• 1905 Citations
20042020

Research output per year

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Personal profile

Research interests

We are interested in developing and studying the differentiation of human pluripotent stem cells to insulin-producing pancreatic beta cells for diabetes cellular therapy and drug screening. We are primarily using tissue engineering approaches to control beta cell/biomaterial interactions to improve this process. Using this strategy, we are generating beta cells from diabetic patients to study the disease and transplanting these cells into diabetic mice.

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Research Output

  • 1905 Citations
  • 14 Article
  • 7 Review article
  • 1 Conference contribution
  • 1 Comment/debate

Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells

Velazco-Cruz, L., Goedegebuure, M. M. & Millman, J. R., Jul 9 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 786.

Research output: Contribution to journalReview article

Open Access
  • 2 Scopus citations

    Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice

    Maxwell, K. G., Augsornworawat, P., Velazco-Cruz, L., Kim, M. H., Asada, R., Hogrebe, N. J., Morikawa, S., Urano, F. & Millman, J. R., Apr 22 2020, In : Science translational medicine. 12, 540, eaax9106.

    Research output: Contribution to journalReview article

  • 8 Scopus citations

    Single-cell RNA sequencing for engineering and studying human islets

    Augsornworawat, P. & Millman, J. R., Dec 2020, In : Current Opinion in Biomedical Engineering. 16, p. 27-33 7 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

    Augsornworawat, P., Maxwell, K. G., Velazco-Cruz, L. & Millman, J. R., Aug 25 2020, In : Cell Reports. 32, 8, 108067.

    Research output: Contribution to journalArticle

    Open Access
  • SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro

    Velazco-Cruz, L., Goedegebuure, M. M., Maxwell, K. G., Augsornworawat, P., Hogrebe, N. J. & Millman, J. R., May 26 2020, In : Cell Reports. 31, 8, 107687.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations