to better understand host immunity and bacterial pathogenesis.

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    Research Output

    Inhibition of fatty acid oxidation promotes macrophage control of mycobacterium tuberculosis

    Chandra, P., He, L., Zimmerman, M., Yang, G., Köster, S., Ouimet, M., Wang, H., Moore, K. J., Dartois, V., Schilling, J. D. & Philips, J. A., Aug 2020, In : mBio. 11, 4, p. 1-15 15 p., e01139-20.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    LC3-associated phagocytosis: host defense and microbial response

    Upadhyay, S. & Philips, J. A., Oct 2019, In : Current Opinion in Immunology. 60, p. 81-90 10 p.

    Research output: Contribution to journalReview article

  • 8 Scopus citations

    Consequence of enhanced LC3-trafficking for a live, attenuated M. tuberculosis vaccine

    Köster, S., Klevorn, T., Papavinasasundaram, K., Sassetti, C. M., Portal-Celhay, C. & Philips, J. A., Feb 8 2018, In : Vaccine. 36, 7, p. 939-944 6 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Mycobacterium tuberculosis type VII secretion system effectors differentially impact the ESCRT endomembrane damage response

    Mittal, E., Skowyra, M. L., Uwase, G., Tinaztepe, E., Mehra, A., Köster, S., Hanson, P. I. & Philips, J. A., Nov 1 2018, In : mBio. 9, 6, e01765-18.

    Research output: Contribution to journalArticle

    Open Access
  • 17 Scopus citations

    Oh, the places you’ll go!

    Philips, J. A., Jan 24 2018, In : Science translational medicine. 10, 425, eaar7522.

    Research output: Contribution to journalReview article