Jeffrey Magee

2024

Disruption of polyunsaturated fatty acid biosynthesis drives STING-dependent acute myeloid leukemia cell maturation and death

Kanefsky, J., Basse, M., Sokei, J., di Martino, O., Valin, L., Jaspers, Y., Martinez, E., Huhn, J., Di Marcantonio, D., Magee, J. A., Goldman, A. R., Tang, H. Y., Ferraro, F., Kemp, S., Wiest, D. L. & Sykes, S. M., May 2024, In: Journal of Biological Chemistry. 300, 5, 107214.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner

Wang, H. C., Chen, R., Yang, W., Li, Y., Muthukumar, R., Patel, R. M., Casey, E. B., Denby, E. & Magee, J. A., Aug 27 2024, In: Cell Reports. 43, 8, 114542.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemia

Eldeeb, M., Yuan, O., Guzzi, N., Thi Ngoc, P. C., Konturek-Ciesla, A., Kristiansen, T. A., Muthukumar, S., Magee, J., Bellodi, C., Yuan, J. & Bryder, D., Feb 28 2023, In: Cell Reports. 42, 2, 112099.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Basal type I interferon signaling has only modest effects on neonatal and juvenile hematopoiesis

Li, Y., Yang, W., Wang, H. C., Patel, R. M., Casey, E. B., Denby, E. & Magee, J. A., Jun 13 2023, In: Blood Advances. 7, 11, p. 2609-2621 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

FLT3^ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiation

Li, Y., Yang, W., Patel, R. M., Casey, E. B., Denby, E., Mendoza-Castrejon, J., Rodriguez-Lopez, P. & Magee, J. A., Mar 23 2023, In: Blood. 141, 12, p. 1442-1456 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Paolino, J., Dimitrov, B., Winger, B. A., Sandoval-Perez, A., Rangarajan, A. V., Ocasio-Martinez, N., Tsai, H. K., Li, Y., Robichaud, A. L., Khalid, D., Hatton, C., Gillani, R., Polonen, P., Dilig, A., Gotti, G., Kavanagh, J., Adhav, A. A., Gow, S., Tsai, J. & Li, Y. D. & 20 others, Ebert, B. L., Van Allen, E. M., Bledsoe, J., Kim, A. S., Tasian, S. K., Cooper, S. L., Cooper, T. M., Hijiya, N., Sulis, M. L., Shukla, N. N., Magee, J. A., Mullighan, C. G., Burke, M. J., Luskin, M. R., Mar, B. G., Jacobson, M. P., Harris, M. H., Stegmaier, K., Place, A. E. & Pikman, Y., 2023, In: Clinical Cancer Research. 29, 22, p. 4613-4626 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2022

A somatic mutation in moesin drives progression into acute myeloid leukemia

Yuan, O., Ugale, A., de Marchi, T., Anthonydhason, V., Konturek-Ciesla, A., Wan, H., Eldeeb, M., Drabe, C., Jassinskaja, M., Hansson, J., Hidalgo, I., Velasco-Hernandez, T., Cammenga, J., Magee, J. A., Niméus, E. & Bryder, D., Apr 2022, In: Science Advances. 8, 16, eabm9987.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice

Bhattacharya, S., Idol, R. A., Yang, W., Rojas Márquez, J. D., Li, Y., Huang, G., Beatty, W. L., Atkinson, J. J., Brumell, J. H., Bagaitkar, J., Magee, J. A. & Dinauer, M. C., May 12 2022, In: Blood. 139, 19, p. 2855-2870 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination

Rosen, S. F., Soung, A. L., Yang, W., Ai, S., Kanmogne, M., Davé, V. A., Artyomov, M., Magee, J. A. & Klein, R. S., Dec 2022, In: Genome medicine. 14, 1, 108.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2021

Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis

Magee, J. A. & Signer, R. A. J., Jan 12 2021, In: Stem Cell Reports. 16, 1, p. 20-28 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy

Chen, R., Okeyo-Owuor, T., Patel, R. M., Casey, E. B., Cluster, A. S., Yang, W. & Magee, J. A., Feb 16 2021, In: Cell Reports. 34, 7, 108751.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Matched targeted therapy for pediatric patients with relapsed, refractory, or high-risk leukemias: A report from the leap consortium

Pikman, Y., Tasian, S. K., Sulis, M. L., Stevenson, K., Blonquist, T. M., Apsel Winger, B., Cooper, T. M., Pauly, M., Maloney, K. W., Burke, M. J., Brown, P. A., Gossai, N., McNeer, J. L., Shukla, N. N., Cole, P. D., Kahn, J. M., Chen, J., Barth, M. J., Magee, J. A. & Gennarini, L. & 33 others, Adhav, A. A., Clinton, C. M., Ocasio-Martinez, N., Gotti, G., Li, Y., Lin, S., Imamovic, A., Tognon, C. E., Patel, T., Faust, H. L., Contreras, C. F., Cremer, A., Cortopassi, W. A., Garrido Ruiz, D., Jacobson, M. P., Dharia, N. V., Su, A., Robichaud, A. L., Saur Conway, A., Tarlock, K., Stieglitz, E., Place, A. E., Puissant, A., Hunger, S. P., Kim, A. S., Lindeman, N. I., Gore, L., Janeway, K. A., Silverman, L. B., Tyner, J. W., Harris, M. H., Loh, M. L. & Stegmaier, K., 2021, In: Cancer discovery. 11, 6, p. 1424-1439 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

2020

Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth

Li, Y., Kong, W., Yang, W., Patel, R. M., Casey, E. B., Okeyo-Owuor, T., White, J. M., Porter, S. N., Morris, S. A. & Magee, J. A., Nov 5 2020, In: Cell Stem Cell. 27, 5, p. 732-747.e7

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98–HOXD13 mouse model of MDS

Monlish, D. A., Greenberg, Z. J., Bhatt, S. T., Leonard, K. M., Romine, M. P., Dong, Q., Bendesky, L., Duncavage, E. J., Magee, J. A. & Schuettpelz, L. G., Aug 2020, In: Experimental Hematology. 88, p. 42-55 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2019

The efficiency of murine MLL-ENL-driven leukemia initiation changes with age and peaks during neonatal development

Okeyo-Owuor, T., Li, Y., Patel, R. M., Yang, W., Casey, E. B., Cluster, A. S., Porter, S. N., Bryder, D. & Magee, J. A., 2019, In: Blood Advances. 3, 15, p. 2388-2399 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2017

PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia

Porter, S. N. & Magee, J. A., Sep 2017, In: Experimental Hematology. 53, p. 43-47 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2016

Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations

Porter, S. N., Cluster, A. S., Yang, W., Busken, K. A., Patel, R. M., Ryoo, J. & Magee, J. A., Nov 23 2016, In: eLife. 5, NOVEMBER2016, e18882.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Pten cell autonomously modulates the hematopoietic stem cell response to inflammatory cytokines

Porter, S. N., Cluster, A. S., Signer, R. A. J., Voigtmann, J., Monlish, D. A., Schuettpelz, L. G. & Magee, J. A., Jun 14 2016, In: Stem Cell Reports. 6, 6, p. 806-814 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

2014

Haematopoietic stem cells require a highly regulated protein synthesis rate

Signer, R. A. J., Magee, J. A., Salic, A. & Morrison, S. J., 2014, In: Nature. 508, 7498, p. 49-54 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

484 Scopus citations

2013

Expression of BCR/ABL p210 from a Knockin Allele Enhances Bone Marrow Engraftment without Inducing Neoplasia

Foley, S. B., Hildenbrand, Z. L., Soyombo, A. A., Magee, J. A., Wu, Y., Oravecz-Wilson, K. I. & Ross, T. S., Oct 17 2013, In: Cell Reports. 5, 1, p. 51-60 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness

Li, Q., Bohin, N., Wen, T., Ng, V., Magee, J., Chen, S. C., Shannon, K. & Morrison, S. J., 2013, In: Nature. 504, 7478, p. 143-147 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

102 Scopus citations

2012

Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression

Magee, J. A., Ikenoue, T., Nakada, D., Lee, J. Y., Guan, K. L. & Morrison, S. J., Sep 7 2012, In: Cell Stem Cell. 11, 3, p. 415-428 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

172 Scopus citations

2006

A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles

Chang, L. W., Nagarajan, R., Magee, J. A., Milbrandt, J. & Stormo, G. D., Mar 2006, In: Genome research. 16, 3, p. 405-413 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element

Magee, J. A., Chang, L. W., Stormo, G. D. & Milbrandt, J., Jan 2006, In: Endocrinology. 147, 1, p. 590-598 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

143 Scopus citations

2003

Haploinsufficiency at the Nkx3.1 locus: A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation

Magee, J. A., Abdulkadir, S. A. & Milbrandt, J., Mar 2003, In: Cancer Cell. 3, 3, p. 273-283 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

121 Scopus citations

2002

Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia

Abdulkadir, S. A., Magee, J. A., Peters, T. J., Kaleem, Z., Naughton, C. K., Humphrey, P. A. & Milbrandt, J., 2002, In: Molecular and cellular biology. 22, 5, p. 1495-1503 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

200 Scopus citations

2001

Expression profiling reveals hepsin overexpression in prostate cancer

Magee, J. A., Araki, T., Patil, S., Ehrig, T., Humphrey, P. A., Watson, M. A., Milbrandt, J., Catalona, W. J. & True, L., Aug 1 2001, In: Cancer research. 61, 15, p. 5692-5696 5 p.

Research output: Contribution to journal › Article › peer-review

356 Scopus citations

1997

Intercompartmental signaling and the regulation of vestigial expression at the dorsoventral boundary of the developing Drosophila wing

Kim, J., Magee, J. & Carroll, S. B., Dec 1 1997, In: Cold Spring Harbor symposia on quantitative biology. 62, p. 283-291 9 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

1996

Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene

Kim, J., Sebring, A., Esch, J. J., Kraus, M. E., Vorwerk, K., Magee, J. & Carroll, S. B., Jul 11 1996, In: Nature. 382, 6587, p. 133-138 6 p.

Research output: Contribution to journal › Article › peer-review

410 Scopus citations

Jeffrey Magee

Research output

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