Jeffrey Milbrandt

James S McDonnell Professor of Genetics, Head of the Department of Genetics, Executive Director of the McDonnell Genome Institute, Professor of Medicine, Professor of Neurology, Professor of Pathology and Immunology

    • 29445 Citations
    1981 …2020

    Research output per year

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    Personal profile

    Research interests

    Axonal degeneration is a major component of many diseases, including hereditary neuropathy, diabetes, amyotrophic lateral sclerosis (ALS), and multiple sclerosis. Mitochondrial dysfunction caused by mutations or toxins is also closely associated with both axonopathy and neurodegenerative disease. Through studies of Wld mutant mice, we found that enzymes involved in cellular energetics (NAD biosynthesis), the longevity-associated protein SIRT1, and resveratrol, a polyphenol found in red wine, can protect against axonal degeneration after injury or mitochondrial damage. To understand how deficits in neuronal metabolism lead to inappropriate responses to stress and result in disease, we are exploring how changes in energy utilization and production influence neuronal function in mice engineered to have deficits in NAD biosynthetic pathways, mitochondrial proteins, and AMP kinase subunits.

    Keywords

    • COVID-19

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    Research Output

    • 29445 Citations
    • 256 Article
    • 6 Comment/debate
    • 4 Review article

    cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons

    Sasaki, Y., Engber, T. M., Hughes, R. O., Figley, M. D., Wu, T., Bosanac, T., Devraj, R., Milbrandt, J., Krauss, R. & DiAntonio, A., Jul 2020, In : Experimental Neurology. 329, 113252.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Cell-autonomous expression of the acid hydrolase galactocerebrosidase

    Mikulka, C. R., Dearborn, J. T., Benitez, B. A., Strickland, A., Liu, L., Milbrandt, J. & Sands, M. S., Apr 21 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 16, p. 9032-9041 10 p.

    Research output: Contribution to journalArticle

  • Disrupting insulin signaling in Schwann cells impairs myelination and induces a sensory neuropathy

    Hackett, A. R., Strickland, A. & Milbrandt, J., May 1 2020, In : Glia. 68, 5, p. 963-978 16 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration

    Summers, D. W., Frey, E., Walker, L. J., Milbrandt, J. & DiAntonio, A., Feb 1 2020, In : Molecular Neurobiology. 57, 2, p. 1146-1158 13 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Domain-centric database to uncover structure of minimally characterized viral genomes

    Bramley, J. C., Yenkin, A. L., Zaydman, M. A., DiAntonio, A., Milbrandt, J. D. & Buchser, W. J., Dec 1 2020, In : Scientific data. 7, 1, 202.

    Research output: Contribution to journalArticle

    Open Access