Jen Heemstra

2025

Development of Dual Aurora-A and Aurora-B Degrading PROTACs for MYCN-Amplified Neuroblastoma

Nelson, S. E., Tucker, J. R., Prado, M. G., Tierney, L. C., Quigley, S. L., Lumpkin, A. T., Dodd, C. J., Hasko, V., Howie, S. L., Aastha, Ody, B. K., Yin, J., Heemstra, J. M. & Turlington, M., Mar 3 2025, In: ChemMedChem. 20, 5, e202400703.

Research output: Contribution to journal › Article › peer-review

EndoVIA for quantifying A-to-I editing and mapping the subcellular localization of edited transcripts

Quillin, A. L., Arnould, B., Knutson, S. D., Flores, T. F. & Heemstra, J. M., Jan 2025, ADARs. Beal, P. (ed.). Academic Press Inc., p. 99-130 32 p. (Methods in Enzymology; vol. 710).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2024

Developing Microelectrode Arrays for the Point-of-Care Multiplex Detection of Metabolites

Chang, Y. C., Arnould, B., Heemstra, J. M. & Moeller, K., Sep 10 2024, In: Analytical Chemistry. 96, 36, p. 14571-14580 10 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Glyoxal Caging of Nucleoside Antivirals toward Self-Activating, Extended-Release Prodrugs

Karloff, D. B., Stubbs, R. T., Ibukun, O. J., Knutson, S. D., James, S. H. & Heemstra, J. M., Oct 30 2024, In: Journal of the American Chemical Society. 146, 43, p. 29402-29406 5 p.

Research output: Contribution to journal › Article › peer-review

Spatial Visualization of A-to-I Editing in Cells Using Endonuclease V Immunostaining Assay (EndoVIA)

Quillin, A. L., Arnould, B., Knutson, S. D. & Heemstra, J. M., Jul 24 2024, In: ACS Central Science. 10, 7, p. 1396-1405 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

The Use of Xenonucleic Acids Significantly Reduces theIn Vivo Drift of Electrochemical Aptamer-Based Sensors

Leung, K. K., Gerson, J., Emmons, N., Heemstra, J. M., Kippin, T. E. & Plaxco, K. W., May 21 2024, In: Angewandte Chemie - International Edition. 63, 21, e202316678.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2023

Catalyst for change: future of DEI in academia

Davis, J. S., Damo, S. A., Spencer, E. C., Murray, S. A., Shuler, H. D., Vue, Z., Heemstra, J. M., Diaz Vazquez, A. & Hinton, A., Apr 2023, In: Trends in Chemistry. 5, 4, p. 245-248 4 p.

Research output: Contribution to journal › Comment/debate

Open Access

9 Scopus citations

Co-immobilization of Enzymes and Aptamers to Create Self-Regenerating Ultrafiltration Membranes for Toxin Removal

Romero-Reyes, M. A., Patterson, K. N. & Heemstra, J. M., Jun 5 2023, In: ACS Materials Letters. 5, 6, p. 1565-1569 5 p.

Research output: Contribution to journal › Article › peer-review

Diversity, Equity and Inclusion in the Laboratory: Strategies to Enhance Inclusive Laboratory Culture

Marshall, A. G., Vue, Z., Beasley, H. K., Neikirk, K., Stephens, D., Wanjalla, C. N., Damo, S. M., Trejo, J. A., Rodriguez-Aliaga, P., Headley, C. A., Shuler, H., Liu, K., Smith, N., Garza-Lopez, E., Barongan, T., Scudese, E., Spencer, E., Heemstra, J., Vazquez, A. D. & Murray, S. A. & 1 others, Hinton, A., Nov 2 2023, In: Molecular cell. 83, 21, p. 3766-3772 7 p.

Research output: Contribution to journal › Comment/debate

Open Access

9 Scopus citations

Elucidating Sequence-Assembly Relationships for Bilingual PNA Biopolymers

Argueta-Gonzalez, H., Swenson, C. S., Skowron, K. J. & Heemstra, J. M., Oct 10 2023, In: ACS Omega. 8, 40, p. 37442-37450 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Forced Intercalation Peptide Nucleic Acid Probes for the Detection of an Adenosine-to-Inosine Modification

Swenson, C. S., Argueta-Gonzalez, H. S., Sterling, S. A., Robichaux, R., Knutson, S. D. & Heemstra, J. M., Jan 10 2023, In: ACS Omega. 8, 1, p. 238-248 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Modular Catalysis: Aptamer Enhancement of Enzyme Kinetics in a Nanoparticle Reactor

Manuel, B. A., Das, S., Sanford, A., Jenkins, M. C., Finn, M. G. & Heemstra, J. M., Apr 10 2023, In: Biomacromolecules. 24, 4, p. 1934-1941 8 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Tracking the Message: Applying Single Molecule Localization Microscopy to Cellular RNA Imaging

Arnould, B., Quillin, A. L. & Heemstra, J. M., May 16 2023, In: ChemBioChem. 24, 10, e202300049.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

2022

Combating small molecule environmental contaminants: detection and sequestration using functional nucleic acids

Sanford, A. A., Manuel, B. A., Romero-Reyes, M. A. & Heemstra, J. M., Jun 6 2022, In: Chemical Science. 13, 26, p. 7670-7684 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

10 Scopus citations

Coping behavior versus coping style: characterizing a measure of coping in undergraduate STEM contexts

Henry, M. A., Shorter, S., Charkoudian, L. K., Heemstra, J. M., Le, B. & Corwin, L. A., Dec 2022, In: International Journal of STEM Education. 9, 1, 17.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Fluorescence Quenching of Xanthene Dyes during Amide Bond Formation Using DMTMM

Patterson, K. N., Romero-Reyes, M. A. & Heemstra, J. M., Sep 20 2022, In: ACS Omega. 7, 37, p. 33046-33053 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Harnessing Nature's Molecular Recognition Capabilities to Map and Study RNA Modifications

Felix, A. S., Quillin, A. L., Mousavi, S. & Heemstra, J. M., Aug 16 2022, In: Accounts of Chemical Research. 55, 16, p. 2271-2279 9 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Mentoring is more important than ever

Heemstra, J. M. & Garg, N. K., Nov 2022, In: Nature Reviews Chemistry. 6, 11, p. 757-758 2 p.

Research output: Contribution to journal › Comment/debate

Open Access

4 Scopus citations

Stimuli-responsive assembly of bilingual peptide nucleic acids

Argueta-Gonzalez, H. S., Swenson, C. S., Song, G. & Heemstra, J. M., Jun 17 2022, In: RSC Chemical Biology. 3, 8, p. 1035-1043 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Systematically Modulating Aptamer Affinity and Specificity by Guanosine-to-Inosine Substitution

Manuel, B. A., Sterling, S. A., Sanford, A. A. & Heemstra, J. M., May 3 2022, In: Analytical Chemistry. 94, 17, p. 6436-6440 5 p.

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

2021

Direct Immunodetection of Global A-to-I RNA Editing Activity with a Chemiluminescent Bioassay

Knutson, S. D., Arthur, R. A., Johnston, H. R. & Heemstra, J. M., Jul 26 2021, In: Angewandte Chemie - International Edition. 60, 31, p. 17009-17017 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Evaluating the effect of ionic strength on PNA:DNA duplex formation kinetics

Swenson, C. S., Lackey, H. H., Reece, E. J., Harris, J. M., Heemstra, J. M. & Peterson, E. M., Aug 2021, In: RSC Chemical Biology. 2, 4, p. 1249-1256 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Protein-based molecular recognition tools for detecting and profiling RNA modifications

Knutson, S. D. & Heemstra, J. M., Aug 2021, In: Current Opinion in Structural Biology. 69, p. 1-10 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

Quantifying fear of failure in STEM: modifying and evaluating the Performance Failure Appraisal Inventory (PFAI) for use with STEM undergraduates

Henry, M. A., Shorter, S., Charkoudian, L. K., Heemstra, J. M., Le, B. & Corwin, L. A., Dec 2021, In: International Journal of STEM Education. 8, 1, 43.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

RE-SELEX: restriction enzyme-based evolution of structure-switching aptamer biosensors

Sanford, A. A., Rangel, A. E., Feagin, T. A., Lowery, R. G., Argueta-Gonzalez, H. S. & Heemstra, J. M., Sep 21 2021, In: Chemical Science. 12, 35, p. 11692-11702 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Sequestration and Removal of Multiple Small-Molecule Contaminants Using an Optimized Aptamer-Based Ultrafiltration System

Romero-Reyes, M. A. & Heemstra, J. M., Sep 15 2021, In: Bioconjugate Chemistry. 32, 9, p. 2043-2051 9 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Sweet sensation: Developing a single-cell fluorescent reporter of glycolytic heterogeneity

Karloff, D. B. & Heemstra, J. M., Nov 18 2021, In: Cell Chemical Biology. 28, 11, p. 1539-1541 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2020

A Scientist's Guide to Social Media

Heemstra, J. M., Jan 22 2020, In: ACS Central Science. 6, 1, p. 1-5 5 p.

Research output: Contribution to journal › Editorial

Open Access

16 Scopus citations

Chemical Profiling of A-to-I RNA Editing Using a Click-Compatible Phenylacrylamide

Knutson, S. D., Korn, M. M., Johnson, R. P., Monteleone, L. R., Dailey, D. M., Swenson, C. S., Beal, P. A. & Heemstra, J. M., Aug 6 2020, In: Chemistry - A European Journal. 26, 44, p. 9874-9878 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Covalent live-cell labeling of proteins using a photoreactive fluorogen

Ayele, T. M., Knutson, S. D. & Heemstra, J. M., 2020, Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Optical Imaging and Conjugation. Academic Press Inc., p. 355-377 23 p. (Methods in Enzymology; vol. 639).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

DNA/TNA mesoscopic modeling of melting temperatures suggests weaker hydrogen bonding of CG than in DNA/RNA

Muniz, M. I., Lackey, H. H., Heemstra, J. M. & Weber, G., Jun 16 2020, In: Chemical Physics Letters. 749, 137413.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

EndoVIPER-seq for Improved Detection of A-to-I Editing Sites in Cellular RNA

Knutson, S. D. & Heemstra, J. M., Jun 1 2020, In: Current protocols in chemical biology. 12, 2, p. e82

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Peptide nucleic acids harness dual information codes in a single molecule

Swenson, C. S. & Heemstra, J. M., Feb 14 2020, In: Chemical Communications. 56, 13, p. 1926-1935 10 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Probing the Mechanism of Structure-Switching Aptamer Assembly by Super-Resolution Localization of Individual DNA Molecules

Lackey, H. H., Peterson, E. M., Harris, J. M. & Heemstra, J. M., May 19 2020, In: Analytical Chemistry. 92, 10, p. 6909-6917 9 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Selective Enrichment of A-to-I Edited Transcripts from Cellular RNA Using Endonuclease V

Knutson, S. D., Arthur, R. A., Johnston, H. R. & Heemstra, J. M., Mar 18 2020, In: Journal of the American Chemical Society. 142, 11, p. 5241-5251 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Single-Molecule Kinetics Show DNA Pyrimidine Content Strongly Affects RNA:DNA and TNA:DNA Heteroduplex Dissociation Rates

Lackey, H. H., Chen, Z., Harris, J. M., Peterson, E. M. & Heemstra, J. M., Feb 21 2020, In: ACS synthetic biology. 9, 2, p. 249-253 5 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Thermoreversible Control of Nucleic Acid Structure and Function with Glyoxal Caging

Knutson, S. D., Sanford, A. A., Swenson, C. S., Korn, M. M., Manuel, B. A. & Heemstra, J. M., Oct 14 2020, In: Journal of the American Chemical Society. 142, 41, p. 17766-17781 16 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

2019

Bilingual Peptide Nucleic Acids: Encoding the Languages of Nucleic Acids and Proteins in a Single Self-Assembling Biopolymer

Swenson, C. S., Velusamy, A., Argueta-Gonzalez, H. S. & Heemstra, J. M., Dec 4 2019, In: Journal of the American Chemical Society. 141, 48, p. 19038-19047 10 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

FAIL is not a four-letter word: A theoretical framework for exploring undergraduate students’ approaches to academic challenge and responses to failure in STEM learning environments

Henry, M. A., Shorter, S., Charkoudian, L., Heemstra, J. M. & Corwin, L. A., Mar 1 2019, In: CBE life sciences education. 18, 1, ar11.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Scopus citations

Fluorogenic photoaffinity labeling of proteins in living cells

Ayele, T. M., Knutson, S. D., Ellipilli, S., Hwang, H. & Heemstra, J. M., May 15 2019, In: Bioconjugate Chemistry. 30, 5, p. 1309-1313 5 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Self-Care Is Not the Enemy of Performance

Heemstra, J. M., Sep 2 2019, In: ChemBioChem. 20, 17, p. 2203-2206 4 p.

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Small-Molecule Sequestration Using Aptamer-Functionalized Membranes

Romero-Reyes, M. A. & Heemstra, J. M., Nov 4 2019, In: ACS Materials Letters. 1, 5, p. 568-572 5 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Thermostability Trends of TNA:DNA Duplexes Reveal Strong Purine Dependence

Lackey, H. H., Peterson, E. M., Chen, Z., Harris, J. M. & Heemstra, J. M., May 17 2019, In: ACS synthetic biology. 8, 5, p. 1144-1152 9 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2018

Biomolecular Assemblies: Moving from Observation to Predictive Design

Wilson, C. J., Bommarius, A. S., Champion, J. A., Chernoff, Y. O., Lynn, D. G., Paravastu, A. K., Liang, C., Hsieh, M. C. & Heemstra, J. M., Dec 26 2018, In: Chemical Reviews. 118, 24, p. 11519-11574 56 p.

Research output: Contribution to journal › Review article › peer-review

83 Scopus citations

Chemical labeling and affinity capture of inosine-containing RNAs using acrylamidofluorescein

Knutson, S. D., Ayele, T. M. & Heemstra, J. M., Sep 19 2018, In: Bioconjugate Chemistry. 29, 9, p. 2899-2903 5 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Collaborating with Undergraduates to Contribute to Biochemistry Community Resources

Haas, K. L., Heemstra, J. M., Medema, M. H. & Charkoudian, L. K., Jan 30 2018, In: Biochemistry. 57, 4, p. 383-389 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

9 Scopus citations

High-Throughput Measurement of Small-Molecule Enantiopurity by Using Flow Cytometry

Tan, Z. & Heemstra, J. M., Sep 4 2018, In: ChemBioChem. 19, 17, p. 1853-1857 5 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

In vitro selection of an XNA aptamer capable of small-molecule recognition

Rangel, A. E., Chen, Z., Ayele, T. M. & Heemstra, J. M., Sep 19 2018, In: Nucleic acids research. 46, 16, p. 8057-8068 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

92 Scopus citations

Single-Molecule Kinetic Investigation of Cocaine-Dependent Split-Aptamer Assembly

Morris, F. D., Peterson, E. M., Heemstra, J. M. & Harris, J. M., Nov 6 2018, In: Analytical Chemistry. 90, 21, p. 12964-12970 7 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Synthesis of comb-shaped DNA using a non-nucleosidic branching phosphoramidite

Ellipilli, S., Phillips, J. D. & Heemstra, J. M., 2018, In: Organic and Biomolecular Chemistry. 16, 25, p. 4659-4664 6 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Jen Heemstra

Research output

Search results