Jeffrey I. Gordon

1995

Moluccella laevis lectin, a marker for cellular differentiation programs in mouse gut epithelium

Falk, P., Lorenz, R. G., Sharon, N. & Gordon, J. I., 1995, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 268, 4 31-4, p. G553-G567

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Organization of the crypt-villus axis and evolution of its stem cell hierarchy during intestinal development

Hermiston, M. L. & Gordon, J. I., 1995, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 268, 5 31-5, p. G813-G822

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T. & Hannon, G. J., Oct 12 1995, In: Nature. 377, 6549, p. 552-557 6 p.

Research output: Contribution to journal › Letter › peer-review

1177 Scopus citations

Simian virus 40 T antigen-induced amplification of pre-parietal cells in transgenic mice. Effects on other gastric epithelial cell lineages and evidence for a p53-independent apoptotic mechanism that operates in a committed progenitor

Li, Q., Karam, S. M. & Gordon, J. I., 1995, In: Journal of Biological Chemistry. 270, 26, p. 15777-15788 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

Thermodynamic Studies of Myristoyl-CoA: Protein N-Myristoyltransferase Using Isothermal Titration Calorimetry

Bhatnagar, R. S. & Gordon, J. I., Jan 1 1995, In: Methods in enzymology. 250, C, p. 467-486 20 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

1994

Biochemical studies of three Saccharomyces cerevisiae acyl-CoA synthetases, Faa1p, Faa2p, and Faa3p

Knoll, L. J., Johnson, D. R. & Gordon, J. I., Jun 10 1994, In: Journal of Biological Chemistry. 269, 23, p. 16348-16356 9 p.

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Comparison of myristoyl-CoA:protein N-myristoyltransferases from three pathogenic fungi: Cryptococcus neoformans, Histoplasma capsulatum, and Candida albicans

Lodge, J. K., Johnson, R. L., Weinberg, R. A. & Gordon, J. I., Jan 28 1994, In: Journal of Biological Chemistry. 269, 4, p. 2996-3009 14 p.

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Differentiation and self-renewal in the mouse gastrointestinal epithelium

Gordon, J. I. & Hermiston, M. L., Dec 1994, In: Current Opinion in Cell Biology. 6, 6, p. 795-803 9 p.

Research output: Contribution to journal › Article › peer-review

228 Scopus citations

Expression of wild-type and mutant simian virus 40 large tumor antigens in villus-associated enterocytes of transgenic mice

Kim, S. H., Roth, K. A., Coopersmith, C. M., Pipas, J. M. & Gordon, J. I., Jul 19 1994, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 15, p. 6914-6918 5 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Genetic analysis of the role of Saccharomyces cerevisiae Acyl-CoA synthetase genes in regulating protein N-myristoylation

Johnson, D. R., Knoll, L. J., Rowley, N. & Gordon, J. I., Jul 8 1994, In: Journal of Biological Chemistry. 269, 27, p. 18037-18046 10 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Genetic and biochemical studies of protein N-myristoylation

Russell Johnson, D., Bhatnagar, R. S., Knoll, L. J. & Gordon, J. I., 1994, In: Annual review of biochemistry. 63, p. 869-914 46 p.

Research output: Contribution to journal › Review article › peer-review

391 Scopus citations

Ileal lipid-binding protein (Illbp) gene maps to mouse Chromosome 11

Birkenmeier, E. H., Rowe, L. B., Crossman, M. W. & Gordon, J. I., Dec 1994, In: Mammalian Genome. 5, 12, p. 805-806 2 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Isothermal titration calorimetric studies of Saccharomyces cerevisiae myristoyl-CoA:Protein N-myristoyltransferase: Determinants of binding energy and catalytic discrimination among Acyl-CoA and peptide ligands

Bhatnagar, R. S., Jackson-Machelski, E., McWherter, C. A. & Gordon, J. I., Apr 15 1994, In: Journal of Biological Chemistry. 269, 15, p. 11045-11053 9 p.

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Lectins are sensitive tools for defining the differentiation programs of mouse gut epithelial cell lineages

Falk, P., Roth, K. A. & Gordon, J. I., 1994, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 266, 6 29-6, p. G987-G1003

Research output: Contribution to journal › Article › peer-review

159 Scopus citations

Paneth cell differentiation in the developing intestine of normal and transgenic mice

Bry, L., Falk, P., Huttner, K., Ouellette, A., Midtvedt, T. & Gordon, J. I., Oct 25 1994, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 22, p. 10335-10339 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

229 Scopus citations

Regional differences in glycoconjugates of intestinal M cells in mice: Potential targets for mucosal vaccines

Giannasca, P. J., Giannasca, K. T., Falk, P., Gordon, J. I. & Neutra, M. R., 1994, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 267, 6 30-6, p. G1108-G1121

Research output: Contribution to journal › Article › peer-review

161 Scopus citations

Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: An assessment of their role in regulating protein N-myristoylation and cellular lipid metabolism

Johnson, D. R., Knoll, L. J., Levin, D. E. & Gordon, J. I., 1994, In: Journal of Cell Biology. 127, 3, p. 751-762 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

145 Scopus citations

Suppressors of nmt1-181, a conditional lethal allele of the Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase gene, reveal proteins involved in regulating protein N-myristoylation

Johnson, D. R., Cok, S. J., Felomann, H. & Gordon, J. I., Oct 11 1994, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 21, p. 10158-10162 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Targeted gene replacement demonstrates that myristoyl-CoA:protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans

Lodge, J. K., Jackson-Machelski, E., Toffaletti, D. L., Perfect, J. R. & Gordon, J. I., Dec 6 1994, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 25, p. 12008-12012 5 p.

Research output: Contribution to journal › Article › peer-review

173 Scopus citations

The mouse ileal lipid-binding protein gene: A model for studying axial patterning during gut morphogenesis

Crossman, M. W., Hauft, S. M. & Gordon, J. I., Sep 1994, In: Journal of Cell Biology. 126, 6, p. 1547-1564 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

88 Scopus citations

The substrate specificity of saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase: Polar probes of the enzyme's myristoyl-CoA recognition site

Lu, T., Li, Q., Katoh, A., Hernandez, J., Duffin, K., Jackson-Machelski, E., Knoll, L. J., Gokel, G. W. & Gordon, J. I., Feb 18 1994, In: Journal of Biological Chemistry. 269, 7, p. 5346-5357 12 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Toxicity of myristic acid analogs toward African trypanosomes

Doering, T. L., Lu, T., Werbovetz, K. A., Gokel, G. W., Hart, G. W., Gordon, J. I. & Englund, P. T., Oct 11 1994, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 21, p. 9735-9739 5 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Use of isografts to study proliferation and differentiation programs of mouse stomach epithelia

Rubin, D. C., Swietlicki, E. & Gordon, J. I., 1994, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 267, 1 30-1, p. G27-G39

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

1993

A comparative analysis of the kinetic mechanism and peptide substrate specificity of human and Saccharomyces cerevisiae myristoyl-CoA:Protein N-myristoyltransferase

Rocque, W. J., McWherter, C. A., Wood, D. C. & Gordon, J. I., May 15 1993, In: Journal of Biological Chemistry. 268, 14, p. 9964-9971 8 p.

Research output: Contribution to journal › Review article › peer-review

106 Scopus citations

An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium

Falk, P., Roth, K. A., Boren, T., Westblom, T. U., Gordon, J. I. & Normark, S., Mar 1 1993, In: Proceedings of the National Academy of Sciences of the United States of America. 90, 5, p. 2035-2039 5 p.

Research output: Contribution to journal › Article › peer-review

251 Scopus citations

A transgenic mouse model for studying the lineage relationships and differentiation program of type II pneumocytes at various stages of lung development

Hansbrough, J. R., Fine, S. M. & Gordon, J. I., May 5 1993, In: Journal of Biological Chemistry. 268, 13, p. 9762-9770 9 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Calixarenes as hosts in aqueous media: Inclusion complexation of ferrocene derivatives by a water-soluble calix[6]arene

Zhang, L., MacÍas, A., Lu, T., Gordon, J. I., Gokel, G. W. & Kaifer, A. E., 1993, In: Journal of the Chemical Society, Chemical Communications. 12, p. 1017-1019 3 p.

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Cell lineage-specific and differentiation-dependent patterns of CCAAT/enhancer binding protein a expression in the gut epithelium of normal and transgenic mice

Chandrasekaran, C. & Gordon, J. I., Oct 1 1993, In: Proceedings of the National Academy of Sciences of the United States of America. 90, 19, p. 8871-8875 5 p.

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated

Hermiston, M. L., Green, R. P. & Gordon, J. I., Oct 1 1993, In: Proceedings of the National Academy of Sciences of the United States of America. 90, 19, p. 8866-8870 5 p.

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Comparison of the acyl chain specificities of human Myristoyl-CoA synthetase and human myristoyl-CoA:Protein N-myristoyltransferase

Kishore, N. S., Wood, D. C., Mehta, P. P., Wade, A. C., Lu, T., Gokel, G. W. & Gordon, J. I., Mar 5 1993, In: Journal of Biological Chemistry. 268, 7, p. 4889-4902 14 p.

Research output: Contribution to journal › Review article › peer-review

76 Scopus citations

Comparison of the patterns of expression of rat intestinal fatty acid binding protein/human growth hormone fusion genes in cultured intestinal epithelial cell lines and in the gut epithelium of transgenic mice

Rottman, J. N. & Gordon, J. I., Jun 5 1993, In: Journal of Biological Chemistry. 268, 16, p. 11994-12002 9 p.

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Escherichia coli-derived rat intestinal fatty acid binding protein with bound myristate at 1.5 Å resolution and I-FABP^Arg106→Gln with bound oleate at 1.74 Å resolution

Eads, J., Sacchettini, J. C., Kromminga, A. & Gordon, J. I., Dec 15 1993, In: Journal of Biological Chemistry. 268, 35, p. 26375-26385 11 p.

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Genetic and biochemical studies of a mutant Saccharomyces cerevisiae myristoyl-CoA:Protein N-myristoyltransferase, nmt72p^Leu99→Pro, that produces temperature-sensitive myristic acid auxotrophy

Johnson, D. R., Duronio, R. J., Langner, C. A., Rudnick, D. A. & Gordon, J. I., Jan 5 1993, In: Journal of Biological Chemistry. 268, 1, p. 483-494 12 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

High resolution X-ray studies of mammalian intestinal and muscle fatty acid-binding proteins provide an opportunity for defining the chemical nature of fatty acid: protein interactions

Scapin, G., Young, A. C. M., Kromminga, A., Veerkamp, J. H., Gordon, J. I. & Sacchettini, J. C., Jun 1993, In: Molecular and Cellular Biochemistry. 123, 1-2, p. 3-13 11 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Macrocycles used as models to probe the interaction of a fatty acid derivative with its natural receptor

Watanabe, S., Tsesarskaja, M., Lynn, B. C., Hernandez, J. C., Lu, T., Li, Q., Gordon, J. I. & Gokel, G. W., Jan 1 1993, In: Pure and Applied Chemistry. 65, 3, p. 467-472 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

MyristolyCoA:protein N-myristoyltransferase as a therapeutic target for inhibiting replication of human immunodeficiency virus-1

Bryant, M. L., McWherter, C. A., Kishore, N. S., Gokel, G. W. & Gordon, J. I., Aug 1 1993, In: Perspectives in Drug Discovery and Design. 1, 1, p. 193-209 17 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

MyristoylCoA:protein N-myristoyltransferase.

Rudnick, D. A., McWherter, C. A., Gokel, G. W. & Gordon, J. I., 1993, In: Advances in enzymology and related areas of molecular biology. 67, p. 375-430 56 p.

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Rat intestinal fatty acid binding protein: A model system for analyzing the forces that can bind fatty acids to proteins

Sacchettini, J. C. & Gordon, J. I., Sep 5 1993, In: Journal of Biological Chemistry. 268, 25, p. 18399-18402 4 p.

Research output: Contribution to journal › Review article › peer-review

108 Scopus citations

Synthesis of myristic acid analogs with anti-HIV activity that may be resistant to metabolic processing by β-oxidation

Devadas, B., Kishore, N. S., Adams, S. P. & Gordon, J. I., Apr 1993, In: Bioorganic and Medicinal Chemistry Letters. 3, 4, p. 779-784 6 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia

Kim, S. H., Roth, K. A., Moser, A. R. & Gordon, J. I., Nov 1993, In: Journal of Cell Biology. 123, 4, p. 877-893 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

99 Scopus citations

Understanding gastrointestinal epithelial cell biology: Lessons from mice with help from worms and flies

Gordon, J. I., Aug 1993, In: Gastroenterology. 105, 2, p. 315-324 10 p.

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Use of Escherichia coli strains containing fad mutations plus a triple plasmid expression system to study the import of myristate, its activation by Saccharomyces cerevisiae Acyl-CoA synthetase, and its utilization by S. cerevisiae myristoyl-CoA:Protein N-myristoyltransferase

Knoll, L. J. & Gordon, J. I., Feb 25 1993, In: Journal of Biological Chemistry. 268, 6, p. 4281-4290 10 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Use of photoactivatable peptide substrates of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p) to characterize a myristoyl-CoA-Nmt1p-peptide ternary complex and to provide evidence for an ordered reaction mechanism

Rudnick, D. A., Rocque, W. J., Mcwherter, C. A., Toth, M. V., Jackson-Machelski, E. & Gordon, J. I., Feb 1 1993, In: Proceedings of the National Academy of Sciences of the United States of America. 90, 3, p. 1087-1091 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Use of transgenic mice to characterize the multipotent intestinal stem cell and to analyze regulation of gene expression in various epithelial cell lineages as a function of their position along the cephalocaudal and crypt-to-villus (or crypt-to-surface epithelial cuff) axes of the gut

Hermiston, M. L. & Gordon, J. I., Oct 1993, In: Seminars in Developmental Biology. 4, 5, p. 275-291 17 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Use of transgenic mice to map cis-acting elements in the liver fatty acid-binding protein gene (Fabpl) that regulate its cell lineage-specific, differentiation-dependent, and spatial patterns of expression in the gut epithelium and in the liver acinus

Simon, T. C., Roth, K. A. & Gordon, J. I., Aug 25 1993, In: Journal of Biological Chemistry. 268, 24, p. 18345-18358 14 p.

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Use of transgenic mice to study regulation of gene expression in the parietal cell lineage of gastric units

Lorenz, R. G. & Gordon, J. I., Dec 15 1993, In: Journal of Biological Chemistry. 268, 35, p. 26559-26570 12 p.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

1992

4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I

Langner, C. A., Lodge, J. K., Travis, S. J., Caldwell, J. E., Lu, T., Li, Q., Bryant, M. L., Devadas, B., Gokel, G. W., Kobayashi, G. S. & Gordon, J. I., Aug 25 1992, In: Journal of Biological Chemistry. 267, 24, p. 17159-17169 11 p.

Research output: Contribution to journal › Article › peer-review