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Jeffrey Ward

Assistant Professor of Medicine

    • 1928 Citations
    20042020

    Research output per year

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    Personal profile

    Research interests

    My research focuses on the identification of tumor specific mutant antigens recognized by the immune system as foreign that serve as the target of a T-cell response against tumors. We take advantage of cancer genomics and bioinformatics techniques to detect tumor-specific mutations that accumulate during transformation and use this information to predict which mutations are potentially antigenic.

    Areas of Clinical Interest

    Cancer/tumor immunotherapy

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    Research Output

    • 1928 Citations
    • 18 Article
    • 2 Comment/debate
    • 1 Conference contribution
    • 1 Review article

    cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity

    Ferris, S. T., Durai, V., Wu, R., Theisen, D. J., Ward, J. P., Bern, M. D., Davidson, J. T., Bagadia, P., Liu, T., Briseño, C. G., Li, L., Gillanders, W., Wu, G. F., Yokoyama, W. M., Murphy, T. L., Schreiber, R. D. & Murphy, K. M., Aug 27 2020, In : Nature. 584, 7822, p. 624-629 6 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Circulating tumor DNA profiling in small-cell lung cancer identifies potentially targetable alterations

    Devarakonda, S., Sankararaman, S., Herzog, B. H., Gold, K. A., Waqar, S. N., Ward, J. P., Raymond, V. M., Lanman, R. B., Chaudhuri, A. A., Owonikoko, T. K., Li, B. T., Poirier, J. T., Rudin, C. M., Govindan, R. & Morgensztern, D., Oct 15 2019, In : Clinical Cancer Research. 25, 20, p. 6119-6126 8 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    MHC-II neoantigens shape tumour immunity and response to immunotherapy

    Alspach, E., Lussier, D. M., Miceli, A. P., Kizhvatov, I., DuPage, M., Luoma, A. M., Meng, W., Lichti, C. F., Esaulova, E., Vomund, A. N., Runci, D., Ward, J. P., Gubin, M. M., Medrano, R. F. V., Arthur, C. D., White, J. M., Sheehan, K. C. F., Chen, A., Wucherpfennig, K. W., Jacks, T. & 3 others, Unanue, E. R., Artyomov, M. N. & Schreiber, R. D., Oct 31 2019, In : Nature. 574, 7780, p. 696-701 6 p.

    Research output: Contribution to journal › Article

    • 64 Scopus citations

    Erratum: High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy (Cell (2018) 175(4) (1014–1030.e19), (S009286741831242X) (10.1016/j.cell.2018.09.030))

    Gubin, M. M., Esaulova, E., Ward, J. P., Malkova, O. N., Runci, D., Wong, P., Noguchi, T., Arthur, C. D., Meng, W., Alspach, E., Medrano, R. F. V., Fronick, C., Fehlings, M., Newell, E. W., Fulton, R., Sheehan, K., Oh, S., Schreiber, R. & Artomov, M., Nov 15 2018, In : Cell. 175, 5, p. 1443 1 p.

    Research output: Contribution to journal › Comment/debate

    • 11 Scopus citations

    Erratum to: Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells (Nature Communications, (2017), 8, 1, (562), 10.1038/s41467-017-00627-z)

    Fehlings, M., Simoni, Y., Penny, H. L., Becht, E., Loh, C. Y., Gubin, M. M., Ward, J. P., Wong, S. C., Schreiber, R. D. & Newell, E. W., Dec 1 2018, In : Nature communications. 9, 1, 3000.

    Research output: Contribution to journal › Comment/debate

    Open Access