Jeffrey Milbrandt

James S McDonnell Professor of Genetics, Head of the Department of Genetics, Executive Director of the McDonnell Genome Institute, Professor of Medicine, Professor of Neurology, Professor of Pathology and Immunology

29445 Citations

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Axonal degeneration is a major component of many diseases, including hereditary neuropathy, diabetes, amyotrophic lateral sclerosis (ALS), and multiple sclerosis. Mitochondrial dysfunction caused by mutations or toxins is also closely associated with both axonopathy and neurodegenerative disease. Through studies of Wld mutant mice, we found that enzymes involved in cellular energetics (NAD biosynthesis), the longevity-associated protein SIRT1, and resveratrol, a polyphenol found in red wine, can protect against axonal degeneration after injury or mitochondrial damage. To understand how deficits in neuronal metabolism lead to inappropriate responses to stress and result in disease, we are exploring how changes in energy utilization and production influence neuronal function in mice engineered to have deficits in NAD biosynthetic pathways, mitochondrial proteins, and AMP kinase subunits.

Keywords

COVID-19

Fingerprint Dive into the research topics where Jeffrey Milbrandt is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

16 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.