Research Output per year
Research Output per year
Personal profile
Research interests
We are interested in developing and studying the differentiation of human pluripotent stem cells to insulin-producing pancreatic beta cells for diabetes cellular therapy and drug screening. We are primarily using tissue engineering approaches to control beta cell/biomaterial interactions to improve this process. Using this strategy, we are generating beta cells from diabetic patients to study the disease and transplanting these cells into diabetic mice.
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Research Output
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Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells
Velazco-Cruz, L., Goedegebuure, M. M. & Millman, J. R., Jul 9 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 786.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice
Maxwell, K. G., Augsornworawat, P., Velazco-Cruz, L., Kim, M. H., Asada, R., Hogrebe, N. J., Morikawa, S., Urano, F. & Millman, J. R., Apr 22 2020, In: Science translational medicine. 12, 540, eaax9106.Research output: Contribution to journal › Review article › peer-review
12 Scopus citations -
Single-cell RNA sequencing for engineering and studying human islets
Augsornworawat, P. & Millman, J. R., Dec 2020, In: Current Opinion in Biomedical Engineering. 16, p. 27-33 7 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation
Augsornworawat, P., Maxwell, K. G., Velazco-Cruz, L. & Millman, J. R., Aug 25 2020, In: Cell Reports. 32, 8, 108067.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro
Velazco-Cruz, L., Goedegebuure, M. M., Maxwell, K. G., Augsornworawat, P., Hogrebe, N. J. & Millman, J. R., May 26 2020, In: Cell Reports. 31, 8, 107687.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations